Clinical trials: Endothelial Function and Arterial Stiffness
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female
Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes
The goal of this clinical trial is to determine the effectiveness of using a freeze-dried wild blueberry powder on cardiometabolic health, cognitive function, and gut microbiota composition in adult women with prediabetes.
- Conditions
- Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female, Adult, Endothelial Function (Reactive Hyperemia)
- Trial name
- NCT06735651
- Testing
- Wild Blueberry
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Georgia State University
Cystic Fibrosis
Investigation of Relationship Between Vascular Functions, Exercise Capacity, and Respiratory Functions in CF
In the literature, there is no study that evaluates the endothelial function and arterial stiffness together and investigates its relationship with exercise capacity and respiratory functions in children with CF of different…
- Trial name
- NCT04259983
- Testing
- Maximal exercise test, Endothelial dysfunction assessment, Arterial stiffness assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hacettepe University
Atherosclerosis
Effects of 10 mg Monacolins on Vascular Health: a Clinical Trial
This will be a double-blind randomized clinical trial carried out on subjects with suboptimal control of LDL-cholesterolemia, following a Mediterranean diet, and treated with a red yeast rice extract (containing 10 mg monacolin K…
- Trial name
- Monasc10_15 (NCT02492464)
- Testing
- Red yeast rice
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Bologna
Diabetes Mellitus
Dulaglutide in Diabetic Patients, Relationship Between Arterial Stiffness, Endothelial Function, Clinical and Laboratory Variables
The study aims to evaluate arterial stiffness and endothelial function indexes and their relationship with clinic and laboratory varible in a group of diabetic patients in treatment with dulaglutide
- Trial name
- NCT03824002
- Testing
- Dulaglutide, Aspart insulin, Glargine
- Where
- Italy
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Smoking Cessation, Arterial Stiffness
The Effect of Cytisine Treatment for Smoking Cessation on Cardiovascular Function in Adult Smokers
Introduction: Pharmacological interventions can enhance smoking cessation success and long-term abstinence. Cytisine, a plant derived alkaloid, is a selective partial agonist at alpha-4 beta-2 nicotinic acetylcholine receptors…
- Conditions
- Smoking Cessation, Arterial Stiffness, Endothelial Dysfunction
- Trial name
- Cytisin-angio (NCT06885970)
- Testing
- Cytisinicline administration
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- University of Athens
Peripheral Artery Disease, Endothelial Dysfunction
Effect of Transcutaneous Vagal Stimulation (TVS) on Endothelial Function in PAD
Peripheral arterial disease (PAD) constitutes a major public health burden. The incidence of PAD increases with age and is associated with other comorbid cardiovascular disorders.
- Conditions
- Peripheral Artery Disease, Endothelial Dysfunction, Autonomic Imbalance
- Trial name
- TVS-PAD (NCT03445754)
- Testing
- TVS
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Oklahoma
Cystic Fibrosis
Longitudinal Assessment of Exercise Capacity and Vascular Function in Patients With CF
This project is an attempt to understand how Orkambi treatment affects exercise capacity and the function of the arteries in CF patients who are homozygous F508del.
- Trial name
- NCT03338595
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Augusta University
Atherosclerosis, Cardiovascular Diseases
INvestigating the Lowest Threshold of Vascular bENefits From LDL Lowering With a PCSK9 InhibiTor in healthY Volunteers
The INTENSITY-LOW study aims to answer if there are any limits to LDL reduction in relation to benefitting vascular health from a mechanistic viewpoint, and therefore potentially limitations to primary prevention in healthy…
- Trial name
- NCT03273972
- Testing
- Written Informed Consent, Inclusion/Exclusion check, Full Clinical Chemistry and Haematology Bloods
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Aging
The Effect of Time-restricted Feeding on Physiological Function in Middle-aged and Older Adults
The purpose of this study is to assess the safety and efficacy of time-restricted feeding (eating within an 8-hour window) for improving physiological function (vascular, motor, cognitive and metabolic function) in healthy…
- Trial name
- NCT02970188
- Testing
- Time Restricted Feeding
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Aortic Coarctation, Arterial Stiffness
Long-term Outcomes and Vascular Evaluation After Coarctation of the Aorta Treatment
Background: Coarctation of the aorta (CoA) can be treated using surgery, balloon angioplasty or stent implantation. Although short-term results are excellent with all three treatment modalities, long term cardiovascular (CV)…
- Conditions
- Aortic Coarctation, Arterial Stiffness, PULSE WAVE VELOCITY, Functional Magnetic Resonance Imaging
