Clinical trials: Endothelial Progenitor Cells
Coronary Artery Disease
Cell Therapy for Coronary Heart Disease
Impaired contractile function after a heart attack and due to coronary heart disease is a major cause of "heart failure" limiting quality of life and prognosis, which cannot be prevented even with optimal standard therapy.
- Trial name
- NCT00289822
- Testing
- intracoronary infusion of progenitor cells
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Congenital Disorders of Glycosylation
Role of the Endothelium in Stroke-like Episode Among CDG Patients
The aim of the study is to evaluate the role of the endothelial barrier in the occurrence of stroke-like episode. And to study the protein C system on the surface of the endothelium.
- Trial name
- PECDG (NCT03250728)
- Testing
- Peripheral blood puncture
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Coronary Syndrome, Myocardial Infarction
Telmisartan Versus Ramipril After Acute Coronary Syndrome
The purpose of this study is to compare the antinflammatory and endothelial progenitor cell (EPC) mobilizing effect of Ramipril and Telmisartan in patients presenting with acute coronary syndrome
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Coronary Disease
- Trial name
- TERACS (NCT00702936)
- Testing
- TELMISARTAN, RAMIPRIL
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Catholic University of the Sacred Heart
Type 2 Diabetes
Effect of Vildagliptin vs. Glibenclamide on Circulating Endothelial Progenitor Cell Number Type 2 Diabetes
The purpose of this study is to evaluate the effect of Dipeptidyl peptidase (DPP) -IV inhibitor Vildagliptin vs. Glibenclamide on circulating endothelial progenitor cells (EPCs) number in type 2 diabetes patients in metformin…
- Trial name
- NCT01822548
- Testing
- Vildagliptin, Glibenclamide, Metformin
- Where
- 2 sites in Italy
- Volunteers
- 64 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
End-stage Kidney Disease, Diabetes Mellitus
Vascular Protective Effect of Rosuvastatin in Arteriovenous Fistula
Background Arteriovenous (AV) fistula is the most common vascular access for long-term hemodialysis in the end-stage renal disease (ESRD) patients. About 25% of these patients are diabetes mellitus.
- Conditions
- End-stage Kidney Disease, Diabetes Mellitus, Arteriovenous Fistula
- Trial name
- NCT01863914
- Testing
- Rosuvastatin
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Sickle Cell Anemia
Sickle Cell Disease and Endothelial Progenitor Cells (EPCs)
Sickle Cell Disease (SCD) is the most prevalent genetic disease of haemoglobin.The underlying abnormality in the red blood cell (RBC) of SCD is the presence of abnormal sickle cell hemoglobin (HbS), which, when deoxygenated…
- Trial name
- DREPANOPEC (NCT00783627)
- Testing
- Angiography
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Transplantation, Kidney, Cardiovascular Abnormalities
CEC/EPC and Cardiovascular Risk in Renal Transplant Recipients
We believe that certain cells in the human body (Circulating Endothelial Cells and Endothelial Progenitor Cells) are related to risk of cardiovascular disease.
- Conditions
- Transplantation, Kidney, Cardiovascular Abnormalities, Cardiovascular Diseases
- Trial name
- CEC (NCT00365833)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Florida
Type 2 Diabetes, Chronic Renal Failure
Rapid Effects Linagliptin on Monocyte Polarization and Endothelial Progenitor Cells in Type 2 Diabetes
Diabetes mellitus is characterized by chronic low grade inflammation, which is worsened by the co-existence of renal failure. One key aspect of chronic inflammatory diseases is the alteration in the polarization profile of…
- Trial name
- NCT01617824
- Testing
- Linagliptin
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- University of Padova
Obesity
Effect of a Mediterranean Diet and Omega-3 Fatty Acids on Oxidative Stress and Endothelial Progenitor Cells (EPC's)
Problem of Interest: A typical American diet that is high in an intake of fats (especially saturated fats and cholesterol) is known to lead to high blood levels of cholesterol, hardening of the arteries, and increases the risk of…
- Trial name
- NCT00166088
- Testing
- Mediterranean Diet, Mediterranean Dietary Supplement
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Fibromuscular Dysplasia, Early Onset CAD
CAUSE Trial: Patient Specific-Cellular Characterization of Fibromuscular Dysplasia and High-Risk Atherosclerotic Endothelium
The purpose of this project is to see if heritable alterations in the function, biology and vascular repair capacity of vascular cells make a major contribution to the burden of coronary artery disease (CAD), fibromuscular…
- Trial name
- NCT01808729
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Diabetes Mellitus, Metabolic Syndrome X
Effect of Statins on Oxidative Stress and Endothelial Progenitor Cells
Thirty-six subjects with hyperlipidemia and metabolic syndrome and/or diabetes were randomized in a double-blind manner to either pravastatin 80 mg or atorvastatin 10 mg daily.
- Conditions
- Diabetes Mellitus, Metabolic Syndrome X, Hypercholesterolemia
- Trial name
- STOPCAP (NCT00166036)
- Testing
- Atorvastatin, Pravastatin
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Emory University
Coronary Artery Disease
Age and Endothelial Progenitor Cell Mobilization
It is hypothesized that aging is associated with reduced vascular injury-induced endothelial progenitor cell activity, resulting in impaired vascular repair and increased vascular disease.
- Trial name
- AGE-PCI (NCT00585949)
- Testing
- Percutaneous Coronary Angioplasty, Angiography
- Where
- 2 sites in United States
- Volunteers
- 123 people
- Sponsor
- Emory University
Acute ST Elevation Myocardial Infarction
REVEAL: Reduction of Infarct Expansion and Ventricular Remodeling With Erythropoietin After Large Myocardial Infarction
The purpose of this study is to evaluate whether erythropoietin can help limit the damage to the heart in patients with acute heart attacks.
- Trial name
- NCT00378352
- Testing
- Epoetin alfa
- Where
- 16 sites in United States
- Volunteers
- 223 people
- Sponsor
- National Institute on Aging (NIA)
Endothelial Dysfunction
The Effect of Tekturna on Endothelial Function and Endothelial Progenitor Cells in Patients With Early Atherosclerosis
We will study the hypothesis that long-term Tekturna treatment will improve endothelial function and the production and function of endothelial progenitor cells (EPCs) in patients with early atherosclerosis.
- Trial name
- NCT01067326
- Testing
- Aliskiren
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Mayo Clinic
Cardiovascular Diseases
Effect of Cilostazol on Endothelial Progenitor Cells and Endothelial Function in High Risk for Cardiovascular Disease
1. The number and function of circulating endothelial progenitor cells (EPCs) are inversely associated with coronary risk factors and atherosclerotic diseases. 2.
- Trial name
- NCT02194686
- Testing
- Cilostazol
- Where
- Taiwan
- Volunteers
- 71 people
- Sponsor
- National Cheng-Kung University Hospital
Haploidentical Hematopoietic Stem Cell Transplantation
Effect of NAC on the Hematopoietic Reconstitution After Haploidentical Hematopoietic Stem Cell Transplantation
The aim of the study is to evaluate the efficacy of the prophylactic administration of N-acetyl-L-cysteine (NAC) in acute leukemia patients with complete remission pre- and post-allotransplant on the occurrence of poor graft…
- Trial name
- NCT03236220
- Testing
- N-acetyl-L-cysteine
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Peking University People's Hospital
Diabetes Mellitus, Type 2, Cardiovascular Diseases
The Impact of Glucose Lowering Therapies on Circulating Endothelial Progenitor Cells and Its Mobilising Factor Stromal Derived Factor-1α in Patients With Type 2 Diabetes
This is a cross-sectional observational study aiming to examine and compare the impact of incretin based therapies i.e. dipeptidyl peptidase-4 (DPP4) inhibitors and glucagon-like peptide-1 (GLP-1) analogues, on endothelial…
- Trial name
- IGLOOS (NCT02694575)
- Where
- United Kingdom
- Volunteers
- 241 people
- Sponsor
- University of Leicester
Peripheral Arterial Disease, Endothelial Dysfunction
Effects of Combined Aerobic and Resistance Training in Patients With Intermittent Claudication
Exercise training improves walking capacity and regional perfusion in patients with Intermittent Claudication (IC). Endothelial Progenitor Cells (EPCs) and Endothelial Microparticles (EMPs) could play an important role in this…
- Trial name
- NCT04302571
- Testing
- combined aerobic and resistance physical activity
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Of Perugia
Systemic Lupus Erythematosus
Physical Exercise, Endothelial Function and Progenitor Endothelial Cells in Systemic Lupus Erythematosus Patients
The purpose of this study is to evaluate the effect of supervised physical exercise on endothelial function and number of endothelial progenitor cells (EPCs) in patients with systemic lupus erythematosus, as well as evaluate the…
- Trial name
- NCT01712529
- Testing
- Supervised physical exercise
- Where
- Brazil
- Volunteers
- 38 people
- Sponsor
- Federal University of São Paulo
Placental Transfusion, Stem Cells
Placental Transfusion Methods and Stem Cells
To measure the levels of endothelial progenitor cells and CD34+ hematopoietic stem cells levels, and placental residual volume by delayed cord clamping, umbilical cord milking or immediate cord clamping in newborns at different…
- Trial name
- NCT03983902
- Testing
- Delayed cord clamping, Umbilical cord milking, Immediate cord clamping
- Volunteers
- 96 people
- Sponsor
- Ankara University