Clinical trials: Endothelial Function
Healthy
Arginine Supplementation to Improve Cardiovascular and Endothelial Function After NSAID Treatment
A single centre, placebo controlled, blinded (participant, investigator, outcome assessor) trial to evaluate the effects of COX-2 inhibition with celecoxib on endothelial function in healthy male volunteers.
- Trial name
- ASCENT (NCT04765644)
- Testing
- Celecoxib, L-arginine + celecoxib
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Transgender, Gender Identity
Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Men
This study will examine markers of vascular endothelial function (vascular health) and metabolic profiles in older versus younger transgender men (people who were assigned female at birth but whose gender identity is male).
- Conditions
- Transgender, Gender Identity, Vascular Stiffness, Vascular Inflammation
- Trial name
- NCT04237467
- Testing
- No intervention
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Vascular Function
Effect of Woodsmoke on Vascular Function
Exposure to air pollution is a well established risk factor for the development of heart disease. Firefighters are exposed to excess air pollution in the form of wood smoke during the extinguishing of forest or woodland fires.
- Trial name
- FIREWOOD (NCT01495325)
- Testing
- Forearm Vascular Study, Badimon Chamber
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Obesity, Insulin Resistance
Vitamin K and Glucose Metabolism in Children at Risk for Diabetes (Vita-K 'n' Kids Study)
The undercarboxylated fractions of the two vitamin K-dependent proteins osteocalcin and matrix Gla protein have been shown to play key roles in type 2 diabetes and cardiovascular disease (at least in mouse models).
- Conditions
- Obesity, Insulin Resistance, Insulin Sensitivity, Prediabetes
- Trial name
- NCT01972113
- Testing
- Low-Dose Vitamin K2 (menaquinone-7; 45 mcg/d), High-Dose Vitamin K2 (menaquinone-7; 90 mcg/d)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Augusta University
Endothelial Dysfunction
Different Oils For Frying and Endothelial Function
The purpose of this study is to compare the effects of the consumption of different oils (olive oil, sunflower oil, sunflower plus dimethyl-polysiloxane, sunflower plus phenols) previously submitted to heating in postprandial…
- Trial name
- NCT00837317
- Testing
- Olive Oil, SF, SF+DMP, SF+phenols
- Where
- Spain
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Reina Sofia de Cordoba
Hypercholesterolemia
Effect of Red Yeast Rice, Phytosterols and L-tyrosol on Lipid Profile and Endothelial Function
A large body of evidence confirm the cholesterol lowering effect of red yeast rice, phytosterols and L-tyrosol. Because their mechanisms of action mime the ones of chemical statins and cholesterol absorption inhibitors, it is…
- Trial name
- NCT03065491
- Testing
- Combined nutraceutical
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Bologna
Metabolic Syndrome
Development of Endothelial Biomarkers
The main objective is to develop and validate new endothelial function markers discriminating and reproducible by assessing the ability to reveal changes in endothelial function in response to positive and negative nutritional…
- Trial name
- NUTREND (NCT02006810)
- Testing
- Induction of endothelial function variations
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Cardiovascular Diseases
Endothelial Effects of VEGF Inhibition In Vivo in Man
Recent developments in chemotherapy, particularly VEGF-inhibitor (VEGFI) drugs, have markedly improved the prognosis of patients with cancer.
- Trial name
- ENDEAVOUR (NCT03557190)
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
COVID-19, Endothelial Dysfunction
Effect of COVID-19 on Endothelial Function
COVID-19 disease (coronavirus disease 2019) primarily affects the respiratory system, using the angiotensin-converting enzyme 2 receptor.
- Trial name
- NCT05500560
- Where
- Greece
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital of Patras
Obesity
Effect of Resistance Training on Microvascular, Hemodynamic and Physical Parameters in Obese Adolescents
The purpose of this study is to investigate the effect os resistance training on microvascular reactivity, endothelial functions, inflammatory markers, blood pressure, heart rate, body composition and physical fitness in obese…
- Trial name
- NCT01692314
- Testing
- Resistance training
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Age Related Cognitive Decline, Alzheimer's Disease
n-3 PUFA for Vascular Cognitive Aging
Brain scans can help identify changes that appear to increase risk for cognitive decline and dementia. Some of these brain changes are thought to reflect actual damage to the small blood vessels that support normal brain…
- Conditions
- Age Related Cognitive Decline, Alzheimer's Disease, Vascular Dementia, Endothelial Dysfunction
- Trial name
- NCT01953705
- Testing
- Omega 3 PUFA
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Healthy, Hypercholesterolemia
The Role of Cyclooxygenase Activity in the Endothelial Function of Hypertensive and Hypercholesterolemic Patients
A layer of cells called the endothelium line the walls of blood vessels. These cells produce substances that control the tone of blood vessels and thus control blood flow through the vessel.
- Conditions
- Healthy, Hypercholesterolemia, Hypertension
- Trial name
- NCT00001742
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Endothelial Progenitor Cells Numbers, Endothelial Function (FMD)
Study Effect of Red Wine Consumption on Endothelial Progenitor Cells and Endothelial Function
Light-to-moderate alcohol consumption has been associated with a reduction of cardiovascular events, and red wine seems to offer more benefits than any other type of alcoholic beverages.
- Trial name
- NCT00755014
- Testing
- red wine
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Ischaemia-reperfusion (IR) Injury
The Effects of C-type Natriuretic Peptide on Human Forearm Blood Vessels
To determine the effects of whether increasing CNP concentrations slightly above normal will improve the functioning of blood vessels after the interruption in the flow of blood.
- Trial name
- NCT01075776
- Testing
- C-type natriuretic peptide (CNP), Saline, Acetylcholine
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Dyslipidemia, Oxidative Stress
Brazil Nut Consumption in Microvascular Endothelial Function, Oxidative Stress and Metabolic Abnormalities
The purpose this research is to check the effect of Brazil Nuts consumption in oxidative stress, metabolic abnormalities and microvascular endothelial function dyslipidemic and hypertensive patients.
- Trial name
- NCT01990391
- Testing
- Brazil nut flour
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
High Blood Pressure
Microcirculation and Inflammatory Markers in Patients With Resistant, Stages 1/2 Hypertension and Normal Blood Pressure
Nailfold videocapillaroscopy (NVC), Venous occlusion Plethysmography (VOP) and inflammatory biomarkers have been used to study endothelial function in patients with resistant hypertension, stages 1 and 2 hypertension and…
- Trial name
- MICRORAH (NCT02759276)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Daniel Alexandre Bottino
Endothelial Dysfunction, Acute Myocardial Infarction (AMI)
Validation of Cor-IS Impedance Spectroscopy Against Ultrasound Flow-Mediated Dilation
This prospective observational study evaluated the Cor-IS bioelectrical impedance spectroscopy technique for the assessment of endothelial function by comparison with ultrasound-based brachial artery flow-mediated dilation (FMD).
- Conditions
- Endothelial Dysfunction, Acute Myocardial Infarction (AMI), Cardiovascular Risk Factors (e.g., Hypertension), Flow Mediated Dilation
- Trial name
- NCT07882550
- Testing
- Cor-IS FMD, Ultrasound FMD
- Where
- Greece
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Smoking, Endothelial Dysfunction
Hookah Smoking, Carbon Monoxide, and Coronary Endothelial Function
Hookah (water pipe) smoking is a new global epidemic. The World Health Organization wants to prohibit all claims that hookah is less harmful than cigarettes and wants hookah products to bear the same warning labels as cigarettes.
- Trial name
- NCT03166787
- Testing
- Charcoal hookah, E-coal hookah, Cigarette
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Cystic Fibrosis, Portal Hypertension
Portal Hypertension and Systemic Endothelial Function
Cystic fibrosis can affect organs other than the lungs. Liver disease affects about 30% of patients: its main manifestation is the development of portal hypertension (PHT).
- Trial name
- ENDOTH-MUCO (NCT02850692)
- Testing
- measure of endothelial function, Blood sample, Hepatic elastography
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hopital Foch
Type 2 Diabetes
Metabolic Causes of Thrombosis in Type 2 Diabetes - Question 1
The purpose of this study is to learn more about why patients with diabetes have increased heart attacks, strokes and other illnesses due to blood clots causing blockage of a blood vessel.
- Trial name
- NCT00574665
- Testing
- Hyperinsulinemic Hyperglycemic Clamp
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University