Clinical trials: Energy Restriction
Obesity
Bone Marrow Adipose Tissue in Relation to Bone and Energy Metabolism in Obesity and Type 2 Diabetes Mellitus
This interventional study is part of a broader research project entitled "Bone Marrow Adipose Tissue in Relation to Bone and Energy Metabolism in Obesity and Type 2 Diabetes Mellitus." The broader project includes both a…
- Trial name
- BOD-BMAT (NCT07731438)
- Testing
- Caloric Restriction
- Where
- 3 sites in Czechia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- General University Hospital, Prague
Calorie Deficiency, Fasting
Effects of Calorie Restriction and Cold Stimuli on Health-related Indicators, Cognitive and Motor Functions
The goal of this clinical trial was to identify if duration of acute calorie restriction (CR)/fasting or combination CR with cold stimuli have any effects on mental and physical health-related markers, and to clarify if different…
- Conditions
- Calorie Deficiency, Fasting, Cold Exposure
- Trial name
- NCT05545943
- Testing
- 2-days of zero calorie restriction and whole-body cold-water immersion, 6-days of calorie restriction, 2-days of zero calorie restriction without whole-body cold-water immersion
- Where
- Lithuania
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Pediatric Obesity
Appetite Response to Exercise- Versus Mixed (Exercise + Dietary Restriction)-Induced Energy Deficit in Adolescents With Obesity
The aim of the present study is to compare the effect of iso-energetic energy deficits induced by energy restriction alone or exercise + dietary restriction (Mixed deficit) on energy intake and appetite feelings in adolescents…
- Trial name
- IDEX2 (NCT04734639)
- Testing
- CON . control condition without exercise / rest condition, Def-Mixed. Condition with a mixed energy deficit induced by exercise + dietary restriction., Def-EI. Condition with an energy-restriction energy deficit
- Where
- France
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Intermittent Fasting
Effects of Timed Restricted Eating on Body Composition, Metabolism, and Cardiovascular Health
This study is looking at whether eating all meals within a 6-hour window each day (called Time-Restricted Eating, or TRE) can improve body composition, metabolism, heart health, and blood markers over 12 weeks.
- Trial name
- NCT07574177
- Testing
- Time-Restricted Eating (TRE), Time-Restricted Eating with Intermittent Energy Restriction (TRE+IER)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of South Alabama
Overweight and Obesity
Sulfur Amino Acids, Energy Metabolism and Obesity
The primary objective of the trial is to establish the effects of dietary sulfur amino acid (SAA) restriction on body weight, body composition and energy expenditure in humans.
- Trial name
- STAY (NCT04701346)
- Testing
- Low SAA diet, High SAA diet
- Where
- Norway
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Overweight, Obesity
The Effects of Including Almonds in a Weight Loss Trial
The purpose of this study is to determine whether inclusion of almonds in a weight loss regimen will augment the rate of weight loss, promote a greater fat mass/fat-free mass ratio of weight loss, improve blood pressure and…
- Trial name
- NCT02360787
- Testing
- Energy restriction, Almonds (15% kcal/day)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Purdue University
Healthy Aging
Effect of a Two-month Carbohydrate-restricted Diet on Energy Metabolism in a Seniors' Residence
The present study will assess the effects on glucose, ketones and other blood biomarkers fuels, cognition, quality of life, physical activity and well-being of a reduced carbohydrate menu (R-CHO) for 2 months in a population…
- Trial name
- SAGE (NCT06022094)
- Testing
- 2 months of reduced carb menus
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Obesity
Sleep Timing on Energy Intake and Energy Expenditure
Studies in healthy young adults have shown that abnormal and undesirable physiological changes are a result of chronic sleep curtailment, with implications on inflammatory status, blood glucose regulation, circulating free fatty…
- Trial name
- NCT05096585
- Testing
- Delayed bedtime sleep restriction, Early wake sleep restriction
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Osteoarthritis, Knee, Hypertension
The Clinical Impact of Diet on Medical Conditions Treated Within Bundled Payment Models: a Pilot Study
Diet interventions (e.g., low-energy diets) are recommended as a treatment for obesity, obese patients with osteoarthritis, hypertension (HTN), and type 2 diabetes (T2D).
