Clinical trials: Endothelial Progenitor Cells
Coronary Artery Disease
Effect of Cocoa Flavanols on Vascular Function
Endothelial dysfunction is associated with a higher incidence of adverse cardiovascular events in patients with coronary artery disease (CAD).
- Trial name
- Cocoa (NCT00553774)
- Testing
- Cocoa Flavanols
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, San Francisco
Type 2 Diabetes Mellitus
Role of Canagliflozin on CD34+ Cells in Patients With Type 2 Diabetes
The investigators hypothesize that Cana may be able to improve number and function of CD34+ endothelial progenitor cells. The investigators also propose that this expected cardiovascular benefit is independent of HbA1C reduction.
- Trial name
- NCT02964585
- Testing
- Canagliflozin
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- George Washington University
Cardiovascular Disease, Cardiomyopathy
Statin Therapy for Ischemic and Nonischemic Cardiomyopathy
The purpose of this study is to see if taking a cholesterol lowering drug Lipitor (Atorvastatin Calcium)will increase the number of endothelial progenitor cells (EPC's) circulating in the blood of heart failure patients taking…
- Conditions
- Cardiovascular Disease, Cardiomyopathy, Heart Disease, Myocardial Disease
- Trial name
- NCT00701220
- Testing
- Atorvastatin Calcium
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Philip Binkley
Coronary Artery Disease, Atherosclerosis
MASCOT - Post Marketing Registry
To collect post marketing surveillance data on patients receiving at least one Combo Bio-Engineered Sirolimus Eluting Stent when used according to the Instructions for Use.
- Trial name
- MASCOT (NCT02183454)
- Testing
- OrbusNeich COMBO stent
- Where
- Netherlands
- Volunteers
- 2,500 people
- Sponsor
- OrbusNeich
Coronary Artery Disease
OCT Evaluation of Early Healing of EPC Capturing (GENOUS) Stent (EGO Study)
All patients who have received GENOUS stent implantation at Queen Mary Hospital for treatment of ischemic heart disease are eligible for this study.
- Trial name
- EGO (NCT01272895)
- Testing
- Coronary Intervention (GENOUS stent)
- Where
- Hong Kong
- Volunteers
- 53 people
- Sponsor
- Prof. Stephen Lee
Stroke
Autologous Endothelial Progenitor Cells Transplantation for Chronic Ischemic Stroke
Stroke is a frequently occurring and common diseases in nervous system,and most of the survivors will remain disorders of motor,sensory and cognition function.Stem cell transplantation provides a promising approach for…
- Trial name
- NCT02605707
- Testing
- Intravenous stem cell transplantation
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Southern Medical University, China
Coronary Artery Disease
Deutsches Dual Therapy Stent Register
The DTS.DE registry is an initiative for the collection of high quality process and historical data of implantations with the COMBO Dual Therapy Stent in Germany.
- Trial name
- DTS Register (NCT02102997)
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- OrbusNeich
Peripheral Artery Disease
Exercise Training Versus Best Medical Treatment Only in Peripheral Artery Disease
The aim of the investigators' study is to analyze the value of supervised exercise training combined with medical therapy versus best medical treatment only with respect to quality of life.
- Trial name
- NCT00926081
- Testing
- Supervised exercise training
- Where
- Austria
- Volunteers
- 120 people
- Sponsor
- Medical University of Vienna
Graft-Versus-Host Disease
Tissue Repair in Stem Cell Transplant Recipients
Primary Objective: 1. To determine whether rhG-CSF treatment will increase the frequency of donor-derived cells contributing to repair of damaged epithelial/endothelial or solid organ-specific tissue caused by graft-versus-host…
- Trial name
- NCT00501228
- Testing
- Filgrastim
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- M.D. Anderson Cancer Center
Peripheral Vascular Diseases, Cardiovascular Diseases
Adipose CELL Derived Regenerative Endothelial Angiogenic Medicine
The main purpose of this study is to evaluate the safety and feasibility of regenerative therapy with expanded adipose derived stroma/stem cells sue, administered intramuscularly in patients with critical leg ischemia.
- Trial name
- ACELLDREAM (NCT01211028)
- Testing
- Expanded autologous ASCs
- Where
- France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Toulouse
Heart Failure
Significance of Regional Ventriculo-arterial Coupling in Patients With Chronic Heart Failure
The investigators hypothesize that the different components of arterial load are coupled with different components of LV function.
- Trial name
- NCT01298258
- Testing
- Aliskiren
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Graft vs Host Disease, Complications of Organ Transplant Stem Cells
CEC Count Changes to Support GvHD Diagnosis.
In consideration of the fact that the vascular endothelium has been shown to be a target of GvHD in early stage and that the count of CEC may represent a marker of endothelial damage, we want to evaluate the changes in CEC counts…
- Conditions
- Graft vs Host Disease, Complications of Organ Transplant Stem Cells, Endothelial Dysfunction
- Trial name
- ALLOCEC (NCT02064972)
- Testing
- Patients undergoing allo-HSCT, who manifest GvHD.
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Acute Coronary Syndrome
Plaque Regression and Progenitor Cell Mobilization With Intensive Lipid Elimination Regimen (PREMIER), Phase I
The purpose of this randomized, multi-site, clinical trial is to determine whether intensive therapy consisting of cholesterol-lowering statin drugs plus apheresis to cleanse the blood of low-density lipoprotein (LDL) cholesterol…
- Trial name
- PREMIER (NCT01004406)
- Testing
- intensive LDL-lowering therapy, standard statin monotherapy
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- VA Office of Research and Development
Coronary Heart Disease, Angina Pectoris
SORT OUT X - Combo Stent Versus ORSIRO Stent
The aim of the Danish Organisation for randomised trials with clinical outcome (SORT OUT) is to compare the safety and efficacy of the ComboTM stent and Orsiro™ stent in the treatment of unselected patients with ischemic heart…
- Conditions
- Coronary Heart Disease, Angina Pectoris, Myocardial Infarction
- Trial name
- SORT OUT X (NCT03216733)
- Testing
- COMBO, ORSIRO
- Where
- 4 sites in Denmark
- Volunteers
- 3,148 people
- Sponsor
- Aarhus University Hospital Skejby
Diabetes Mellitus, Type 2
Functional Investigation of Endothelial Function and Regenerative Cell Exhaustion
FIERCE is an observational cross-sectional study. Approximately 90 individuals living with type 2 diabetes (T2D) and/or individuals living without diabetes will be randomized (2:1).
- Trial name
- FIERCE (NCT06108388)
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Canadian Medical and Surgical Knowledge Translation Research Group
Type 2 Diabetes Mellitus, Atherosclerosis
Effects of 5-day Statin Withdrawal on Endothelial Progenitor Cells and Inflammatory Markers in Type 2 Diabetic Patients
Statins are commonly prescribed to lower cardiovascular risk in primary and secondary prevention. Despite their well known efficacy, statin withdrawal is a common event.
- Conditions
- Type 2 Diabetes Mellitus, Atherosclerosis, Dyslipidemia
- Trial name
- SStatin-EPC (NCT01600690)
- Testing
- Statin withdrawal
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- University of Padova
Diabetic Foot
Autologous Endothelial Progenitor Cells Treatment of Diabetic Foot
The vascular pathologic basis of diabetic foot include arterial obstruction and micro-circulation defects.The latest technology of arterial reconstruction can only rebuild blood flow of anterior,posterior tibial artery and…
- Trial name
- NCT02474381
- Testing
- EPCs plus PTA, Single PTA
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Injury of Radial Artery at Wrist and Hand Level, Injury; Ulnar Artery, Hand and Wrist
Effect of Cell Surface Markers and Lymphoid Cell Distribution on the Arterial Tissue Repair (ECLAR)
The radial and ulnar artery injuries related with the wrist cut are frequently encountered. There are many factors which are effective on the improvement of these arterial structures was repaired with microsurgical techniques.
- Trial name
- ECLAR (NCT02421081)
- Testing
- vessel microsurgery, tendon repair, nerve microsurgery
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- TC Erciyes University
Shock, Septic
Neuromuscular Electrical Stimulation and Septic Shock
The study will investigate the effects of neuromuscular electrical stimulation (NMES) in patients with septic shock. The objective of this study will be investigate the effects of neuromuscular electrical stimulation (NMES) in…
- Trial name
- NCT03193164
- Testing
- Neuromuscular Electrical Stimulation, Decubitus Position with the limbs raised to 20º
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- University of Sao Paulo
Endothelial Dysfunction, Diabetes Mellitus, Type 1
Novel Therapeutics and Endothelial Dysfunction in T1DM Patients
The aim of study is impact of additional treatment with new antidiabetic drugs (semaglutide or empagliflozine) compared to control group in T1DM patients - impact on endothelial function measured by FMD and FPF, arterial…
- Conditions
- Endothelial Dysfunction, Diabetes Mellitus, Type 1, Biomarkers, Endothelial Progenitor Cells
- Trial name
- ENDIS (NCT05857085)
- Testing
- Semaglutide Pen Injector [Ozempic], Empagliflozin 10 MG
- Where
- Slovenia
- Volunteers
- 90 people
- Sponsor
- General and Teaching Hospital Celje