Clinical trials: Endothelial Dysfunction
Kidney Disease, Left Ventricular Hypertrophy
Do Xanthine Oxidase Inhibitors Reduce Both Left Ventricular Hypertrophy and Endothelial Dysfunction in Cardiovascular Patients With Renal Dysfunction?
Cardiovascular related disease is the main cause of death in patients with kidney disease, and "oxidative stress" is thought to be a major contributor by promoting thickening of the heart muscle and stiffening of the arteries.
- Trial name
- NCT00688480
- Testing
- Allopurinol
- Where
- United Kingdom
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- A. D. Struthers
Endothelial Dysfunction
Bioefficacy of Phenolic Acids
The objective is to demonstrate the effect of phenolic acids on endothelial function.
- Trial name
- NCT01781559
- Testing
- phenolic acid
- Where
- Australia
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Diabetes Mellitus, Type 1, Hypertension
Correlation of Flicker Induced and Flow Mediated Vasodilatation in Patients With Endothelial Dysfunction and Healthy Volunteers.
A couple of studies have shown that illuminating the eye with diffuse flickering light is accompanied by an increase of retinal vessel diameters, optic nerve head blood flow and retinal blood flow.
- Conditions
- Diabetes Mellitus, Type 1, Hypertension, Hypercholesterolemia, Regional Blood Flow
- Trial name
- NCT00432029
- Testing
- Forearm blood flow measurement, Flow mediated dilation (FMD), Zeiss Retinal Vessel Analyzer (RVA), Stimulation with Flicker-light
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
End Stage Renal Diseases, Renal Failure
Advanced Ultrasound Applications for Predicting AVF Outcomes
Haemodialysis is a renal replacement therapy that can be introduced to patients with end-stage renal disease (ESRD) to help them maintain a good healthy life.
- Conditions
- End Stage Renal Diseases, Renal Failure, Chronic Kidney Diseases
- Trial name
- AUAPAVFO (NCT04141358)
- Testing
- Advanced ultrasound measurements
- Where
- United Kingdom
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Limb Ischemia, Ischemic Preconditioning
Model System for Transient Forearm Blood Vessel Dysfunction
This study will develop a model system that can be used to test medications for improving the ability of blood vessels to resist damage from diseases such as heart attack and stroke.
- Trial name
- NCT00453531
- Testing
- Limb Ischemia, Acetylcholine
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Endothelial Dysfunction
Evaluation of a New Non-Invasive Device for Detection of Endothelial Dysfunction
The purpose of the study is to investigate the sensitivity and specificity of the Endotect compared with an ultrasound device in a flow-mediated vasodilatation (FMD) test.
- Trial name
- NCT00650741
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lavi Cardiatec
Endothelial Dysfunction, Inflammation
The Cardiovascular Effects of Electronic Hookah Vaping
Hookah (water-pipe) tobacco smoking has quickly grown to become a major global tobacco epidemic among youth; with electronic (e-) hookahs more recently increasing in popularity especially among young female adults, who endorse…
- Conditions
- Endothelial Dysfunction, Inflammation, Oxidative Stress
- Trial name
- NCT03690427
- Testing
- Traditional hookah smoking, Electronic hookah vaping
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Endothelial Dysfunction
Effect of the HIV Protease Inhibitors Atazanavir and Lopinavir/Ritonavir on Cardiovascular Disease Risk Factors
HIV protease inhibitors (PIs) are a class of antiretroviral drugs used to inhibit viral replication. They do so by interfering with a key step in the replication process.
- Trial name
- NCT00720590
- Testing
- Atazanavir, Lopinavir/ritonavir
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Vascular Disease, Heart Disease
Gap Junction Potentiation of Endothelial Function With Rotigaptide
Hypothesis - Rotigaptide will improve endothelial function in the context of endothelial dysfunction. The lining of blood vessels (endothelium) can react to hormones in the blood stream causing the blood vessel muscle to relax…
- Trial name
- NCT00901563
- Testing
- Rotigaptide, Forearm vascular study
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS)
Effect of R-spondin3 on Sepsis Induced Endothelial Dysfunction
Sepsis is the most frequent risk factor for ALI/ARDS. Meanwhile, Pulmonary is the most vulnerable organ to fail in response to sepsis, vascular endothelial dysfunction is a central event in the pathophysiology of sepsis.
- Trial name
- NCT04546919
- Testing
- sepsis
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Endothelial Dysfunction
Cardiovascular Health Effects of Flavanol Rich Chocolate
In the CHOC study the investigators will examine the effect of chocolate flavanols on vascular function, inflammation, oxidative stress and markers of endothelial function.
- Trial name
- CHOC (NCT01308892)
- Testing
- High flavanol chocolate, Low flavanol chocolate, High fat challenge
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Endothelial Dysfunction
Effects of Carbon Monoxide Breathing on Blood Vessel Function
In healthy young adults 18-39 years of age, the investigators will determine if intermittent inhalation a 0.1% CO, from a 1-liter bag once every minute for 30-40 minutes, at a level that approaches the CO boost with hookah…
- Trial name
- NCT03067701
- Testing
- Carbon Monoxide
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Cystic Fibrosis, Portal Hypertension
Portal Hypertension and Systemic Endothelial Function
Cystic fibrosis can affect organs other than the lungs. Liver disease affects about 30% of patients: its main manifestation is the development of portal hypertension (PHT).
- Trial name
- ENDOTH-MUCO (NCT02850692)
- Testing
- measure of endothelial function, Blood sample, Hepatic elastography
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hopital Foch
Sexual Dysfunction, Endothelial Dysfunction
Effects of Lifestyle-modification Induced Weight Loss on Sexual and Urinary Function, and Quality of Life in Obese Men
This study aims to evaluate the extent to which weight loss of 5-10% from baseline, induced by exercise and diet, improves metabolic and inflammatory profile, endothelial function, erectile function, sexual desire, lower urinary…
- Conditions
- Sexual Dysfunction, Endothelial Dysfunction, Quality of Life, Inflammation
- Trial name
- NCT01554735
- Testing
- Exercise and diet
- Where
- Singapore
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Changi General Hospital
Emotions, Endothelial Dysfunction
Study of the Effects of Negative Emotions on Endothelial Function
Study aims and hypotheses are as follows: Primary Hypotheses: Compared to the neutral condition, the anger recall task will acutely induce endothelial dysfunction by impairing endothelium-dependent arterial vasodilation…
- Trial name
- PUME (NCT01909895)
- Testing
- Anger Induction, Depressed Mood Induction, Anxiety Induction
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Columbia University
Nonalcoholic Fatty Liver Disease, Glucose Metabolism Disorders
Effects of Fructose Restriction on Liver Steatosis
Nonalcoholic fatty liver disease (NAFLD) is an emerging health problem as it can lead to end stage liver failure and cardiovascular complications. Diet play an important role in the development of NAFLD.
- Conditions
- Nonalcoholic Fatty Liver Disease, Glucose Metabolism Disorders, Endothelial Dysfunction
- Trial name
- FRUITLESS (NCT03067428)
- Testing
- Glucose, Fructose
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Prediabetes, Obesity
Effects of Antidiabetic Medications on the Postprandial State in Prediabetes
This project addresses cardiovascular disease risk in patients with prediabetes. Levels of lipids after eating a meal ("postprandial lipids") are strong independent predictors of cardiovascular risk.
- Trial name
- NCT02104739
- Testing
- Exenatide, Saxagliptin, Exenatide extended-release (ER)
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Childhood Obesity, Endothelial Dysfunction
Mechanisms of Atherogenesis During Post-prandial Time in Childhood Obesity
Childhood obesity is increasing at a fast pace, together with its complications. The aim of the present study is to assess several candidate triggering agents, mechanisms and intermediate phenotypes of atherosclerosis during the…
- Conditions
- Childhood Obesity, Endothelial Dysfunction, Inflammation, Insulin Resistance
- Trial name
- NCT01502826
- Testing
- standardized mixed meal
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Heart Failure, Heart Diseases
Effects of Passive Heat Therapy on Oxygen Consumption and Cardiovascular Fitness in Adults
The purpose of this study is to determine if enhanced endothelial arterial distensibility observed with heat therapy translates into improved cardiorespiratory fitness.
- Conditions
- Heart Failure, Heart Diseases, Cardiovascular Diseases, Endothelial Dysfunction
- Trial name
- NCT04026126
- Testing
- Heat Therapy Treatment
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Metabolic Syndrome, Vascular Compliance
Orange Juice, Hesperidin and Their Role in Vascular Health Benefit
Although epidemiological studies have associated the consumption of sugary beverages with adverse health effects, experimental studies have demonstrated that the metabolic response of the human body to fruit juice as compared to…
- Conditions
- Metabolic Syndrome, Vascular Compliance, Predisposition to Cardiovascular Disease
- Trial name
- HESPER-HEALTH (NCT04731987)
- Testing
- Beverage consumption
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand