Clinical trials: Endoplasmic Reticulum Stress
Periodontitis, Gingivitis and Periodontal Diseases
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)
This observational cross-sectional study investigates the levels of mitochondria-endoplasmic reticulum contact site (MERC) proteins in saliva and gingival crevicular fluid (GCF) of individuals with different periodontal…
- Conditions
- Periodontitis, Gingivitis and Periodontal Diseases, Biomarker Discovery and Validation, Pathways
- Trial name
- EKNMERC-GCF-SL (NCT07601685)
- Testing
- ELISA Biomarker Analysis, Calcium Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Inonu University
Recurrent Pregnancy Loss, Endoplasmic Reticulum Stress
Evaluation of Endoplasmic Reticulum Stress in Patients With Recurrent Pregnancy Loss
To evaluate endoplasmic reticulum stress in women with recurrent pregnancy loss and those who had healthy births in the same age group. The level of the unfolded protein X box binding protein 1 (XBP-1) is measured.
- Trial name
- NCT04455256
- Testing
- x box binding protein
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Periodontitis, Gingivitis
Endoplasmic Reticulum Stress Response in Periodontal Disease
Periodontal disease causes inflammation and damage to the tissues that support the teeth. This study looks at whether stress inside gum cells contributes to this damage.
- Trial name
- NCT07751419
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Inonu University
Type 2 Diabetes Mellitus
Effects of Dietary Supplement Tauroursodeoxycholic Acid on Vascular Function
The purpose of the present study is to determine if use of dietary supplement tauroursodeoxycholic acid enhances insulin-stimulated leg blood flow and glucose disposal.
- Trial name
- NCT03331432
- Testing
- Tauroursodeoxycholic acid
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Missouri-Columbia
Endoplasmic Reticulum Stress, Viral Infection
Modulate Cellular Stress in the Immune Cells to Reduce Rate of Symptomatic Viral Infection
To determine the efficacy of metformin in reducing the rate of symptomatic YF17D infection, and to elucidate the effects of metformin on YF17D viremia and the downstream adaptive immune response, we hereby propose a randomised…
- Conditions
- Endoplasmic Reticulum Stress, Viral Infection, Yellow Fever
- Trial name
- NCT04267809
- Testing
- Metformin Hydrochloride, Calcium and Vitamin D
- Where
- Singapore
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Polycystic Ovary Syndrome
Involvement of Reticulum Endoplasmic Stress in the Physiopathology of Polycystic Ovary Syndrome
The main objective of the present project is to evaluate the relevance of reticulum stress in the pathogenesis of polycystic ovary syndrome (PCOS), focusing particularly on the underlying mechanisms of insulin resistance, which…
- Trial name
- PI12/1984 (NCT02302326)
- Testing
- Metformin, Myo-inositol + folic acid
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Adenoiditis Acute Infective
Relationship of Endoplasmic Reticulum Stress and Adenoid Diseases
Adenoid tissue is a significant organ for the performing of immune systems in children. The Endoplasmic Reticulum (ER), is an organelle needed for the care of a stable function of cells.
- Trial name
- NCT04583631
- Testing
- Adenoidectomy surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Selcuk University
Type 1 Diabetes
Tauroursodeoxycholic Acid (TUDCA) in New-Onset Type 1 Diabetes
Clinically, the ability to slow or prevent beta cell demise can prevent or improve the course of type 1 diabetes. The immune-mediated destruction of beta cells that is an apparent major pathological basis for the disease, has led…
- Trial name
- NCT02218619
- Testing
- Tauroursodeoxycholic Acid (TUDCA)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Robin Goland, MD
Type 2 Diabetes, Prediabetes
The Effect of A-lipoic Acid (ALA) on Fatty Acid-induced Impairment of Glucose-stimulated Insulin Secretion
Chronically elevated free fatty acids impair insulin sensitivity and insulin secretion (ie lipotoxicity) by a combination of oxidative stress, endoplasmic reticulum (ER) stress and inflammation.
- Trial name
- NCT01056497
- Testing
- alpha lipoic acid
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Covid19, Endoplasmic Reticulum Stress
High GRP78 Levels in Covid-19 Infection: A Case-Control Study
Covid-19 infection was declared a global pandemic by WHO on March 11, 2020. GRP78 protein is known to be involved in the intrusion of numerous viruses.
