Clinical trials: Endometriosis Related Pain
Endometriosis, Endometriosis-related Pain
Relugolix for Endometriosis Associated Pain
Endometriosis is a chronic, estrogen-dependent condition frequently associated with pelvic pain and reduced quality of life. Relugolix combination therapy (CT), an oral GnRH receptor antagonist-based treatment, has demonstrated…
- Conditions
- Endometriosis, Endometriosis-related Pain, Pelvic Pain Syndrome
- Trial name
- RELAX (NCT07440043)
- Testing
- Patients with a diagnosis of endometriosis receiving treatment with Relugolix CT, according to clinical practice,
- Volunteers
- 33 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Endometriosis, Endometriosis-related Pain
Histologic Comparison of Ablative Techniques for Endometriosis
To our knowledge, no other human studies directly compare the effectiveness of the various ablative technologies. We set out to design a study to directly compare ablative energy sources and evaluate their ability to destroy…
- Conditions
- Endometriosis, Endometriosis-related Pain, Endometriosis Pelvic, Endometriosis; Peritoneum
- Trial name
- NCT06414083
- Testing
- Diathermy, CO2 Laser, Argon Beam Coagulator
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- TriHealth Inc.
Endometriosis-related Pain, Dyspareunia Deep
Pathways for Patient-centered Diagnosis and Management of Endometriosis-associated Deep Dyspareunia
The purpose of this study is to evaluate the acceptability and effectiveness of two tools that may help address the management of deep dyspareunia: 1) A phallus length reducer (PLR, brand name: Ohnut), consisting of 4…
- Trial name
- NCT04370444
- Testing
- Phallus Length Reducer, Self-assessment of dyspareunia
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- BC Women's Hospital & Health Centre
Endometriosis
The Impact of Yoga on Endometriosis-Related Pain
The central hypothesis of the investigators is that the practice of yoga will result in an improvement of endometriosis related pain symptoms for women with endometriosis.
- Trial name
- NCT06559852
- Testing
- Yoga
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Milton S. Hershey Medical Center
Pelvic Pain Associated With Endometriosis or Adenomyosis, Pelvic Pain Associated With Refractory Endometriosis
Efficacy and Tolerability of TENS in Endometriosis-related Pain
ELECTRE is a single-center, randomized, prospective, longitudinal, controlled, two-arm, single-blind study lasting 4 weeks (P1 investigation phase) after a 4-week run-in period.
- Conditions
- Pelvic Pain Associated With Endometriosis or Adenomyosis, Pelvic Pain Associated With Refractory Endometriosis, Endometriosis
- Trial name
- ELECTRE (NCT07393295)
- Testing
- Conventional TENS, Microstimulation TENS
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Monath Electronic
Endometriosis, Endometriosis Ovary
EHP-5 in Preoperative Assessment in Women With Endometriosis
There is no validated tool in quality-of-life assessment of women with endometriosis in Croatia. First aim is to validate Endometriosis Health Profile-5 (EHP-5) before implementing this questionnaire in clinical practice.
- Conditions
- Endometriosis, Endometriosis Ovary, Endometriosis-related Pain, Quality of Life
- Trial name
- EHP-5CRO (NCT04491305)
- Testing
- Surgically treated women with endometriosis and confirmed diagnosis
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- University of Zagreb
Endometriosis, Endometriosis Related Pain
Dronabinol As an Adjunct for Reducing Pain (DARP)-Texas Children's Hospital
This exploratory, proof-of-concept study is a double-blind (participants and investigators will be blinded), placebo-controlled, randomized, two-arm clinical trial of Marinol [dronabinol, synthetic Δ9-tetrahydrocannabinol (THC)]…
- Conditions
- Endometriosis, Endometriosis Related Pain, Endometriosis, Pain
- Trial name
- NCT06834997
- Testing
- Dronabinol Capsules
- Where
- 2 sites in United States
- Sponsor
- Baylor College of Medicine
Endometriosis, Pain
Endocare® (Single Care) in Pain-related Endometriosis
Endocare® treatment is a stand-alone software medical device, which is composed of a mobile application and an accessory VR headset, intended to mitigate the pain for patients prone to endometriosis.
- Trial name
- NCT04650516
- Testing
- Virtual reality, Digital control
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Lucine
Endometriosis-related Pain
The Role of Thread Embedding Acupuncture for Pain and Quality of Life in Endometriosis Patients
Endometriosis is a common gynecological problem, with pain as the main problem. Pain can be felt for years, in high intensity, continuous, unpredictable, and disrupts the patient's daily life, thereby reducing the quality of…
- Trial name
- NCT06438744
- Testing
- Thread embedding acupuncture (TEA) + standard therapy
- Where
- Indonesia
- Volunteers
- 10 people
- Sponsor
- Universitas Indonesia
Adenomyosis of Uterus
Association of Ultrasound Features of the Myometrium Suggestive of Adenomyosis and Clinical Symptoms
The goal of this study/research is to assess the relationship between ultrasound features of the myometrium suggestive of adenomyosis and clinical symptoms of adenomyosis and to establish a reporting system for adenomyosis…
- Trial name
- MUSA3 (NCT07397715)
- Where
- 5 sites in Belgium, Poland and 2 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Swiss GO Trial Group
Endometriosis
Letrozole vs Danazol for Endometriosis-Related Pain: Randomized Trial
Background: Endometriosis is a chronic gynecological condition defined by the ectopic presence of endometrial glands and stroma outside the uterine cavity, most commonly diagnosed via laparoscopy.
