Clinical trials: Endothelium, Vascular
Atherosclerosis, Hypercholesterolemia
Rosuvastatin Affecting Aortic Valve Endothelium
Recent studies support the hypothesis that aortic stenosis (AS) develops due to atherosclerosis affecting the aortic valve endothelium.
- Trial name
- NCT00114491
- Testing
- Rosuvastatin
- Where
- Portugal
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hospital Pedro Hispano
Central Retinal Vein Occlusion
Assessing the Efficacy and Safety of Brolucizumab Versus Aflibercept in Patients With Visual Impairment Due to Macular Edema Secondary to Central Retinal Vein Occlusion
The purpose of this study was to evaluate the efficacy and safety of brolucizumab in treatment of patients with macular edema (ME) secondary to central retinal vein occlusion (CRVO).
- Trial name
- RAVEN (NCT03810313)
- Testing
- Brolucizumab 6 mg, Aflibercept 2 mg
- Where
- 120 sites in United States, Australia and 18 more
- Volunteers
- 493 people
- Sponsor
- Novartis Pharmaceuticals
Renal Cell Carcinoma
Study of GDC-0980 Versus Everolimus in Participants With Metastatic Renal Cell Carcinoma Who Have Progressed on or Following Vascular Endothelial Growth Factor- (VEGF) Targeted Therapy
Study PIM4973g is a multicenter, international, open-label Phase II trial. Participants with metastatic renal cell carcinoma who have progressed on or after VEGF targeted therapy will be randomized in 1:1 to two groups either to…
- Trial name
- NCT01442090
- Testing
- Everolimus, GDC-0980
- Where
- 22 sites in United States, France and 3 more
- Volunteers
- 85 people
- Sponsor
- Genentech, Inc.
Vascular Anomaly, Generalized Lymphatic Anomaly
Identification of Biomarkers for Patients with Vascular Anomalies
The study will use blood (serum and plasma) and tissue obtained from participants undergoing prescribed surgical resection of vascular anomalies of interest proposed in this study.
- Conditions
- Vascular Anomaly, Generalized Lymphatic Anomaly, Kaposiform Hemangioendothelioma, Kaposiform Lymphangiomatosis
- Trial name
- NCT03001180
- Where
- 2 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Dynamic Strength Exercise Session, Isometric Strength Exercise Session
Acute and Chronic Effects of Combined Training on BP in Hypertensives
Dynamic strength training (DST) is widely recognized for promoting neuromuscular adaptations such as increased strength and hypertrophy.
- Conditions
- Dynamic Strength Exercise Session, Isometric Strength Exercise Session, Combined Exercise Session, Control Session (CON)
- Trial name
- COMBAT-H (NCT07470450)
- Testing
- Combined strength training, Dynamic strength training, Acute Isometric Exercise Session.
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of Rio Grande do Sul
Diabetic Macular Edema
Diabetic Macular Edema Asian Response (DEAR) Study: Biomarkers for Response to Aflibercept in Asian Patients With Center Involving DME
To investigate whether ocular imaging and proteomic biomarkers; and systemic biochemical, metabolomic, and genetic biomarkers predict treatment response to intravitreal aflibercept in a cohort of patients with DME.
- Trial name
- NCT03197480
- Testing
- Aflibercept Injection [Eylea]
- Where
- Singapore
- Volunteers
- 36 people
- Sponsor
- Singapore National Eye Centre
Vascular Disease, Peripheral, Physical Inactivity
Inter-individual Physiological Response to a Training and Detraining Period in Cardiometabolic Risk Factors Subjects
Background: Although exercise training is a well described therapy for some cardiometabolic diseases such as obesity, type 2 diabetes, arterial hypertension, and metabolic syndrome, there is scarcity of knowledge about the…
- Conditions
- Vascular Disease, Peripheral, Physical Inactivity, Arterial Hypertension, Endothelial Dysfunction
- Trial name
- VASCU-HEALTH (NCT05710653)
- Testing
- Exercise training intervention
- Where
- Chile
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Cristian Alvarez
Coronary Artery Disease
COMPARE-II- Vasomotion and Imaging Substudy
The purpose of the study is to compare strut coverage and neointimal thickness between everolimus eluting (XIENCE-V® or PROMUS® stent) and biolimus A9 eluting NOBORI Stent 14 months after stent implantation and to determine the…
- Trial name
- COMPARE-IT (NCT01329237)
- Testing
- dynamic physical exercise and OCT imaging
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Freiburg
Coronary Artery Disease, Acute Kidney Injury
Endothelial Glycocalyx Damage in Acute Kidney Injury
Abstract Significance: Cardiac surgery-associated acute kidney injury (CSA-AKI) is common and has serious immediate and long-term sequelae.
