Clinical trials: Endothelial Progenitor Cells
Traumatic Brain Injury
Effect of Recombinant Erythropoietin on Numbers of Circulating Endothelial Progenitor Cells in People With Persistent Symptoms During the Subacute Period After Traumatic Brain Injury
Background: Traumatic brain injury (TBI) injures blood vessels in the brain. Endothelial progenitor cells (EPCs) help the body form new blood vessels.
- Trial name
- NCT02226848
- Testing
- Erythropoeitin
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Colorectal Cancer
Chemoradiation and Endothelial Progenitor Cells in Colorectal Cancer
Colorectal cancer (CRC) is one of the common malignancies worldwide, accounting for a significant percentage of cancer mortality.
- Trial name
- NCT00325871
- Testing
- concurrent chemoradiation
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Mackay Memorial Hospital
Coronary Artery Disease, Type II Diabetes Mellitus
Innovative Strategies For Risk Reduction Following CABG
Background: Treatment targets for cardiac risk factor reduction are not being met. Therefore, there is a need for new strategies to assist patients in meeting these goals.
- Trial name
- NCT00462436
- Testing
- Consumption of Dietary Portfolio
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Unity Health Toronto
Coronary Arteriosclerosis
Endothelial Progenitor Cells and Risk Factors for Coronary Artery Disease
This study will measure and compare the levels of endothelial progenitor cells (EPCs) in the blood of people with and without risk factors for atherosclerosis (hardening of the arteries) to see if there is a relationship between…
- Trial name
- NCT00013975
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
Effect of Nitric Oxide Donor on Endothelial Progenitor Cells in Patients With Coronary Artery Disease
Regular exercise reduces the risk of heart problems, in part because it improves the work of the endothelium (the cells that line blood vessels).
- Trial name
- NCT00090558
- Testing
- nitroglycerin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Type 2 Diabetes Mellitus
Exercise Endothelial Progenitor Cells (EPCs) and Type 2 Diabetes
The discovery of the role of endothelial progenitor cells (EPCs) and their involvement in the cardiovascular complications of type 2 diabetes (T2DM) would quickly have a significant impact on the millions of Americans who have…
- Trial name
- EPC-DM (NCT01176578)
- Testing
- Aerobic Exercise Training
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Baltimore VA Medical Center
Pulmonary Idiopathic Arterial Hypertension
Endothelial Progenitor Cells and Pulmonary Idiopathic Arterial Hypertension
Endothelial dysfunction ultimately represents an imbalance between the magnitude of injury and the capacity for repair. Current evidence established that endothelial progenitor cells (EPC) participate in several models of…
- Trial name
- NCT00551408
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Unidad de Investigacion Clinica en Medicina S.C.
Endothelial Progenitor Cells, Coronary Artery Disease
Tracking Endothelial Cells in Arterial Injury
We plan to track the migratory behaviour of culture-expanded enothelial outgrowth cells in the context of vascular injury sustained during elective coronary angiography.
- Conditions
- Endothelial Progenitor Cells, Coronary Artery Disease, Vascular Injury, Coronary Angiography
- Trial name
- NCT02975518
- Testing
- Administration of radio labelled endothelial outgrowth cells
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University of Edinburgh
Endothelial Dysfunction, Cardiovascular Risk Factor
Intracoronary Features in the Prognosis of Endothelial Dysfunction and MACES in Population With Acute Coronary Syndrome
Coronary Artery Disease (CAD) is common in Mexico, while morbidity and mortality is high. Drug therapy can relieve angina pain and stabilize plaque, but it is not able to re-flow a coronary artery.
- Conditions
- Endothelial Dysfunction, Cardiovascular Risk Factor, Coronary Syndrome, Acute
- Trial name
- iphoneSPACE (NCT03583047)
- Where
- Mexico
- Volunteers
- 45 people
- Sponsor
- Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
Type 2 Diabetes
Vascular Endothelium Changes After Bariatric Surgery (Endothelial Progenitor Cells)
Improvement in cardiovascular mortality is related to changes in pathologic autoantibodies and in the number of circulating functional replicative competent endothelial progenitor cells (EPC's) after bariatric surgery.
