Clinical trials: Endoscopic Hemostasis
Duodenal Bleeding
Haemostatic Gel Prophylaxis for Post Duodenal Endoscopic Resection Bleeding
The purpose of this study is to test whether prophylactic application of haemostatic gel will reduce the rate of clinically significant bleeding requiring intervention (such as blood transfusion, admission to hospital, other…
- Trial name
- PURASTAT (NCT05746884)
- Testing
- duodenal mucosectomy, ampullectomy
- Where
- France
- Volunteers
- 67 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Endoscopic Submucosal Dissection, Endoscopic Submucosal Dissection (ESD)
The Improvement Effect of Real-time Artificial Intelligence Assisted Identification of Bleeding Points on Hemostasis Efficiency in Endoscopic Submucosal Dissection
The goal of this clinical trial is to learn if an artificial intelligence (AI) system that identifies bleeding points in real time can help stop bleeding faster during endoscopic submucosal dissection (ESD) - a minimally invasive…
- Trial name
- NCT07495137
- Testing
- AI real-time assistance in endoscopic submucosal dissection (ESD) for bleeding spot identification and marking
- Volunteers
- 160 people
- Sponsor
- Qilu Hospital of Shandong University
Upper Gastrointestinal Hemorrhage
Standard Endoscopic Hemostasis Versus OVESCO Severe Non-variceal UGI Hemorrhage
The primary specific aim is to perform a randomized controlled trial (RCT) to compare 30 day rebleed rates and other clinical outcomes of patients with severe, non-variceal upper GI hemorrhage (NVUGIH) - ulcers and Dieulafoy's…
- Trial name
- NCT03065465
- Testing
- Over-the-scope hemoclipping device, Standard endoscopic treatment
- Where
- 2 sites in United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- CURE Digestive Diseases Research Center
Upper GI Bleeding, Proton Pump Inhibitors
PPI Infusion Versus Oral Acid Pump Inhibitors for Bleeding Peptic Ulcers
Vonoprazan (VPZ), an oral potassium-competitive acid blocker (P-CAB) has emerged as an alternative potent acid-suppressant.It has a faster onset of action in 1 day (3-5 days in PPI), and is more stable in acidic condition than…
- Trial name
- NCT05582174
- Testing
- Vonoprazan, esomeprazole
- Where
- 8 sites in China
- Volunteers
- 594 people
- Sponsor
- Chinese University of Hong Kong
Nonvariceal Upper Gastrointestinal Bleeding
Effectiveness of 'Nexpowder' for Hemostatic Treatments of Nonvariceal, Upper Gastrointestinal Bleeding
A prospective, multi-center, randomized controlled trial to evaluate safety and effectiveness of endoscopic hemostatic powder, 'Nexpowder' for hemostatic treatments of nonvariceal upper gastrointestinal bleeding.
- Trial name
- NCT04124588
- Testing
- Nexpowder (Hemostatic powder), Conventional Technique
- Where
- 3 sites in South Korea
- Volunteers
- 348 people
- Sponsor
- Next Biomedical Co., Ltd.
Sinusitis
Triamcinolone Packing Following Endoscopic Sinus Surgery
Endoscopic sinus surgery (ESS) is a well-established treatment strategy for medically refractory chronic rhinosinusitis. Middle meatus spacers are currently used following ESS to prevent scarring, synechiae formation, and middle…
- Trial name
- NCT04841343
- Testing
- Triamcinolone
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of California, Los Angeles
Gastro Intestinal Bleeding
The Role of Hypertonic Dextrose Spray as Endoscopic Topical Hemostatic Agent for Acute Non-Variceal Upper GI Bleeding
This study is conducted to evaluate the effectivity of hypertonic dextrose spray as an endoscopic topical hemostatic agent, compared to conventional agent (adrenaline injection, followed by hemoclip or thermocoagulation), in…
- Trial name
- NCT04979273
- Testing
- Dextrose 40 % in Water, Adrenaline 1 Mg/mL Solution for Injection, argon plasma coagulation
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Gastrointestinal Hemorrhage
Seraseal for Endoscopic Hemostasis
Patients with active gastrointestinal bleeding can be included. 5ml of SerasealTM/Fastact (Wortham Laboratories, Chattanooga, USA), a CE-certified medical product for in human intraoperative use as hemostatic agent, is topically…
- Trial name
- NCT02349490
- Testing
- Seraseal / Fastact Hemostatic agent (combined activated factors IIa, VIIa, IXa, Xa )
- Where
- 4 sites in Austria, Germany
- Volunteers
- 37 people
- Sponsor
- Medical University of Vienna
Epistaxis, Anterior Ethmoid Artery
Cauterization of the Anterior Ethmoidal Artery by Transconjunctival Approach
The incidence of epistaxis varies from 7 to 14% in the general population and represents 30 per 100,000 emergency room admissions in adults. Most nasal bleeding is self-limiting without the need for specific medical treatment.
- Trial name
- AEA (NCT05663099)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Gastrointestinal Hemorrhage
Effectiveness Study of the BioVac Direct Suction Device in Upper Gastrointestinal Bleeding
Upper endoscopy is performed for upper gastrointestinal bleeding (bleeding in the esophagus, stomach, or part of the duodenum) to identify and potentially treat the cause of bleeding.
