Clinical trials: Endothelial Cell Density Loss
Hard Nuclear Cataract, Phacoemulsification Cataract Surgery
Study on the Surgical Strategy of Corneal Endothelial Protection for Hard Nuclear Cataract Patients
In this study, we compared two types of phacoemulsification commonly used in cataract surgery to evaluate their effect on the prognosis of patients with hard nuclei.
- Conditions
- Hard Nuclear Cataract, Phacoemulsification Cataract Surgery, Endothelial Cell Density Loss, Central Corneal Thickness
- Trial name
- NCT06991374
- Testing
- combined burst mode, torsional mode
- Where
- China
- Volunteers
- 207 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Glaucoma, Endothelial Cell Loss, Corneal
Changes in Corneal Endothelial Cell Density After Transscleral ab Interno Glaucoma Gel Stent Implantation
The objective of this study is to evaluate the change of endothelial cell count after XEN45 in patients with or without cataract operation.
- Trial name
- NCT04547036
- Testing
- XEN45
- Where
- Austria
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Paracelsus Medical University
Corneal Endothelial Cell Loss
Comparative Study of Specular Microscopes for Endothelial and Corneal Cell Measurements
The primary objective of this clinical study is to collect clinical data to support an FDA 510(k) submission for the Topcon Specular Microscope SP-1P.
- Trial name
- NCT02138266
- Testing
- Topcon Specular Microscope SP-1P, Konan Specular Microscope CELLCHEK XL
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Topcon Medical Systems, Inc.
Corneal Endothelial Cell Loss
Second Comparative Study of Specular Microscopes for Endothelial and Corneal Cell Measurements
The primary objective of this clinical study is to collect additional clinical data to support an FDA 510(k) submission for the Topcon Specular Microscope SP-1P.
- Trial name
- NCT02427256
- Testing
- Topcon Specular Microscope SP-1P, Konan Specular Microscope CELLCHEK XL
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Topcon Medical Systems, Inc.
Endothelial Cell Density Loss
Endothelial Changes in Diabetic and Non-diabetic Patients Undergoing Phacoemulsification
The aim of this study is to evaluate and compare specular endothelial changes in diabetic and non-diabetic patients undergoing phacoemulsification by assessing endothelial cell density, coefficient of variation, and percentage of…
- Trial name
- NCT07369388
- Testing
- Phacoemulsification
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
Corneal Endothelial Cell Loss, Ozone Therapy
Effect of Systemic Ozone Therapy on Corneal Endothelium
This study evaluates the safety of systemic ozone therapy on the corneal endothelium, a vital non-renewable tissue that maintains corneal transparency.
- Trial name
- OZON-CORNEA (NCT07718100)
- Testing
- Systemic Ozone Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Diabetes Mellitus, Corneal Endothelial Cell Loss
Effect of Intracameral Dexamethasone After Phacoemulsification in Diabetics on Corneal Endothelial Cell Density
The prevalence of diabetes mellitus (DM) is rapidly growing worldwide. One major concern with diabetes mellitus is how it may affect vision in different ways; including the increased risk of developing cataract.
- Conditions
- Diabetes Mellitus, Corneal Endothelial Cell Loss, Dexamethasone Adverse Reaction, Corneal Endothelial Decompensation
- Trial name
- DIABEDEX (NCT03361709)
- Testing
- Dexamethasone, Saline Solutions, Intraocular
- Sponsor
- Cairo University
Endothelial Cell Density Loss
Study of Endothelial Cell Condition After Cataract Surgery Performed Using Capsulorhexis or ZEPTO
This study will use images of the subjects' corneal endothelium obtained using non-invasive specular microscopy to obtain corneal endothelial cell density, the coefficient of variation in endothelial cell size, and the percentage…
- Trial name
- ZEPTO (NCT04882189)
- Testing
- Imaging
- Where
- 4 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centricity Vision, Inc.
Cataract, Endothelial Cell Density
Trial Comparing miLOOP Device Assisted Phacoemulsification vs Standard Surgery for Dense Cataracts: Effects on Endothelial Cell Loss, Energy Use, and Vision Recovery
The goal of this clinical trial is to find out if using the miLOOP device during cataract surgery confers additional protection against cornea (endothelial) cells loss by reducing the amount of ultrasound energy needed.
- Conditions
- Cataract, Endothelial Cell Density, Cumulative Dispersive Energy
- Trial name
- NCT07898007
- Testing
- The miLOOP utilizes a nickel-titanium (nitinol) loop to ensnare and exert centripetal cutting forces on the lens nucleus with decreasing loop diameter, Conventional phacoemulsification cataract surgery
- Where
- Malaysia
- Volunteers
- 68 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Cataract
Viscoat Versus Visthesia. A Comparative Study of Post-cataract Endothelial Cell Loss
Objective of this study is the comparative assessment of the beneficial impact of the Viscoat viscoelastic (OVD) and Visthesia OVD on endothelial cells and corneal edema following torsional-ip cataract extraction surgery.
- Trial name
- NCT02304861
- Testing
- Viscoat, Visthesia
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- Democritus University of Thrace
Corneal Endothelial Cell Loss, Mydriasis
Effect of Intracameral Injection of Mydriatic Plus Anaesthetic Combination on Corneal Endothelial Count in Phaco
Study evaluates safety of intracameral injection of Fydrane (tropicamide 0.02%, phenylephrine 0.31% and lidocaine 1%) on corneal endothelium, and efficiency in maintaining pupillary dilatation during phacoemulsification surgery.
- Conditions
- Corneal Endothelial Cell Loss, Mydriasis, Cataract
- Trial name
- NCT04396301
- Testing
- Fydrane®: (Manufacturer DELPHARM TOURS, FRANCE).
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Glaucoma
Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial
Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial (DECLARE) is a multi-center, outcome-masked, randomized clinical trial.
- Trial name
- DECLARE (NCT05924477)
- Testing
- Sulcus tube placement, Anterior chamber (AC) tube placement
- Where
- 8 sites in United States, Canada
- Volunteers
- 226 people
- Sponsor
- University of Pennsylvania
Corneal Endothelial Cell Loss
Comparative Study of Specular Microscopes for Measurements of Cell Density, Coefficient of Variation and Hexagonality
The primary objective of this clinical study is to collect clinical data to support an FDA 510(k) submission for the Nidek CEM-530 Center point method and Corner point method.
- Trial name
- NCT02276638
- Testing
- Specular Microscope Nidek CEM-530, Specular Microscope Konan CELLCHEK XL
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Nidek Co. LTD.