Clinical trials: Endotoxemia
Healthy Volunteers, Sepsis
The Role of the P2Y12 Receptor in Tissue Factor Induced Coagulation
Severe sepsis still carries a high mortality rate despite advantages in intensive care medicine and antimicrobial therapy. The inflammatory and procoagulant host response to infection are intricately linked and interactions…
- Trial name
- NCT01099566
- Testing
- Prasugrel
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Septic Shock, Endotoxemia
Open-label Evaluation of Polymyxin B Hemoperfusion for Septic Shock
Open-label, non-controlled study of standard care plus the TORAYMYXIN PMX-20R (PMX cartridge) in subjects who have endotoxemia and septic shock.
- Trial name
- EUPHORIA (NCT02825329)
- Testing
- TORAYMYXIN PMX-20R
- Sponsor
- Spectral Diagnostics (US) Inc.
Oxidative Stress, Inflammation
Probiotic Sport Study
We investigate the impact of a probiotic-based dietary supplement on oxidative stress and endotoxemia before and after strenuous exercise.
- Conditions
- Oxidative Stress, Inflammation, Endotoxemia
- Trial name
- NCT01474629
- Testing
- probiotic-based dietary supplement
- Where
- Austria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Green Beat
Colorectal Inflammation
Effects of a Western-type Diet on Colorectal Inflammation
This study will look at the inflammatory (changes usually associated with infection/injury to the body) and bowel permeability (bowel's ability to allow contents to enter the body) effects of a Western-style diet (high fat and…
- Trial name
- NCT00866450
- Testing
- Western style diet (high fat and low in calcium), Prudent-style diet (low fat and high in calcium)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Rockefeller University
Endotoxemia
Anti-Inflammatory Effect of Statins in the Human Endotoxin Model
The purpose of this study is to determine the effects of HMG-CoA reductase inhibitor pretreatment on inflammation and coagulation activation in human endotoxemia.
- Trial name
- NCT00309374
- Testing
- LPS 2ng/kg intravenous bolus, Simvastatin 80mg; administered daily p.o. over 5 days, Rosuvastatin 40mg; administered daily p.o. over 5 days
- Where
- Austria
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Cardiovascular Diseases, Endotoxemia
Cardiometabolic Benefits of Potatoes Mediated Along the Gut-Vessel Axis in Adults With Metabolic Syndrome
This study is focused on assessing potential health benefits of daily consumption of potatoes, specifically its resistant starch content (i.e.
- Conditions
- Cardiovascular Diseases, Endotoxemia, Endothelial Dysfunction, Postprandial Hyperglycemia
- Trial name
- NCT03624569
- Testing
- Bagel, Potato
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Ohio State University
Healthy Volunteers
The Genetics of Evoked Responses to Niacin and Endotoxemia: The GENE Study
The purpose of this study is to determine genetic factors that affect responses to niacin therapy and endotoxemia in healthy volunteers.
- Trial name
- GENE (NCT00953667)
- Testing
- Immediate Release Niacin, Extended Release Niacin, Endotoxin
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Endotoxemia
The Effects of Oral Dipyridamole Treatment on the Innate Immune Response During Human Endotoxemia
During sepsis and septic shock the immune response can be overwhelming leading to excessive tissue damage, organ failure and death.
- Trial name
- NCT01091571
- Testing
- Dipyridamole, LPS
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Anemia of Chronic Disease
Pharmacokinetics/Pharmacodynamics of NOX-H94 in the Human Endotoxemia Model
The purpose of this study is to assess the effect of the anti-hepcidin Spiegelmer NOX-H94 on iron homeostasis during systemic inflammation induced by endotoxin.
- Trial name
- NCT01522794
- Testing
- NOX-H94
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- TME Pharma AG
Suspected or Diagnosed Endotoxemia Casued by Gram-negative Bacteria
Remove LPS Registry
This registry will collect and validate regulatory-grade real-world data (RWD) on the usage of the LPS-Adsorber and the outcomes from using the LPS-Adsorber in various patient populations (various sub-registries) that also have…
- Trial name
- NCT05260099
- Testing
- LPS Adsorber
- Sponsor
- Alteco Medical AB
Endotoxemia
The Effects of Acetylsalicylic Acid on Immunoparalysis Following Human Endotoxemia
Rationale: The last years, research focus has moved to immunostimulatory agents in order to restore or increase the functionality of the immune system during sepsis-induced immunoparalysis.
- Trial name
- SALYCENDO (NCT02922673)
- Testing
- Aspirin
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Sepsis, Immune Deficiency
Assessing the Effects of CytoSorb Hemoperfusion on the Development on Immunoparalysis
In this randomized, open-label study, the investigators will assess whether CytoSorb hemoperfusion will prevent or attenuate the development of immunoparalysis in healthy volunteers undergoing repeated experimental endotoxemia.
- Conditions
- Sepsis, Immune Deficiency, Hemoperfusion, Blood Purification
- Trial name
- EndoSorb (NCT04643639)
- Testing
- CytoSorb hemoperfusion
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Patients With Periodontal Disease
Role Of Phospholipid Transfer Proteins (Pltp) On Endotoxemia Caused By Buccal Inflammation
This is a transversal double-centre study. Patients will be recruited from outpatient consultations. They will have buccal inflammation caused by periodontal disease (frequent oral infections, mostly with GRAM (-) bacteria).
- Trial name
- TOXIB (NCT01950962)
- Testing
- Sampling of blood
- Where
- France
- Volunteers
- 242 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Menopause Related Conditions, Cardiovascular Risk
Polyphenol Metabolism and Personalized Nutrition in Menopause (PolyPause).
The study aims to evaluate the role of the gut microbiome and phageome in explaining interindividual variability in the metabolic response to polyphenol-rich nutraceuticals among menopausal women.
- Trial name
- PolyPause (NCT07182370)
- Testing
- Capsules containing plant extracts, including resveratrol, ellagic acid and isoflavones
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- National Research Council, Spain
Liver Cirrhosis, Coagulation Disorder
Rifaximin in Cirrhosis: Effects on Endotoxin and Haemostatic Indexes
Rifaximin is an antibiotic that acts locally in the gastrointestinal tract with a broad spectrum of antibacterial activity. The efficacy of rifaximin is well documented in the prevention of acute hepatic encephalopathy.
- Conditions
- Liver Cirrhosis, Coagulation Disorder, Platelet Disorder, Endotoxemia
- Trial name
- NCT06630572
- Testing
- Rifaximin
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Roma La Sapienza
Metabolic Syndrome, Metabolic Endotoxemia
Alleviation Of Metabolic Endotoxemia In Adults With Metabolic Syndrome With Milk Fat Globule Membrane
Metabolic syndrome (MetS) adults (n = 24; 18-65 y) will be enrolled to complete a 2-arm, double-blind, randomized controlled, crossover trial.
- Trial name
- NCT03860584
- Testing
- MFGM-enriched full-fat dairy milk, Soy phospholipid/lecithin milk
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Ohio State University
Cirrhosis
Rifaximin Predicts the Complications of Decompensated Cirrhosis
Cirrhotic patients are predisposed to intestinal dysmotility, bacterial overgrowth, and increased intestinal permeability all leading to an increase in bacterial translocation and increased endotoxemia.
- Trial name
- NCT02074280
- Testing
- rifaximin
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Shanghai Changzheng Hospital
Endotoxemia, Diet, Healthy
Cereals and Intestinal Function
The aim of the present study is to determine the effect of dietary fiber on intestinal function in healthy subjects.
- Trial name
- NCT04019457
- Testing
- Dietary intervention
- Where
- Austria
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Innate Immune Response
The Effects of Concentration/Meditation on the Innate Immune Response During Human Endotoxemia
The innate immune response is the first line of defense against invading pathogens. Ideally, the inflammatory response is tightly regulated leading to both adequate protection to invading pathogens as well as limitation of an…
- Trial name
- NCT01352871
- Testing
- Concentration / meditation, lipopolysaccharide
- Where
- Netherlands
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Pancreatitis, Acute, Hyperglycaemia
Glucose Levels in Acute Pancreatitis and the Impact of Insulin Depletion and Bacterial Endotoxaemia
There are currently no early predictive biomarkers for severity of acute pancreatitis (AP) that would allow stratification of patients for potential early interventional therapies.
- Trial name
- GLIDE (NCT06972238)
- Volunteers
- 30 people
- Sponsor
- Manchester University NHS Foundation Trust