Clinical trials: Energy Metabolism
Energy Metabolism
Acute Effects of Caffeine on Mitochondrial Function in Peripheral Blood Mononuclear Cells
This randomized, double-blind, placebo-controlled crossover study will evaluate the acute effects of caffeine consumption on substrate utilization, resting energy metabolism, and mitochondrial function in peripheral blood…
- Trial name
- MITOCAFFEINE (NCT07873047)
- Testing
- Caffeine (5 mg/kg)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Resting Metabolic Rate, Energy Metabolism
Within-Individual Variability of Resting Metabolic Rate Over 12 Weeks
This prospective observational study aims to characterize within-individual variability in resting metabolic rate (RMR) over a 12-week period using high-frequency repeated measurements under standardized conditions.
- Trial name
- NCT07628764
- Testing
- Repeated Measurement of Resting Metabolic Rate
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Cardiovascular Diseases, Natriuretic Peptides
GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study
Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are associated with an increased likelihood of the development of diabetes…
- Conditions
- Cardiovascular Diseases, Natriuretic Peptides, Cardiometabolic Diseases, Energy Expenditure
- Trial name
- NCT05216042
- Testing
- Study diet, Exercise capacity VO2 max determination, Exercise Challenge
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Physical Fitness, Mitochondrial Function, Bioenergetics
Effects of Acute Exercise in Fasting and Fed States in Individuals With Different Aerobic Fitness Levels
The aim of this study is to investigate the effects of aerobic fitness level, feeding status, and acute exercise on whole-body metabolic fuel utilization and mitochondrial function in peripheral blood mononuclear cells (PBMCs) in…
- Conditions
- Physical Fitness, Mitochondrial Function, Bioenergetics, Mitochondria, Energy Metabolism
- Trial name
- NCT07813403
- Testing
- Acute Moderate-Intensity Cycling Exercise, Ad Libitum Mixed Meal
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Resting Metabolic Rate, Energy Metabolism
Observing Performance of Haptic Vibrotactile Trigger Technology by Measuring Changes in Resting Metabolic Rate: Assessment and Analysis
This study evaluates whether a drug-free, non-invasive topical patch embedded with Haptic Vibrotactile Trigger Technology (VTT) - the IGNITE Patch (The Super Patch Company) - is associated with changes in resting metabolic rate…
- Conditions
- Resting Metabolic Rate, Energy Metabolism, Haptic Technology, Vibrotactile Stimulation
- Trial name
- OPTIMA (NCT07781384)
- Testing
- IGNITE Patch (Active), Inactive patch
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- SuperPatch Limited LLC
Poor Energy Levels, Poor Metabolism
A Clinical Trial to Evaluate the Effects of a Supplement on Supporting Signs of a Healthy Metabolism
This study evaluates the effects of Love Wellness Energize, a dietary supplement, on supporting signs of a healthy metabolism in women aged 25-45 who report poor energy levels, perception of poor metabolism, difficulty with…
- Conditions
- Poor Energy Levels, Poor Metabolism, Difficulty With Weight Management, Bloating
- Trial name
- NCT07765407
- Testing
- Love Wellness Energize
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Love Wellness
Diabetes Mellitus, Cardiovascular Diseases
NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals
Black individuals are more likely to have decreased insulin sensitivity which results in a high risk for the development of cardiometabolic disease. The reasons for this are incompletely understood.
- Conditions
- Diabetes Mellitus, Cardiovascular Diseases, Insulin Sensitivity/Resistance, Metabolic Disease
- Trial name
- NCT04055428
- Testing
- Sacubitril, Valsartan 97-103 mg Oral Tablet, Valsartan 160 mg, Intravenous Glucose Tolerance Test
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Energy Metabolism, Exercise
Energy Cost and Metabolic Intensity of Pilates Exercises in Older Adults
Pilates is one of the most popular forms of exercise among older adults worldwide. However, no study has measured how many calories a Pilates session burns or how hard the body works during it in people aged 60 and over.
- Conditions
- Energy Metabolism, Exercise, Aging
- Trial name
- NCT07621523
- Testing
- Mat Pilates, Equipment-Based Pilates, Treadmill Walking
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual do Norte do Parana
Movement Disorders, Energy Metabolism
Validating a New Machine-Learned Accelerometer Algorithm Using Doubly Labeled Water
The purpose of this study is to validate previously developed physical function-clustered specific machine-learned accelerometer algorithms to estimate total daily energy expenditure (TDEE) in individuals with general movement…
- Trial name
- ValiDLW (NCT05736302)
- Testing
- Doubly-Labeled Water
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Milwaukee
Bone Remodeling, Energy Metabolism
Retrospective Monocentric Evaluation of Biomarkers Associated With Bone, Muscle and Energy Metabolism
Bone is a metabolically active tissue undergoing continuous remodeling through the coordinated actions of osteoclasts (resorption), osteoblasts (formation), and osteocytes (regulation).
- Trial name
- OVAD (NCT07454252)
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Overweight , Obesity, Energy Metabolism
Mapping Metabolic Organ Plasticity in Energy Adaptation
Brief Summary (Plain Language) Many people who lose weight experience a slowdown in their metabolism that is greater than expected.
- Trial name
- MAP (NCT07415213)
- Testing
- Calorie Restriction (CR), Time Restricted Eating (TRE), Resistance Training (RT)
- Where
- Israel
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Obesity, Energy Balance
Activity, Adiposity, and Appetite in Adolescents 2 Intervention
The objective of the study is to quantify the relationship between physical activity, metabolic function, and appetite in adolescents.
- Conditions
- Obesity, Energy Balance, Appetite, Metabolism
- Trial name
- AAAA2INT (NCT05443347)
- Testing
- Aerobic exercise, Newsletter
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Cardiovascular Diseases, Insulin Sensitivity/Resistance
VITAL-IMPACT: Improving Cardiometabolic Health in Black Individuals Through Therapeutic Augmentation of Cyclic Guanosine Mono-Phosphate Signaling Pathway
This study investigates the potential of vericiguat, a soluble guanylate cyclase stimulator, to improve cardiometabolic health in obese Black individuals with insulin resistance by directly enhancing cyclic guanosine…
- Conditions
- Cardiovascular Diseases, Insulin Sensitivity/Resistance, Metabolic Disease, Metabolism
- Trial name
- VITAL-IMPACT (NCT06320951)
- Testing
- Vericiguat 10 MG, Insulin Sensitivity Test, Resting Energy and Exercise Energy Expenditure Assessment
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Insulin Resistance, Obesity & Overweight
Effects of Ketone Bodies on Insulin Sensitivity
KETO-SENSE is a clinical research study investigating how ketone bodies affect energy metabolism and insulin sensitivity in humans.
- Conditions
- Insulin Resistance, Obesity & Overweight, Energy Metabolism, Ketone Body Metabolism
- Trial name
- KETO-SENSE (NCT07359625)
- Testing
- Growth Hormone, Human, Oral ketone supplement (KetoAid®, KE4)
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Energy Metabolism
Effect of a Physical Exercise Session Performed During a 24-34 Hour Fasting Period on Energy Metabolism and Cognitive Function in Healthy Adults
This study explores the impact of high-intensity exercise during fasting on energy metabolism and cognitive function in healthy adults.
- Trial name
- IMS (NCT05919979)
- Testing
- 34-hour fasting in sedentary conditions, 34-hour fasting with high-intensity exercise
- Where
- Spain
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Energy Metabolism
Dynamic Effects of Different Dietary Interventions on Visceral Fat and Biochemical Markers
This randomized clinical trial aims to evaluate the dynamic effects of various dietary interventions on visceral fat and biochemical markers among healthy adults.
- Trial name
- NCT06754306
- Testing
- Balanced diet (100% energy), 16+8 time-restricted eating group (100% energy), 16+8 time-restricted eating group (75% energy)
- Where
- China
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Computer Simulation, Energy Expenditure
Modelling of Energy Expenditure From Heart Rate, Accelerometry and Other Physiological Parameters
At this time, 24h energy expenditure is rarely assessed under free-living conditions for specific individuals because of the lack of cheap and accurate software/materials to record the energy expenditure.
- Conditions
- Computer Simulation, Energy Expenditure, Energy Metabolism
- Trial name
- Modelheart (NCT01209572)
- Testing
- calorimetric chamber, Free living conditions
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Energy Metabolism
Erythrocyte Transport of Lactate During Exercise (TELE Project)
The goals of this clinical trial are: 1. to study lactate kinetic between plasma and erythrocytes during an intervallic exercise and its subsequent recovery, considering the blood pH, the genotype for the T1470A polymorphism of…
- Trial name
- TELE (NCT06104150)
- Testing
- Intervallic submaximal exercise test
- Where
- 2 sites in Spain
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Technical University of Madrid
Infant Body Composition and Metabolism, Metabolism
Studying Phenotypic Risks for Obesity and Underlying Traits in Young Infants
The purpose of this research study is to understand how infants metabolize different meals and to develop clinical tools which identify infants as having two different phenotypes.
- Conditions
- Infant Body Composition and Metabolism, Metabolism, Energy Expenditure, Infant Formula
- Trial name
- SPROUT (NCT07096011)
- Testing
- Meal Test - Human Milk, Meal Test - Infant Formula
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Energy Metabolism
Very Low Ketogenic Diet and Energy Expenditure
This study aimed at evaluating the effectiveness of the active phase of a very low-calorie ketogenic diet in females with obesity lasting 28 days on body weight, body composition and energy metabolism using a metabolic chamber.
- Trial name
- NCT06252077
- Testing
- very low ketogenic diet
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pisa