- Trial name
- NCT04628637
- Testing
- Serum protein level analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Kafkas University
Cardiac Surgery
Study of the Expression of Endoplasmic Reticulum Stress During Extracorporeal Circulation in Humans
The links between systemic inflammation, endothelial dysfunction and endoplasmic reticulum (ER) stress in pre-clinical models make it an interesting potential therapeutic target, but there are no data describing SRE during severe…
- Trial name
- STRECH (NCT03722979)
- Testing
- Cardiac surgery
- Where
- France
- Volunteers
- 53 people
- Sponsor
- University Hospital, Rouen
Tracheal Intubation, Extracorporeal Membrane Oxygenation
Mechanism of Nitric Oxide on Ventilator-induced Diaphragm Dysfunction with Extracorporeal Membrane Lung Assistance
The goal of this clinical trial is to explore the effect of NO treatment on diaphragm function after mechanical ventilation with ECMO assistance.
- Conditions
- Tracheal Intubation, Extracorporeal Membrane Oxygenation, Nitric Oxide, Ventilator-induced Diaphragmatic Dysfunction
- Trial name
- NCT06660784
- Testing
- Nitric Oxide
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhongnan Hospital
HIV Related Insulin Resistance, Protease Inhibitor Related Insulin Resistance
Tauroursodeoxycholic Acid for Protease-inhibitor Associated Insulin Resistance
Rates of cardiovascular disease and diabetes are more than 2-fold greater in HIV infected people than the general population. Protease inhibitor booster antiretroviral therapy (PI-ART) which is used by ~50% of HIV infected people…
- Conditions
- HIV Related Insulin Resistance, Protease Inhibitor Related Insulin Resistance, Endoplasmic Reticulum Stress
- Trial name
- NCT01877551
- Testing
- Tauroursodeoxycholic acid
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Washington University School of Medicine
Diabetes Mellitus, Type 2, Insulin Response
Effects of TUDCA on Endothelial Function in Type 2 DM
The pilot study is designed to investigate the acute and chronic effects of the diet supplement tauroursodeoxycholic acid (TUDCA) on endothelial function in participants with type 2 diabetes mellitus.
- Conditions
- Diabetes Mellitus, Type 2, Insulin Response, Endothelial Dysfunction
- Trial name
- NCT03462940
- Testing
- Tauroursodeoxycholic acid
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Boston University
Tonsillitis, Tonsillar Hypertrophy
Relationship of Endoplasmic Reticulum Stress and Tonsillar Tissue Diseases
Tonsillar tissue is a significant organ for the performing of immune systems in children. The Endoplasmic Reticulum (ER), is an organelle needed for the care of a stable function of the cells.
- Conditions
- Tonsillitis, Tonsillar Hypertrophy, Immune System Diseases
- Trial name
- NCT04653376
- Testing
- Tonsillectomy surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Selcuk University
Polycythemia Vera, Essential Thrombocythemia
Endoplasmic Reticulum Stress and Resistance to Treatments in Ph-negative Myeloproliferative Neoplasms
The aim of this study is to evaluate the endoplasmic reticulum stress markers as predictive for response to hydroxyurea in polycythemia vera (PV) and essential thrombocythemia (ET).
- Trial name
- PhiNESS (NCT02823184)
- Testing
- RNA sample of total leukocytes before start of treatment
- Where
- 7 sites in France
- Volunteers
- 148 people
- Sponsor
- University Hospital, Bordeaux
ACHROMATOPSIA 7, Achromatopsia
PBA Use for Treatment of ATF6-/- Patients
Some patients with achromatopsia, an inherited disorder characterized by partial or complete loss of color vision, carry mutations in ATF6.
- Trial name
- NCT04041232
- Testing
- PBA
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Columbia University
Effect of High Protein Diet on Endoplasmic Reticulum Stress
Effect of Protein on Endoplasmic Reticulum Stress
This study was planned to provide information about the effect of short-term high protein diet (HPD) feeding on endoplasmic reticulum stress. The definition of HPDs cannot be determined exactly.
- Trial name
- NCT06621901
- Testing
- High Protein Diet, Normal Protein Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Obesity, NAFLD
ER Stress in NAFLD
The investigators overall hypothesis is that exacerbation of endoplasmic reticulum (ER) stress in the liver is associated with significant alterations in phosphatidylcholines that drive the NASH phenotype in obese humans.
- Trial name
- NCT01807910
- Testing
- methyl-D9-choline
- Where
- United States
- Sponsor
- Vanderbilt University
Hypertension
Targeting Endoplasmic Reticulum Stress in Human Hypertension
There is strong evidence suggesting that endoplasmic reticulum stress contributes to neurogenic and vascular hypertension in various animal models, however this has never been explored in humans.
- Trial name
- NCT06025630
- Testing
- TUDCA
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of North Texas Health Science Center