Clinical trials: Endothelium, Vascular
Coronary Artery Disease, Graft Failure
Clinical Effect of No-touch Harvesting Technique in OPCABG
This study aims to investigate the clinical effect of the new saphenous vein harvesting technique "No-touch" in off-pump coronary artery bypass grafting(OPCABG), comparing to the conventional technique.
- Trial name
- NCT03729531
- Testing
- Conventional vein harvesting technique, no-touch vein harvesting technique
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Anzhen Hospital
ANCA Associated Vasculitis, Cardiovascular Diseases
ETA and AT1 Antagonism in ANCA-vasculitis (SPARVASC)
ANCA-associated vasculitis is an autoimmune disease that causes damage to blood vessels. This leads to organ damage with the number of organs affected and the severity of damage varying significantly between patients.
- Conditions
- ANCA Associated Vasculitis, Cardiovascular Diseases, Kidney Diseases
- Trial name
- SPARVASC (NCT05630612)
- Testing
- Sparsentan
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Edinburgh
Peripheral Artery Disease
DUAL Pathway Inhibition to Improve Endothelial Function in Peripheral Artery Disease
Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis, causing patients to be at high risk of major adverse cardiovascular and limb events.
- Trial name
- DUAL-PAD (NCT04218656)
- Testing
- Rivaroxaban 2.5 Mg Oral Tablet
- Where
- 2 sites in Netherlands
- Volunteers
- 159 people
- Sponsor
- Radboud University Medical Center
Chronic Obstructive Pulmonary Disease
Inhaled Corticosteroids (ICS) on Pulmonary Endothelial Function in COPD
The study objective is to determine whether an ICS added for 4 weeks to a baseline treatment with a Long-Acting Beta-adrenergic Agonist (LABA) and Long-Acting Muscarinic Antagonist (LAMA) combination improves pulmonary vascular…
- Trial name
- NCT05607719
- Testing
- Bevespi, Bretzri
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Miami
Sepsis
Midkine and ACE-Ang II Induced Endothelial Injury in Sepsis
Plasma midkine has reported to be elevated in infection and a regulator of angiotensin-converting enzyme (ACE). We aimed to investigate the plasma midkine in septic patients and its association with 28-day mortality and organ…
- Trial name
- NCT02605681
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
Endometrial Carcinoma
Trisenox® in Women With Metastatic Endometrial Cancer
The primary purpose of this study is to see whether women who have already received chemotherapy for their endometrial cancer, or who have disease that has spread outside of the uterus, will respond to the drug arsenic trioxide…
- Trial name
- NRR (NCT01184053)
- Testing
- Arsenic trioxide
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Pancreatic Cancer, Adenocarcinoma of the Pancreas
Phase I Study of Gemcitabine, Sorafenib and Radiotherapy in Patients With Unresectable Pancreatic Cancer
The purpose of this study is to evaluate the safety and tolerability of the combined treatment of Sorafenib (BAY 43-9006) with Gemcitabine and radiotherapy in patients with localized unresectable pancreatic cancer.
- Trial name
- NCT00375310
- Testing
- Gemcitabine, Sorafenib, Radiotherapy
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Indiana University
Adverse Childhood Experiences, Endothelial Dysfunction
ACEs, SIRT1, and Premature Vascular Aging in Humans
Adverse childhood experiences (ACEs) are directly related to cardiovascular morbidity and mortality, and impaired vascular endothelial function (VEF) is an independent predictor of future cardiovascular disease (CVD) risk [1, 2].
- Trial name
- NCT07073352
- Testing
- Nicotinamide Riboside
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Metabolic Syndrome
The Impact of Free Fatty Acid Reduction on Vascular Function in the Metabolic Syndrome
This study will test the hypothesis that reducing the release of free fatty acids (FFA) from fat cells will restore insulin-mediated, endothelium-dependent vasodilation in people with the metabolic syndrome.
- Trial name
- NCT00759291
- Testing
- acipimox
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Metastatic Breast Cancer, Bone Metastases
Zometa and Circulating Vascular Endothelial Growth Factor (VEGF) in Breast Cancer Patients With Bone Metastasis
The primary objective of this study is to evaluate the effects of Zometa (zoledronic acid, 1 mg per week versus 4 mg every four weeks) on the circulating vascular endothelial growth factor (VEGF) levels in breast cancer patients…
- Trial name
- NCT00524849
- Testing
- Zoledronic acid
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Fudan University
Metabolic Syndrome, Vascular Injury
Therapeutic Strategies to Reduce Endothelial Ischemia-reperfusion Injury
The objective of this clinical trial is to better understand how lactate, a naturally occurring energy substance, can be used to lessen damage to the vascular system in adults with a high cardiovascular disease risk.
- Conditions
- Metabolic Syndrome, Vascular Injury, Ischemic Preconditioning, Endothelial Function (reactive Hyperemia)
- Trial name
- NCT06825143
- Testing
- Ischemic preconditioning, Intravenous lactate infusion, No ischemic preconditioning (control)
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Gary Van Guilder
Iris
VEGF in Iris Tissue in Primary Congenital Glaucoma
Estimation of vascular endothelial growth factor (VEGF) in iris tissue specimen in primary congenital glaucoma through Immunohistochemistry.
- Trial name
- NCT05484050
- Testing
- Immunohistochemistry analysis
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Hassan Lotfy Fahmy
Vascular Disease, Endothelial Dysfunction
Effects of Almonds on Vascular Reactivity in Patients With Coronary Artery Disease
This is a study of the effects of 3 oz almonds added daily to a National Cholesterol Education Program Therapeutic Lifestyle Changes (TLC) diet in improving endothelial function in patients with Coronary Artery Disease.
- Conditions
- Vascular Disease, Endothelial Dysfunction, Heart Disease, Cardiovascular Diseases
- Trial name
- NCT00782015
- Testing
- Almonds
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Tufts University
Atherosclerosis
Effect of Enhanced External Counterpulsation (EECP) on Subclinical Atherosclerosis
Shear stress maybe the most crucial local factor affecting atherogenesis. The present study investigated the effect of exposure to increased shear stress promoted by Enhanced External Counterpulsation (EECP) on the progression of…
- Trial name
- SESA (NCT01106495)
- Testing
- Enhanced External Counterpulsation (EECP), Simvastatin
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sun Yat-sen University
Neovascular Glaucoma, Neovascularization
KDR2-2 Suspension Eyedrop in the Treatment of Neovascular Glaucoma (KDR-NVG) Trial
The clinical trial is aimed to evaluate the anti-neovascular effect of KDR2-2 suspension eyedrop in the treatment of neovascular glaucoma.
- Trial name
- KDR-NVG (NCT04844619)
- Testing
- 4mg/ml KDR2-2 suspension eyedrop, 16mg/ml KDR2-2 suspension eyedrop
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sun Yat-sen University
PAD, Claudication
Safety Study of MultiGeneAngio in Patients With Peripheral Arterial Disease (PAD)
The purpose of this study is to evaluate the safety and activity of increasing doses of MultiGeneAngio, a cell therapy product produced from the patient's own cells, as potential treatment for patients with peripheral arterial…
- Trial name
- NCT00390767
- Testing
- MultiGeneAngio
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- MultiGene Vascular Systems Ltd.
Neovascular Age-Related Macular Degeneration
Neovascular Morphology and Persistent Disease Activity Among Patients With NV AMD
Neovascular Age-Related Macular Degeneration (NV AMD) remains the leading cause of vision loss among people over 65. Intravitreal injections with drugs that block VEGF have revolutionized treatment of NV AMD.
- Trial name
- NCT02367365
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Duke University
Vasodilation
Effects of Exercise Training on Vascular Endothelial Function of Patients Submitted to Coronary Artery Bypass Graft
Objective: To observe the effects of exercise training on vascular endothelial function in patients undergoing coronary artery bypass graft (CABG) alone in phase III after six months of Cardiac rehabilitation programs (CRP).
- Trial name
- NCT02265107
- Testing
- exercise training
- Where
- Brazil
- Volunteers
- 9 people
- Sponsor
- Universidade Federal do Rio Grande (FURG)
Chronic Kidney Disease
Iplasma IL6, Procalcitonin and VEGF and Dialysate Level in CAPD Patients
The aim of study was to evaluated the correlation between plasma levels, dialysate appearance rate of VEGF, inflammatory cytokines (IL- 6, procalcitonin) and PSTR, dialysis adequacy in CAPD patients.
- Trial name
- NCT02881892
- Testing
- Measure plasma and dialysate level of IL-6, procalcitonin and VEGF
- Where
- Thailand
- Volunteers
- 26 people
- Sponsor
- Bangkok Metropolitan Administration Medical College and Vajira Hospital
Hypertension
The Effect of Kiwi on Blood Pressure, Endothelial Function, Antioxidant Capacity and Gene Expression
The purpose of this study is to determine whether the intake of kiwi fruits will reduce systolic and diastolic blood pressure compared to intake of apples.
- Trial name
- NCT00948363
- Testing
- Kiwi fruits, Apple
- Where
- 2 sites in Norway
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
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