Clinical trials: Enteritis
Crohn's Disease, Short Bowel Syndrome
Citrulline: A Plasmatic Marker to Assess and Monitor Small Bowel Crohn's Disease Patients
Citrulline is an amino acid produced in the intestine and in the liver, but the liver does not contribute significantly to circulating citrulline concentrations.
- Conditions
- Crohn's Disease, Short Bowel Syndrome, Malabsorption Syndromes, Celiac Disease
- Trial name
- NCT00138879
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- St Mark's Hospital Foundation
Eosinophilic Gastrointestinal Disorders (EGID), Eosinophilic Esophagitis
Registry for Eosinophilic Gastrointestinal Disorders (REGID)
Develop Registry tool
- Conditions
- Eosinophilic Gastrointestinal Disorders (EGID), Eosinophilic Esophagitis, Eosinophilic Disorder
- Trial name
- EoE (NCT01382563)
- Where
- 8 sites in United States
- Volunteers
- 34 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Acute Radiation Enteritis
Prevention of Acute Radiation Enteritis With Glutamine
Ionizing radiation has cytotoxic effects, and is commonly used as treatment for neoplasm. A common adverse effect of radiation is acute diarrhoea.
- Trial name
- NCT00828399
- Testing
- Glutamine, Whole protein
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Castilla-León Health Service
Enteritis
A Dose Ranging Study of Delayed Release Beclomethasone for Prevention of Acute Enteritis in Patients With Rectal Cancer
The purpose of this study is to evaluate the safety and preliminary efficacy of four doses of SGX201 in subjects with rectal cancer treated with concurrent radiation and chemotherapy.
- Trial name
- NCT01073384
- Testing
- SGX201 (delayed release beclomethasone 17,21-dipropionate)
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Soligenix
Radiation Enteritis
CMTS0515-auWMT for Radiation Enteritis
This is a randomized controlled trial to explore the exploring the non-inferiority of CMTS0515-augmented WMT compared to WMT.
- Trial name
- NCT07331688
- Testing
- CMTS0515-augmented washed microbiota transplantation, Washed Microbiota Transplantation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Ileal Pouch
Study of EXE-346 Live Biotherapeutic to Reduce High Bowel Movement Frequency in Subjects With an IPAA (PROF)
The aim of this study is to assess the safety and preliminary efficacy of treatment with EXE-346, a live biotherapeutic, which may reduce bowel movement frequency in patients with an ileal pouch-anal anastomosis (IPAA) and lead…
- Trial name
- PROF (NCT05938465)
- Testing
- EXE-346
- Where
- 8 sites in United States
- Volunteers
- 50 people
- Sponsor
- Exegi Pharma, LLC
Sepsis, Bacteraemia
Optimising Diagnosis and Antibiotic Prescribing for Acutely Ill Children in Primary Care
Acute illness is the most common presentation of children attending ambulatory care settings. Serious infections (e.g. meningitis, sepsis, pyelonephritis, pneumonia) are rare, but their impact is quite large (increased morbidity…
- Conditions
- Sepsis, Bacteraemia, Meningitis, Abscess
- Trial name
- ERNIE2 (NCT02024282)
- Testing
- Use of C-reactive protein (CRP) point of care test, Brief intervention and parent leaflet, Finger Pulse Oximeter
- Where
- 2 sites in Belgium
- Volunteers
- 8,962 people
- Sponsor
- KU Leuven
Cancer, Diarrhea
Impact of Probiotics BIFILACT® on Diarrhea in Patients Treated With Pelvic Radiation
In this double-blinded randomized clinical trial study, investigators assessed probiotic used to prevent or delay radiation induced grade moderate to severe diarrhea with patient treated for pelvic cancer.
- Conditions
- Cancer, Diarrhea, Abdominal Pain, Quality of Life
- Trial name
- NCT01839721
- Testing
- Bifilact®
- Where
- Canada
- Volunteers
- 246 people
- Sponsor
- CHU de Quebec-Universite Laval
Clostridium Enterocolitis, Antibiotic-Associated Diarrhea
Efficacy of Metronidazole Versus Metronidazole and Rifampin in CDAD Treatment
What is the difference between the use of one drug (Oral Metronidazole) versus the use of this same drug combined with another drug (Rifampin) in treatment of bacteria and infection-associated diarrhea in patients? This infection…
- Conditions
- Clostridium Enterocolitis, Antibiotic-Associated Diarrhea, Pseudomembranous Colitis, Pseudomembranous Enterocolitis
- Trial name
- NCT00182429
- Testing
- Metronidazole and Rifampin
- Where
- 4 sites in Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Anal Cancer, Colorectal Cancer
Octreotide in Preventing or Reducing Diarrhea in Patients Receiving Chemoradiotherapy for Anal or Rectal Cancer
RATIONALE: Octreotide may be effective in preventing or controlling diarrhea in patients who are undergoing chemoradiotherapy for anal or rectal cancer. It is not yet known whether octreotide is effective in treating diarrhea.
