Clinical trials: Endothelial Progenitor Cells
Diabetes Mellitus
Efficacy and Safety of Pioglitazone in Treating Subjects With Vascular Complications Associated With Type 2 Diabetes Mellitus.
The purpose of this study is to determine the efficacy of pioglitazone compared to glibenclamide, once daily (QD), taken together with metformin and lifestyle modification in type 2 diabetic subjects with cardiovascular disease.
- Trial name
- SPLENDOR (NCT00770835)
- Testing
- Pioglitazone and Metformin, Glibenclamide and Metformin
- Where
- 2 sites in Italy
- Volunteers
- 39 people
- Sponsor
- Takeda
Metabolic Syndrome X
Effect of Exercise Training on the Function of the High Density Lipoprotein (HDL)-Cholesterol, Endothelial Function and Endothelial Progenitor Cells in Patients With Metabolic Syndrome(HERMET-Study)
The purpose of the present study is to characterize the quality of HDL-Cholesterol in patients with metabolic syndrome and reduced blood HDL-Cholesterol levels and to examine the effect of exercise training on the…
- Trial name
- HERMET (NCT00515476)
- Testing
- physical exercise
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Sinusoidal Obstruction Syndrome
Sinusoidal Obstruction Syndrome for Stem Cell Transplant Patients Biomarker Study
The goal of this is to learn more about stem cell transplant and complications that some people have after their transplants, in particular sinusoidal obstruction syndrome (SOS), also called veno-occlusive disease of the liver.
- Trial name
- SOSBiomarker (NCT03132337)
- Testing
- Serial Blood Draws
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Indiana University
Leukemia, Multiple Sclerosis
Post-transfusion Platelet Count
The purpose of this study is to identify how the platelet count, complement system and endothelial markers are affected over time, after platelet transfusion in 4 different hematological patient groups.
- Trial name
- NCT02601131
- Testing
- Platelet transfusion
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Region Skane
Coronary Artery Disease, Refractory Angina
Safety and Efficacy of Autologous Endothelial Progenitor Cell CD 133 for Therapeutic Angiogenesis
The purpose of this study is to determine whether transendocardial injections of autologous endothelial progenitor cells CD 133 is safe and feasible in patients with refractory angina.
- Trial name
- PROGENITOR (NCT00694642)
- Testing
- Selected CD 133+ cells
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Pilar Jimenez Quevedo
Type 2 Diabetes, Impaired Renal Function
Linagliptin's Effect on CD34+ Stem Cells
Type 2 diabetes is a national epidemic. Diabetes has undesirable effects on blood vessels which may contribute to heart disease. Endothelial Progenitor Cells (EPCs) are found in the blood.
- Trial name
- NCT02467478
- Testing
- Linagliptin
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- George Washington University
Hematopoietic Stem Cell Transplant (HSCT), Endothelial Injury
Pravastatin as a Prophylactic to Reduce Endothelial Injury in Pediatric Patients With Elevated Body Mass Index
Chemotherapy and radiation used in patients undergoing bone marrow transplant (BMT) disrupts the endothelial lining (a thin layer of cells inside the blood vessels) which is found all throughout the body including the kidney…
- Trial name
- NCT05524246
- Testing
- Pravastatin
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Peripheral Arterial Diseases
Effect of Cilostazol Endothelial Progenitor Cells and Collateral Formation in Peripheral Occlusive Artery Disease (PAOD)
1. The number and function of circulating endothelial progenitor cells (EPCs) are inversely associated with coronary risk factors and atherosclerotic diseases such as PAOD. 2.
- Trial name
- NCT01952756
- Testing
- Cilostazol
- Where
- Taiwan
- Volunteers
- 44 people
- Sponsor
- National Cheng-Kung University Hospital
Endothelial Function, Oxidative Stress
Black Forest Cocoa Flavanol Supplementation and Health Trial
This randomized, double-blind, controlled clinical trial will evaluate the effects of daily cocoa flavanol supplementation on vascular and inflammatory biomarkers in healthy adult men aged 30 to 75 years.
- Conditions
- Endothelial Function, Oxidative Stress, Inflamation, Vascular Health
- Trial name
- NCT07747714
- Testing
- Cocoa Flavanol Supplement, Low-Flavanol Control Powder
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The Black Forest LLC
Endothelial Dysfunction, Inflammation in Cardiopulmonary and Vascular Disease States
Samples From Human Subjects to Facilitate Basic, Translational and Clinical Research
Background: This study is designed to provide samples to help us study the genes your blood cells are making as well as the proteins, sugars, fats, vitamins and other metabolites found in your blood or urine.
- Conditions
- Endothelial Dysfunction, Inflammation in Cardiopulmonary and Vascular Disease States, Healthy Volunteers
- Trial name
- NCT03253705
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Aortic Aneurysm
Reference Values of Circulating Endothelial Progenitor Cells
Circulating endothelial progenitor cells CD34+144+CD14- et CD34+VEGF-R2+CD14- have been shown to be inversely correlated to aortic aneurysm size. However reference values have not yet been determined.
- Trial name
- ANOPEC2 (NCT01918969)
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hopital Jean Minjoz
Macular Degeneration
A Safety Study in Healthy Volunteers to Evaluate Safety, How Fast the Drug is Absorbed, and the Side Effects of the Drug in Humans
This study is to evaluate the safety, absorption rate and side effects associated with the study drug. Healthy volunteers will be given a single dose of the drug in Part 1.
- Trial name
- NCT01051700
- Testing
- GW786034
- Where
- 3 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Myocardial Infarction, Acute
Cilostazol and Endothelial Progenitor Cell
To assess impact of adjunctive cilostazol on endothelial progenitor cell (EPC) mobilization in patients with acute myocardial infarction (To reveal the role of cilostazol in up-regulation of EPC count)
- Trial name
- EPISODE (NCT04407312)
- Testing
- Cilostazol Tablets, Aspirin, Clopidogrel
- Volunteers
- 60 people
- Sponsor
- Gyeongsang National University Hospital
Stable Coronary Artery Disease
Mobilization of Endothelial Progenitor Cells Induced by Atorvastatin in Patients With Stable Coronary Artery Disease Treated With Anti-CD 34 Antibodies Coated Stents
The purpose of this study is to evaluate the extent of the mobilization of endothelial progenitor cells induced by low versus high dose atorvastatin after 4 weeks of treatment, in patients treated with anti-CD 34 antibodies…
- Trial name
- NCT00911339
- Testing
- Atorvastatin
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Idiopathic Pulmonary Arterial Hypertension
Safety and Feasibility of Autologous Endothelial Progenitor Cells Transplantation in Patients With Idiopathic Pulmonary Arterial Hypertension
Recent researches indicate that impairment of vascular and endothelial homeostasis plays a major role in the initiation and development of IPAH.We have recently reported the safety and feasibility data for autologous endothelial…
- Trial name
- NCT00641836
- Testing
- Transplantation of autologous endothelial progenitor cells
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Zhejiang University
Obesity, Hypoandrogenism
Clomiphene Citrate for the Treatment of Obesity Related Male Hypogonadism
Hypogonadism is a clinical condition that can be associated with obesity in man. Controversy exists regarding if its a condition that needs to be treated.
- Trial name
- NCT02380755
- Testing
- Clomiphene Citrate
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- University of Sao Paulo
Peripheral Arterial Disease
Autologous CD133(+) Cells as an Adjuvant to Below the Knee Percutaneous Transluminal Angioplasty
The main aim of the present study was to evaluate the therapeutic potential and safety of transarterial infusion of granulocyte colony stimulating factor (G-CSF) mobilized cluster of differentiation (CD) 133(+) cells when…
- Trial name
- NCT02915796
- Testing
- G-CSF + CD133(+) cells, G-CSF, percutaneous transluminal angioplasty (PTA)
- Where
- China
- Volunteers
- 345 people
- Sponsor
- Shanghai 10th People's Hospital
Inflammatory Response
Removal Of CytoKines With cytoSorbenTs After Inflammatory Response Reaction During Cardiac Surgery
Detailed knowledge about the association between systemic inflammation and endothelial progenitor cell (EPCs) activation during extracorporeal circulation (ECC) is lacking.
- Trial name
- ROCKSTAR (NCT06286280)
- Testing
- cytokine adsorber (CytoSorb®)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Giessen
Leg Pain, Ulcer
Stem Cell Study for Patients With Leg Ulcer/Gangrene
The purpose of this study is to determine if stem cell therapy with one's own cells (autologous cells) delivered intramuscularly to one's leg with ulcer and/or gangrene due to poor blood flow will be safe and if it will relieve…
- Conditions
- Leg Pain, Ulcer, Gangrene, Ischemia
- Trial name
- NCT00221143
- Testing
- Autologous peripheral blood CD34 positive cell therapy
- Where
- 2 sites in Japan
- Volunteers
- 15 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Dilated Cardiomyopathy
Intracoronary Infusion of Autologous Bone Marrow Cells for Treatment of Idiopathic Dilated Cardiomyopathy
The main aim of the study is to determine whether intracoronary infusion of autologous bone marrow mononuclear cells can improve the ventricular function of patients with idiopathic dilated cardiomyopathy.Secondary end-points…
- Trial name
- NCT00629096
- Testing
- Intracoronary infusion of autologous bone marrow cells
- Where
- Spain
- Volunteers
- 27 people
- Sponsor
- Fundación Pública Andaluza Progreso y Salud