Clinical trials: Eosinophilia
Eosinophilic Esophagitis, Sensory Disorder
Sensory Processing Issues in Eosinophilic Esophagitis
Feeding dysfunction and/or dysphagia are the main symptoms of eosinophilic esophagitis (EoE). Also, these symptoms may be a part of sensory processing disorders.
- Trial name
- NCT06187753
- Testing
- Sensory Profile
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gazi University
Eosinophilic Esophagitis (EoE)
Surface EMG Testing on Swallowing in EoE Patients
Evaluating swallowing food with surface electromyography (EMG) machine in patients with Eosinophilic Esophagitis
- Trial name
- sEMG (NCT07156357)
- Testing
- Surface Electromyography, Fiberoptic Endoscopic Evaluation of Swallowing
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Asthma; Eosinophilic
Patients With Severe Eosinophilic Asthma Treated With Benralizumab
Retrospective, multicenter, routine clinical practice study with consecutive inclusion of adult patients with severe eosinophilic asthma receiving benralizumab treatment.
- Trial name
- Asthma (NCT05078281)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Eosinophilic Esophagitis
Proof of Concept Study of OC000459 in Eosinophilic Esophagitis
This will be a randomised, double blind, placebo controlled, parallel group evaluation of the effect of OC000459 given orally for eight weeks on active eosinophilic esophagitis.
- Trial name
- NCT01056783
- Testing
- OC000459
- Where
- Switzerland
- Volunteers
- 26 people
- Sponsor
- Oxagen Ltd
Allergic Bronchopulmonary Aspergillosis, ABPA
Real-World Effectiveness of Depemokimab in Allergic Bronchopulmonary Aspergillosis With Severe Eosinophilic Asthma
An open-label study will evaluate effects of Depemokimab in the treatment of severe eosinophilic asthma in patients with allergic bronchopulmonary aspergillosis
- Conditions
- Allergic Bronchopulmonary Aspergillosis, ABPA, Severe Eosinophilic Asthma
- Trial name
- NCT07828327
- Testing
- Depemokimab
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Qianfoshan Hospital
Eosinophilic Esophagitis
A Prospective Study of the Four Food Elimination Diet for Treatment of Eosinophilic Esophagitis
This study is to observe the efficacy of the four food elimination diet.
- Trial name
- NCT05176262
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Severe Eosinophilic Asthma
A Real World Study to Capture Clinical and Patient Centered Outcomes in Adults With Severe Eosinophilic Asthma Treated With Benralizumab.
Severe eosinophilic asthma (SEA) is associated with poor disease control and compromised health-related quality of life (HRQoL), leading to a substantial psychosocial and economic disease burden.
- Trial name
- EMPOWAIR (NCT05440656)
- Testing
- Cohort
- Where
- 13 sites in Greece
- Volunteers
- 152 people
- Sponsor
- AstraZeneca
Eosinophilic Esophagitis
Changes in Esophageal Distensibility With Proton Pump Inhibitors in Patients With Esophageal Eosinophilia: A Pilot Study
This pilot study will explore whether treatment of eosinophilic inflammation in the esophagus is associated with an improved distensibility of the esophagus.
- Trial name
- EOE (NCT03312686)
- Testing
- endoflip
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Indiana University
Eosinophilic Asthma
A Study of KT-621 Administered Orally to Adult Participants With Moderate to Severe Eosinophilic Asthma
This Phase 2b study is designed to evaluate the safety and efficacy of KT-621 in participants with uncontrolled moderate to severe eosinophilic asthma.
- Trial name
- BREADTH (NCT07323654)
- Testing
- KT-621
- Where
- 81 sites in United States, Argentina and 11 more
- Volunteers
- 264 people
- Sponsor
- Kymera Therapeutics, Inc.
Epithelioid Hemangioma of Bone, Epithelioid Hemangioma
Epithelioid Hemangioma of Bone And Soft Tissue
The controversy surrounding epithelioid hemangioma diagnosis stems from its somewhat aggressive clinical characteristics, including multifocal presentation and occasional lymph node involvement.
- Trial name
- EE-META (NCT03169595)
- Testing
- Surgery
- Volunteers
- 70 people
- Sponsor
- Istituto Ortopedico Rizzoli
Allergy, Asthma
Evaluation and Long-Term Follow-Up of Patients With Allergic and Inflammatory Disorders
This study will evaluate and follow patients with various allergic, hypersensitivity and inflammatory disorders. The protocol is not designed to test new treatments; patients will be managed with standard of care therapies.
- Conditions
- Allergy, Asthma, Allergic Rhinitis, Mastocytosis
- Trial name
- NCT00557895
- Where
- United States
- Volunteers
- 288 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Asthma; Eosinophilic
Efficacy and Safety of CHF 6532 in Patients With Uncontrolled Severe Eosinophilic Asthma
The purpose of this phase III Study is to demonstrate the efficacy of at least one dose of CHF 6532 on moderate and severe asthma exacerbations rate compared to placebo.
- Trial name
- PERSEA (NCT04049175)
- Testing
- Treatment A, Treatment B, Treatment C
- Where
- Bulgaria
- Volunteers
- 810 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Severe Eosinophilic Asthma, Nasal Polyps
RANS. Study in Patients With Severe Eosinophilic Asthma and Nasal Polyps.
The purpose of this observational study is to describe the population of patients with SEA + NP who have been prescribed FASENRA and assess available clinical outcomes for both NP and asthma.
- Trial name
- RANS (NCT05180357)
- Testing
- FASENRA(benralizumab)
- Where
- 45 sites in United States, France and 4 more
- Volunteers
- 273 people
- Sponsor
- AstraZeneca
Asthma; Eosinophilic, Severe Asthma
Efficacy of Mepolizumab in Severe Asthmatics on a Long Term (MESILICO)
Interleukin (IL)-5 is the main cytokine responsible for the activation of eosinophils, hence therapeutic strategies have been investigated and developed for clinical use.
- Conditions
- Asthma; Eosinophilic, Severe Asthma, Late-Onset Asthma
- Trial name
- MESILICO (NCT04612556)
- Testing
- Mepolizumab 100 MG [Nucala]
- Where
- Greece
- Volunteers
- 45 people
- Sponsor
- Aristotle University Of Thessaloniki
Eosinophilic Esophagitis
Use of Topical Budesonide in the Treatment of Eosinophilic Esophagitis
This study is designed to evaluate whether or not oral viscous budesonide is effective in treating children with Eosinophilic Esophagitis.
- Trial name
- NCT00638456
- Testing
- Budesonide plus Prevacid
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Ranjan Dohil
Severe Eosinophilic Asthma, Psychological Distress
Severe Asthma, MepolizumaB and Affect: SAMBA Study
This is a real-life pragmatic non-randomised study to explore the impact of mepolizumab on the emotional and affective outcomes of patients with severe eosinophilic asthma and their partners.
- Conditions
- Severe Eosinophilic Asthma, Psychological Distress, Anxiety, Depression
- Trial name
- SAMBA (NCT04680611)
- Testing
- no study intervention. Patients receive standard clinical care
- Where
- 6 sites in United Kingdom
- Volunteers
- 120 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Eosinophilic Asthma, Asthma; Eosinophilic
A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Severe Eosinophilic Asthma.
This study will assess the efficacy and safety of dexpramipexole as an adjunctive oral therapy in participants with inadequately controlled asthma with an eosinophilic phenotype and a history of asthma exacerbations.
- Conditions
- Eosinophilic Asthma, Asthma; Eosinophilic, Asthma
- Trial name
- EXHALE-2 (NCT05763121)
- Testing
- Dexpramipexole Dihydrochloride
- Where
- 401 sites in United States, Argentina and 18 more
- Volunteers
- 1,061 people
- Sponsor
- Areteia Therapeutics
Eosinophilic Esophagitis
Efficacy and Safety APT-1011 in Adolescent Subjects With Eosinophilic Esophagitis (EoE) - A Sub-Study of the FLUTE-2 Trial
This is a randomized, double-blind, placebo-controlled study of APT-1011, followed by an open-label extension (OLE) in adolescents (≥12 to <18 years) with EoE.
- Trial name
- FLUTEEN (NCT05083312)
- Testing
- APT-1011
- Where
- 3 sites in United States, Australia
- Volunteers
- 6 people
- Sponsor
- Ellodi Pharmaceuticals, LP
Eosinophilic Esophagitis (EoE)
Study to Investigate the Efficacy and Safety of Dupilumab in Pediatric Patients With Active Eosinophilic Esophagitis (EoE)
The Primary objective is to demonstrate the efficacy of dupilumab treatment compared with placebo in pediatric patients with active eosinophilic esophagitis (EoE) based on histologic improvement meeting validated histologic…
- Trial name
- EoE KIDS (NCT04394351)
- Testing
- Dupilumab
- Where
- 27 sites in United States, Canada
- Volunteers
- 102 people
- Sponsor
- Regeneron Pharmaceuticals
Eosinophilic Esophagitis
CEGIR 7807: Validation of Online Cohort of EGID Patients Enrolled in RDCRN CEGIR Contact Registry
The purpose of this study is to validate the online cohort of EGID patients enrolled in the RDCRN CEGIR CR. In order to achieve this objective, the investigators will determine the agreement between self-reported EGID information…
- Trial name
- NCT03382678
- Where
- 2 sites in United States
- Volunteers
- 187 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati