Clinical trials: Endoscopic Surgical Procedures
Transanal Endoscopic Surgery
Perianal Operating Scope Feasibliity
This protocol will test a new prototype of a peri-anal access device, with increased flexible length and a captured operative field, for feasibility in patients immediately prior to their scheduled peri-anal procedure.
- Trial name
- NCT02807792
- Testing
- Perianal access device
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Minnesota
Paranasal Sinus Cancer, Nasal Cavity Tumor
A Clinical Trial of Endoscopic Surgery Followed by Chemotherapy and Proton Radiation for the Treatment of Tumors in the Sinus and Nasal Passages
This study is being done to test a new treatment plan for large tumors in the sinus or nasal cavity that will include endoscopic surgery plus chemotherapy and proton-beam radiation therapy.
- Conditions
- Paranasal Sinus Cancer, Nasal Cavity Tumor, Nasal Cavity Adenocarcinoma
- Trial name
- NCT03274414
- Testing
- Cisplatin, Adjuvant Proton Radiotherapy, Endoscopic Resection
- Where
- 5 sites in United States
- Volunteers
- 3 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Intracerebral Haemorrhage
Early Minimally Invasive Image Guided Endoscopic Evacuation of Intracerebral Haemorrhage (EMINENT-ICH)
This is an open-labelled, single centre randomised controlled trial evaluating the efficacy of early minimally invasive image-guided hematoma evacuation in combination with the current best medical treatment compared to best…
- Trial name
- EMINENT-ICH (NCT05681988)
- Testing
- Early minimally invasive image guided endoscopic hematoma evacuation, Best medical treatment (BMT)
- Where
- 10 sites in Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Recurrent Nasopharyngeal Carcinoma
Early Recurrent Nasopharyngeal Cancer: the Effect of Surgery vs IMRT
This study is a multicenter RCT to compare 3-year overall survival(OS) rate, progression free survival(PFS),local progression free survival(LPFS),regional progression free survival(RPFS),distant metastasis free survival(DMFS)…
- Trial name
- NCT04215510
- Testing
- endonasal endoscopic surgery, radiation therapy(IMRT)
- Where
- 3 sites in China
- Volunteers
- 286 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Carcinoma, Non-Small-Cell Lung
Assessment of Surgical sTaging vs Endoscopic Ultrasound in Lung Cancer: a Randomized Clinical Trial (ASTER Study)
Lung cancer is one of the most prevalent cancers and has a very high mortality. Both treatment and prognosis depend on the staging.
- Trial name
- NCT00432640
- Testing
- Endoscopic ultrasound staging, Surgical staging
- Where
- 4 sites in Belgium, Netherlands and 1 more
- Volunteers
- 240 people
- Sponsor
- University Hospital, Ghent
Nasopharyngeal Carcinoma
Tirelizumab Plus Surgery vs Surgery Alone for Recurrent Nasopharyngeal Carcinoma
Through open-label, single-center, randomised clinical trials, we intend to demonstrate that PD-1 treatment added to salvage surgery could further decrease the rate of disease progression and improve the survival outcome of…
- Trial name
- NCT05092217
- Testing
- Tirelizumab, salvage surgery
- Volunteers
- 80 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Genetic Predisposition, Breast Cancer
Pre Pectoral Implant for Immediate Breast Reconstruction Using Single Port Endoscopy in Prophylactic Indication
Implant-based reconstruction is currently the most common choice for mastectomy reconstruction. Whatever the choice of mastectomy incision, a scar remains on or near the breast volume.
- Trial name
- MRIMOP (NCT03838549)
- Testing
- Prophylactic mastectomy with immediate breast reconstruction
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Kidney Calculi
Effect of Anesthesia Type on Surgeon Workload During Endoscopic Kidney Stone Surgery
This prospective observational study aims to evaluate the association between anesthesia type and surgeon-perceived workload and surgical ergonomics in adult patients undergoing flexible ureteroscopy and retrograde intrarenal…
- Trial name
- RIRS-ERG (NCT07763600)
- Testing
- General Anesthesia (GA), Spinal Anesthesia (SA)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Malatya Governor Research Hospital
Obesity, Obesity, Morbid
Biological Sample Repository for Gastrointestinal Disorders
The goal of this observational study has the purpose of collecting biological samples from obese patients undergoing evaluation for weight loss by means of medical or endoscopic therapies; and of post bariatric surgery patients…
- Conditions
- Obesity, Obesity, Morbid, Obesity, Primary, Gastro-Intestinal Disorder
- Trial name
- NCT05874726
- Testing
- Blood Collection, Urine Collection, Tissue Sample Collection
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Pichamol Jirapinyo, MD, MPH
Lumbar Spondylolisthesis, Unilateral Biportal Endoscopy
A RCT of UBE vs. MIS-TLIF in Lumbar Spondylolisthesis
Unilateral biportal endoscopy (UBE) is a new spinal minimally invasive technique improved for the treatment of lumbar spondylolisthesis (LSP).
