Clinical trials: Endoscopic Submucosal Dissection (ESD)
Colonic Polyp
Endoscopic Submucosal Dissection (ESD) Versus Endoscopic Mucosal Resection (EMR) for Large Non Pedunculated Colonic Adenomas: a Randomized Comparative Trial
Initially developed in Japan for the treatment of endemic superficial gastric cancers, endoscopic submucosal dissection (ESD) allows resection of pre-neoplastic and neoplastic lesions of the digestive tract into a single…
- Trial name
- RESECT COLON (NCT03962868)
- Testing
- Experimental procedure : ESD, Comparison procedure: WF-piece meal EMR
- Where
- 6 sites in France
- Volunteers
- 360 people
- Sponsor
- University Hospital, Limoges
Colorectal Neoplasms
EMR Versus ESD for Resection of Large Distal Non-pedunculated Colorectal Adenomas
Endoscopic resection of adenomas in the colon is the cornerstone of effective colorectal cancer prevention. Endoscopic mucosal resection (EMR) is currently the most used technique for resection of large distal colorectal…
- Trial name
- MATILDA (NCT02657044)
- Testing
- EMR, ESD
- Where
- Netherlands
- Volunteers
- 212 people
- Sponsor
- UMC Utrecht
Early Gastric Cancer, Gastric Adenoma
Fibrin Glue After ESD for High Risk Patients of Bleeding
It is a prospective randomized controlled study to look for effectiveness of fibrin glue to prevent bleeding in high-risk patients after endoscopic submucosal dissection in gastric neoplasm.
- Trial name
- NCT04602689
- Testing
- Human fibrinogen concentrate
- Where
- South Korea
- Volunteers
- 134 people
- Sponsor
- Seoul National University Hospital
Colonic Polyp, Colonic Neoplasms
Additive Hemostatic Efficacy of EndoClot After EMR or ESD in the Gastrointestinal Tract
The investigators want to verify in a randomised trial, the effectiveness of EndoClotTM in preventing post-procedural bleeding after EMR (Endoscopic Mucosal Resection) or ESD (Endoscopic Submucosal Dissection) for sessile lesions…
- Conditions
- Colonic Polyp, Colonic Neoplasms, Colonic Dysplasia
- Trial name
- NCT02688699
- Testing
- EndoClot
- Volunteers
- 288 people
- Sponsor
- University of Turin, Italy
Superficial Esophageal Cancer
Human (Autologous) Oral Mucosal Cell Sheet Transplantation After ESD in Patients With Superficial Esophageal Cancer
The purpose of this study is to evaluate the efficacy and safety of esophageal epithelial regenerative treatment by the transplantation of the product, CLS2702C, to the esophageal wound site after extensive ESD for superficial…
- Trial name
- NCT02866019
- Testing
- CLS2702C/CLS2702D
- Where
- 3 sites in Japan
- Volunteers
- 10 people
- Sponsor
- CellSeed Inc.
Colo-rectal Cancer
Efficacy of a Hemostatic Agent (PuraStat®) in Reducing Delayed Bleeding After Endoscopic Submucosal Dissection
The problem of delayed bleeding after endoscopic resection is becoming important due to the growing number of indications for anti-aggregation or anticoagulant treatment for cardiovascular reasons in the aging populations.
- Trial name
- NCT05031325
- Testing
- Endoscopic submucosal dissection with Purastat
- Where
- France
- Volunteers
- 288 people
- Sponsor
- Mathieu Pioche
Early Gastric Cancer, Endoscopic Submucosal Dissection
The Relationship Between Scar Formation and ESD Depth in Therapy for Gastric Carcinoma
This study is a single-center, prospective, group-controlled clinical trial, aiming to clarify the relationship between the depth of dissection and scar formation in the treatment of early gastric cancer by ESD, and to provide…
- Trial name
- NCT05323929
- Testing
- ESD
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Esophageal Lesion, Barrett Esophagus
Endoscopic Submucosal Dissection (ESD)
This registry is to evaluate the procedural and clinical outcomes in patients undergoing endoscopic submucosal dissection. All patients will receive standard of medical care and no experimental interventions will be performed.
- Conditions
- Esophageal Lesion, Barrett Esophagus, Gastrointestinal Lesions
- Trial name
- ESD (NCT05468008)
- Testing
- Endoscopic Submucosal Dissection
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- AdventHealth
Rectal Neuroendocrine Tumor
Endoscopic Treatment of Rectal Neuroendocrine Tumor(NET) Less Than 10mm
Cap-assisted endoscopic mucosal resection (EMR-C) and endoscopic submucosal dissection (ESD) have both been reported to be effective treatment methods for small rectal neuroendocrine tumor (NET) in limited studies.
- Trial name
- NCT03982264
- Testing
- ESD procedure, EMR-C procedure
- Volunteers
- 90 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Colorectal Neoplasms, Endoscopic Submucosal Dissection
Evaluation of Endoscopic Submucosal Dissection (ESD) Efficacy
Superficial rectal tumors could be removed by ESD with two major advantages showed by the literature: high rate of monobloc resection and R0 resection. Hence, recurrence rate was lower than ERM therapy.
- Trial name
- DISSECMUC (NCT01879904)
- Testing
- Endoscopic submucosal dissection (ESD)
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colorectal Neoplasms
Follow-up After Oncological Resection by Endoscopic Colorectal ESD (Endoscopic Submucosal Dissection)
Colorectal cancer is a common and leading cause of death. Pre-cancerous lesions, as well as some so-called superficial cancers, can be resected via endoscopy.
- Trial name
- FORCE (NCT07871227)
- Testing
- Surgery, Radiochimiotherapy
- Where
- 14 sites in France
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Bordeaux
Patient Compliance
Effect of Questionnaires and Feedback on the Patient Compliance for Endoscopic Surveillance After ESD
Endoscopic submucosal dissection (ESD) is now considered the standard treatment for early gastrointestinal neoplasms. However, there is still a possibility of developing local recurrence or metachronous neoplasia after ESD.
- Trial name
- NCT06092281
- Testing
- Questionnaire, Questionnaire without compliance-related education
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Colorectal Tumor
Transanal Tube Drainage in Endoscopic Submucosal Dissection of the Colorectal Tumor
We design the clincal trial to investigate the efficacy of transanal tube drainage in colorectal ESD.
- Trial name
- NCT02973490
- Testing
- Transanal Tube Drainage
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Fudan University
Esophageal Cancer
SLND Versus Non-Dissection Following ESD for T1a Stage Esophageal Squamous Cell Carcinoma
This is a study from Fujian Cancer Hospital Thoracic of Surgery Project, numbered as FJCHTOSP-1. Systematically mediastinal Lymph Node Dissection (SLD) Versus Non-Dissection Following Endoscopic Submucosal Dissection (ESD) for…
- Trial name
- NCT06979986
- Testing
- Endoscopic Submucosal Dissection with Systematically mediastinal Lymph Node Dissection, Endoscopic Submucosal Dissection without SLND
- Volunteers
- 102 people
- Sponsor
- Fujian Cancer Hospital
Gastrointestinal Neoplasms
Utility of OverStitch Sx After ESD
This study is a prospective study where the investigators will make a database of all the patients who have received this procedure and will document various outcomes (i.e.
- Trial name
- NCT04361227
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Baylor College of Medicine
Colorectal Neoplasia, Colorectal Superficial Neoplasia
Trial of Underwater Versus Gas-Insufflation Colorectal Endoscopic Submucosal DisseEtion
Colorectal endoscopic submucosal dissection (ESD) enables en bloc resection of large superficial colorectal neoplasia but remains technically demanding and may be limited by suboptimal visualization, intraprocedural bleeding…
- Conditions
- Colorectal Neoplasia, Colorectal Superficial Neoplasia, Colorectal Precancerous Lesions
- Trial name
- TIDE (NCT07490574)
- Testing
- Underwater ESD (UESD), Conventional Gas-Assisted ESD (GESD)
- Where
- Italy
- Volunteers
- 295 people
- Sponsor
- University of Roma La Sapienza
Gastric Dysplasia, Gastric Cancer in Situ
Endoscopic Closure of Gastric ESD Defect
This is a pilot study to investigate the usefulness of closure of mucosal defect after gastric endoscopic submucosal dissection (ESD) in patients that are at high risk of post-procedural haemorrhage.
- Trial name
- NCT04282707
- Testing
- Endoscopic closure of ESD defect, Gastric ESD without closure of ESD defect
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Superficial Esophageal, Gastric or Colorectal Lesions
Validation of AI-ENDO System in Endoscopic Submucosal Dissection
This study is a pilot trial designed to evaluate the feasibility and safety of Al-ENDO assisted ESD in patients with gastrointestinal superficial lesions.
- Trial name
- NCT07392268
- Testing
- AI-ENDO system, Conventional ESD
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Rectal Neuroendocrine Tumors
Modified Double Snare Assisted EMR (mDS-EMR) VS ESD for Rectal Neuroendocrine Tumors Smaller Than 1cm
The aim of this study is evaluating and safety and efficacy between the modified double snare EMR and ESD. It is intended to prove that for rectal neuroendocrine tumors within 1 cm, the complete resection rate of the mDS-EMR is…
- Trial name
- NCT07373015
- Testing
- modified double snare assisted endoscopic mucosal resection, endoscopic submucosal dissection
- Volunteers
- 118 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Colorectal Lesions, Endoscopic Submucosal Dissection (ESD)
Effect of Simplified Robot (FASTER) Assisted Versus Conventional Endoscopic Submucosal Dissection (ESD) for Colorectal Lesions
This study aims to compare the outcomes of Simplified Robot (FASTER) assisted Endoscopic Submucosal Dissection (ESD) with conventional ESD in the treatment of colorectal lesions.
- Conditions
- Colorectal Lesions, Endoscopic Submucosal Dissection (ESD), FASTER Robot
- Trial name
- NCT07354867
- Testing
- FASTER robot-assisted ESD group, Conventional ESD group
- Volunteers
- 40 people
- Sponsor
- Kaiyun Liu