Clinical trials: Endothelium, Vascular
Diabetic Macular Edema
Relationship Between Dyslipidemia and The Response of Diabetic Macular Edema to Intravitreal Injection of Anti Vascular Endothelial Growth Factor Agents
Diabetic retinopathy (DR) is considered the main etiology of blindness among working-age adults, and Diabetic macular edema (DME) is the main reason for vision loss related to DR .
- Trial name
- NCT06205979
- Testing
- Ranibizumab Injection [Lucentis], Aflibercept Injection [Eylea]
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Diabetes Mellitus, Diabetic Nephropathy
The Effect of Green Tea or Cocoa Extracts in Endothelial Dysfunction in Patients With Diabetes Mellitus
The purpose of this study is to determine whether green tea or cocoa extracts are effective in improve endothelial dysfunction in patients with diabetes mellitus and nephropathy and arterial hypertension.
- Conditions
- Diabetes Mellitus, Diabetic Nephropathy, Arterial Hypertension
- Trial name
- NCT01130727
- Testing
- green tea extract, cocoa extract rich in polyphenols, low polyphenol cocoa extract
- Where
- Brazil
- Volunteers
- 51 people
- Sponsor
- University of Campinas, Brazil
Cardiovascular Diseases, Endothelial Dysfunction
Anti-Inflammatory Drug and Endothelial Function
In this randomized double-blinded clinical trial, 400mg of hydroxychloroquine will be given daily to people over the age of 65 years with moderate-severe obstructive sleep apnea for 8 weeks.
- Conditions
- Cardiovascular Diseases, Endothelial Dysfunction, Sleep Apnea, Atherosclerosis
- Trial name
- HOLD (NCT04161339)
- Testing
- Hydroxychloroquine
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Foetal Growth Restriction
Maternal Serum Vascular Endothelial Growth Factor in Pregnant Women With Foetal Growth Restriction
In this study we explore To explore the role of maternal serum vascular endothelial growth factor (VEGF) in pregnancies complicated by foetal growth restriction.
- Trial name
- VEGF in FGR (NCT02245477)
- Testing
- obstetric Ultrasound, serum Vascular Endothelial Growth Factor
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Beni-Suef University
Arterial Hypertension, Resistant Arterial Hypertension
Systemic Microvascular Function in Patients With Resistant Hypertension After Renal Sympathetic Denervation
It has been proposed that the modulation of the activity of the sympathetic nervous system, through renal sympathetic denervation, besides reducing blood pressure, would promote an improvement in vascular reactivity and…
- Trial name
- NCT03243045
- Testing
- Renal sympathetic denervation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Hypertension, Cardiovascular Diseases
Impact of Dairy Consumption on Hypertension: a Clinical Study
Hypertension and endothelial dysfunction are being increasingly recognized as key etiological factors in the development of atherosclerosis and subsequent cardiovascular disease (CVD).
- Trial name
- PLAT (NCT01776216)
- Testing
- Dairy diet, Control diet
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Laval University
Metastatic Renal Cell Carcinoma
Clinical Outcomes for Patients With Renal Cell Carcinoma Who Received First-Line Sunitinib
This is a retrospective, longitudinal cohort study that assessed clinical outcomes of patients with metastatic renal cell carcinoma (mRCC) who received sunitinib as first-line treatment.
- Trial name
- NCT04076787
- Testing
- Sunitinib
- Where
- Canada
- Volunteers
- 1,769 people
- Sponsor
- Pfizer
Endothelial Dysfunction, Autonomic Dysfunction
Upper- and Lower-body Resistance Exercise With and Without Blood Flow Restriction on Hemodynamics and Vascular Function
The American College of Sports Medicine (ACSM) recommends that resistance exercise performed at greater than 70% one repetition maximum (1 RM) is necessary to induce strength gains and muscular hypertrophy (ACSM, 2009).
- Trial name
- NCT03225898
- Testing
- Resistance Exercise with Blood Flow Restriction, High-intensity Resistance Exercise
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kent State University
Renal Cell Carcinoma
Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With Recurrent Disease During or After Anti-PD-(L)1 Therapy (MK-3475-03C/KEYMAKER-U03)
Substudy 03C is part of a larger research study that is testing experimental treatments for renal cell carcinoma (RCC). The larger study is the umbrella study (U03).
- Trial name
- NCT07049926
- Testing
- Belzutifan, Zanzalintinib
- Where
- 33 sites in United States, Chile and 6 more
- Volunteers
- 140 people
- Sponsor
- Merck Sharp & Dohme LLC
Vascular Reactivity, Serum Biomarkers
MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers
To examine vascular reactivity and inflammatory biomarkers via quantitative magnetic resonance imaging (MRI) and blood serum, respectively, in a crossover study where active vapers (electronic cigarette users) and smokers will…
- Trial name
- AeCE (NCT05271578)
- Testing
- Standardized Electronic Research Cigarette, Nicotine Research Cigarette
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Sepsis, Septic Shock
DDX17 Orchestrate Septic Vascular Endothelial Pyroptosis by Controlling Gasdermin D Pore Formation
Objective: To investigate the correlation between plasma levels of DDX17 and GSDMD with vascular endothelial dysfunction and prognosis of in sepsis patients. Design: A single center, prospective, observational research.
- Trial name
- NCT06013033
- Volunteers
- 60 people
- Sponsor
- Zhongda Hospital
Cutaneous Arteriovenous Malformations
Identification of Genetic and Cellular Markers Associated With Vascular Endothelial Modifications in Cutaneous Arteriovenous Malformations
Cutaneous Arteriovenous malformations (AVM's) rare congenital high-flow vascular malformations in which arteries and veins are directly connected through a complex web of abnormal arteries and veins instead of a normal capillary…
- Trial name
- NCT01774916
- Testing
- blood samples
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Hypertension
Acute Effect of Photobiomodulation in Individuals with Hypertension
This is a randomized, double-blind and sham-controlled clinical trial that aims to evaluate and compare the acute effect of full-body photobiomodulation (PBM) and modified ILIB (Intravascular laser irradiation of blood) on blood…
- Trial name
- NCT06678698
- Testing
- Panel Effective Photobiomodulation Therapy, Modified ILIB Photobiomodulation Therapy
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- Universidade Federal de Sao Carlos
Wet Macular Degeneration
Caregiver Burden of Wet Age-related Macular Degeneration (wAMD) in Japan
This study aims at investigation of the caregiver burden of Wet Age-related Macular Degeneration (wAMD) patients and at the assessment of how much of caregiver burden could be reduced in transitioning from Pro Re Nata to…
- Trial name
- NCT02541084
- Testing
- Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
- Where
- Japan
- Volunteers
- 72 people
- Sponsor
- Bayer
ST Elevation Myocardial Infarction
Relationship Between Left Ventricular Remodeling, Coronary Endothelial Function and Myocardial Fibrosis Using Positron Emission Tomography in Patients With ST-elevation Myocardial Infarction
Left ventricular remodeling is a common complication in patients with ST-elevation myocardial infarction (STEMI ) and may lead to heart failure.
- Trial name
- REMOD-TEP (NCT02789098)
- Testing
- (15)-O water positron emission tomography and Biomarkers
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Caen
Neovascular Age-Related Macular Degeneration
Anti-angiOpoeitin 2 Plus Anti-vascular eNdothelial Growth Factor as a therapY for Neovascular Age Related Macular Degeneration: Evaluation of a fiXed Combination Intravitreal Injection
The primary objective of the study is to compare the efficacy of intravitreal (IVT)-administered REGN910-3 compared to intravitreal aflibercept injection (IAI).
- Trial name
- ONYX (NCT02713204)
- Testing
- REGN910-3, Intravitreal Aflibercept Injection (IAI)
- Where
- 87 sites in United States
- Volunteers
- 365 people
- Sponsor
- Regeneron Pharmaceuticals
Subclinical Atherosclerotic Cardiovascular Disease, Neurocognitive Decline
MISTIC Study: Atherosclerosis, Neurocognition & Cardiovascular Signaling
The MISTIC study is a non-profit, cross-sectional clinical research project aimed at investigating the relationship between atherosclerosis and both cardiovascular and cognitive function in adult populations.
- Trial name
- MISTIC (NCT07520643)
- Testing
- Peripheral Vascular Imaging, Coro-CT, Neurocognitive Assesment
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Juvenile Idiopathic Arthritis, Juvenile Arthritis
Effectiveness and Feasibility of a Home-based Exercise Program for Adolescents With Juvenile Idiopathic Arthritis
This study will aim to test the effectiveness and feasibility of a technology-supported home-based exercise program in adolescents with JIA.
- Conditions
- Juvenile Idiopathic Arthritis, Juvenile Arthritis, Juvenile Rheumatoid Arthritis
- Trial name
- THE_JIA (NCT05114343)
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo General Hospital
Neovascular (Wet) Age-related Macular Degeneration
A Study to Learn How Well Aflibercept Injected Into the Eye Works and How Safe it is When Given in Customized Treatment Intervals in Patients With an Eye Disease Called Neovascular Age-related Macular Degeneration After Start of Treatment
Researchers are looking for a better way to treat people who have neovascular (wet) age-related macular degeneration (nAMD or wet AMD).
- Trial name
- XPAND (NCT05473715)
- Testing
- Aflibercept(BAY86-5321, Eylea)
- Where
- 3 sites in Canada, United Kingdom
- Volunteers
- 3 people
- Sponsor
- Bayer
Cardiac Complication, Vascular Diseases
Evaluation of Reporting of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor Inhibitors Associated Cardiovascular Adverse reactioN.
Antiangiogenics (AAs) which are vascular endothelial growth factor (VEGF) or VEGF receptor (VEGFR) inhibitors might have high grade adverse events (AEs) on the cardio-vascular system.
- Trial name
- VEGAN (NCT03413176)
- Testing
- Cardiac complication induced by VEGF/VEGFR inhibitor
- Where
- France
- Volunteers
- 150,000 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
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