Clinical trials: Endomicroscopy
Peripheral Pulmonary Lesions
Optical Biopsy for Peripheral Pulmonary Lesions
The purpose of the study is to describe confocal laser endomicroscopy (CLE) interpretation criteria for different types of peripheral pulmonary lesions (PPLs), with histopathological correlation, and to perform the validation of…
- Trial name
- NCT06457087
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shanghai Chest Hospital
Bowel Endometriosis
The Application of Probe-based Confocal Laser Endomicroscopy in the Diagnosis of Deep Endometriosis
Endometriosis is defined as the presence of endometrial glands and stroma outside of the uterus.Endometriosis affects 5%-15% of women in the reproductive age.
- Trial name
- NCT02547909
- Testing
- probe-based Confocal Laser Endomicroscopy, Cellvizio, fluorescein 10%
- Where
- Israel
- Sponsor
- Dr. Ofir Harnoy MD
Pancreatic Neoplasms, CHRONIC PANCREATITIS
Needle-based Confocal Endomicroscopy Examination of Pancreatic Masse
Introduction: Pancreatic cancer is one of the most aggressive malignancies with only 5% of patients being alive at five years. EUS (endoscopic ultra sound) is an established, sensitive diagnostic tool in pancreatic cancer and for…
- Trial name
- NCT01734967
- Testing
- needle based CLE, EUS-FNA
- Where
- 2 sites in Denmark, Romania
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Obesity
Identification of In-vivo Probe Based Confocal Laser Endomicroscopy Cellular Characteristics in Obese Women
Previous studies have shown that histological changes in the gastric mucosa between obese and non-obese individuals do exist. Understanding these histological differences (between obese and non-obese individuals) might elucidate…
- Trial name
- NCT02781961
- Testing
- cellvizio
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Sheba Medical Center
Pancreatic Cysts
Confocal Endomicroscopy of Pancreatic InVivo
Confocal laser endomicroscopy (CLE) is a novel and highly promising imaging method for that allows in vivo imaging of the mucosal layer at resolution of approximately 1 micron.
- Trial name
- NCT01035008
- Testing
- Endoscopic Ultrasound (EUS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Cervix Cancer, Endometrium Cancer
Probe-based and Needle-based Confocal Laser Endomicroscopy During Gynaecological Procedures.
The protocol aims at demonstrating the technical feasibility and safety of doing endomicroscopic imaging (both probe-based confocal laser endomicroscopy (pCLE) and needle-based confocal laser endomicroscopy, nCLE) during…
- Conditions
- Cervix Cancer, Endometrium Cancer, Ovarian Cancer, Carcinoma in Situ of Fallopian Tube
- Trial name
- NCT02221076
- Testing
- Confocal Laser Endomicroscopy (CLE)
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Mauna Kea Technologies
Pancreatic Cysts
Diagnosis of Pancreatic Cysts: Endoscopic Ultrasound With Fine Needle Aspiration (EUS/FNA), Direct Visualization, and Confocal Laser-induced Endomicroscopy-A Pilot Study
The purpose of this study is to assess the yield of combination modalities in the diagnosis of pancreatic cysts using EUS/FNA, Fiber optics (direct visualization probe), and prototype needle based confocal laser-induced…
- Trial name
- NCT01447238
- Testing
- Direct visualization and needle based confocal laser-induced endomicroscopy miniprobe
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of California, Irvine
Cancer of Digestive System, Ovarian Cancer
Feasibility Study for Robotic Endomicroscopy to Better Define Resection Strategies (PERSEE)
This study aims at demonstrating the feasibility of probe-based confocal laser endomicroscopy (pCLE) and needle-based confocal laser endomicroscopy (nCLE).
- Trial name
- PERSEE (NCT02312167)
- Testing
- confocal laser endomicroscopy
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Institut Mutualiste Montsouris
Gastric Cancer (Diagnosis), Gastric High-grade Intraepithelial Neoplasia
Comparison of the Sensitivity of pCLE and Pathological Biopsy Before ESD
Pathological biopsy before endoscopic submucosal dissection (ESD) the gastric lesion plays an important role in differentiating the pathological nature of the lesion and guiding treatment decisions.
- Conditions
- Gastric Cancer (Diagnosis), Gastric High-grade Intraepithelial Neoplasia, Gastric Low-grade Intraepithelial Neoplasia, Gastritis
- Trial name
- NCT07088744
- Testing
- Probe-based Confocal Laser Endomicroscopy, Pathological biopsy
- Where
- 4 sites in China
- Volunteers
- 169 people
- Sponsor
- Changhai Hospital
Barrett Esophagus
Predict Recurrence of Barrett's Esophagus After Complete Eradication of Intestinal Metaplasia
Researchers are trying to see if the Nvision® Imaging System (VLE) can accurately determine the risk of recurrent Barrett's esophagus in patients with Barrett's esophagus which have been clear of disease.
- Trial name
- NCT03670134
- Testing
- The Nvision VLE Imaging System
- Sponsor
- Mayo Clinic
Prostate Cancer
Clinical Trial for a Robotic Endomicroscopy to Better Define Resection Strategies Applied to Urology Surgery
This multicenter study aimed at assessing the feasibility of Probe-based Confocal Laser Endomicroscopy (pCLE) during Robotic-Assisted Radical Prostatectomy or Laparoscopic Radical Prostatectomy for intra-operative…
- Trial name
- PERSEE II (NCT03561857)
- Testing
- Confocal Laser Endomicroscopy
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Mauna Kea Technologies
Healthy
Pilot Study for Imaging of the Esophagus Using Tethered Capsule OCT Endomicroscopy With Distal Scanning
The purpose of this study is to test feasibility of a redesigned tethered capsule catheter that contains an integrated micro-motor. Investigators will be testing imaging of this new technology in healthy volunteers.
- Trial name
- NCT02947997
- Testing
- OFDI capsule
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Barrett's Esophagus Without Dysplasia, Barrett's Esophagus With Dysplasia
Volumetric Laser Endomicroscopy With Intelligent Real-time Image Segmentation (IRIS)
This is a prospective randomized clinical trial examining how IRIS (Intelligent Real-time Image Segmentation) affects biopsy patterns in VLE (Volumetric laser endomicroscopy).
- Conditions
- Barrett's Esophagus Without Dysplasia, Barrett's Esophagus With Dysplasia, Barrett's Esophagus With Low Grade Dysplasia, Barrett's Esophagus With High Grade Dysplasia
- Trial name
- NCT03814824
- Testing
- IRIS (Intelligent real-time image segmentation), VLE (Volumetric laser endomicroscopy)
- Where
- 3 sites in United States
- Volunteers
- 148 people
- Sponsor
- Northwell Health
Prostate Cancer
Focal Prostate Imaging With CLE and OCT
The current limitations in prostate cancer diagnostics lead to over- and undertreatment for a significant fraction of patients. Confocal Laser Endomicroscopy (CLE) and Optical Coherence Tomography (OCT) are focal imaging…
- Trial name
- FPI (NCT03253458)
- Testing
- Confocal Laser Endomicroscopy
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Flow Determination
Real-time Observation of Microcirculatory Hemodynamics in Gastric Intestinal Metaplasia by Confocal Laser Endomicroscopy
The morphologic change of microvessels has the clinical value to distinguish cancerous from non-cancerous mucosa. The aim of this study was to observe gastric mucosa microcirculatory hemodynamic changes real-time using pCLE…
- Trial name
- NCT02595151
- Testing
- CLE
- Where
- China
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Shandong University
Inflammatory Bowel Disease, Crohn's Disease
Endoscopy and Endomicroscopy for Assessment of Mucosal Healing in Inflammatory Bowel Disease (IBD)
Inflammatory bowel disease (IBD) encompasses two major forms of chronic intestinal disorders, Crohn's disease and ulcerative colitis (UC).
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT01524120
- Testing
- Endoscopy (EPK-i, Pentax, Tokyo, Japan), Endomicroscopy (iCLE, Pentax, Tokyo, Japan)
- Where
- Germany
- Sponsor
- University of Erlangen-Nürnberg Medical School
Breast Cancer Invasive, Breast Cancer Surgery
Confocal Histolog Scanner in Routine Breast-Conserving Surgery (CHiB)
The clinical performance study is collecting data from the use of a CE mark product used within the scope of its intended purpose to intraoperatively visualize tissue specimen.
- Conditions
- Breast Cancer Invasive, Breast Cancer Surgery, Lumpectomy, Confocal Laser Endomicroscopy
- Trial name
- CHiB (NCT06958991)
- Testing
- Histolog Scanner
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Fribourg
Colorectal Polyps
Confocal Laser Endomicroscopy With Topical Cresyl Violet for Colorectal Polyps
Probe-based confocal laser endomicroscopy (pCLE) has been shown to a reliable diagnostic method enabling in vivo microscopic imaging during ongoing endoscopy.
- Trial name
- NCT03620695
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shandong University
Gastroesophageal Reflux Disease
Diagnostic Value of Flexible Spectral Imaging Color Enhancement (FICE) Plus Probe-based Confocal Laser Endomicroscopy (pCLE) for Minimal Change Esophageal Reflux Disease (MERD) Diagnosis
Gastroesophageal reflux disease (GERD) patients without obvious mucosal break by endoscopy were examined by FICE, followed by confocal. Validity scores for MERD diagnosis were analyzed.
- Trial name
- NCT02336100
- Testing
- Endoscopy (FICE and pCLE)
- Where
- Thailand
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- King Chulalongkorn Memorial Hospital
Barrett's Esophagus, Esophageal Adenocarcinoma
Confocal Endomicroscopy for Barrett's Esophagus
The purpose of this study is to determine if confocal laser endomicroscopy (CLE) can improve detection of Barrett's esophagus, dysplasia, and early esophageal cancer.
- Trial name
- CEBE (NCT00487695)
- Testing
- confocal laser endomicroscopy (CLE), standard endoscopy (EGD)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Johns Hopkins University