Clinical trials: Endoscopic Ultrasound (EUS)
Pancreas Neoplasms, Lymphatic Metastasis
Prospective Multi-center, Single Blinded, Randomized, Controlled Trial of EUS-FNB and EUS-FNA on Solid Occupying Lesion
The purpose of this study is to compare the diagnosis accuracy of FNA and FNB biopsy on pancreatic, retroperitoneal, mediastinum and pelvic cavity solid occupying lesions.
- Conditions
- Pancreas Neoplasms, Lymphatic Metastasis, Neoplasm Metastases, Unknown Primary Neoplasm Metastasis
- Trial name
- NCT02327065
- Testing
- EUS-FNA (EchoTip Ultra), EUS-FNB (EchoTip ProCore)
- Where
- China
- Volunteers
- 408 people
- Sponsor
- Huazhong University of Science and Technology
Pancreatic Cancer
EUS-CPN: A Retrospective Review
The purpose of this retrospective study is to measure the safety of EUS-CPN in patients that have undergone this procedure in the last decade.
- Trial name
- NCT00577564
- Where
- United States
- Sponsor
- Indiana University
Pancreatic Neoplasms, Mediastinal Neoplasms
22G-Adapt Needle Biopsy Versus Fine-needle Aspiration in Endoscopic Ultrasound-guided Sampling of Solid Lesions
The investigators conduct a multicenter randomized controlled study to evaluate the diagnostic value and safety of 22G Adapt Aspiration puncture needle for histopathology of solid lesions.
- Conditions
- Pancreatic Neoplasms, Mediastinal Neoplasms, Abdominal Neoplasm, Excluding Pancreas Neoplasm
- Trial name
- NCT06563232
- Testing
- FNA group, Adapt FNB group
- Where
- China
- Volunteers
- 656 people
- Sponsor
- Huazhong University of Science and Technology
Primary Aldosteronism, Aldosterone-Producing Adenoma
Endoscopic Ultrasound-guided Radiofrequency Ablation in Primary Aldosteronism
In this study, the investigators will perform endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) treatment of left-sided adrenal tumours in patients with primary aldosteronism (PA) and in patients with mild autonomous…
- Conditions
- Primary Aldosteronism, Aldosterone-Producing Adenoma, Hypercortisolism
- Trial name
- NCT05368090
- Testing
- EUS-RFA of left adrenal tumour in PA with AVS-verified left lateralisation, EUS-RFA of left adrenal tumour in PA, "debulking group", EUS-RFA of left adrenal tumour in MACS with AVS-verified left lateralisation
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Haukeland University Hospital
Portal Hypertension
Direct Portal Pressure Measurement Via Endoscopic Ultrasound in Advanced Chronic Liver Disease (EVADIPP)
A minimally invasive procedure to directly assess portal pressure gradient under endoscopic ultrasound guidance (EUS-PPG) has become available and initial data have proved the technique to be safe.
- Trial name
- EVADIPP (NCT06266260)
- Testing
- EUS PPG measurement
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Suspected Malignant Lesions
A Prospective Study of Thin Prep Versus Papanicolau in Suspected Malignant Lesions During Endoscopic Ultrasound (EUS)
Objective: The purpose of this study was to compare the performance of the monolayer preparation (Cyto Lyt or Thin prep) to the routine use of Papanicolau methods on the analysis of specimens obtained using EUS-FNA.
- Trial name
- NCT00716196
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Indiana University
Pancreatic Adenocarcinoma, Chronic Pancreatitis
Endoscopic Ultrasound Elastography in Pancreatic Masses
The aim of the study is to assess elastography during EUS examinations of focal pancreatic masses, and to consequently differentiate benign versus malignant pancreatic masses in a prospective multi-center design.
- Trial name
- EUS-EG (NCT00909103)
- Where
- 18 sites in Belgium, Denmark and 8 more
- Volunteers
- 285 people
- Sponsor
- University of Medicine and Pharmacy Craiova
Gastroenterology, Lesions
Evaluation of Diagnostic Yield of EUS-Guided Tissue Sampling
All patients will receive standard medical care and no experimental interventions will be performed. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is a well-established procedure commonly used for the…
- Trial name
- NCT02979509
- Testing
- Endoscopic ultrasound- (EUS) guided tissue sampling
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Florida
Neoplasms, Infection
A Multi-center, Prospective, Single-blind, Controlled Trial Comparing Diagnostic Value of Different EUS-FNA Techniques
The aim of this study is to compare endoscopic ultrasound guided-fine needle aspiration (EUS-FNA) with a standard 22-gauge needle using "standard suction", "slow-pull" and "wet suction" for thoracic/abdominal solid/solid-cystic…
- Conditions
- Neoplasms, Infection, Inflammation, Lymphoma
- Trial name
- EUS-FNA (NCT03674710)
- Testing
- Standard suction, slow-pull, wet suction, Standard suction, wet suction, slow-pull, Slow-pull, standard suction, wet suction
- Where
- 4 sites in China
- Volunteers
- 300 people
- Sponsor
- Shanghai Zhongshan Hospital
Complication
Safety and Efficiency of Electrocautery-enhanced Lumen-apposing Stents - a Single Center Experience
Lumen approximating stents have been used in interventional endoscopy to treat retentions in the upper gastrointestinal tract for 10 years.