- Conditions
- Anal Cancer, Colorectal Cancer, Drug/Agent Toxicity by Tissue/Organ, Radiation Enteritis
- Trial name
- NCT00075868
- Testing
- octreotide acetate
- Where
- 112 sites in United States
- Volunteers
- 233 people
- Sponsor
- Radiation Therapy Oncology Group
Pouchitis
GM-CSF, Fosfomycin and Metronidazole for Pouchitis in Ulcerative Colitis Patients After Restorative IPAA Surgery
This study will examine whether the application of GM-CSF, fosfomycin and metronidazole locally in the pouch is safe and effective in the treatment of pouchitis for patients with ulcerative colitis, and whether treatment changes…
- Trial name
- NCT04979832
- Testing
- GM-CSF, fosfomycin and metronidazole
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Zealand University Hospital
Enteritis Caused by Radiation
Multiple Ascending Dose Study to Assess the Pharmacokinetics, Safety, and Tolerability of Orally Administered SYN 020
This is a Phase 1, randomized, double-blind, placebo-controlled, multiple-ascending-dose study to assess the PK, safety, and tolerability of SYN-020 oral delayed release capsules (SYN 020) in healthy adults.
- Trial name
- NCT05045833
- Testing
- SYN-020 Delayed Release Capsule
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Theriva Biologics, Inc.
Acute Radiation Enteritis
Improvement Effect of Dexamethasone Enema for Acute Radiation-induced Rectal Injury
Research Objective and Principle: Through a randomized controlled study, evaluate the effectiveness of dexamethasone in improving radiation-induced rectal injury in rectal cancer patients undergoing pelvic radiotherapy, thereby…
- Trial name
- NCT07548736
- Testing
- Experimental Group (dexamethasone enema), Control group (dexamethasone enema)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Pouchitis, Hyperbaric Oxygen Therapy
Hyperbaric Oxygen Therapy for Antibiotic Refractory Pouchitis
The aim of current study is to evaluate the effect of hyperbaric oxygen therapy for the treatment of chronic antibiotic-refractory pouchitis.
- Trial name
- HBOT-pouch (NCT03526796)
- Testing
- Hyperbaric oxygen therapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Jinling Hospital, China
Prostate Cancer, Radiotherapy Side Effect
PROstate CAncer Radiotherapy - Bowel Quality of Life (PROCAR-BQ)
This is a prospective pilot study to evaluate the mean increase of bowel symptoms after pelvic radiotherapy (RT) in prostate cancer (PCa) patient using the validated \& newly translated EORTC-QLQ PRT20 module.
- Conditions
- Prostate Cancer, Radiotherapy Side Effect, Bowel Dysfunction, Quality of Life
- Trial name
- PROCAR-BQ (NCT05880446)
- Testing
- Bowel symptoms & QoL assessment
- Where
- Belgium
- Volunteers
- 41 people
- Sponsor
- Jules Bordet Institute
Radiotherapy Induced Diarrhea, Acute Radiation Enteritis
Efficacy and Safety of Adjunctive Use of Rifaximin In Preventing Radiotherapy-induced Diarrhea in Cancer Patients
Preclinical data indicate that rifaximin could be repurposed as a novel strategy for preventing and reducing the severity of gastrointestinal damage, particularly diarrhea, that results from pelvic irradiation.
- Conditions
- Radiotherapy Induced Diarrhea, Acute Radiation Enteritis, Prostate Cancer, Cervical Adenocarcinoma
- Trial name
- NCT06783153
- Testing
- Rifaximin 550 MG, Standard Care Chemoradiation
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Pouchitis, Inflammatory Bowel Diseases
Faecal Microbiota Transplantation in the Treatment of Chronic Pouchitis
Patients with the chronic bowel disease pouchitis is disabled by bloody diarrhoea and abdominal pain often followed by fever. Pouchitis is an inflammation in a pouch, a reservoir formed by the small intestine in the management of…
- Conditions
- Pouchitis, Inflammatory Bowel Diseases, Ulcerative Colitis
- Trial name
- MicroPouch (NCT04100291)
- Testing
- Faecal microbiota transplantation
- Where
- 2 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- Ole Thorlacius-Ussing, MD, DMSc, Professor of Surgery
Acute Radiation Enteritis
Preventive Efficacy of Bergmann Enema for Acute Radiation-induced Rectal Injury in Rectal Cancer Patients Undergoing Short-course Radiotherapy
Research Objective and Principle: To evaluate the effectiveness of Bergmann enema in preventing acute radiation-induced rectal injury in patients with rectal cancer, thereby providing a basis for treatment options for potential…
- Trial name
- NCT07302126
- Testing
- Bergmann enema
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Crohn's Disease, Peritoneal Carcinomatosis With Intestinal Occlusion
CAre of Patients With PArenteral Nutrition At Home
This research aims to give an overview of a number of aspects related to the quality of care for adult patients on home parenteral nutrition.
- Conditions
- Crohn's Disease, Peritoneal Carcinomatosis With Intestinal Occlusion, Radiation Enteritis, Chronic Diarrhea
- Trial name
- CAPANAH (NCT01545063)
- Where
- 13 sites in Belgium
- Volunteers
- 39 people
- Sponsor
- KU Leuven
Eosinophilic Esophagitis, Eosinophilic Gastritis
Eosinophilic Gastrointestinal Disorders Patient Registry
The Eosinophilic Gastrointestinal Disorders (EGIDS) Registry is a longitudinal study that does not involve medical interventions, but serves as a record of demographics, characteristics of disease and treatment, utilization…
- Conditions
- Eosinophilic Esophagitis, Eosinophilic Gastritis, Eosinophilic Enteritis, Eosinophilic Colitis
- Trial name
- NCT01779154
- Where
- United States
- Sponsor
- Arkansas Children's Hospital Research Institute