Clinical trials: Endovascular Thrombectomy
Stroke, Endovascular Thrombectomy
Improving Neuroprotective Strategy for Ischemic Stroke With Sufficient Recanalization After Thrombectomy by Edaravone Dexborneol
To explore the safety and efficacy of edaravone dexborneol for the treatment of acute ischemic stroke patients who received endovascular thrombectomy.
- Trial name
- NCT04667637
- Testing
- edaravone dexborneol
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Hui-Sheng Chen
Acute Deep Venous Thrombosis
Endovascular Therapy in Patients With Acute Deep Vein Thrombosis
Despite optimal anticoagulation therapy of patients with proximal deep vein thrombosis (DVT), there is still high number of patients suffering from post-thrombotic syndrome (PTS) due to the chronic venous occlusion, suboptimal…
- Trial name
- LEVANTE (NCT05827120)
- Testing
- Mechanical / pharmacomechanical thrombectomy plus local catheter directed thrombolysis, Local catheter directed thrombolysis alone
- Where
- 3 sites in Slovakia
- Volunteers
- 110 people
- Sponsor
- National Institute of Cardiovascular Diseases, Slovakia
Stroke, Hypothermia Treatment
Prognostic Biomarkers for Selective Intra-Arterial Cooling Infusion Combined with Endovascular Thrombectomy in Acute Ischemic Stroke Based on Proteomics and Metabolomics.
Endovascular Thrombectomy has emerged as a pivotal treatment modality for acute ischemic stroke. However, despite successful thrombus removal, a substantial proportion of patients still experience poor outcomes.
- Trial name
- NCT06665386
- Testing
- hypothermia
- Where
- China
- Volunteers
- 258 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
Rapid Local Ischemic Postconditioning on Stroke After Thrombectomy
The main goal of this study is to find out if a new, quick "brain rescue" procedure can help people recover better from a severe stroke caused by a large vessel occlusion.
- Trial name
- RAPIDIMPROVE (NCT07598799)
- Testing
- High-dose RL-IPostC, Low-dose RL-IPostC
- Where
- China
- Volunteers
- 448 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Ischemic Stroke
Treatment With Intent to Generate Endovascular Reperfusion
Tigertriever is a CE marked mechanical revascularization device indicated to restore blood flow by removing thrombus from a large intracranial vessel in patients experiencing ischemic stroke within 8 hours of symptom onset.
- Trial name
- TIGER (NCT03474549)
- Testing
- Tigertriever revascularization device
- Where
- 17 sites in United States, Israel
- Volunteers
- 160 people
- Sponsor
- Rapid Medical
Acute Cerebrovascular Accident
Effect of Individualized Versus Standard Bp Management During MT for Anterior Ischemic Stroke
DETERMINE is a multicenter, prospective, randomised, open, blinded end-point assessed (PROBE) trial, to evaluate two approaches of blood pressure (BP) management during mechanical thrombectomy for acute ischemic stroke due to an…
- Trial name
- DETERMINE (NCT04352296)
- Testing
- Individualized blood pressure, Standard blood pressure
- Where
- France
- Volunteers
- 433 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Stroke Acute
Fusion Imaging in Endovascular Thrombectomy for Acute Ischemic Stroke
Endovascular thrombectomy (EVT) is the standard of care for acute ischemic stroke (AIS) caused by a large vessel occlusion. Successful recanalization is one of the most important factors for a good patient outcome, especially…
- Trial name
- FUSE-IT (NCT06975696)
- Testing
- Standard endovascular thrombectomy with Fusion, Standard EVT without Fusion
- Where
- 4 sites in Finland, Sweden
- Volunteers
- 300 people
- Sponsor
- Region Skane
Acute Stroke
SEACOAST 1- SEdAtion With COllAteral Support in Endovascular Therapy for Acute Ischemic Stroke
SEACOAST 1 is a prospective, randomized, blinded endpoint trial comparing collateral vigor and clinical outcomes, with different forms of GA in patients with acute ischemic stroke due to anterior circulation large vessel…
- Trial name
- SEACOAST (NCT03737786)
- Testing
- Tight control of end-tidal CO2 levels
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of California, Los Angeles
Stroke
Berlin PRehospital Or Usual Delivery of Acute Stroke Care
Prehospital stroke care in specialized ambulances increases thrombolysis rates, reduces alarm-to-treatment times, and improves prehospital triage. Preliminary analyses suggest cost-effectiveness.
- Trial name
- B_PROUD (NCT02869386)
- Testing
- STEMO, Regular care
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- Charite University, Berlin, Germany
Stroke, Acute Ischemic, Endovascular Thrombectomy
ACT-GLOBAL IA Thrombolysis(ACT-REACT-004)Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632
Study Design and Duration: This domain will be conducted as part of ACT-GLOBAL platform trial and will have the nested domain name of REACT.
- Conditions
- Stroke, Acute Ischemic, Endovascular Thrombectomy, Acute Ischemic Stroke AIS
- Trial name
- ACT-REACT (NCT07687056)
- Testing
- Tenecteplase or Alteplase- depending upon availability at each treating centre, Control
- Where
- 13 sites in Australia, Canada
- Volunteers
- 1,500 people
- Sponsor
- University of Calgary
Stroke, Acute
Efficacy and Safety of Nerinetide in Participants With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy Excluding Thrombolysis
The primary purpose of this study is to determine if a single dose of nerinetide can reduce global disability in people who have had a stroke and are selected for endovascular therapy without the use of a tissue plasminogen…
- Trial name
- ESCAPE-NEXT (NCT04462536)
- Testing
- Nerinetide
- Where
- 81 sites in United States, Australia and 7 more
- Volunteers
- 850 people
- Sponsor
- NoNO Inc.
Acute Ischemic Stroke (AIS), Endovascular Thrombectomy
Exploration and Establishment of an Early Warning System for Futile Reperfusion - A I S
The goal of this prospective cohort registration study is to establish an early warning system for futile recanalization in acute ischemic stroke by analyzing multi-omics information to identify key regulatory nodes and target…
- Conditions
- Acute Ischemic Stroke (AIS), Endovascular Thrombectomy, Neurovascular Unit- Brain Lymphatic System
- Trial name
- NCT07045987
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Xijing Hospital
Acute Ischemic Stroke
ATILA Project: Aspirin Versus Tirofiban in Endovascular Treatment for Patients With Acute Ischemic Stroke Due to Tandem Lesion
Patients with tandem lesions (TL) are defined as patients with an acute ischemic stroke (AIS) with occlusion of an intracranial vessel of the anterior circulation and an occlusion or severe stenosis (70-99%) of the origin of the…
- Trial name
- ATILA (NCT05225961)
- Testing
- Tirofiban, Acetylsalicylic acid
- Where
- 13 sites in Spain
- Volunteers
- 240 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Acute Ischemic Stroke, Arterial Thrombosis
Intra-arterial Thrombolysis After Successful Thrombectomy for Acute Ischemic Stroke in the Posterior Circulation (IAT-TOP)
The CHOICE study suggested that the use of adjunct intra-arterial alteplase after successful endovascular reperfusion in large vessel occlusion acute ischemic strokes may result in a greater likelihood of excellent neurological…
- Conditions
- Acute Ischemic Stroke, Arterial Thrombosis, Posterior Circulation Brain Infarction
- Trial name
- NCT05897554
- Testing
- intra-arterial alteplase
- Where
- China
- Volunteers
- 247 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Ischemic Stroke
Optimizing Patient's Selection for Endovascular Treatment in Acute Ischemic Stroke
SELECT is a multicenter, observational prospective study implementing a protocol to acquire imaging and clinical variables known to affect clinical outcomes after endovascular therapy in an effort to evaluate and compare the…
- Trial name
- SELECT (NCT02446587)
- Testing
- Mechanical Thrombectomy
- Where
- 9 sites in United States
- Volunteers
- 500 people
- Sponsor
- The University of Texas Health Science Center, Houston
Acute Ischemic Stroke
Medical Management With Endovascular Thrombectomy Versus Medical Management Alone in Patients Presenting Beyond 24 Hours of Last Known Well
SELECT LATE trial aims to evaluate if addition of endovascular thrombectomy to medical management in patients presenting with acute ischemic stroke and a proximal large vessel occlusion in the anterior circulation between 24 and…
- Trial name
- SELECT LATE (NCT07115940)
- Testing
- Endovascular Thrombectomy, Medical Management
- Where
- 6 sites in United States
- Volunteers
- 408 people
- Sponsor
- Amrou Sarraj
Brain Stroke, Stenting Treatment
Emergent Large Vessel Occlusion Endovascular Rescue Therapy With Underlying Intracranial Stenosis
The study objective is to establish the safety and efficacy of endovascular adjunct stenting for patients undergoing mechanical thrombectomy (MT) that are found to have residual stenosis (70-99%) following attempted clot…
- Conditions
- Brain Stroke, Stenting Treatment, Acute Ischemic Stroke
- Trial name
- EVEREST (NCT07356284)
- Testing
- Mechanical Thrombectomy plus adjunct stenting, Mechanical Thrombectomy
- Where
- United States
- Volunteers
- 342 people
- Sponsor
- ProMedica Health System
Acute Ischemic Stroke
Infarct Growth After Intravenous Tocilizumab in Adults With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy - ILLUMINATE
The goal of this phase II, placebo-controlled intervention study is to investigate whether tocilizumab, an interleukin-6 (IL-6) receptor inhibitor, may have a neuroprotective effect by reducing infarct growth in adults with acute…
- Trial name
- Illuminate (NCT07870681)
- Testing
- Tociliuzumab
- Where
- 6 sites in Denmark, Norway
- Volunteers
- 156 people
- Sponsor
- Oslo University Hospital
Endovascular Thrombectomy
Patient Selection Using MR With Non-Perfusion Imaging for Endovascular Treatment Within 6 to 24 Hours
We will conduct a multicenter, prospective, randomized, open-label, blinded endpoint trial with a non-inferiority design in patients who present 6 to 24 hours after symptom onset with LVO.
- Trial name
- MIELS (NCT05735301)
- Testing
- Endovascular, Drug
- Where
- China
- Volunteers
- 352 people
- Sponsor
- Tianjin Huanhu Hospital
Endovascular Thrombectomy
Medical Imaging Screening for Posterior-circulation Ischemic Stroke
Patients with ischemic stroke in the posterior circulation continue to have high rates of mortality and disability, even with aggressive treatment.
- Trial name
- NCT06094569
- Testing
- Endovascular Therapy
- Where
- 4 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Tianjin Huanhu Hospital