Clinical trials: Endovascular Treatment
Acute Ischemic Stroke
Hyperbaric Oxygen After Stroke Thrombectomy: A Multicenter Randomized Trial on Safety and Efficacy
1. The goal of this clinical trial is to evaluate the efficacy and safety of hyperbaric oxygen (HBO)in stroke patients after endovascular treatment 2.
- Trial name
- NOTICE-1 (NCT07049692)
- Testing
- Hyperbaric Oxygen Therapy, Conventional therapy group
- Where
- 2 sites in China
- Volunteers
- 424 people
- Sponsor
- Beijing Chao Yang Hospital
Hepatocellular Carcinoma, Portal Vein Tumor Thrombus
Endovascular Brachytherapy Combined With Stent Placement and TACE for HCC With Main Portal Vein Tumor Thrombus
It is a prospective and multi-center clinical research in China to compare the efficacy, safety and related impact factors between TACE alone and endovascular brachytherapy combined with stent placement and TACE for HCC with main…
- Trial name
- NCT02971345
- Testing
- Stent and Iodine-125 seed strand implantation, Stent, Iodine-125 seed
- Where
- China
- Volunteers
- 253 people
- Sponsor
- Shanghai Zhongshan Hospital
Stroke Acute
EnDOvascular Therapy for Late WiNdow IschEmic Stroke Patients Selected bY AutoMatic Plain ComputErized Tomography
The DONE SYMPLE Investigator-initiated phase III prospective, randomized, open-label, blinded endpoint-controlled clinical trial.
- Trial name
- DONE SYMPLE (NCT07001852)
- Testing
- Endovascular Therapy (Mechanical Thrombectomy), Standard Medical Management
- Where
- 2 sites in United States, Armenia
- Volunteers
- 500 people
- Sponsor
- Santiago Ortega Gutierrez
Asymptomatic Carotid Artery Stenosis
Efficacy and Safety Study of Endovascular Treatment of Asymptomatic Carotid Artery Stenosis
This study is a multicenter, prospective, open-label, endpoint-blinded, randomized controlled trial designed to evaluate the safety and efficacy of endovascular stenting combined with optimal medical therapy versus optimal…
- Trial name
- NCT06899399
- Testing
- Endovascular treatment, Best medical treatment
- Where
- China
- Volunteers
- 982 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
Collateral-based reSetting of Endovascular Treatment Time Window for Stroke (CoSETS)
This study is a prospective, partly randomized, multi-center, Phase III, controlled trial, designed to show that the onset-to-puncture time (OPT) for good functional outcome (defined by modified Rankin Scale score at 3 months…
- Trial name
- NCT03234634
- Testing
- endovascular thrombectomy
- Where
- South Korea
- Volunteers
- 291 people
- Sponsor
- Yonsei University
Stroke, Acute, Neuroprotection
Normobaric Hyperoxia With Extended-Window Endovascular Therapy for Acute Ischemic Stroke (OPENS-EXTEND)
Although endovascular therapy (EVT) has substantially improved recanalization rates and extended the treatment window for acute ischemic stroke, fewer than half of patients achieve functional independence despite successful…
- Conditions
- Stroke, Acute, Neuroprotection, Normobaric Hyperoxia, Endovascular Treatment
- Trial name
- NCT07717216
- Testing
- Oxygen (Normobaric Hyperoxia), Endovascular Therapy
- Volunteers
- 314 people
- Sponsor
- Weifang Medical University
Abdominal Aortic Aneurysm Without Rupture
New MRI Techniques for Diagnosis and Treatment of Patients With Abdominal Aortic Aneurysms
An abdominal aortic aneurysm (AAA) is a pathological dilatation of the aorta in the belly which can rupture leading to bleeding within the belly. To prevent rupture elective surgery can be performed.
- Trial name
- MARVY (NCT05976711)
- Testing
- Magnetic resonance imaging (with PROUD software)
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Deep Vein Thrombosis
Comparison Of Different Mechanical Thrombectomy Devices in Endovascular Treatment of Acute Iliofemoral Venous Thrombosis
A head-to-head comparison of two different types of percutaneous mechanical thrombectomy (PMT) - ClotTriever System versus aspiration thrombectomy (including rheolytic thrombectomy) - in patients with acute iliofemoral deep vein…
- Trial name
- NCT07622212
- Testing
- Percutaneous mechanical thrombectomy by ClotTriever System, Percutaneous mechanical thrombectomy by aspiration or rheolytic thrombectomy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- RenJi Hospital
Stent Stenosis, Intracranial Hypertension
Endovascular Stenting Treatment for Patients With Internal Jugular Vein Stenosis
This is a prospective, randomized, single-center clinical study aiming to explore the safety and efficacy of venous stenting for patients with internal jugular vein stenosis (IJVS).
- Conditions
- Stent Stenosis, Intracranial Hypertension, Headache, Tinnitus
- Trial name
- NCT03373292
- Testing
- Venous stenting for internal jugular vein stenosis, One-month routine medical treatment followed by venous stenting for internal jugular vein stenosis
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Aortic Aneurysm
Adjunctive Treatment With Doxycycline to Enhance the Durability of Endovascular Aortic Aneurysm Repair
The durability of endovascular aneurysm repair (EVAR) has been limited by development of endoleaks which may be secondary to progressive aortic degeneration by matrix metalloproteases (MMP).
- Trial name
- NCT00126204
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- The Foundation for Barnes-Jewish Hospital
Ischemic Stroke
Monitoring Stroke Patients With Near-infrared Spectroscopy Before, During and After Endovascular Treatment
The purpose of this study is to examine the hemodynamics of stroke patients with near-infrared spectroscopy before, during and after endovascular treatment and their relations to disabilities and mortality 3 months after…
- Trial name
- NCT03738644
- Testing
- Monitoring with near-infrared spectroscopy
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Helle Klingenberg Iversen
Acute Ischemic Stroke
EmboTrap ® II Revascularization Device (Neuravi) in Acute Ischemic Stroke
The primary aim of Registrap study is to assess the safety and effectiveness of the EmboTrap®II Clot Retriever device (Neuravi) in patients with acute ischemic stroke from large vessel occlusion.
- Trial name
- NCT03601702
- Testing
- Mechanical thrombectomy with EmboTrap ® II Device
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Niguarda Hospital
Acute Stroke
SEACOAST 1- SEdAtion With COllAteral Support in Endovascular Therapy for Acute Ischemic Stroke
SEACOAST 1 is a prospective, randomized, blinded endpoint trial comparing collateral vigor and clinical outcomes, with different forms of GA in patients with acute ischemic stroke due to anterior circulation large vessel…
- Trial name
- SEACOAST (NCT03737786)
- Testing
- Tight control of end-tidal CO2 levels
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of California, Los Angeles
Cerebral Aneurysm
Hydrogel Endovascular Aneurysm Treatment Trial
This research study is being done to test the effectiveness of a new generation FDA approved device for treating aneurysms compared to the current standard device for endovascular aneurysm treatment which is bare platinum coils.
- Trial name
- HEAT (NCT01407952)
- Testing
- HydroCoil Embolic System, Control (bare platinum coils)
- Where
- 44 sites in United States, Canada
- Volunteers
- 600 people
- Sponsor
- Northwestern University
Ischemic Stroke, Medium Vessel Occlusion
Intra-arterial Tenecteplase for Acute Medium Vessel Occlusion Stroke
The ANGEL-MeVO-TNK is a multicentered, prospective, randomized, open label, blinded endpoint (PROBE) phase III trial. A total of 488 AIS patients (age ≥18 years) with acute MeVO-AIS (occlusion of the M2/M3, the A1/A2/A3, the…
- Conditions
- Ischemic Stroke, Medium Vessel Occlusion, Tenecteplase, Endovascular Treatment
- Trial name
- ANGEL-MeVO-TNK (NCT07357987)
- Testing
- Intra-arterial Tenecteplase, standard medical management
- Where
- China
- Volunteers
- 488 people
- Sponsor
- Beijing Tiantan Hospital
End Stage Kidney Disease, Chronic Kidney Diseases
The WavelinQ™ Arterio-Venous Endovascular Fistula: A Global, Post-Market Investigation
This is a global, multi-center, prospective, post-market, confirmatory, interventional, non-randomized, single-arm clinical investigation evaluating arteriovenous fistula (AVF) creation by means of the WavelinQ™ EndoAVF System in…
- Conditions
- End Stage Kidney Disease, Chronic Kidney Diseases, Kidney Failure, Kidney Insufficiency
- Trial name
- WAVE-Global (NCT04626427)
- Testing
- WavelinQ™ EndoAVF System
- Where
- 3 sites in Belgium, Greece and 1 more
- Volunteers
- 21 people
- Sponsor
- C. R. Bard
Aortoiliac Occlusive Disease, Endovascular Treatments
Iliac Stent-Grafts in TASC C-D Lesions
This study aims to evaluate the midterm outcomes of patients with advanced aortoiliac artery narrowing (TASC C-D lesions) who were treated with covered iliac stent-grafts instead of open surgery.
- Conditions
- Aortoiliac Occlusive Disease, Endovascular Treatments, Peripheral Arterial Disease(PAD)
- Trial name
- NCT07048925
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Samsun University
Vascular Anomalies, Hemorrhage
Safety and Efficacy Of Amber Peripheral Liquid Embolic System
A prospective, single-arm, multicenter, open-label, First-in-Human \& Pivotal Study to assess the safety and efficacy of amber SEL-P in 70 patients requiring peripheral embolization: vascular anomalies, hemorrhages, aneurysms…
- Conditions
- Vascular Anomalies, Hemorrhage, Aneurysm, Pseudoaneurysm
- Trial name
- OPAL (NCT06456125)
- Testing
- amber SEL-P Peripheral Liquid Embolic System
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- LVD Biotech S.L
Arterial Occlusive Diseases
A Prospective Study: the Value of Using iFlow and PBV in the Endovascular Treatment of Infrapopliteal Arterial Occlusive Diseases
Color coded blood flow and blood perfusion techniques are applied to the endovascular treatment of infrapopliteal arterial occlusion,to establish a method of quantitative evaluation of blood flow and tissue perfusion,to improve…
- Trial name
- NCT03248323
- Testing
- dyna-pbv
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Thrombolysis, Deep Vein Thrombosis
Contemporary Endovascular Therapies in Treatment of Acute Iliofemoral Deep Vein Thrombosis
The goal of this initial proof of principle single arm cohort trial is to determine if contemporary endovascular venous intervention, compared with a 1:1 propensity-matched medical therapy arm of the ATTRACT trial, significantly…
- Trial name
- CLEAR-DVT (NCT03901872)
- Testing
- Contemporary endovascular venous intervention by Zelante pharmacomechanical thrombolysis
- Where
- United Kingdom
- Volunteers
- 65 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust