Clinical trials: Enhanced Care
Colorectal Cancer (CRC)
Normobaric Oxygen Therapy in Colorectal Cancer Patients
Colorectal cancer (CRC) patients undergoing chemotherapy often experience anemia, oxidative stress, and immune suppression, significantly impacting their quality of life and treatment outcomes.
- Trial name
- NBO-ONCO (NCT06946004)
- Testing
- Normobaric oxygen therapy
- Where
- Poland
- Volunteers
- 254 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland
Pancreas and Hepatobiliary Cancer Patients
Cardiopulmonary Resuscitation (CPR) Video to Enhance Advance Care Planning in Advanced Upper Gastrointestinal Cancer Patients
Advance care planning involves thinking about choices if the patient becomes sick, and is important for everyone. It does not matter if the patients are ill or healthy.
- Trial name
- NCT01105806
- Testing
- (CPR) video and questionnaires, cardiopulmonary resuscitation (CPR) narrative script and questionnaires
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Depressive Disorder
The ACHIEVA Study of Enhanced Pharmacist Care on Antidepressant Use and Response
This a comparative study of enhanced pharmacist care and regular care of patients starting on antidepressants. When providing participants with enhanced care pharmacists will use the Health Professional's Antidepressant…
- Trial name
- NCT00356655
- Testing
- Psychoeducation
- Where
- Canada
- Volunteers
- 106 people
- Sponsor
- University of Alberta
Phlebitis, Thrombophlebitis
Implementing an Evidence-based, Standardized Care Bundle Targeting Register Nurses and Anaesthesiologists, to Enhance Patient Safety and Quality of Intravascular Access Devices Care Management - The Safe-IVADs Project. A Longitudinell Implementation Intervention With an Embedded Process Evaluation.
The goal of this observational study spanning over three years is to evaluate the effectiveness of implementing a co-designed, care bundle on intravascular access device (IVAD) quality and nurses and anaesthesiologist knowledge…
- Conditions
- Phlebitis, Thrombophlebitis, Infiltration of Peripheral IV Therapy, Extravasation Injury
- Trial name
- NCT07524608
- Testing
- The Safe IVADs project
- Where
- Sweden
- Volunteers
- 700 people
- Sponsor
- Sahlgrenska University Hospital
Chronic Illnesses
An Enhanced Medical Home for High-Risk Chronically Ill Children
The purpose of this study is to assess whether an enhanced medical home providing comprehensive care is cost-effective in preventing serious illness (death, pediatric intensive care admission, or hospital stay >7d) among…
- Trial name
- NCT02128776
- Testing
- Comprehensive care medical home, Usual Care
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cancer, Colo-rectal Cancer
Early Discharge After Colorectal Surgery
RECUPERA-C is a prospective observational pilot study evaluating the feasibility and safety of an early discharge strategy within 48 hours after minimally invasive colorectal surgery.
- Trial name
- RECUPERA-C (NCT07827378)
- Volunteers
- 97 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Chronic Pain, Opioid Use Disorders
Mindfulness-Oriented Recovery Enhancement For Chronic Pain and Prescription Opioid Misuse in Primary Care
The central aim of this study is to test the efficacy of Mindfulness-Oriented Recovery Enhancement (MORE), an intervention designed to disrupt the risk chain leading from chronic pain to prescription opioid misuse and addiction.
- Trial name
- NCT02602535
- Testing
- Mindfulness-Oriented Recovery Enhancement, Support Group
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Utah
Glioma
Evaluation of Diagnostic Performances of 18F-FDOPA PET KInetics
the investigators hypothesise that 18F-FDOPA PET kinetic parameters are good biomarkers to characterise suspected LGG brain lesions that exhibit no contrast on MRI, for identifying aggressive lesions.
- Trial name
- KING (NCT05512403)
- Testing
- PET/CT with 18F-DOPA
- Where
- France
- Volunteers
- 88 people
- Sponsor
- Central Hospital, Nancy, France
Continuity of Care, Patient Safety
Automatic Feedback Indicator to Enhance the Hospital Discharge Communication Between Acute Care and Primary Care.
This study, titled "Automated Indicator Feedback for Improving the Quality of Discharge Letters: A Cluster-Randomized Controlled Trial" (FIAQ-LS), aims to evaluate whether continuous real-time feedback to hospital teams can…
- Conditions
- Continuity of Care, Patient Safety, Hospital Discharge Communication Processes, Communication
- Trial name
- FIAQLS (NCT06835153)
- Testing
- Monthly Performance Feedback with Dashboards (Automated Audit and Feedback)
- Where
- France
- Volunteers
- 132,000 people
- Sponsor
- University Hospital, Grenoble
Critically Ill, Intensive Care Unit
PERFormance Enhancement of the Canadian Nutrition Guidelines by a Tailored Implementation Strategy: The PERFECTIS Study
Canadian Critical Care Nutrition Guidelines assist health practitioners in identifying best practices for feeding critically ill patients.