- Conditions
- Osteoarthritis, Knee, Hypertension, Type 2 Diabetes, Obesity
- Trial name
- NCT05735873
- Testing
- Low-energy diet
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Individuals at Risk of Developing Diabetes
Daily vs Intermittent Restriction of Energy: Controlled Trial to Reduce Diabetes Risk (DIRECT)
In this randomized controlled trial, the investigators will compare the long term effectiveness of intermittent fasting (IF) versus an energy matched moderate calorie restriction (CR) over 18 months, and relative to a non-active…
- Trial name
- NCT03689608
- Testing
- Intermittent Fasting (IF), Daily Restriction (DR), standard care (SC)
- Where
- Australia
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
Relative Energy Deficiency in Sport
Impact Loading Effect on Bone Biomarkers in Female Runners
This study is a randomized, cross-over intervention study that will evaluate the effect of brief, high-impact loading exercises on biomarkers of bone metabolism in energy-restricted female runners.
- Trial name
- NCT05341700
- Testing
- Impact Load Exercises, No Impact Load Exercises
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Aging, Cognitive Decline
Intermittent Energy Restriction and Chewing on Neural Stem Cell Ageing and Adult Hippocampal Neurogenesis Associated Cognition
Extended bouts of periodic mastication and intermittent energy restriction (IER) may improve cognitive performance in the context of adult hippocampal neurogenesis in an ageing population.
- Trial name
- ChANgE (NCT03457870)
- Testing
- Intermittent Energy Restriction, Chewing, Chewing + Intermittent Energy Restriction
- Where
- United Kingdom
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- King's College London
Obesity, Insulin Sensitivity/Resistance
Energy -Sensing Metabolites in Caloric Restriction
General integrated goal of the coordinated project: To elucidate the role of succinate and other metabolites derived from the intestinal microbiota such as Short Chain Fatty Acids (SCFAs), as energy sensing metabolites in the…
- Conditions
- Obesity, Insulin Sensitivity/Resistance, Diabetes Type 2
- Trial name
- NCT05031572
- Testing
- dietary intervention
- Where
- Spain
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Healthy
Acute Metabolic Effects of Carbohydrate Restriction at Varying Energy Levels
This study investigates how different low-carbohydrate diets affect metabolism and hunger in overweight adults. We will measure metabolic rates and blood metabolites.
- Trial name
- NCT06387940
- Testing
- nEB Diet, followed for 36 hours, LC25 Diet, followed for 36 hours, LCEB Diet, followed for 36 hours
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Weight Loss, Obesity
The Effect of Branched-Chain Amino Acid Supplementation and Exercise on Body Composition During Energy Restriction
This double blind placebo study will take place over an 8 week treatment period of diet and exercise. All participants (n=16), in two groups, will be placed on the same hypocaloric diet and exercise program.
- Trial name
- NCT02630238
- Testing
- Branched-Chain Amino Acid Supplementation, Exercise, Diet
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Western Ontario, Canada
Weight Loss, Time Restricted Feeding
TRE: Microbiome, Metabolic Health and Bone
In the Time-Restricted Eating: Microbiome and Bone (TREMBO) study, the primary goal is to determine the effect of time-restricted eating with caloric restriction compared to caloric restriction alone on bone health, as well as…
- Conditions
- Weight Loss, Time Restricted Feeding, Bone Loss
- Trial name
- TREMBO (NCT05548517)
- Testing
- Time Restricted Eating (TRE), Calorie Restriction
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Obesity
Study to Assess the Effects of High Protein Diet in Obesity, the LOWER Study
This program is carried out in a dedicated outpatient-clinic in the city of Hengelo for the evaluation and treatment of subjects with obesity.
- Trial name
- LOWER (NCT00862953)
- Testing
- Normal protein energy-restricted, High protein energy-restricted
- Where
- Netherlands
- Volunteers
- 317 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Obesity, Weight Loss
Effects of Intermittent Versus Continuous Energy Restriction on Metabolic Adaptation in Women With Obesity
One of the major challenges for treating obesity is to maintain a weight reduced state on the long term due to the high rate of weight regain.
- Trial name
- BREAK (NCT05184361)
- Testing
- Intermittent energy restriction (IER), Continuous energy restriction (CER)
- Where
- Portugal
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Weight Loss
Effects of Two Weeks of 5:2 Intermittent Energy Restriction on Basal and Postprandial Metabolism
Worldwide, a third of adults were overweight in 2016, and 13% were obese. Excess energy intake results in weight gain. Excess fat increases the risk of disease (eg.
- Trial name
- NCT04138160
- Testing
- 5:2 Intermittent energy restriction, Continuous energy restriction
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Isolated Impaired Fasting Glucose
Low-calorie Diet in Isolated Impaired Fasting Glucose
This study aims to evaluate the preliminary efficacy of a low-calorie diet (LCD) intervention in addressing the underlying pathophysiological abnormalities and improving fasting hyperglycemia among individuals with isolated…
- Trial name
- NCT06451055
- Testing
- Low-calorie diet, Routine dietary and physical activity habits
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University