- Trial name
- NCT05471583
- Testing
- Main group
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- King's College London
Type 2 Diabetes Mellitus Related Endothelial Dysfunction
Effects of Atazanavir Treatment on Type 2 Diabetes Mellitus Related Endothelial Dysfunction
The purpose of this study is to determine whether atazanavir use is of influence on the endothelial dysfunction associated with type 2 diabetes mellitus.
- Trial name
- DM2ATV (NCT00696722)
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Radboud University Medical Center
Coronary Artery Disease
Effect of Cilostazol on Endothelial Progenitor Cells and Endothelial Function in Coronary Artery Disease
1. The number and function of circulating endothelial progenitor cells (EPCs) are inversely associated with coronary risk factors and atherosclerotic diseases such as coronary artery disease (CAD) and cardiovascular high risk. 2.
- Trial name
- NCT02174939
- Testing
- Cilostazol
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Cheng-Kung University Hospital
Solid Tumor
A Study of Injection HB002.1T in Subjects With Solid Tumor
The objectives of this study are to evaluate the safety, tolerability, and pharmacokinetic profile of HB002.1T, a human immunoglobulin Fc fusion protein containing domain 2 and flanking sequence of vascular endothelial growth…
- Trial name
- NCT03636750
- Testing
- HB002.1T
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Huabo Biopharm Co., Ltd.
Endothelial Function
Endothelial Function Assessed With BOLD-MRI
The purpose of this study is to assess the applicability of a new SSFP-based BOLD sensitive MRI sequence in evaluating endothelial function. Endothelial function will be tested in a setting of reactive hyperemia in the forearm.
- Trial name
- EFBOLD-MRI (NCT00575120)
- Testing
- ischemia reperfusion
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Reproductive Techniques
Vascular Endothelial Growth Factor Levels in Patients Undergoing Embryo Transfer
Assessing the relationship between the VEGF levels in blood and the IVF protocol
- Trial name
- NCT04261660
- Testing
- NO intervention
- Volunteers
- 90 people
- Sponsor
- Carmel Medical Center
Advanced Solid Tumor, Refractory Tumor
A Clinical Study of Recombinant Human Vascular Endothelial Inhibitor in Combination With PRaG for Advanced Refractory Non-small Cell Lung Cancer
Exploring the efficacy and safety of recombinant human vascular endothelial inhibitor (Endo) in combination with Bragg therapy in advanced refractory non-small cell lung
- Trial name
- NCT06047860
- Testing
- Radiotherapy, PD-1/PD-L1 inhibitor, Granulocyte-macrophage colony-stimulating factor subcutaneous injection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Exudative Age-related Macular Degeneration
Evaluation of Retinal and Vascular Features in Macular Degeneration After Intravitreal Injections of Bevacizumab
This study evaluates the retinal and vascular features in patients with macular degeneration under the effects of Bevacizumab intravitreal injections using optical coherence tomography and optical coherence tomography angiography.
- Trial name
- NCT04138420
- Testing
- Bevacizumab Injection
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- Federico II University
Depressive Disorder, Depression
Exploring Effects of Electroconvulsive Therapy on the Human Brain in Depression - The Danish ECT/MRI Study
The main purpose of this study is to determine whether electroconvulsive therapy (ECT) causes any structural or functional brain changes and thus indicating its mechanism of action.
- Conditions
- Depressive Disorder, Depression, Depressive Disorder, Major
- Trial name
- NCT03040388
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- University of Copenhagen
Endothelial Dysfunction, Atherosclerosis
Blood Markers for Inflammation and Coronary Artery Vasoreactivity Testing in Patients With Chest Pain and Normal Coronary Arteries
The investigators are hoping to discover the cause of chest pain in patients with a normal coronary arteriogram. For patients with chest pain coronary angiography is the standard method by which the blood vessels of the heart can…
- Conditions
- Endothelial Dysfunction, Atherosclerosis, Inflammation, Myocardial Ischemia
- Trial name
- ACOVA (NCT01162824)
- Testing
- Acetylcholine, Adenosine
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- St George's Healthcare NHS Trust
Hookah Smoking
Effects of Hookah (Waterpipe) Smoking on Blood Vessel Function
The purpose of this study is to assess the acute effects of Hookah (waterpipe) smoking on blood vessel function. Hookah smoking has been shown to immediately increase blood pressure and heart rate which could result in damage in…
- Trial name
- NCT03616002
- Testing
- Hookah smoking
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Choroidal Neovascularization, Punctate Inner Choroidopathy
Long-term Outcome of Punctate Inner Choroidopathy or Multifocal Choroiditis With Active Choroidal Neovascularization Managed With Anti-vascular Endothelial Growth Factor
To evaluate the long-term outcome of active choroidal neovascularization (CNV) in punctate inner choroidopathy (PIC) or multifocal choroiditis (MFC) after anti-vascular endothelial factor treatment.
- Trial name
- NCT03793400
- Testing
- Bevacizumab Injection
- Where
- Taiwan
- Volunteers
- 22 people
- Sponsor
- Changhua Christian Hospital
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