Clinical trials: Endothelial Progenitor Cells
Endothelial Progenitor Cells Numbers, Endothelial Function (FMD)
Study Effect of Red Wine Consumption on Endothelial Progenitor Cells and Endothelial Function
Light-to-moderate alcohol consumption has been associated with a reduction of cardiovascular events, and red wine seems to offer more benefits than any other type of alcoholic beverages.
- Trial name
- NCT00755014
- Testing
- red wine
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Acute Ischemic Stroke
Vascular Endothelial Growth Factor and Endostatin in Angiogenesis After Acute Ischemic Stroke
Vascular endothelial growth factor (VEGF) and Endostatin (ES) participate angiogenesis after cerebral ischemia. Circulating endothelial progenitor cells (EPCs) also play a crucial role in neovascularization and tissue repair…
- Trial name
- NCT02157896
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai 6th People's Hospital
Contrast Agent, Endothelial Function
The Effect of Contrast Agent on Endothelial Function in Healthy Men
Contrast medium is essential for diagnosis of many diseases. However, recent studies showed that contrast agents can induce renal injury and is associated with poor long-term clinical outcome, especially in diabetes.
- Conditions
- Contrast Agent, Endothelial Function, Cytokines, Apoptosis of Endothelial Progenitor Cell
- Trial name
- NCT01895699
- Testing
- Contrast agent
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xiang Guang-da
Diabete Type 2, Cardio Vascular Disease
Role of Endothelial Progenitor Cells Dysregulation and Inflammation in the Pathophysiology of Cardiovascular Complications of Type 2 Diabetes
This study aims to isolate endothelial progenitor cells (EPCs) from participants with type 2 diabetes (T2D) and cardiovascular complications and to comprehensively characterize EPC dysfunction.
- Trial name
- NCT07556497
- Where
- Qatar
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Weill Cornell Medical College in Qatar
Acute Coronary Syndromes
Prognostic Value of Biomarkers Associated With Endothelial Progenitor Cells Mobilization in Acute Coronary Syndromes
This prospective study aimed to validate a new prognostic approach of endothelial progenitor cells associated biomarkers in patients with acute coronary syndromes .
- Trial name
- NCT02117037
- Testing
- blood sample
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Acute Ischemic Stroke
Safety and Preliminary Efficacy of Allogeneic Endothelial Progenitor Cells (EPCs) in Patients With Acute Ischemic Stroke
This is a multicenter, randomized, double-blind, placebo-controlled, dose-Escalation clinical study to investigate the safety and efficacy of EPCs transplantation in Acute ischemic stroke.
- Trial name
- NCT05993884
- Testing
- iEPCs
- Where
- 2 sites in China
- Volunteers
- 27 people
- Sponsor
- Allife Medical Science and Technology Co., Ltd.
Primary Myelofibrosids
JAK2V617F Mutated Endothelium Has a Stem Cell Potential in Primary Myelofibrosis: a New Disease Ontogenesis for Chronic Myeloproliferative Disorders
The present project aims to experimentally test the hypothesis that JAK2V617F mutated endothelium in primary myelofibrosis (PMF) we discovered in 2013 represents an embryonic-like hemogenic endothelium and is part of the…
- Trial name
- NCT07607392
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Cardiovascular Disease, Chronic Kidney Disease
Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease
Introduction: Chronic kidney disease (CKD) is now an important public health issue. While 0.1% of the population is on dialysis, approximately 4.5% of subjects have renal dysfunction (glomerular filtration rate <60 ml/min/1.73…
- Conditions
- Cardiovascular Disease, Chronic Kidney Disease, Chronic Renal Disease, Hypertension
- Trial name
- NCT01155128
- Testing
- exercise aerobic
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Federal University of Pelotas
Diabetes, Diabetic Retinopathy
Effects of Fenofibrate on Endothelial Progenitor Cells in Diabetes
Long-standing diabetes is often complicated by retinopathy. The mechanisms that induce the development of diabetic retinopathy are incompletely understood and include alterations in bone marrow derived vasculogenic cells called…
- Trial name
- NCT01927315
- Testing
- Fenofibrate 145 mg
- Where
- Italy
- Volunteers
- 41 people
- Sponsor
- University of Padova
Coronary Artery Disease
Endothelial Progenitor Cells
Vascular stenosis as a result of neointimal hyperplasia is a major clinical problem that has an impact on multiple and diverse disciplines, including cardiology (coronary restenosis), cardiothoracic and vascular surgery…
- Trial name
- NCT01686269
- Testing
- blood collecting
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Far Eastern Memorial Hospital
Atherosclerosis
Impact of Sarpogrelate in the Function of Endothelial Progenitor Cells
The purpose of this study is to evaluate the effects of Sarpogrelate in endothelial progenitor cells of patients with atherosclerosis.
- Trial name
- NCT01548274
- Testing
- Sarpogrelate
- Where
- Japan
- Volunteers
- 20 people
- Sponsor
- Aichi Gakuin University
Exercise Anaphylaxis
The Impact of High Intensity Exercise Upon EPC Number and Function in Young Women
The purpose of the study is to examine the effects of different exercise intensity training programs upon blood vessel function and circulating blood cells involved in blood vessel repair in young women.
- Trial name
- NCT01314573
- Testing
- Sprint interval exercise, Maximal continuous exercise
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Type 2 Diabetes Mellitus, Coronary Artery Disease
Study Effects of Ginkgo Biloba Extract on Endothelial Cell Function and Genetic Effects on the Response to Ginkgo Biloba Extract in Diabetic Patients With Stable Coronary Artery Disease
Type 2 diabetes is associated with a markedly increased risk for atherosclerotic coronary arteries and cerebrovascular diseases.
- Trial name
- NCT01038050
- Testing
- Ginkgo Biloba Extract (GBE)
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
SDF-1 is an Important Cytokine for Neovascularization. Cleavage of SDF-1 is Reduced by DPPIV Inhibitors
Functional Improvement of Progenitor Cells and Endothelial Function by Vildagliptin in Diabetes Mellitus (FINNjA-DM).
SDF-1, an important cytokine for neovascularisation is cleaved by (dipeptidyl peptidase IV) DPPIV. The aim of this study is to assess the effect of the dipeptidyl peptidase IV inhibitor vildagliptin (Galvus®) on endothelial…
- Trial name
- FINNjA-DM (NCT00936234)
- Testing
- Vildagliptin
- Where
- Germany
- Sponsor
- Johann Wolfgang Goethe University Hospital
Preeclampsia, Postpartum
MSC Exosome Therapy for Post-Preeclampsia Endothelial Dysfunction
--- Why Is This Study Being Done? Women who have preeclampsia during pregnancy face a much higher risk of heart disease later in life.
- Conditions
- Preeclampsia, Postpartum, Endothelial Injury, Exosome Multiomics
- Trial name
- EXITPE (NCT07183384)
- Testing
- Mesenchymal Stem Cell-Derived Exosomes
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Universitas Padjadjaran
Liver Cirrhosis
Evaluate Safety and Efficacy of Autologous Bone Marrow-derived Endothelial Progenitor Cells in Advanced Liver Cirrhosis
Endothelial Progenitor Cells (EPC) represent a small cellular population of bone marrow and peripheral blood cells. EPCs are recruited into injured tissues and play an important role in regeneration and reparation.
- Trial name
- NCT01333228
- Testing
- Autologous bone marrow-derived endothelial progenitor cells
- Where
- Spain
- Volunteers
- 14 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Hypertension
Effect of Nebivolol on Oxidative Stress and Endothelial Progenitor Cells
Hypertension, or high blood pressure, is a common disease that affects many Americans, and can lead to devastating consequences such as heart attack, stroke, and death if not treated.
- Trial name
- NCT01041287
- Testing
- Nebivolol, Metoprolol succinate
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Emory University
Thoracic or Abdominal Aortic Aneurysm With no Indication for Surgical Treatment
Follow up of Patients With Aortic Aneurysm by Dosage of Circulant Endothelial Progenitor Cells
The study aims to investigate the existence of a reliable correlation between the progression of aortic diameters and blood levels of circulant endothelial progenitor cells CD34+ in patients with not surgical aortic aneurysms.
- Trial name
- ANOPEC 3 (NCT02919709)
- Testing
- blood taking
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Obesity, Atherosclerosis
Endothelial Dysfunction in Obese Children
The purpose of this study is to objectify the effect of diet and exercise on early markers of atherosclerosis in obese children.
- Trial name
- EDOC (NCT01461226)
- Testing
- Exercise training, Usual care
- Where
- 3 sites in Belgium
- Volunteers
- 61 people
- Sponsor
- University Hospital, Antwerp
Central Nervous System
Investigating Endothelial Precursor Cells (EPCs)
Recent studies suggest that cells in the bone marrow-endothelial precursor cells (EPCs)-can provide a blood supply to cancerous tumors.
- Trial name
- NCT00067067
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)