Clinical trials: Endometrium
Infertility, Endometriosis
Platelet Rich Plasma Uterine Infusion
Platelet Rich Plasma (PRP), a rich source of important growth factors, has been shown to significantly affect the body's ability to heal and regenerate tissues.
- Trial name
- NCT06621342
- Testing
- PRP Experimental
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Cancer of Ovary, Endometrium Cancer
The Effect of Logotherapy on Mental Health in Gynecological Cancer Patients
Gynecological cancers negatively affect women's sexuality, fertility, body image, and self-perception, resulting in deterioration in their psychological health.
- Conditions
- Cancer of Ovary, Endometrium Cancer, Cervix Cancer
- Trial name
- NCT05246462
- Testing
- Logotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Infertility, Infertility, Female
The Outcome of Two Protocols Used to Prepare Endometrium for Frozen Embryo Transfer
This is a RCT to test the outcome of two protocols used for preparation of the endometrium for frozen blastocyst embryo transfer
- Conditions
- Infertility, Infertility, Female, Infertility, Male
- Trial name
- NCT04507022
- Testing
- Estradiol Valerate, Progesterone, Aromatase inhibitor
- Where
- Egypt
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Rahem Fertility Center
Fertility, Implantation, Embryo
Cycle-to-cycle Variability of Progesterone in the Endometrium in Patients Undergoing an Euploid Blastocyst Transfer in a Hormone Replacement Therapy (HRT) Cycle (PROMICOFET)
This study looks at progesterone, a hormone that prepares the womb lining (endometrium) for pregnancy, in women having a frozen embryo transfer after IVF.
- Trial name
- PROMICOFET (NCT07818278)
- Testing
- Oestrogel® 0.75 mg (estradiol transdermal gel), Progesterone 200 mg vaginal capsules, Endometrial biopsy
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Menopause
Hormone Replacement Therapy on the Postmenopausal Endometrium
Healthy postmenopausal women, amenorrheic for 1-10 years, aged 45-60 years and in use of follicle stimulating hormone > 30 mille-International unit/milliliters (mIU/mL), will participate in the study.
- Trial name
- NCT02384408
- Testing
- Endometrial Biopsy, Transvaginal Ultrasound, Endometrial Immunohistochemical
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidade do Vale do Sapucai
Endometrium
Endometrial Dating by Ex-vivo Imaging of Endometrial Biopsies of In-vitro Fertilization Candidate Participants
To evaluate the correlation between cycle day determination by clinical signs, study participant testimony, endometrium histopathology biopsy and ex-vivo imaging of the uterus endometrium.
- Trial name
- NCT04288843
- Where
- 2 sites in Israel
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Fertigo Medical Ltd
Infertility
Endometrial Biopsy in Infertile Patients
When a woman becomes pregnant, the fertilized egg attaches itself to the lining of the uterus (endometrium). The endometrium is constantly changing throughout a woman's menstrual cycle in response to the female hormones estrogen…
- Trial name
- NCT00064935
- Testing
- Endometrial biopsy
- Where
- 8 sites in United States
- Volunteers
- 880 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Contraception
Transdermal Contraceptive Patch - Endometrial Effects Study
The aim of the present study is to investigate the effects of the transdermal patch on the endometrium in healthy women who require contraception.
- Trial name
- NCT00896571
- Testing
- Ethinylestradiol/Gestogene (BAY86-5016)
- Where
- Germany
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Bayer
Postmenopausal Bleeding
Vocal in Assessment of Endometrium in Postmenopause
The unbalanced estrogen with no progesterone will lead to endometrial thickening .This thickening result in endometrial hyperplasia \& carcinoma and lead to irregular bleeding
- Trial name
- NCT03404154
- Testing
- 3D ultrasound, Dilatation and curretage
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Aljazeera Hospital
Endometrium Cancer, Oxidative Stress
Evaluation of Thiol Disulfide Balance in Stage 1 Endometrium Cancer
The purpose of this study is to investigate thiol-disulfide balance in early stage endometrium cancer patients.
- Trial name
- NCT04175067
- Testing
- Disulphide(μmol/L), Total Oxidant Capacity(μmolH2O2Equiv/L)
- Where
- Turkey (Türkiye)
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Infertility, Asherman's Syndrome
Platelet-rich Plasma (PRP) for Endometrial Regeneration and Repair
Patients with intrauterine adhesions (Asherman's Syndrome) and persistent thin endometrial lining in in vitro fertilization (IVF) treatment programs, particularly those resistant to standard therapies, present a significant…
- Trial name
- PRP-E (NCT02825849)
- Testing
- Intrauterine infusion of platelet rich plasma
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Infertility Due to Nonimplantation
Autologous Intrauterine Platelet-Rich Plasma Instillation And Endometrial Scratching for Thinned Endometrium
aim of that study is to compare the effect between autologous intrauterine Platelet-Rich Plasma instillation and three snip hysteroscopic endometrial scratching for thinned endometrium.
- Trial name
- NCT04240860
- Testing
- platlet rich plasma, endometrial scratch
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Healthy
Comparison of Blood Levels of Two Formulations of the Selective Hormone Receptor Modulator CDB-2914
This study will compare blood levels of the drug CDB-2914 in healthy women receiving the compound in crystalline powder form with the blood levels of women receiving an identical dose of the drug in micronized form.
- Trial name
- NCT00041899
- Testing
- CDB-2914, COB-2914
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Endometrial Carcinoma
Low Dose Aspirin to Lower Inflammation and Prevent Endometrial Cancer in Postmenopausal Women With Non-atrophic Endometrial Changes and Pain
This phase IV trial studies whether low dose aspirin can be used to lower inflammation and prevent endometrial cancer in postmenopausal women with changes in the endometrial tissue that are not related to thinning (non-atrophic…
- Trial name
- NCT07281547
- Testing
- Biospecimen Collection, Low-Dose Aspirin, Patient Observation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Infertility, Female, ENDOMETRIAL RECEPTIVITY
Impact of Different Doses and Routes of Exogenous Progesterone Administration on Endometrial Receptivity Parameters
After so many years conducting artificial endometrial preparation cycles for embryo transfer, there is no clear indication about which is the optimal dose of exogenous progesterone in this scenario to optimize the outcome.
- Trial name
- PROGENDO (NCT04499131)
- Testing
- Progesterone, Artificial Cycle (no intervention)
- Where
- Spain
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Metformin, CA Endometrium
Comparison of the Effectiveness Metformin for Deceasing Proliferative Marker in Endometrial Cancer Cells
Comparison of the effectiveness metformin versus placebo for deceasing proliferative marker Ki-67 expression in endometrial tumours when given for 4 weeks before hysterectomy in endometrial cancer cells.
- Trial name
- NCT03618472
- Testing
- Metformin Hydrochloride 850 MG
- Where
- Thailand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Extracellular Vesicles
Isolation and Characterization of the Extracellular Vesicles Secreted by the Human Endometrium
The main aim of this study is to describe the morphology, size distributions and specific markers of the different vesicles populations present in the human endometrial fluid.
- Trial name
- NCT02797834
- Testing
- Endometrial fluid collection
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Igenomix
Fertility
The Effect of Progesterone on Human Endometrium
This study evaluates the relationship between progesterone levels and endometrial gene expression
- Trial name
- NCT04323683
- Testing
- Microarray
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Postmenopause
Use of the Synthetic Hormone CDB-2914 in Treating Symptoms of Menopause
This study will examine the safety and effectiveness of a synthetic hormone, CDB-2914, for treating symptoms of menopause. It will compare the effects of estrogen and CDB-2914 with those of estrogen and progesterone in…
- Trial name
- NCT00009659
- Testing
- CDB 2914
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Endometriosis
Somatic Stem Cells in Endometriosis
Human endometrium is a very dynamic tissue characterized by cyclical process of proliferation, differentiation and cellular shedding as part of each menstrual cycle. This issue suggests the presence of somatic stem cells.
- Trial name
- NCT01412138
- Testing
- genetic analysis
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Igenomix