Clinical trials: Energy Restriction
Obesity
The Effect of Prebiotic Fibres on Weight Loss in an Overweight and Obese Population
The aim of this study is to investigate whether a diet supplemented with two prebiotic fibres induces greater changes in body weight compared to placebo during 12 weeks of energy restriction in an obese/overweight population.
- Trial name
- MNGII (NCT03135041)
- Testing
- Fiber-containing dietary supplement
- Where
- Denmark
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Healthy
Short-term Regulation of Energy and Macronutrient Balance: Impact of Energy Flux
Aim of the study is to investigate the impact of energy flux (achieved by changes in physical activity) under the conditions of energy balance, caloric restriction and overfeeding in healthy subjects.
- Trial name
- EF (NCT03361566)
- Testing
- physical activity, energy intake
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Pediatric Obesity
Appetite Response to Exercise- Versus Mixed (Exercise + Dietary Restriction)-Induced Energy Deficit in Adolescents With Obesity
The aim of the present study is to compare the effect of iso-energetic energy deficits induced by energy restriction alone or exercise + dietary restriction (Mixed deficit) on energy intake and appetite feelings in adolescents…
- Trial name
- IDEX2 (NCT04734639)
- Testing
- CON . control condition without exercise / rest condition, Def-Mixed. Condition with a mixed energy deficit induced by exercise + dietary restriction., Def-EI. Condition with an energy-restriction energy deficit
- Where
- France
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Healthy
Effect of Exercise on Appetite in Response to Meals During Energy Restriction
This study's primary aim is to investigate the acute effect of an exercise bout (30 minutes) on appetite and appetite-regulatory hormone responses during energy restriction.
- Trial name
- NCT06895837
- Testing
- Severe-energy restriction, Severe-energy restriction with exercise
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Overweight and Obesity
Sulfur Amino Acids, Energy Metabolism and Obesity
The primary objective of the trial is to establish the effects of dietary sulfur amino acid (SAA) restriction on body weight, body composition and energy expenditure in humans.
- Trial name
- STAY (NCT04701346)
- Testing
- Low SAA diet, High SAA diet
- Where
- Norway
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Overweight and Obesity
Metabolic Effects of Morning 16/8 Fasting
A study to address the effects of early-day fasting on fat tissue mobilization in comparison to a typical isocaloric Mediterranean and a low-carbohydrate breakfast.
- Trial name
- NCT04293003
- Testing
- fasting, Low carbohydrate, Mediterranean
- Where
- Greece
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Obesity, Abdominal
The Impact Of An Intermittent Energy Restricted Diet On Insulin Sensitivity In Men and Women With Central Obesity
An intermittent energy restricted (IER) diet may modify cardio-metabolic disease risk factors compared to an energy-matched continuous energy restricted (CER) diet.
- Trial name
- Met-IER (NCT02679989)
- Testing
- Intermittent Energy Restriction, Continuous Energy Restriction
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- King's College London
Protein, Healthy
Dietary Protein Restriction and Health
The incidence of type 2 diabetes worldwide has increased significantly over the past decades, which is associated with changing dietary habits and physical inactivity.
- Conditions
- Protein, Healthy, Diet
- Trial name
- LOWPRO (NCT06267235)
- Testing
- Dietary protein restriction
- Where
- Denmark
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Time Restricted Feeding
Prolonged Overnight Fast, Energy Metabolism and Skeletal Muscle Anabolic Sensitivity
Recent research shows that timing of nutritional intake and daily periods of fasting may have important health effects. In humans, limiting daily food intake to a narrow window (typically ~8 hours) can bring about some beneficial…
- Trial name
- NCT05420181
- Testing
- Short 10hr fast, Long 16h fast
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Energy Restriction, Sleep Deprivation
Brain Energy and Cognition
This proposed laboratory study will extend previous findings on relationships between cognitive function and nutritional status to conditions that more closely resemble military operations where aerobic exercise, inadequate…
- Trial name
- NCT01603550
- Testing
- Sleep Deprivation, Energy Restriction
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Glucose and Lipid Metabolism
The Effects of 24-hour Fasting or Carbohydrate Restriction on Postprandial Metabolic Responses
Most individuals spend the majority of the day in a fed state, making postprandial blood glucose and lipid regulation a central component of metabolic health.
