Clinical trials: Environmental Enteric Dysfunction
Environmental Enteric Dysfunction
Lactoferrin and Lysozyme Supplementation for Environmental Enteric Dysfunction
Randomized, double-blind, placebo controlled trial of daily lactoferrin and lysozyme supplementation in improving environmental enteric dysfunction in Malawian children
- Trial name
- NCT02925026
- Testing
- Lactoferrin, Lysozyme
- Where
- Malawi
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Environmental Enteric Dysfunction
Capsule Endomicroscopy for Visualization of the Small Intestine in EED Population in Pakistan
This pilot study will test the feasibility and tolerability of the tethered OCT capsule and Trans Nasal Endomicroscopy probe and accessory devices for imaging the small intestine in subjects with EED and a matched non-EED cohort.
- Trial name
- NCT04275167
- Testing
- Tethered Capsule Endomicroscope/Trans Nasal Endomicroscope
- Where
- Pakistan
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Environmental Enteric Dysfunction, Zinc Deficiency
Effects of EED on Zn Absorption and Retention in Children From a Standard Dose
The overall objective is to determine the impact of EED on zinc absorption and homeostasis, and its impact on the absorptive capacity of vitamin A absorption of young children (18-24 months of age) in an austere setting with high…
- Conditions
- Environmental Enteric Dysfunction, Zinc Deficiency, Vitamin A Deficiency
- Trial name
- ZEED1 (NCT02760095)
- Testing
- 3 mg zinc sulfate supplement, 0.5 mg of 13C10-retinyl-acetate
- Where
- 2 sites in United States, Bangladesh
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Environmental Enteric Dysfunction (EED), Malnutrition
The Maternal EED Study
Undernutrition among women of reproductive age is more common in South Asia than in any other region. In South Asia, the prevalence of maternal undernutrition varies between 10 and 40%.
- Conditions
- Environmental Enteric Dysfunction (EED), Malnutrition, Women of Reproductive Age, Gut Microbiota
- Trial name
- NCT05862363
- Testing
- Microbiota-directed balanced energy protein (MD-BEP), Ready-to-use supplementary food-balanced energy protein (RUSF-BEP), Esophagogastroduodenoscopy (EGD)
- Where
- Bangladesh
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Birth Weight, Pregnancy Preterm
Maternal EED and Aflatoxin Birth Outcomes Study Uganda
This prospective cohort study focuses on the relationship between maternal environmental enteric dysfunction (EED) and maternal aflatoxin B1 exposure and birth outcomes, particularly infant anthropometry and gestational age, in…
- Conditions
- Birth Weight, Pregnancy Preterm, Aflatoxins Toxicity, Inflammatory Response
- Trial name
- NCT03429257
- Testing
- Exposures of interest: Maternal EED and Aflatoxin Exposure
- Where
- Uganda
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Tufts University
Enteropathy
The Impact of Legumes vs Corn-soy Flour on Environmental Enteric Dysfunction in Rural Malawian Children 6-11 Months
To determine if 6 months of legume-based complementary foods is effective in reducing or reversing EED and linear growth faltering in a cohort of Malawian children, aged 6-11 months to see if these improvements are correlated…
- Trial name
- NCT02472262
- Testing
- Cow pea complementary food, Corn soy flour, Common bean
- Where
- Malawi
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Environmental Enteric Dysfunction
PTM202 for the Treatment of Environmental Enteric Dysfunction (EED)
The purpose of this study is to assess the effectiveness of PTM202 in treating environmental enteric dysfunction.
- Trial name
- NCT03263871
- Testing
- PTM202, micro-nutrient sprinkles
- Where
- Bangladesh
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Amino Acid, Stunting, Environmental Enteric Dysfunction
The Efficacy of Amino Acid Supplementation in Treating Environmental Enteric Dysfunction Among Children At Risk of Malnutrition
A randomised controlled open label clinical trial to determine whether addition of indispensable amino acids (IAA) to standard complementary food will reduce occurrence of Environmental Enteric Dysfunction (EED) compared with…
- Trial name
- NCT06617130
- Testing
- Corn soy bean blended flour porridge plus indispensable amino acid
- Where
- Malawi
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Kamuzu University of Health Sciences
Malnutrition Pregnancy, Malnutrition in Children
Early Life Malnutrition, Environmental Enteric Dysfunction and Microbiome Trajectories
Malnutrition in women of reproductive age remains a public health concern in Sub-Saharan Africa (SSA). Malnutrition during pregnancy affects foetal growth with a tendency of the exposed infants to also develop it.
- Conditions
- Malnutrition Pregnancy, Malnutrition in Children, Malnutrition (Calorie), Environmental Enteric Dysfunction
- Trial name
- UZBCS-2 (NCT07195006)
- Testing
- Malnutrition in pregnancy as exposure, Poor WASH living conditions as exposure
- Where
- Zimbabwe
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Environmental Enteric Dysfunction, Zinc Deficiency
Effects of EED on Zn Absorption and Retention in Children From a MNP
The overall objective is to determine the impact of EED on total daily zinc absorption of young Bangladeshi children (18-24 months of age) in an austere setting with high rates of diarrhea, stunting, and micro-nutrient…
- Trial name
- ZEED2 (NCT02758444)
- Testing
- Micronutrient Powder (MNP) + 15 mg Zn, MNP + 10 mg Zn, MNP + 5 mg Zn
- Where
- 2 sites in United States, Bangladesh
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Environmental Enteropathy
The Impact of Legumes vs Corn-soy Flour on Environmental Enteric Dysfunction in Rural Malawian Children 1-3 Year Olds
To determine if 12 months of legume-based complementary foods is effective in reducing or reversing EED and linear growth faltering in a cohort of Malawian children, aged 12-35 months to see if these improvements are correlated…
- Trial name
- NCT02472301
- Testing
- cowpeas complementary food, corn-soy flour, common bean complementary food
- Where
- Malawi
- Volunteers
- 337 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Environmental Enteric Dysfunction
Acceptability and Efficacy of Enterade (VS001) in Children at Risk for Environmental Enteric Dysfunction in Bangladesh
This is a pilot study to assess the feasibility and acceptability of a trial of Enterade (VS001) to treat environmental enteric dysfunction in children from a low-income setting. Preliminary data on efficacy will also be obtained.
- Trial name
- NCT05291559
- Testing
- Enterade
- Where
- Bangladesh
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Urinary Tract Infections, Malnutrition
Effect of Hygiene and Menstrual Hygiene Interventions on Learning and Psychosocial Wellbeing in Madagascar
A previous study in schools in rural Madagascar found that a bundle of hygiene-focused interventions substantially improved girls' learning outcomes.
- Conditions
- Urinary Tract Infections, Malnutrition, Inflammation, Stress
- Trial name
- KILONGA2 (NCT07702916)
- Testing
- Peer leadership/sensitization + sanitary pads, School infrastructure
- Where
- Madagascar
- Volunteers
- 3,080 people, healthy volunteers welcome
- Sponsor
- University of California Santa Cruz
Environmental Enteric Dysfunction
OCT Guided Trans Nasal Imaging of the Small Intestine in Adults
The investigators are seeking healthy adult participants 18-60 years and healthy pregnant women in their 2nd trimester of pregnancy for a research study to assess a new imaging device.
- Trial name
- NCT04984447
- Testing
- TNIB Catheter
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Stunting, Environmental Enteric Dysfunction
Safety, Acceptability, and Feasibility of Enterade®
This is a randomized, double-blinded, placebo-controlled pilot study to determine the safety, acceptability, and feasible pediatric dosage/tolerability of enterade® solution, an amino acid-based oral rehydration solution…
- Trial name
- SAFE (NCT03782272)
- Testing
- Enterade
- Where
- Kenya
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- PATH
Stunting, Environmental Enteric Dysfunction
The Effect of Bovine Colostrum/ Egg Supplementation in Young Malawian Children
The trial will consist of adding either a supplement of 4.3g egg powder + 5.7g bovine colostrum or a control flour along with a multiple micronutrient powder to the diets of healthy Malawian children 9 months of age.
- Trial name
- NCT03801317
- Testing
- BC/ egg, Control, multiple micronutrient
- Where
- Malawi
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Rotavirus Infections, Environmental Enteric Dysfunction
SaniVac Trial - Sanitation and Oral Rotavirus Vaccine Performance
This is a controlled cohort study to assess the effect of improved sanitation on oral rotavirus vaccine performance in low-income urban neighbourhoods of Maputo, Mozambique.
- Conditions
- Rotavirus Infections, Environmental Enteric Dysfunction, Enteric Infections
- Trial name
- NCT03313128
- Testing
- Sanitation
- Where
- Mozambique
- Volunteers
- 261 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine