Clinical trials: Endophthalmitis
Endophthalmitis, Infectious Endophthalmitis
Vitrectomy Combined With Povidone-Iodine Vitreous Irrigation for Infectious Endophthalmitis
Infectious endophthalmitis is a severe infection inside the eye that can rapidly cause permanent vision loss or loss of the eye.
- Trial name
- NCT07888205
- Testing
- Povidone-iodine intravitreal irrigation with povidone-iodine containing 0.0025% available iodine, BSS intravitreal irrigation solution
- Volunteers
- 38 people
- Sponsor
- Beijing Tongren Hospital
Endophthalmitis
Nanopore Sequencing in Ophthalmology
In this pilot study, the feasibility of the Oxford Nanopore MinION to identify pathogens from vitrectomy samples in eyes with endophthalmitis shall be assessed.
- Trial name
- NCT05372861
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Graz
Cataract, Postoperative Endophthalmitis
Intracameral Levofloxacin Versus Moxifloxacin After Cataract Surgery
This randomized study aims to compare the safety and efficacy of intracameral levofloxacin versus intracameral moxifloxacin administered at the end of phacoemulsification cataract surgery.
- Trial name
- NCT07850414
- Testing
- Levofloxacin, Moxifloxacin
- Volunteers
- 93 people
- Sponsor
- Assiut University
Endophthalmitis
Safety and Efficacy of Intracameral Zimoxin for Prevention of Endophthalmitis After Cataract Surgery
Intracameral injection of 0.1% moxifloxacin solution after cataract surgery to prevent endophthalmitis
- Trial name
- NCT03244072
- Testing
- Moxifloxacin
- Where
- United States
- Volunteers
- 60,000 people, healthy volunteers welcome
- Sponsor
- Jason Ahee, M.D.
Endophthalmitis, Endophthalmitis Postoperative
Phacovitrectomy Versus Pars Plana Vitrectomy Alone for Post-Intravitreal Injection Endophthalmitis
This prospective comparative interventional study evaluated the anatomical and visual outcomes of phacovitrectomy versus pars plana vitrectomy (PPV) alone in patients with post-intravitreal injection endophthalmitis.
- Conditions
- Endophthalmitis, Endophthalmitis Postoperative, Intravitreal Injection Patients
- Trial name
- NCT07717944
- Testing
- Phacovitrectomy, Pars plana vitrectomy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Benha University
Endophthalmitis
First-line Surgical Versus Medical Treatment: A Retrospective Study From 2014 to 2024 in Brest (BRESTE)
The goal of this observational cohort study is to evaluate the impact of early pars plana vitrectomy (PPV) on visual outcomes in adults diagnosed with acute endophthalmitis.
- Trial name
- BRESTE (NCT07514845)
- Testing
- Early pars plana vitrectomy (PPV) with intravitreal antibiotics
- Where
- France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Brest
Uveitis Posterior Non-Infectious, Inflammation Eye
Targeting Immunosuppressive Treatment for Non-infectious Uveitis Using Aqueous Humor Cytokine Profiles
This multicenter, prospective, interventional, non-pharmacological study aims to investigate whether the intraocular cytokine profile is associated with the therapeutic response to immunosuppressive drugs in patients with…
- Conditions
- Uveitis Posterior Non-Infectious, Inflammation Eye, Uveitis, Uveitis, Anterior
- Trial name
- PRIN_NIU (NCT07262437)
- Testing
- to improve clinical practice in treatment of non-infective uveitis
- Where
- 3 sites in Italy
- Volunteers
- 220 people
- Sponsor
- University of Milan
Endophthalmitis
Vascular Changes Associated With Endophthalmitis.
This study aims to describe and investigate vascular changes associated with exogenous endophthalmitis, as well as to create a photo library where they are evidenced
- Trial name
- NCT07175311
- Testing
- Multimodal imaging findings
- Where
- Mexico
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Asociación para Evitar la Ceguera en México
Uveitis, Scleritis and Episcleritis
Demographics and Clinical Characteristics of Ocular Inflammatory Diseases in Singapore
This is a retrospective study analyzing demographics, clinical characteristics, treatment received, and outcomes of ocular inflammatory diseases that presented to the Singapore National Eye Centre (SNEC).
- Conditions
- Uveitis, Scleritis and Episcleritis, Endophthalmitis, Masquerade Syndromes
- Trial name
- NCT07176130
- Testing
- No Intervention: Observational Cohort
- Where
- Singapore
- Volunteers
- 200 people
- Sponsor
- Singapore National Eye Centre
Endophthalmitis, Keratitis
Complex Ocular Infection, Optimization of Microbiological Diagnosis
The purpose of this study is to evaluate the impact of different technique to optimize the microbiological diagnosis of the COI. Metagenomic for the endophtalmitis Multiplex polymerase chain reaction for corneal abscesses
- Trial name
- ICODIA (NCT05432336)
- Testing
- NGS for endohtalmitis / Multiplex PCR for keratitis
- Where
- France
- Volunteers
- 153 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Endophthalmitis Postoperative Acute
A Feasibility Randomised Controlled Trial of Early Vitrectomy for Post-operative Exogenous Endophthalmitis
This randomised clinical trial will explore the feasibility and acceptability of carrying out early vitrectomy surgical treatment compared to standard treatment in acute endophthalmitis.
- Trial name
- EVIAN (NCT04522661)
- Testing
- Vitrectomy, Intravitreal antibiotics
- Where
- United Kingdom
- Volunteers
- 63 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Inflammation Eye
Bromfenac Versus Dexamethasone After Cataract Surgery
The aim of the study is to compare bromfenac to dexamethasone eye drops to control inflammation after cataract surgery. Inflammation in the anterior chamber of the eye will be measured by a Laser Flare Photometer (LFP).
- Trial name
- BVD (NCT03317847)
- Testing
- Bromfenac 0.09 % Ophthalmic Solution, Dexamethasone 0.1% ophthalmic suspension
- Where
- Italy
- Volunteers
- 92 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Inflammation and Pain Following Ocular Surgery
RTA 408 Ophthalmic Suspension for the Treatment of Ocular Inflammation and Pain Following Ocular Surgery
This study assesses the efficacy and safety of two concentrations of RTA 408 Ophthalmic Suspension in the treatment of patients who have inflammation and pain following ocular surgery.
- Trial name
- NCT02065375
- Testing
- Omaveloxolone Ophthalmic Suspension 1.0%, Omaveloxolone Opthalmic Suspension 0.5%
- Where
- 6 sites in United States
- Volunteers
- 109 people
- Sponsor
- Biogen
Endophthalmitis Following Cataract Surgery
Compare PPV With and Without Silicone Oil in Managing Postoperative Endophthalmitis
Comparing PPV with and without silicone oil in managing postoperative endophthalmitis
- Trial name
- Endopthalmitis (NCT06990607)
- Testing
- Pars plana Vitrectomy, Silicone Oil
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Benha University
Endophthalmitis
Clinical Features and Visual Prognosis of Infectious Endophthalmitis
The aim of this observational study was to retrospectively examine the clinical data of patients with infectious endophthalmitis and to analyse their clinical characteristics.
- Trial name
- NCT06755177
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhongnan Hospital
Endophthalmitis
Evaluation and Risk Factors of Post-traumatic Endophthalmitis
1. identify the incidence of post-traumatic endophthalmitis and the related risk factors influencing its development. 2. study the clinical- microbiological profile and evaluate the functional and anatomical outcomes of…
- Trial name
- NCT06673784
- Testing
- ophthalmic saline eye drops, Saline
- Volunteers
- 41 people
- Sponsor
- Assiut University
Ocular Surface Symptom, Ocular Surface Disease
Efficacy and Safety of Topical Cyclosporine 0.05% and Lifitgrast on the Ocular Surface Symptom After Photorefractive Keratectomy in Feiz Hospital, Isfahan, 2024
The goal of this clinical trial is to compare the administration of 2 drugs, cyclosporine 0.05% (Restasis) and Lifitgrast (Xiidra) before PRK, in reducing the ocular surface symptom of patients after PRK.
- Conditions
- Ocular Surface Symptom, Ocular Surface Disease, Eye Pain, Eye Inflammation
- Trial name
- NCT06624384
- Testing
- Group 1 drug, Group 3: Drug and palcebo
- Where
- Iran
- Volunteers
- 150 people
- Sponsor
- Mohsen Pourazizi
Endophthalmitis
Evaluation do Early Pars Plana Vitrectomy in Acute Endophthalmitis
Our study will evaluate the efficacy of early PPV in acute endophthalmitis and attempt to prove its greater effectiveness for combating infection when compared to eyes that received only intravitreal antibiotic therapy
- Trial name
- NCT04192994
- Testing
- Intravitreal Antibiotic Injection, Pars Plana Vitrectomy
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Federal University of São Paulo
Post Operative Endophthalmitis
Effectiveness and Safety of 0.5% Moxifloxacin Hydrochloride Ophthalmic Solution in Perioperative Sterilization in Patients Undergoing Ophthalmic Surgery
This is a non-interventional, uncontrolled, prospective, multicenter, post marketing surveillance study.
- Trial name
- NCT05413980
- Testing
- Moxifloxacin hydrochloride ophthalmic solution
- Where
- 9 sites in India
- Volunteers
- 102 people
- Sponsor
- Novartis Pharmaceuticals
Endophthalmitis
Ozurdex Endophtamitis Cohort, Prognostic Assessment at 12 Months
OZURDEX endophthalmitis is a rare and potentially very serious pathology. Different treatments can be carried out early and change the functional prognosis of the patient.
- Trial name
- NCT06268561
- Testing
- Visual acuity analysis, Intraocular pressure analysis, Analysis of optical coherence tomography (OCT) images
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne