Clinical trials: Enteropathy
Diverticular Disease of Colon, Diverticulosis, Colonic
Prevalence of Segmental Colitis Associated With Colic Diverticulosis (SCAD)
Colonic diverticula are common in Western countries, affecting up to 60% of subjects over 70 years of age. In about 80% of patients, colonic diverticula remain asymptomatic (diverticulosis), while approximately 20% of patients…
- Trial name
- NCT04279821
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Roma La Sapienza
Environmental Enteropathy
Effectiveness of Micronutrient Supplementation and Fish Oil + Micronutrient Supplementation in the Treatment of Environmental Enteropathy
The purpose of this study is to investigate the therapeutic effectiveness of micronutrients (full RDA) and micronutrients + fish oil as separate interventions in restoring normal gut absorptive and immunological function as…
- Trial name
- NCT01593033
- Testing
- Fish oil and Micronutrient Supplementation, Micronutrient Supplement
- Where
- Malawi
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Colorectal Cancer
Analgesic Efficacy of Free-opioid Anesthesia for Colorectal Surgery
Objectives: To compare free-opioid anesthesia (the combination of epidural anesthesia, intravenous lidocaine, ketamine, propofol, and sevoflurane) and opioid anesthesia (fentanyl, propofol and sevoflurane) regarding…
- Trial name
- NCT06042816
- Testing
- Free-opioid anesthesia, opioid anesthesia
- Where
- Vietnam
- Volunteers
- 49 people
- Sponsor
- Vietnam Military Medical University
Locally Advanced Rectal Cancer (LARC)
Application and Exploration of Personalized ctDNA-MRD Detection Technology in Predicting the Efficacy of Neoadjuvant Therapy for Rectal Cancer
This study is a single-center, prospective, observational clinical trial enrolling patients with locally advanced rectal cancer (cT3-4aN0M0 and cT1-4aN1-2M0).
- Trial name
- ctDNA-MRD-RC (NCT07393048)
- Testing
- Personalized ctDNA-MRD Detection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Friendship Hospital
Cancer, Sigmoid, Cancer, Rectum
Effect of Endovascular Inferior Mesenteric Artery Embolization on Colonic Perfusion Prior to Rectal Surgery for Rectal Tumor or Sigmoid Colon Surgery
The investigators hypothesize that a primary embolization, 3-4 weeks before surgery, would allow development of vascular collaterality, in particular for the marginal artery which will ensure a better colonic perfusion.
- Trial name
- AMIREMBOL (NCT03628248)
- Testing
- embolization of the inferior mesenteric artery, Inferior mesenteric artery ligation
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Coeliac Disease
Virtual Dietetic Interventions in Patients With Coeliac
This clinical study is exploring whether a pre-recorded, on-demand webinar led by specialist dietitians can be as effective as traditional one-on-one appointments in helping people newly diagnosed with coeliac disease learn to…
- Trial name
- NCT07172555
- Testing
- Virtual Dietetic First-Appointment Webinar for Coeliac Disease, Standard Dietetic Consultation (Face-to-Face or Telephone)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Colorectal Cancer
Polyp Measurement Device
Colorectal cancer is the second-leading cause of cancer death in the United States. Colorectal cancer screening is recommended to begin at age 50 years for most men and women at average risk for this disease.
- Trial name
- NCT03856255
- Testing
- Micro-Tech Endoscopic Gauge
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Crohn Disease of Ileum
Ileocolic Resection for Complex Crohn's Disease
Laparoscopic ileocolic resection is the preferred surgical approach for patients with ileocecal Crohn's disease (CD). Objective of this study was to evaluate the efficacy of a minimally invasive gas-less ileocolic resection in…
- Trial name
- NCT03950726
- Testing
- ileocolic resection
- Volunteers
- 27 people
- Sponsor
- University of Roma La Sapienza
Breast Cancer, Lung Cancer
Ontario-wide Cancer TArgeted Nucleic Acid Evaluation
Substantial progress has been made in the treatment of cancer through the use of targeted therapies, but what works for one patient might not work for another patient.
- Conditions
- Breast Cancer, Lung Cancer, Colorectal Cancer, Melanoma
- Trial name
- OCTANE (NCT02906943)
- Where
- 7 sites in Canada
- Volunteers
- 10,000 people
- Sponsor
- University Health Network, Toronto
Colorectal Cancer
Comparative Effectiveness of CTC & OC
The goal of this study is to compare the findings of virtual (CT-colonography) with findings of optical colonoscopies to determine if virtual colonoscopy is suitable for colorectal cancer surveillance.
- Trial name
- NCT02143115
- Testing
- Optical colonoscopy, CT-Colonography
- Where
- 5 sites in United States
- Volunteers
- 244 people
- Sponsor
- Fox Chase Cancer Center
Breast Cancer Screening, Cervical Cancer Screening
Cancer Awareness Among Syrian Migrants
This study aims to develop and evaluate a theory-based educational intervention to improve cancer screening participation among Syrian migrants in Turkey.
- Conditions
- Breast Cancer Screening, Cervical Cancer Screening, Colorectal Cancer Screening, Cancer Prevention Behavior
- Trial name
- NCT07541105
- Testing
- PMT-Based Cancer Screening Educational Intervention, PMT-Based Cancer Screening Education Program
- Volunteers
- 30 people
- Sponsor
- Toros University
Colorectal Cancer
SCRT Followed by Camrelizumab Combined With Fluzoparib and Chemotherapy as Neoadjuvant Therapy for LARC
To explore the safety and efficacy of neoadjuvant therapy for locally advanced rectal cancer with short course radiotherapy followed by camrelizumab combined with fluzoparib and chemotherapy
- Trial name
- NCT06516445
- Testing
- SCRT, Camrelizumab, Fluzoparib
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Huazhong University of Science and Technology
IBS, Diarrhea Predominant
Transcutaneous Electrical Acustimulation for IBS-D: A Multicenter Study
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent abdominal pain and altered bowel habits.
- Trial name
- NCT07425145
- Testing
- Portable stimulator
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First People's Hospital of Foshan
Intestinal Obstruction, Pelvic Organ Prolapse
Biological Mesh Versus Synthetic Mesh in Interdisciplinary RRP With SCP
The purpose of the pilot study is to demonstrate the safety and efficacy of a biological mesh compared to a standard synthetic mesh for the planned procedure in the above-mentioned clinical picture.
- Conditions
- Intestinal Obstruction, Pelvic Organ Prolapse, Rectal Prolapse
- Trial name
- BioSynIRS (NCT06245577)
- Testing
- Laparoscopic mesh sacropexy (vagina, cervix) combined with resection rectopexy
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Evangelisches Klinikum Köln Weyertal gGmbH
Constipation, Pain, Postoperative
Opioid Induced Bowel Dysfunction in Patients Undergoing Cesarean Section
Constipation is common in pregnant women. Surgery, anaesthesia and opioid analgesics may further impair bowel function. The aim of the present study was to evaluate if oxycodone-naloxone combination compared to oxycodone reduced…
- Trial name
- oksisektio (NCT02571881)
- Testing
- Caesarean section, Oxycodone, oxycodone-naloxone
- Where
- Finland
- Volunteers
- 57 people
- Sponsor
- Kuopio University Hospital
Hemorrhoids, Pain
Topical Anesthesia Versus Placebo to Decrease Pain in Rubber Band Ligation for Treatment of Internal Hemorrhoids
Rubber band ligation is a simple and effective procedure for the management of hemorrhoidal disease. However, 90% of patients have some degree of discomfort associated with the procedure and up to 40% develop clinically…
- Trial name
- NCT02130830
- Testing
- Topical 2,5% lidocaine + 2,5% prilocaine gel
- Where
- Chile
- Volunteers
- 80 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Appendicitis
Practical Advantages of Single-port Over Three-port Laparoscopic Appendectomy in Children
Despite growing popularity, practical advantages of single-port laparoscopic appendectomy (SLA) over conventional three-port laparoscopic appendectomy (CLA) have yet to be established well in pediatric population.
- Trial name
- PASTA (NCT03106467)
- Testing
- Single-port laparoscopic appendectomy, Three-port laparoscopic appendectomy
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Hallym University Medical Center
Chemotherapeutic Agent Toxicity, Colorectal Cancer
Biomarkers in Predicting Neurotoxicity in Patients With Colorectal Cancer Receiving Oxaliplatin
RATIONALE: Studying samples of blood in the laboratory from patients receiving oxaliplatin for cancer may help doctors learn more about changes that occur in DNA and identify biomarkers related to neurotoxicity.
- Conditions
- Chemotherapeutic Agent Toxicity, Colorectal Cancer, Neurotoxicity
- Trial name
- NCT00884767
- Testing
- FOLFOX regimen, fluorouracil, leucovorin calcium
- Where
- France
- Volunteers
- 206 people
- Sponsor
- Institut Cancerologie de l'Ouest
Fecal Incontinence, Encopresis
Biofeedback Vs Electrical Stimulation in Treatment of Fecal Incontinence
Fecal incontinence is one of the most psychological frustrating problems. It occurs in children due to many causes. There is a wide range of non-invasive therapeutic approaches like Kegel exercise, Biofeedback, and posterior…
- Conditions
- Fecal Incontinence, Encopresis, Fecal Soiling
- Trial name
- NCT04380571
- Testing
- Biofeedback, Electrical stimulation, Traditional treatment
- Where
- Egypt
- Volunteers
- 93 people
- Sponsor
- Cairo University
Stage III (IIIB or IIIC) Colon Cancer
A Study Evaluating Regorafenib Following Completion of Standard Chemotherapy for Patients With Colon Cancer
This study is a randomized, double-blind, post-chemotherapy, adjuvant phase III clinical trial. The primary aim of this study is to determine the value of regorafenib in improving disease-free survival (DFS).
- Trial name
- ARGO (NCT02664077)
- Testing
- Regorafenib
- Where
- 51 sites in United States
- Volunteers
- 34 people
- Sponsor
- NSABP Foundation Inc