- Trial name
- NCT07250191
- Testing
- Fasting, Carbohydrate restriction
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Bath
Caloric Restriction, Exercise
Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery
The objective of this study is to determine whether maintaining a eugonadal state, during severe, sustained energy deficit, attenuates physiological decrements, particularly the loss of lean body mass.
- Trial name
- OPS (NCT02734238)
- Testing
- Sesame Oil, testosterone enanthate
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Women's Health: Female Athlete/Female Athlete Triad
Technique of Restriction of Blood Flow Associated With the Ergonomic Cycle of Upper Limbs in Women
Finding alternatives to improve variables such as strength and anaerobic resistance is a subject of highly studied clinical intervention.
- Trial name
- Kaatsu-BFR (NCT03618004)
- Testing
- Experimental group, Control group
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Real Fundación Victoria Eugenia
Obesity
The Impact of Sleep Restriction on Gastric Emptying, Appetite and Energy Intake
This study aims to examine if partial sleep deprivation results in alterations blood markers and subjective markers of homeostatic, and hedonic appetite, as well as provide initial data as to the impact of sleep restriction on…
- Trial name
- NCT05953285
- Testing
- Sleep restriction
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Mitochondrial Diseases, Myalgic Encephalomyelitis Chronic Fatigue Syndrome
The Precision Mito- Mito Map COMPASS Study
Mito Map is a research tool that produces an Energy Score from information provided by a participant. This remote observational study has an initial enrollment target of 400 adults across seven prespecified cohorts: healthy…
- Conditions
- Mitochondrial Diseases, Myalgic Encephalomyelitis Chronic Fatigue Syndrome, Post-COVID-19 Condition, Postural Orthostatic Tachycardia Syndrome
- Trial name
- COMPASS (NCT07856121)
- Testing
- Mito Map Energy Score and Home Functional Assessments
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- AI Agent Vault, Inc. d/b/a Precision Mito
Obesity Prevention
Acute Time-Restricted Eating in Young Healthy Males
This study compared the metabolic response to three different eating windows (morning fast,12pm-8pm; evening fast, 8am-4pm; control, 8am-8pm).
- Trial name
- NCT05309798
- Testing
- Evening Fasting, Morning Fasting, Control
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Nottingham Trent University
Deficiency; Calorie
Effect of 24 h Severe Energy Restriction on Appetite Regulation and Ad-libitum Energy Intake
Long term maintenance of weight loss is generally poor, which is at least partly due to increased feelings of hunger associated with restricting what can be eaten.
- Trial name
- NCT02696772
- Testing
- Energy intake
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Intermittent Fasting
Effects of Timed Restricted Eating on Body Composition, Metabolism, and Cardiovascular Health
This study is looking at whether eating all meals within a 6-hour window each day (called Time-Restricted Eating, or TRE) can improve body composition, metabolism, heart health, and blood markers over 12 weeks.
- Trial name
- NCT07574177
- Testing
- Time-Restricted Eating (TRE), Time-Restricted Eating with Intermittent Energy Restriction (TRE+IER)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of South Alabama
Overweight and Obesity
The Effects of Combined Energy and Carbohydrate Restriction on Exercise Capacity
The effect of calorie restriction combined with low or moderate carbohydrate availability on exercise capacity, metabolism and metabolic health indicators will be measured in a randomized parallel group design.
- Trial name
- CHO-EX (NCT06381908)
- Testing
- Calorie-restriction with low carbohydrate, Calorie-restriction with moderate carbohydrate
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Bone Resorption, Bone Atrophy
The Effects of Low Energy Availability and High Impact Jumping on Markers of Bone (re)Modelling in Females
Osteoporosis is worldwide health epidemic categorized by poor bone health, primarily diagnosed by low bone mineral density, and costs healthcare systems billions every year.
- Conditions
- Bone Resorption, Bone Atrophy, Energy Supply; Deficiency, Female Athlete Triad
- Trial name
- NCT04790019
- Testing
- Low energy availability, High impact jumping
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Loughborough University