- Trial name
- PERFECTIS (NCT01168128)
- Testing
- Tailored Change Strategy
- Where
- 5 sites in United States, Canada
- Volunteers
- 278 people
- Sponsor
- Daren K. Heyland
Hypertension, Pregnancy-Induced, HELLP Syndrome
PROTECT-Africa: Biomarker Validation for Preeclampsia Triage
Preeclampsia is a serious high blood pressure condition that can develop during pregnancy. It is one of the leading causes of death and illness for mothers and babies in Africa.
- Conditions
- Hypertension, Pregnancy-Induced, HELLP Syndrome, Eclampsia, Fetal Growth Retardation
- Trial name
- PROTECT-Africa (NCT07810439)
- Where
- Zimbabwe
- Volunteers
- 1,106 people
- Sponsor
- Africa Clinical Research Network (ACRN)
Overactive Bladder
Interventions to Enhance Medication Persistence and Compliance in Patients With Overactive Bladder
Study Objectives: To explore the effectiveness of adjunctive intervention to enhance the medication compliance and persistence in patients with Overactive Bladder (OAB), thereby to improve treatment outcomes Study Hypothesis…
- Trial name
- NCT01515722
- Testing
- Health education intervention (HEI)
- Where
- 13 sites in South Korea
- Volunteers
- 692 people
- Sponsor
- Samsung Medical Center
Cognitive Impairment, Dementia With Behavioral Disturbance
The Care for America's Aging Study
Care for America's Aging is a randomized pilot study investigating whether a home health aide training intervention consisting of enhanced dementia-specific curriculum content will improve: 1) behavioral symptoms of older adult…
- Conditions
- Cognitive Impairment, Dementia With Behavioral Disturbance, Dementia, Alzheimer Disease
- Trial name
- CfAA (NCT06021704)
- Testing
- Enhanced home health aide training in dementia and dementia-related behaviors
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Acute Kidney Injury
PRevention of Acute Kidney Injury Initiated With Electronic Surveillance Enhancement
Introduction: Acute kidney injury (AKI) increases mortality, hospital cost, and rate of progression toward end stage kidney disease 1-4. Early diagnosis and management of AKI is known to improve the above mentioned outcomes.
- Trial name
- PRAISE (NCT01621152)
- Testing
- Conventional management arm, AKI sniffer instigated AKI management
- Where
- United States
- Volunteers
- 2,266 people
- Sponsor
- Mayo Clinic
Rib Fractures, Rib Trauma
Costal Fracture Assessment for Relief and Enhancement of Quality of Life
This study explores the impact of rib fractures on patient well-being and quality of life, aiming to identify effective interventions for pain relief and functional improvement.
- Trial name
- CARE (NCT06405841)
- Testing
- Survey, Pain management
- Where
- 4 sites in Italy
- Volunteers
- 950 people
- Sponsor
- Ospedali Riuniti Trieste
Type 2 Diabetes, Gestational Diabetes Mellitus (GDM)
Co-designing Enhanced Models of Care for First Nations Children at Risk for Childhood-onset Type 2 Diabetes
The overall objective: to co-design and implement targeted and timely community led strategies to improve the health of the Next Generation and end the intergenerational impact of T2D in this population.
- Trial name
- NCT07692321
- Testing
- Breastfeeding and perinatal education and support, Purchasing HbA1c machines for communities, Continuous Glucose Monitoring
- Where
- Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Multi-morbidity, Non-communicable Diseases
Estonia's Enhanced Care Management Impact Evaluation
Estonia's aging population faces an increasing burden of non-communicable diseases (NCDs) and a growing population suffers with multiple chronic conditions.
- Trial name
- ECM (NCT05829642)
- Testing
- Enhanced Care Management
- Where
- Estonia
- Volunteers
- 2,389 people
- Sponsor
- Harvard School of Public Health (HSPH)
CMV, Lung Transplant Recipient
Combination Letermovir and Standard of Care Antiviral for Enhanced Antiviral Response in Cytomegalovirus Infection in Lung Transplant Recipients
The primary objective of the CLEAR-CMV trial is to evaluate the efficacy of letermovir therapy plus standard of care (SOC) antiviral compared to SOC plus placebo in achieving clearance of CMV viremia by week 3 in lung transplant…
- Trial name
- CLEAR-CMV (NCT07235683)
- Testing
- Letermovir, Valganciclovir/Ganciclovir
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Cancer, Chemotherapy-induced Peripheral Neuropathy
Clinician Decision Support Algorithm for Chemotherapy-Induced Peripheral Neuropathy
This research study is evaluating how well a decision support tool works to improve clinicians' use of recommended chemotherapy-induced peripheral neuropathy (CIPN) assessment and management strategies in participants receiving…
- Trial name
- NCT03514680
- Testing
- CIPN Assessment and Management Algorithm
- Where
- United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer, Medication Adherence
Motivational Enhancement Therapy to Improve Adherence to Aromatase Inhibitors
The proposed research is a randomized controlled investigation of the efficacy of motivational interviewing (MI) to improve adherence to aromatase inhibitors (AI) in a community sample of patients with poor adherence to AIs.
- Trial name
- MI for AIs (NCT02883361)
- Testing
- Motivational enhancement therapy, Attention Control
- Where
- Canada
- Sponsor
- University of Calgary