- Trial name
- LET-DAN RCT (NCT07183787)
- Testing
- Letrozole, danazol
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Sidra Salman
Endometriosis, Endometriosis Related Pain
Efficacy of Physical Therapy Treatment in Endometriosis and Its Relationship to Adherence Rates.
The main objective of this study is to know if the application of both therapies, neuroscience pain education plus therapeutic exercise will modify pain, catastrophizing and quality of life in endometriosis.
- Conditions
- Endometriosis, Endometriosis Related Pain, Endometriosis, Pain, Endometriosis-related Pain
- Trial name
- NCT06795243
- Testing
- PAIN NEUROSCIENCE EDUCATION AND THERAPEUTIC EXERCISE PROGRAM, USUAL CARE
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- University of Seville
Endometriosis, Pelvic Pain
Cannabidiol for the Treatment of Pelvic Pain in Endometriosis (DREAMLAND)
The objective of this work is to conduct a randomized, double-blind, placebo-controlled clinical trial to assess the efficacy and safety of cannabis extract in women with endometriosis who have already undergone hormonal…
- Trial name
- DREAMLAND (NCT05670353)
- Testing
- Cannabis Derivatives, Hormonal Contraceptive Agents
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo
Endometriosis-related Pain
A Phase IIa Clinical Study to Assess the Efficacy and Safety of GenSci048 in Patients With Moderate to Severe Endometriosis-Associated Pain
This study is designed to evaluate the safety and efficacy of GenSci048 for moderate to severe endometriosis-associated pain treatment.
- Trial name
- NCT06963177
- Testing
- GenSci048
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Prolapse; Female, Endometriosis-related Pain
Functional Links Between the Temporomandibular Joint and the Pelvis in Gynecology
1 Recruitment. 2. Collection of written consents for the study. 3. Random assignment to groups with and without intervention. 4.
- Trial name
- TMJ and Pelvis (NCT05978414)
- Testing
- Visceral therapy
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Poznan University of Physical Education
Endometriosis, Endometriosis, Rectum
Patient Reported Outcomes After Surgery for Rectal Endometriosis
To describe the difference in patient reported outcomes after conservative treatment in comparison to radical rectal surgery in patients with deep endometriosis infiltrating the rectum (up to 15cm from the anus with at least…
- Conditions
- Endometriosis, Endometriosis, Rectum, Endometriosis-related Pain, Endometriosis; Bowel
- Trial name
- PROCURE (NCT04204707)
- Testing
- PROMS
- Where
- 2 sites in Belgium, Hungary
- Volunteers
- 294 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Endometriosis, Endometriosis-related Pain
Conventional Laparoscopy Versus Robotic Surgery for Pain Relief in Patients With Deep Infiltrating Endometriosis
Background: Endometriosis is a common disease, affecting women in their reproductive age suffering from infertility, adnexal masses and chronic pelvic pain, obstruction of the bowel or urinary tract.
- Conditions
- Endometriosis, Endometriosis-related Pain, Endometriosis Pelvic
- Trial name
- NCT05362838
- Testing
- robotic-assisted laparoscopy, Conventional laparoscopy
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Endometriosis-related Pain, Endometriosis
Pelvic Neuro-Angiogenesis in Deep Endometriosis
Endometriosis is observed in one out of every ten women in society, causing endometrial cells to be found outside their normal location in the body and proliferate in other locations, leading to fibrosis in the tissue due to the…
- Conditions
- Endometriosis-related Pain, Endometriosis, Deep Endometriosis, Endometriosis; Peritoneum
- Trial name
- NCT06286371
- Testing
- Laparoscopic Endometriosis Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Uludag University
Endometriosis Related Pain
SPIRIT 2: Efficacy and Safety Study of Relugolix in Women With Endometriosis-Associated Pain
The purpose of this study is to determine the benefit and safety of relugolix 40 milligrams (mg) once daily, co-administered with low-dose estradiol (E2) and norethindrone acetate (NETA) compared with placebo for 24 weeks, on…
- Trial name
- NCT03204331
- Testing
- Relugolix, Estradiol/norethindrone acetate
- Where
- 91 sites in United States, Australia and 9 more
- Volunteers
- 623 people
- Sponsor
- Myovant Sciences GmbH
Endometriosis, Physical Inactivity
Chronic Pelvic Pain in Endometriosis
Endometriosis is a chronic, inflammatory disease affecting 10% (1 out of 10) of women of reproductive age. Pelvic pain is common among women with endometriosis.
- Conditions
- Endometriosis, Physical Inactivity, Chronic Pelvic Pain Syndrome, Quality of Life
- Trial name
- NCT05863663
- Testing
- questionnaire
- Where
- Hungary
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- University of Pecs