Clinical trials: Enlarged Heart
Lymphocytic Myocarditis (Disorder), Heart Failure
Micophenolate Mofetil Versus Azathioprine in Myocarditis
The study is aimed at studying the direct efficacy of mycophenolate mofetil (mycophenolate mofetil, CellCept, Genentech, N015393/02, 12.08.2009) (in combination with corticosteroids (methylprednisolone, Metypred, Orion, 003467…
- Conditions
- Lymphocytic Myocarditis (Disorder), Heart Failure, Dilated Cardiomyopathy, Cardiomyopathies
- Trial name
- NCT05237323
- Testing
- mycophenolate mofetil 2 g per day, azathioprine of 150 [75; 150] mg per day
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Chronic Respiratory Failure
Fibroblast Growth Factor 23 in Chronic Respiratory Failure
Fibroblast growth factor 23 (FGF23) is a key hormone of the mineral metabolism produced in bone and acting on the kidney to lower phosphatemia.
- Trial name
- EFIC-RES (NCT05258370)
- Testing
- Dosage, Cardiac echography
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension, Left Ventricular Hypertrophy
Vitamin D Therapy to Reduce Cardiac Damage Among Vulnerable Hypertensive Patients
This project seeks to reduce the disparity in hypertensive heart disease which exists for African-Americans who have poorly controlled hypertension (HTN), also known as blood pressure (BP).
- Trial name
- AdDReaCH (NCT01360476)
- Testing
- cholecalciferol (Vitamin D)
- Where
- United States
- Volunteers
- 354 people
- Sponsor
- Wayne State University
Dilated Cardiomyopathy
A Clinical Study of Immunoadsorption Therapy for Dilated Cardiomyopathy
Dilated cardiomyopathy (DCM) causes significant morbidity and mortality and is the third most common cause of heart failure and the most frequent reason for heart transplantation.
- Trial name
- NCT02915718
- Testing
- protein A immunoadsorption
- Where
- China
- Volunteers
- 7 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Cardiomyopathy, Dilated
Vitamin D Supplementation Can Improve Heart Function in Idiopathic Cardiomyopathy
Vitamin D deficiency could be a high risk for cardiovascular diseases. It has been recently reported that vitamin D deficiency is another cause of heart failure and cardiomyopathies.
- Trial name
- NCT02517814
- Testing
- Vitamin D
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hillel Yaffe Medical Center
Hypertension, Diabetes Mellitus, Type 2
Effects of SGLT2 Inhibitor on Hemodynamic Parameters in Resistant Hypertensive Subjects
New strategies trying to achieve blood pressure control and consequently reduce cardiovascular risk in resistant hypertensive subjects are promising.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Blood Pressure, Obesity
- Trial name
- NCT03089333
- Testing
- Dapagliflozin 10mg, Glibenclamide 5Mg Tablet
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- University of Campinas, Brazil
Coronary Artery Disease, Coronary Stenosis
The PICCOLETO XIII REVEAL-DCB Cohort A Study
To characterize, using paired coronary computed tomography angiography (CCTA), longitudinal changes in coronary atherosclerotic plaque, lumen dimensions, and vessel remodeling between baseline and mid-term follow-up in de novo…
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Coronary Restenosis, Coronary Atherosclerosis
- Trial name
- REVEAL-DCB-A (NCT07868523)
- Volunteers
- 200 people
- Sponsor
- Fondazione Ricerca e Innovazione Cardiovascolare ETS
Dilated Cardiomyopathy
Withdrawal of Medication in Recovered DCM
Randomized study of medication withdrawal in patients who have recovered LV function in Dilated Cardiomyopathy.
- Trial name
- WrecEF (NCT02770443)
- Testing
- withdrawal, standard of CARE
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- McGill University
Children, Chronic Renal Failure
Effect of Strict Blood Pressure Control and ACE-Inhibition on Progression of Chronic Renal Failure in Pediatric Patients
In children with chronic kidney disease, progression to end-stage renal failure is associated with high patient morbidity and poor quality of life.
- Conditions
- Children, Chronic Renal Failure, Hypertension, Acquired Kidney Disease
- Trial name
- ESCAPE (NCT00221845)
- Testing
- ACE Inhibition, Intensified Blood Pressure Control, Add-on Angiotensin Receptor Blockade
- Where
- 33 sites in Czechia, France and 10 more
- Volunteers
- 400 people
- Sponsor
- Heidelberg University
Dilated Cardiomyopathy (DCM), Ischemic Cardiomyopathy
Dilated cardiomYopathy iNtervention With Allogeneic MyocardIally-regenerative Cells (DYNAMIC)
To determine the safety profile of CAP-1002 administered by multi-vessel intracoronary infusion in subjects with DCM. The study will further explore safety and exploratory efficacy endpoints of CAP-1002.
- Conditions
- Dilated Cardiomyopathy (DCM), Ischemic Cardiomyopathy, Nonischemic Cardiomyopathy, Heart Failure
- Trial name
- DYNAMIC (NCT02293603)
- Testing
- Allogeneic Cardiosphere-Derived Cells (CDCs)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Capricor Inc.