- Trial name
- EPC (NCT01213940)
- Testing
- pre-bariatric weight loss program, bariatric surgery
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of South Alabama
Coronary Artery Disease
Effect of Exercise Training on the Function of HDL-Cholesterol, Endothelial Function and Endothelial Progenitor Cells in Patients With Coronary Artery Disease (HERCET-Study)
Patients with coronary artery disease are characterized by an increased cardiovascular risk and they often have low blood high density lipoprotein (HDL)-cholesterol levels or HDL-cholesterol with modified vasculoprotective…
- Trial name
- HERCET (NCT00457379)
- Testing
- physical exercise
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Type 2 Diabetes
Prospective Influence of Bedtime Insulin Glargine on Mobilization and Function of Endothelial Progenitor Cells
In this trial, it will be studied whether early addition of the long acting insulin analogue Glargine is capable of increasing the number and differentiation of endothelial progenitor cells (EPC) in patients with type 2 diabetes…
- Trial name
- NCT00523393
- Testing
- Insulin Glargin, Human Insulin
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Heidelberg University
- Aortic Aneurysm
Circulating Endothelial Progenitor Cells and Aortic Aneurysm
We aimed to see if aortic aneurysms could be followed-up by circulating endothelial progenitor cells CD34+144+CD14- and CD34+VEGF-R2+CD14- blood level.
- Trial name
- ANOPEC3 (NCT01918982)
- Volunteers
- 40 people
- Sponsor
- Hopital Jean Minjoz
Scleroderma, Systemic, Scleroderma, Diffuse
Effect of Sildenafil on the Microcirculatory Blood Flow and Endothelial Progenitor Cells in Systemic Sclerosis
Early phases of systemic sclerosis is characterized by inflammatory and microvasculature alterations. Sildenafil citrate has been shown to have vasodilatory effects and to enhance vasculogenesis.
- Conditions
- Scleroderma, Systemic, Scleroderma, Diffuse, Scleroderma, Limited, Raynaud Phenomenon
- Trial name
- NCT01347008
- Testing
- Sildenafil citrate
- Where
- Brazil
- Volunteers
- 41 people
- Sponsor
- Federal University of São Paulo
Diabetes Mellitus, Ischemic Heart Disease
Allogeneic Mesenchymal Human Stem Cell Infusion Therapy for Endothelial DySfunctiOn in Diabetic Subjects With Symptomatic Ischemic Heart Disease. (ACESO-IHD)
The purpose of this study is to test the hypothesis that allogeneic Mesenchymal Stem Cells (MSCs) promote systemic and coronary endothelial repair through rescue of bone marrow progenitors in type 2 diabetic patients with…
- Trial name
- ACESO-IHD (NCT04776239)
- Testing
- 100 million Allogeneic Mesenchymal Human Stem Cells
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Joshua M Hare
Stroke, Infarction, Middle Cerebral Artery
Autologous Bone Marrow Stromal Cell and Endothelial Progenitor Cell Transplantation in Ischemic Stroke
The purpose of this study is to evaluate the feasibility, efficacy, and safety of autologous transplantation of ex vivo expanded bone marrow stromal cells (BMSCs)and endothelial progenitor cells (EPCs) for treatment of patients…
- Trial name
- AMETIS (NCT01468064)
- Testing
- Autologous BMSCs transplantation, Autologous EPCs transplantation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Southern Medical University, China
Carotid Artery Diseases, Atherosclerosis
Effect of Valsartan on Carotid Artery Disease
The EFFERVESCENT trial is designed to evaluate the effects of a specific ARB, called valsartan, on atherosclerosis. The investigators want to know if treatment with valsartan will increase the blood levels of markers responsible…
- Trial name
- NCT00208767
- Testing
- Valsartan
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Emory University
Stable Angina
Safety and Efficacy Study of Endothelial Progenitor Cell Capture Stent With 1 Months Dual Antiplatelet Therapy
Thanks to rapid reendothelialization derived from the pro-healing property of the EPC capture stent, 1-month dual antiplatelet therapy (DAPT) is recommended after EPC capture stent implantation.
- Trial name
- INNOVATION (NCT01394848)
- Testing
- Endothelial cell capture stent with 1 month clopidogrel, Everolimus eluting stent with 12 month clopidogrel, Atorvastatin 20mg loading
- Where
- South Korea
- Volunteers
- 1 people
- Sponsor
- Yonsei University
Non-Small Cell Lung Cancer, Chronic Obstructive Pulmonary Disease
Detection of Circulating Endothelial Progenitors Cells (EPCs) in Non-small Cell Lung Cancer (NSCLC)
Bone-marrow-derived progenitor cells (EPCS) play an important role in neovascularization and tumor growth. In lung cancer, angiogenesis is an important event in mechanisms of tumor proliferation and metastasis.
- Trial name
- CBNPC:PCE (NCT00826683)
- Testing
- Enumeration of endothelial cell progenitor in peripheral blood by flow cytometry, Endothelial cell progenitor characterization by primary cell cultures
- Where
- France
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Non-alcoholic Fatty Liver Disease
Effect of Phytosterols on Nonalcoholic Fatty Liver Disease
Phytosterols are plant sterols . Phytosterols have anti-inflammation effect. Investigators have a hypothesis: phytosterols reduce oxidative stress , enhance Insulin-like growth factor-1(IGF-1) and endothelial progenitor…
- Trial name
- NCT01875978
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- China Medical University Hospital