- Trial name
- NCT05210842
- Testing
- Endoscopy
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Salzburger Landeskliniken
Gastric Outlet Obstruction
EUS-GE vs ES for Palliation of Gastric Outlet Obstruction
Gastric outlet obstruction (GOO) is a common complication of luminal malignancies which is associated with substantial morbidity.
- Trial name
- NCT03259763
- Testing
- Lumen-apposing metal stent, Self-expandable metal stent
- Where
- 9 sites in United States, Canada and 5 more
- Volunteers
- 112 people
- Sponsor
- Johns Hopkins University
Biliary Disease, Pancreatitis
Los Angeles Prospective GI Biliary and EUS Series
Endoscopic retrograde cholangiopancreatography and endoscopic ultrasound are increasingly being used to manage complex disease of the bile duct, pancreas and cancer.
- Conditions
- Biliary Disease, Pancreatitis, Gastrointestinal Neoplasms
- Trial name
- NCT02196935
- Testing
- clinical course
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- University of Southern California
Pancreatic Cancer, Stomach Neoplasms
Modified Wet Suction Versus Capillary Techniques for EUS Guided Fine Needle Aspiration and Biopsy of Solid Lesions
The purpose of the study is to compare two particular techniques of tissue (capillary vs wet-suction techniques) sampling during endoscopic ultrasound guided fine needle aspiration/biopsy (EUS-FNA/FNB) of a solid lesion to…
- Trial name
- NCT02919553
- Testing
- modified wet-suction technique, Capillary "slow pull" technique
- Sponsor
- Loma Linda University
Pancreatic Cancer
Pharmacotyping of Pancreatic Patient-derived Organoids
EUS-FNB samples will be used for organoid cultures, which will be co-cultured with cancer associated fibroblasts derived from the surrounding stroma of the lesion.
- Trial name
- NCT05196334
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 88 people
- Sponsor
- Herlev Hospital
Pancreatic Diseases
The 22G Franseen Needle Combined With Different Aspiration Techniques for Endoscopic Ultrasound-guided Fine-needle Biopsy
The goal of this clinical study is to compare the tissue adequacy, cellularity, blood contamination, accuracy, sensitivity, specificity of the 22G Franseen needle combined with three different suction techniques (dry-suction…
- Trial name
- NCT07023549
- Testing
- ABC, ACB, BAC
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Changhai Hospital
Pancreatic Neoplasms, Pancreatitis
Contrast EUS of the Pancreas
RATIONALE: Endoscopic Ultrasound (EUS) is the leading method to evaluate the pancreas but there may be difficulty characterizing small lesions, tumors which are not adenocarcinomas and neoplasia in the setting of pancreatitis.
- Conditions
- Pancreatic Neoplasms, Pancreatitis, Pancreatic Cyst
- Trial name
- NCT02863770
- Testing
- EUS enhanced with contrast to evaluate pancreas
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Southern California
Liver Cirrhosis, Liver Diseases
Endoscopic Ultrasound-Guided Portosystemic Pressure Gradient Measurements
The objective of the study is to collect and report technical success of direct endoscopic ultrasound guided hepatic and portal vein pressure measurement obtained with EchoTip® Insight™ in patients with cirrhosis who are referred…
- Conditions
- Liver Cirrhosis, Liver Diseases, Hypertension, Portal
- Trial name
- NCT04668664
- Testing
- EchoTip® Insight™ Portosystemic Pressure Gradient Measurement System (EchoTip® Insight™)
- Where
- 7 sites in United States, Australia and 1 more
- Volunteers
- 70 people
- Sponsor
- Cook Research Incorporated
Cirrhosis, Vascular Diseases
Endoscopic Ultrasound-Guided Portosystemic Pressure Gradient Measurements
Portal hypertension (PHT) is the main consequence of advanced chronic liver diseases (ACLD) and is often associated with severe complications leading to increased morbidity and mortality.
- Trial name
- EUSPREM (NCT06216509)
- Testing
- Endoscopic ultrasound pressure measurement
- Where
- Romania
- Volunteers
- 50 people
- Sponsor
- Institutul Regional de Gastroenterologie & Hepatologie Prof. dr. Octavian Fodor
Liver Diseases
Wet Heparin for Obtaining Liver Tissue for EUS Guided Liver Biopsy
Since its inception, endoscopic ultrasound with fine needle aspiration (EUS-FNA) has proven a valuable diagnostic and prognostic tool for evaluating a diverse number of pathologies.
- Trial name
- NCT03103997
- Testing
- EUS-guided liver biopsy
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Pancreatic Tumors
Standard Versus Fanning Techniques for Endoscopic Ultrasound-Fine Needle Aspiration (EUS-FNA)
Endoscopic Ultrasound (EUS)-guided biopsy is the most ideal technique for evaluating a growth in the pancreas. EUS-guided biopsies yield a definitive diagnosis in greater than 80% of cases.
- Trial name
- NCT01501903
- Testing
- Standard, Fanning
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Shyam Varadarajulu