Clinical trials: Enlarged Heart
Heart Failure, Cardiomyopathies
Towards Understanding the Phenotype of Cardiovascular Disease in CKD - TRUE-Type-CKD Study
Premature cardiovascular disease (CVD) is the leading cause of death in patients with kidney disease (CKD). Excessive cardiac mortality is thought to be secondary to non-atherosclerotic processes, with left ventricular (LV)…
- Conditions
- Heart Failure, Cardiomyopathies, Chronic Kidney Diseases, Hypertrophy, Left Ventricular
- Trial name
- TRUE-TypeCKD (NCT03749551)
- Testing
- cardiac magnetic resonance (CMR) post haemodialysis
- Where
- Germany
- Volunteers
- 276 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Cardiomyopathy, Dilated, Cardiomyopathy, Hypertrophic
Association of Insulin Resistance and FGF21 on Cardiac Function in Pediatric Dilated Cardiomyopathy
This study will investigate whether there is an association between insulin resistance and cardiac function in children with dilated or hypertrophic cardiomyopathy.
- Conditions
- Cardiomyopathy, Dilated, Cardiomyopathy, Hypertrophic, Insulin Resistance
- Trial name
- NCT04222101
- Testing
- Oral glucose tolerance test
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Le Bonheur Children's Hospital
Hypertrophic Cardiomyopathy
Paced Dyssynchrony and Myocardial Perfusion IN apiCal Hcm
Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease. A relatively common subgroup of HCM patients have apical HCM - a type of heart muscle disease that causes abnormal muscle thickening towards the tip…
- Trial name
- PINCHcm (NCT04231032)
- Testing
- Asynchronous dual chamber pacing (DOO) with paced ventricular activation, Asynchronous atrial pacing (AOO) with intrinsic ventricular activation
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- Barts & The London NHS Trust
Chronic Heart Failure, Coronary Disease
Role of Endothelial Function, Muscular Fitness and Metabolism in Functional Activity in Patients With Chronic Heart Failure (CHF)
Shortness of breath, fatigue, and exercise intolerance are clinical symptoms of chronic heart failure (CHF). Recent studies suggested that peripheral impairment was the major cause of clinical symptoms, and mechanism may be…
- Conditions
- Chronic Heart Failure, Coronary Disease, Dilated Cardiomyopathy
- Trial name
- NCT01139086
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Left Ventricular Hypertrophy
Screening of Fabry Disease in Patients With Left Ventricular Hypertrophy Detected in Echocardiography
The purpose of this study is to determine the prevalence in Belgium of Fabry disease in patients with unexplained hypertrophic cardiomyopathy measured by echocardiography and to determine in Fabry patients which was the most…
- Trial name
- NCT02221141
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- Laurence Gabriel
Atrial Fibrillation, Rheumatic Heart Disease
Surgical Prevention of Atrial Fibrillation in Patients With Rheumatic Mitral Valve Lesion and Left Atrium Enlargement
This study evaluates the safety and efficiency of surgical prevention of atrial fibrillation in patients with valvular heart disease and left atrium enlargement
- Trial name
- NCT02474108
- Testing
- surgical prevention of atrial fibrillation, cardiomonitor
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Ischemic Cardiopathy, Dilated Cardiomyopathy
Translational Research GRICS-CineCardiac
This project is a pilot study which aims at showing the feasibility of free breathing cardiac MRI using GRICS (Generalized Reconstruction by Inversion of Coupled System)software in a clinical environment.
- Trial name
- NCT06878768
- Testing
- Additional free breathing MR acquisitions
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Metabolic Syndrome, Insulin-resistance
Metabolic and Cardiovascular Effects of Armolipid Plus in Subjects With Metabolic Syndrome
Aim of the study is to evaluate the effects of Armolipid Plus on insulin sensitivity in patients with MetS and increased LV mass.
- Conditions
- Metabolic Syndrome, Insulin-resistance, Left Ventricular Hypertrophy
- Trial name
- ARMP-11 (NCT02295176)
- Testing
- Armolipid Plus
- Where
- 3 sites in Italy
- Volunteers
- 159 people
- Sponsor
- Rottapharm
Cardiomyopathy, Dilated
Autologous Stem Cells in Pediatric Patients With Dilated Cardiomyopathy
The purpose of this study is to determine whether an autologous stem cell infusion through catheterism is safe and effective in the treatment of pediatric dilated cardiomyopathy. Process: 1.
- Trial name
- NCT01504594
- Testing
- Intracoronary autologous stem cell infusion
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Heart Failure, Dilated Cardiomyopathy
Orodispersible Minitablets of Enalapril in Children With Heart Failure Due to Dilated Cardiomyopathy
Paediatric clinical trial in 50 children, from 1 month to less than 12 years of age, suffering from heart failure due to dilated cardiomyopathy, to obtain paediatric pharmacokinetic and pharmacodynamic data of enalapril and its…
- Trial name
- LENA-WP08 (NCT02652728)
- Testing
- Enalapril Orodispersible Minitablet
- Where
- 6 sites in Austria, Hungary and 3 more
- Volunteers
- 50 people
- Sponsor
- Ethicare GmbH
Hypertrophy, Left Ventricular, Hypertension
Effect of a Targeted Notification and Clinical Support Pathway on Individuals With Left Ventricular Hypertrophy
The electronic health record contains vast amounts of cardiovascular data, including potential clues that an individual may have unrecognized cardiac conditions.
- Conditions
- Hypertrophy, Left Ventricular, Hypertension, Cardiomyopathies
- Trial name
- NOTIFY-LVH (NCT05713916)
- Testing
- Intervention: Population Health Coordinator
- Where
- United States
- Volunteers
- 648 people
- Sponsor
- Massachusetts General Hospital
Left Ventricular Hypertrophy, Hypertension
Response of the Myocardium to Hypertrophic Conditions in the Adult Population
Hypertension and aortic stenosis are the two leading conditions that cause thickening of the heart muscles (left ventricular hypertrophy). Left ventricular hypertrophy is initially adaptive to maintain optimal heart function.
- Conditions
- Left Ventricular Hypertrophy, Hypertension, Myocardial Fibrosis
- Trial name
- NCT02670031
- Testing
- Cardiovascular Magnetic Resonance, Echocardiogram, Electrocardiogram
- Where
- Singapore
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Dilated Cardiomyopathy (DCM)
Protein A Immunoadsorption in Dilated Cardiomyopathy (RPIA-DCM)
This study is a multicenter, dual-arm and randomized controlled clinical trial. Sixty patients with dilated cardiomyopathy and positive β1-adrenergic receptor autoantibodies were selected and randomly divided into an…
- Trial name
- NCT06922851
- Testing
- Immunoadsorption
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Atrial Fibrillation, Hypertension,Essential
Left Atrial Enlargement: A Crucial Indicator for Identifying Atrial Fibrillation in Patients With Hypertension
Based on the data of inpatients with hypertension and a cross-sectional study with a large sample size, this study aims to find the early warning value of the left anteroposterior atrial diameter for the possible occurrence of…
- Conditions
- Atrial Fibrillation, Hypertension,Essential, Left Atrial Dilatation
- Trial name
- NCT06359873
- Testing
- CHA2DS2-VASc score, C2HEST score, and left atrial diameter (LAD)
- Where
- China
- Volunteers
- 58,427 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Myocardial Infarction, Dilated Cardiomyopathy
Arrhythmia Prediction Trial
Patients with Ischaemic and Dilated Cardiomyopathy, face an increased risk for Arrhythmic Sudden Cardiac Death. The purpose of this study is to estimate the performance of Modern Non-Invasive Indices and the performance of…
- Conditions
- Myocardial Infarction, Dilated Cardiomyopathy, Heart Failure
- Trial name
- APRET (NCT02175836)
- Where
- Greece
- Volunteers
- 500 people
- Sponsor
- University of Athens
Cardiac Remodeling, Ventricular, Right Ventricular Hypertrophy
Longitudinal Analysis of Right Ventricular Remodeling in Response to Prolonged Strength Training Using 3D-echocardiography
Right ventricular (RV) physiological remodeling in response to prolonged strength exercise remains poorly studied. This prospective, non-randomized, single-center study, proposes to follow 24 healthy sedentary volunteers who will…
- Trial name
- FORCE-VD (NCT04187170)
- Testing
- Strength physical training
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Cardiomyopathy, Hypertrophic, Cardiomyopathy, Dilated
National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry
The goal of this observational study is to develop a registry of Brazilian patients with hereditary cardiovascular diseases, combining clinical and genomic data.
- Conditions
- Cardiomyopathy, Hypertrophic, Cardiomyopathy, Dilated, Cardiomyopathy Restrictive, Arrhythmogenic Right Ventricular Dysplasia
- Trial name
- RENOMICA-Hcor (NCT06546137)
- Testing
- whole genome sequencing
- Where
- 27 sites in Brazil
- Volunteers
- 1,211 people
- Sponsor
- Hospital do Coracao
Disorders Associated With Peritoneal Dialysis
Assessment of Bioimpedance and Vitamin D and LV Mass in PD Patients (FLUID Study)
The main purpose of this study is to compare the effects of using bio-impedance analysis to guide management of fluid status versus routine clinical care on heart structure.
- Trial name
- FLUID (NCT01045980)
- Testing
- Bioimpedance and Vitamin D, Usual care and Vitamin D
- Where
- 2 sites in Canada
- Volunteers
- 74 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Primary Cardiomyopathy, Dilated Cardiomyopathy
Risk Stratification in Children and Adolescents With Primary Cardiomyopathy
RIKADA is a prospective study performing systematic family screening including clinical and genetic testing in pediatric patients with primary cardiomyopathy and their first-degree relatives with the aim to facilitate risk…
- Conditions
- Primary Cardiomyopathy, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Left Ventricular Noncompaction
- Trial name
- RIKADA (NCT03572569)
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- German Heart Institute
Athletes Heart
Semmelweis Sport Study
The aim of the present proposal is to investigate the development of distinct morphological, functional, biochemical and molecular aspects of short- and long-term sport-induced changes in the heart, to get a better understanding…
- Trial name
- NCT03025737
- Where
- Hungary
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Semmelweis University Heart and Vascular Center