- Conditions
- Lumbar Spondylolisthesis, Unilateral Biportal Endoscopy, Minimally Invasive Technique, Surgical Treatment
- Trial name
- NCT05480267
- Testing
- surgical treatment for lumbar spondylolisthesis
- Volunteers
- 340 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cubital Tunnel Syndrome
Presence of the Arcade of Struthers on Preoperative Ultrasound
To determine the correlation between the presence of the arcade of Struthers on preoperative ultrasound and during endoscopic surgery for cubital tunnel syndrome, and to determine the reliability of a portable ultrasound probe to…
- Trial name
- NCT04658511
- Testing
- Ultrasound
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Christine M. Kleinert Institute for Hand and Microsurgery
Spinal Stenosis, Spondylolisthesis
ESCAPE : Evaluation of Spinal Conservation by Endoscopic Procedures to Avoid Fusion
The recent development and expansion of endoscopic surgery has made it possible to offer an alternative to this therapeutic escalation.
- Trial name
- ESCAPE (NCT06950853)
- Where
- 13 sites in France
- Volunteers
- 375 people
- Sponsor
- University Hospital, Bordeaux
Dental Anesthesia, Nasal Surgical Procedures
Hemodynamic and Pharmacokinetic Analysis of Oxymetazoline Absorption
Oxymetazoline is an α-adrenergic agonist that is commonly used as a topical sympathomimetic agent in over-the-counter decongestant sprays.
- Conditions
- Dental Anesthesia, Nasal Surgical Procedures, Intranasal Drug Administration
- Trial name
- NCT02062996
- Testing
- Oxymetazoline
- Where
- United States
- Sponsor
- Richard Cartabuke
Gastrointestinal Neoplasms, Achalasia
ConMed Beamer Study
This is a prospective registry of all patients who endoscopic submucosal dissection (ESD), per-oral endoscopic myotomy (POEM) and gastric per-oral endoscopic myotomy (G-POEM) using ConMed Electrosurgical unit for submucosal…
- Conditions
- Gastrointestinal Neoplasms, Achalasia, Gastroparesis
- Trial name
- NCT04752670
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Baylor College of Medicine
Rhinocerebral Mucormycosis
Endoscopic Surgical Treatment of Rhino-Sinusal Mucormycosis
Radical endoscopic transnasal surgery associated with medical treatment with liposomal amphotericine B may increase the local control of Rhino-Sinusal Mucormycosis and the survival rate.
- Trial name
- MICCA (NCT02226705)
- Testing
- Multiple transnasal endoscopic surgeries
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Recurrent Nasopharyngeal Carcinoma
Camrelizumab and Chemotherapy Combined With Endoscopic Surgery for Recurrent Nasopharyngeal Carcinoma
To explore the effect of Camrelizumab and chemotherapy combining with endoscopic surgery in the treatment of recurrent nasopharyngeal carcinoma.
- Trial name
- NCT05011227
- Testing
- Camrelizumab, Chemotherapy, endoscopic surgery
- Where
- 7 sites in China
- Volunteers
- 100 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Uterine Diseases
Hysterectomy by Transabdominal Laparoscopy or NOTES
Objective: To randomly compare hysterectomy by vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) versus laparoscopy uterus in women with benign gynecological pathology.
- Trial name
- HALON (NCT02631837)
- Testing
- vNOTES hysterectomy, LSC hysterectomy
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Imelda Hospital, Bonheiden
Perforated Eardrum
Inhalational Anesthesia vs TIVA in Endoscopic Tympanoplasty
This study aims to prospectively compare surgical field quality and intraoperative blood loss between general inhalational anesthesia to total intravenous anesthesia (TIVA) alone in subjects undergoing endoscopic ear surgery.
- Trial name
- TIVA (NCT05993039)
- Testing
- Isoflurane Inhalant Product, Sevoflurane inhalant product, Propofol injection
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Our Lady of the Lake Hospital
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Preoperative Stapokibart for Endoscopic Sinus Surgery in Chronic Rhinosinusitis With Nasal Polyps
This is a single-center, randomized, double-blinded, placebo-controlled clinical trial in adults with moderate-to-severe chronic rhinosinusitis with nasal polyps (CRSwNP) who have no previous nasal surgery.
- Trial name
- NCT07616609
- Testing
- Stapokibart
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Beijing Tongren Hospital
Blood Loss, Surgical
Assessment of Nebulized Tranexamic Acid in Functional Endoscopic Sinus Surgery Using Modena Bleeding Score
The aim of this study is to investigate the effect of preoperative administration of intravenous or nebulized tranexamic acid on surgical field, blood loss, anesthetic consumption and hemodynamics of patients undergoing FESS.
- Trial name
- NCT06725732
- Testing
- Tranexamic Acid (TXA), Tranexamic Acid
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University