- Trial name
- NCT02150941
- Testing
- BioVac Direct Suction Device, Standard Endoscopy Suction
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
GastroIntestinal Bleeding
Effectiveness and Safety of Nexpowder as an Endoscopic Hemostatic Treatment
In patients who show signs of bleeding and bleeding after polypectomy such as EMR and ESD for polyps with a diameter of 2 cm or more in the lower gastrointestinal tract, the effectiveness and safety of Nexpowder as an endoscopic…
- Trial name
- NCT05884931
- Testing
- Nexpowder, Conventional Treatment
- Where
- 3 sites in South Korea
- Volunteers
- 66 people
- Sponsor
- Next Biomedical Co., Ltd.
Gastric Cancer, Colon Nos Polypectomy Tubular Adenoma
Phase III Open-labeled Study of NPO-11 in Patients Undergoing Therapeutic Upper Gastrointestinal Endoscopy
Patients who require therapeutic upper gastrointestinal endoscopy, such as polypectomy, endoscopic hemostasis, percutaneous endoscopic gastrostomy (PEG), endoscopic mucosal resection (EMR) and endoscopic submucosal dissection…
- Conditions
- Gastric Cancer, Colon Nos Polypectomy Tubular Adenoma, Gastric Adenoma
- Trial name
- NCT01411189
- Testing
- Menthol
- Where
- Japan
- Volunteers
- 33 people
- Sponsor
- Nihon Pharmaceutical Co., Ltd
Chronic Sinusitis
The Hemostatic and Hemodynamic Effects of Adrenaline During Endoscopic Sinus Surgery
Obtaining adequate hemostasis is crucial during endoscopic sinus surgery. Submucosal injection of local anaesthetic containing adrenaline has frequently been used to improve surgical milieu.
- Trial name
- NCT00852410
- Testing
- 1% lidocaine with 1:100,000 adrenaline, 1% lidocaine with 1:200,000 adrenaline
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Endoscopy, Peptic Ulcer
High Dose Versus Standard Dose Proton Pump Inhibitor (PPI) in High-risk Bleeding Peptic Ulcers After Combined Endoscopic Treatment
The study was designed to evaluate the efficacy an adjuvant use of standard dose or high dose of proton pump inhibitor after combined endoscopic hemostasis therapy.
- Conditions
- Endoscopy, Peptic Ulcer, Bleeding, Proton Pump Inhibitors
- Trial name
- NCT00709046
- Testing
- High dose pantoprazole infusion, Standard dose pantoprazole infusion
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- National Taiwan University Hospital
Upper Gastrointestinal Bleeding
Trial of Hemospray Plus Epinephrine Injection Versus Endoscopic Hemoclip
The non-variceal upper gastrointestinal bleeding is defined as gastrointestinal bleeding located proximal to the angle of Treitz, whose cause is not related to esophagogastric varices or gastropathy of portal hypertension.
- Trial name
- NCT02537353
- Testing
- Metal clips, Hemospray, Endoscopy Exam
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Gastrointestinal Bleeding From Malignancy
HemosprayTM for Gastrointestinal Bleeding From Cancer
Title: The efficacy of hemostatic powder TC-325 versus standard endoscopic treatment for gastrointestinal bleeding from malignancy; a multi-center randomized trial Background: Gastrointestinal (GI) bleeding arising from malignant…
- Trial name
- NCT03855904
- Testing
- TC-325
- Where
- Thailand
- Volunteers
- 112 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Gastrointestinal Hemorrhage
Bipolar Hemostatic Forceps Versus Standard Therapy in Acute Non-variceal Upper GI Bleeding
Bipolar hemostatic forceps will be tested against standard therapy in active, non-variceal, upper gastrointestinal bleeding by a prospective, randomized trial
- Trial name
- BeBop (NCT05353062)
- Testing
- Hemostatic therapy, Endoscopic therapy with hemoclip +/- injection of epinephrine solution
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Theresienkrankenhaus und St. Hedwig-Klinik GmbH
Colonic Polyps
The Efficacy and Safety of a Hybrid Hemostatic Device (ClearCoajet)
The ClearCoajet is a new hemostasis device with a hybrid function (Coagulation + Injection) and is developed to provide effective coagulation, injection, and marking around lesions without changing devices during the endoscopic…
- Trial name
- NCT05737017
- Testing
- ClearCoajet
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Seoul St. Mary's Hospital
Bleeding Peptic Ulcer
Over-the-scope Clip Versus Through-the-scope Clip for Endoscopic Hemostasis of High Risk Bleeding Peptic Ulcers
To compare in a multicenter, prospective, randomized, controlled trial the efficacy and safety of OTSC versus TTS clip for first-line hemostasis of high risk bleeding peptic ulcers
- Trial name
- OTSCvsTTS (NCT03551262)
- Testing
- OTSC, TTS clip
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Azienda USL Modena
Bleeding Peptic Ulcer
The Use of OTSC in LBGDU to Standard Endoscopic Hemostatic Methods
In managing bleeding gastroduodenal ulcers, endoscopic control of bleeding is the first line treatment-further bleeding after endoscopic hemostasis is associated with a 3-fold increase in mortality.
- Trial name
- OTSC-LBGDU (NCT06196710)
- Testing
- Over-the-scope Clips, Hemo-clipping
- Sponsor
- Chinese University of Hong Kong