Dilated Cardiomyopathy
Effect of Rosuvastatin on Left Ventricular Remodeling
The purpose of this study is to examine the the effect of the HMG-CoA reductase inhibitor Rosuvastatin on left ventricular remodeling in patients with dilated cardiomyopathy.
- Trial name
- NCT00505154
- Testing
- Rosuvastatin
- Where
- Norway
- Volunteers
- 75 people
- Sponsor
- Oslo University Hospital
Left Ventricular Hypertrophy
Multi-Modality Echocardiographic Techniques in Pathological Left Ventricular Hypertrophy Adults
This multicenter clinical study aims to evaluate the multi-modality echocardiographic parameters in patients with different pathological left ventricular hypertrophy (LVH) and investigate the correlation between echocardiographic…
- Trial name
- MET-LVH (NCT05719337)
- Testing
- Echocardiography
- Where
- 22 sites in China
- Volunteers
- 660 people
- Sponsor
- First Hospital of China Medical University
Cardiovascular Diseases, Carotid Intimal Media Thickness
Association of Mean Platelet Volume and Cardiovascular Disease in Children With End Stage Renal Disease.
Cardiovascular disease (CVD) is the major risk factor for death in end stage renal diseases (ESRD). Approximately 80% of ESRD patients have some degrees of left ventricular abnormalities at initiation of dialysis.
- Conditions
- Cardiovascular Diseases, Carotid Intimal Media Thickness, Left Ventricular Hypertrophy, Mean Platelet Volume
- Trial name
- NCT03759002
- Testing
- Imaging, Blood sampling
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Aortic Valve Stenosis, Heart Failure
Left Atrial Volume Index in Asymptomatic Aortic Stenosis
Aortic stenosis results in increased filling pressures of the heart. Size and function of the left atrium may be a marker for more advanced heart disease (heart failure) in patients with severe aortic stenosis, not presenting any…
- Trial name
- LAVIAS (NCT02395107)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Cardiovascular Disease (CVD), Heart Failure
Study of the Progression of Chronic Cardiovascular Conditions
This study will collect physiologic data in patients with cardiovascular conditions and observe the natural history of those conditions for research purposes.
- Conditions
- Cardiovascular Disease (CVD), Heart Failure, Aortic Stenosis, Aortic Stenosis Disease
- Trial name
- OCORO (NCT07420907)
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Prolaio
Dilated Cardiomyopathy, Heart Failure
Dilated Cardiomyopathy Detection Using AI and Screening With Mobile Technology (DCM-DETECT)
This is a prospective, single-arm clinical trial in which participants with dilated cardiomyopathy will invite their first degree relatives to undergo mobile cardiac, electrocardiogram screening.
- Conditions
- Dilated Cardiomyopathy, Heart Failure, Heart Disease
- Trial name
- DCM-DETECT (NCT06688396)
- Testing
- Mobile 6L AI-EKG Screening
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Lancaster General Hospital
Persistent Atrial Fibrillation, Right Atrial Enlargement
Adjunctive Right Atrial Ablation for Persistent Atrial Fibrillation With Right Atrial Enlargement
This is retrospective cohort study testing whether patients with persistent atrial fibrillation and right atrial enlargement may benefit from adjunctive right atrial ablation.
- Trial name
- NCT05227586
- Testing
- Circumferential pulmonary vein isolation + linear ablation + bi-atrial mapping + left atrial driver ablation, Circumferential pulmonary vein isolation + linear ablation + bi-atrial mapping + left atrial driver ablation + right atrial driver ablation
- Where
- China
- Volunteers
- 195 people
- Sponsor
- Shanghai Chest Hospital
Cardiomyopathy, Dilated, Sudden Cardiac Death
Prediction of Sudden Cardiac Death in Dilated Cardiomyopathy
PREDICT-DCM Trial is a multi-centre, prospective observational trial including patients with DCM undergoing cardiac magnetic resonance imaging (CMR) prior to ICD or event recorder implantation.
- Trial name
- PREDICT-DCM (NCT03224156)
- Testing
- Cardiac Magnetic Resonance Imaging
- Where
- 2 sites in Germany
- Volunteers
- 150 people
- Sponsor
- University Hospital Heidelberg
Hypertension
The COlchicine HypERtENsion Trial
The purpose of this study to investigate the effects of colchicine on measures of vascular and cardiac function in patients with hypertension.
- Trial name
- COHERENT (NCT04916522)
- Testing
- Colchicine
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Herlev and Gentofte Hospital
Anemia, Kidney Failure
A Safety and Efficacy Study for Epoetin Alfa in Pre-dialysis Subjects.
The purpose of this study is to determine if using Eprex, to maintain hemoglobin within the normal range, will prevent or delay the progression of left ventricular mass growth.
- Conditions
- Anemia, Kidney Failure, Left Ventricular Hypertrophy
- Trial name
- NCT00364260
- Testing
- epoetin alfa
- Volunteers
- 172 people
- Sponsor
- Janssen-Ortho Inc., Canada