- Trial name
- LOVE-COARCT (NCT03262753)
- Testing
- Surgery, Balloon dilation, Stent
- Where
- Portugal
- Volunteers
- 90 people
- Sponsor
- Centro Hospitalar de Lisboa Central
Atherosclerosis
Arterial Function and Atherosclerosis in Essential Thrombocythemia
The aim of the study is to examine (a) whether patients with JAK2 V617F positive ET in comparison to age-and sex-matched, apparently healthy control subjects show more advanced progression of arterial stiffness, pulse-wave…
- Trial name
- NCT03828422
- Testing
- imaging
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Heart Failure With Reduced Ejection Fraction, Endothelial Dysfunction
Effect of Transcutaneous Vagal Stimulation (TVS) on Endothelial Function and Arterial Stiffness in HFrEF
Heart failure (HF) is the leading cause of hospitalization in the US. Endothelial dysfunction, characterized by the decreased vasodilatory capacity of the vascular endothelium, is rampant in atherosclerotic diseases such as…
- Trial name
- NCT03380156
- Testing
- TVS
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Oklahoma
Acute Coronary Syndrome
Comparison of Ticagrelor vs. Prasugrel on Inflammation, Arterial Stiffness, Endothelial Function, and Circulating Endothelial Progenitor Cells in Diabetic Patients With Non-ST Elevation Acute Coronary Syndrome (NSTE-ACS) Requiring Coronary Stenting
To investigate pleiotropic effects of ticagrelor in addition to its antiplatelet effects in type 2 diabetic patients with non-ST elevation acute coronary syndrome by measuring inflammatory markers, circulating number of…
- Trial name
- NCT02487732
- Testing
- Ticagrelor, Prasugrel
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Korea University Anam Hospital
Cardiovascular Diseases, Vitamin D Deficiency
The Effect of Vitamin D Statues on Endothelial Function
In the United States, cardiovascular disease causes over one-third of all deaths and vitamin D deficiency is an epidemic. An increasing body of data suggests that low vitamin D status adversely impacts the cardiovascular system.
- Trial name
- CVD Cookie (NCT01049048)
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Vascular Health, Autonomic Function
Vascular and Neuro-inflammatory Effects of Endurance Exercise Training in African Americans
The purpose of this study is to test the effects of endurance exercise training on arterial structure and function, and to examine potential mechanisms producing changes in arterial structure and function in young (18-35 years of…
- Trial name
- VINE (NCT01024634)
- Testing
- Endurance Exercise
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Rheumatoid Arthritis, Inflammation
Effects of Interleukin-6 Inhibition on Vascular, Endothelial and Left Ventricular Function in Rheumatoid Arthritis
Recent studies show beneficial effect of the inhibition of interleukin-6 (IL-6) activity on vascular and left ventricular (LV) function.
- Trial name
- NCT03288584
- Testing
- Tocilizumab (Actemra®), Other biological agent, Corticosteroid and non-biological agents.
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Athens
Diabetes Mellitus, Type 2
The Cardiovascular Effect of GLP-1 Agonist, SGLT2 Inhibitor and Their Combination
A. Four groups of patients with type 2 diabetes mellitus with high or very high cardiovascular risk or heart failure with preserved ejection fraction (HFpEF) will be studied before and at 6 and 12 months of treatment: 60 patients…
- Trial name
- NCT03878706
- Where
- Greece
- Volunteers
- 240 people
- Sponsor
- University of Athens
Hypertension (Without Type 2 Diabetes Mellitus), High Blood Pressure
Wild Blueberries for Gut, Brain, and Heart Health in Adults With High Blood Pressure
The purpose of the study is to determine the effectiveness of wild blueberries on cardiovascular health, cognitive function, and gut microbiota composition in non-Hispanic Black and White adults with elevated blood pressure.
- Conditions
- Hypertension (Without Type 2 Diabetes Mellitus), High Blood Pressure, Male, Female
- Trial name
- NCT06735599
- Testing
- Wild Blueberry
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Georgia State University
French PNNS Guidelines in Vascular Function
Impact of Dietary Status on Vascular Function Before and After a Standardized Breakfast. An "Exposed/Unexposed" Study Embedded in the SUVIMAX2 Cohort
In France, primary cardiovascular and metabolic prevention is supported by the French National Program for Nutrition and Health (PNNS: Programme National Nutrition Santé).
- Trial name
- Nutri-MicroVas (NCT01579409)
- Testing
- PNNS guidelines
- Where
- France
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Obesity
Effects of Weight Loss on Vascular Function in Obese Subjects
To evaluate the effect of weight loss on vascular function in obese with poor cardiovascular health. The investigators will evaluate the effects of weight loss on total and central body adiposity, blood pressure, central…
- Trial name
- NCT04198519
- Testing
- Weight Loss
- Where
- 2 sites in Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mario Fritsch Neves