Clinical trials: Eosinophilic Esophagitis (EoE), open to volunteers
Eosinophilic Esophagitis
Pediatric Eosinophilic Esophagitis (pedEoE): Effect of Allergen Heat Denaturation on EoE Remission: a Pilot Trial
The objective of the study is to study whether the introduction of heated food products (more specifically heated hen's egg and/or cow's milk) in children with EoE would be possible without re-occurrence of the eosinophilic…
- Trial name
- NCT06381219
- Testing
- Implementation of cow's milk in decreasingly heated forms, Implementation of hen's egg in decreasingly heated forms
- Where
- Belgium
- Volunteers
- 36 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Eosinophilic Esophagitis (EoE)
Effect of Dupilumab on the Muscle Function of the Esophagus (food Pipe) in Participants with Eosinophilic Esophagitis (EoE)
The goal of this study is to research Dupilumab, an FDA approved medication in treating patients diagnosed with Eosinophilic esophagitis (EoE). The drug works by controlling allergic inflammation of the esophagus.
- Trial name
- NCT06665971
- Testing
- Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT]
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Eosinophilic Esophagitis (EoE)
Trial of Partial Enteral Nutrition With Dairy Free Diet in Eosinophilic Esophagitis
This study aims to introduce a new dietary therapy for Eosinophilic Esophagitis (EoE) patients by using partial enteral nutrition (PEN) to enhance remission rates and explore how this approach affects immune function, gut…
- Trial name
- NCT07234825
- Testing
- Partial enteral nutrition (PEN) with dairy elimination, Dairy elimination alone
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Kate Farms Inc
Eosinophilic Esophagitis (EoE), Dysphagia, Esophageal
The DiNAM-EoE-C Study: Esophageal Distensibility and Novel Assessment of Motility in Eosinophilic Esophagitis
Eosinophilic esophagitis is a chronic immune-mediated disease that may progress to fibrostenotic remodeling, leading to symptoms such as dysphagia, chest pain, and food impaction.
- Trial name
- DiNAM-EoE-C (NCT07708467)
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Eosinophilic Gastrointestinal Disorders (EGID)
Elimination Diet Strategies and Histologic Remission in Children With Eosinophilic Gastrointestinal Disorders
This prospective observational cohort study aims to evaluate clinical and histologic outcomes of elimination diets in children aged 2-17 years with eosinophilic gastrointestinal disorders (EGIDs).
- Trial name
- NCT07779772
- Testing
- Elimination Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Cukurova University
Eosinophilic Esophagitis
Eosinophilic Esophagitis: Towards Improved Management
The current project aims to improve the care for children and adolescents with eosinophilic esophagitis in a collaborative effort involving pediatric units at Oslo Unversity Hospital and Helse Bergen, Norway.
- Trial name
- EoStim (NCT06991881)
- Testing
- Biobank sampling for new biomarkers
- Where
- 2 sites in Norway
- Volunteers
- 80 people
- Sponsor
- Oslo University Hospital
Eosinophilic Gastrointestinal Disorders (EGIDs)
Dupilumab Therapy for EGIDs
This is a single-center observational study to investigate the efficacy and tolerability of dupilumab in children with refractory eosinophilic gastrointestinal disorders.
- Trial name
- NCT07257835
- Testing
- Dupilumab - Standard Dose, subcutaneous injection
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Children's Hospital of Fudan University
Eosinophilic Esophagitis
Zemaira Eosinophilic Esophagitis Pilot Study
This is a prospective, open-label drug study that will examine the effects of Zemaira (alpha-1 trypsin inhibitor) in patients with Eosinophilic Esophagitis.
- Trial name
- ZEEPS (NCT05485155)
- Testing
- Alpha-proteinase inhibitor
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Eosinophilic Esophagitis (EoE)
Tolerability of Baked Dairy Protein in Eosinophilic Esophagitis Patients With Cow Milk Protein Trigger
Eosinophilic esophagitis (EoE) is a chronic immune mediated disease characterized by eosinophilic infiltration in esophageal epithelium and resulting in esophageal dysfunction.
- Trial name
- NCT06756581
- Testing
- baked milk product diet
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Shaare Zedek Medical Center
Eosinophilic Esophagitis (EoE)
Trans-Cervical and Trans-abdominal Ultrasound for Monitoring Esophageal Thickness in Eosinophilic Esophagitis
Eosinophilic Esophagitis (EoE) is a chronic inflammatory disease characterized by eosinophilic infiltration of the esophageal mucosa, leading to symptoms of dysphagia and food impaction.
- Trial name
- NCT07057986
- Testing
- Trans cervical or abdominal ultrasound
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Eosinophilic Esophagitis, Eosinophilic Gastroenteritis
Eosinophilic Gastrointestinal Disorders Registry
The purpose of this study is to learn more about Eosinophilic Gastrointestinal Disorders (EGIDs). With this registry we hope to find out more about the symptoms that patients have during their treatment, the quality of life they…
- Conditions
- Eosinophilic Esophagitis, Eosinophilic Gastroenteritis, Eosinophilic Colitis, Eosinophilic Gastrointestinal Disease
- Trial name
- NCT05199532
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Eosinophilic Gastritis, Gastroparesis
Study of Gastric Motility in Eosinophilic Gastritis
Purpose: The study is a cross-sectional observational study designed to determine if eosinophilic gastritis (EG) results in gastric motility impairment.
- Conditions
- Eosinophilic Gastritis, Gastroparesis, Gastric Motility Disorder
- Trial name
- OAT-FEED (NCT05229432)
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Eosinophilic Esophagitis
Prospective Registry of EoSinophilic esOphagitis
This is a prospective registry of all the Eosinophilic Esophagitis (EoE) patients referred to the third level referral centre of San Raffaele Scientific Institute
- Trial name
- PRESO (NCT06443346)
- Testing
- Eosinophilic Esophagitis
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- IRCCS San Raffaele
Eosinophilic Esophagitis
A Trial to Evaluate EP-104GI in Adults With Eosinophilic Esophagitis (EoE).
A Phase 1b/2 study to explore the safety, efficacy and pharmacokinetics of EP-104GI in adults with eosinophilic esophagitis (EoE).
- Trial name
- RESOLVE (NCT05608681)
- Testing
- EP-104GI, Matching vehicle control
- Where
- 23 sites in Australia, Canada and 4 more
- Volunteers
- 117 people
- Sponsor
- Eupraxia Pharmaceuticals Inc.
Eosinophilic Esophagitis
Characteristics and Inflammatory Markers in Children With Eosinophilic Esophagitis (EoE)
Single center observational and specimen banking study for children with eosinophilic esophagitis EoE to gauge natural history and inflammatory markers
- Trial name
- EoE (NCT03980886)
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- University of California, San Diego
Eosinophilic Esophagitis (EoE)
Natural History of Eosinophilic Esophagitis in Adult and Pediatric Population
Eosinophilic esophagitis (EoE) is a Th2-mediated disease induced by ingestion of ambiental and alimentary allergens. Incidence of EoE is increasing in recent years. Young male subjects are more often affected by EoE.
- Trial name
- NCT07614633
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Eosinophilic Esophagitis
Tolerability of Goat Milk Protein in Eosinophilic Esophagitis Patients With Cow Milk Protein Trigger
Eosinophilic esophagitis (EoE) is a chronic immune mediated disease characterized by eosinophilic infiltration in esophageal epithelium and resulting in esophageal dysfunction.
- Trial name
- NCT05180578
- Testing
- Goat milk diet
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Shaare Zedek Medical Center
Eosinophilic Esophagitis
Dupilumab Versus Topical Corticosteroid Effectiveness - Comparison in the Treatment of Stenotic EoE
The goal of this clinical trial is to [primary purpose: e.g., learn if intervention or health behavior can treat, prevent, diagnose etc.] in [describe participant population/primary condition; could include any of the following…
- Trial name
- DeTECTS (NCT06705387)
- Testing
- Dupilumab, Fluticasone
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Colorado, Denver
Dysphagia, Esophageal Stricture
Impact of Body Positioning on EndoFLIP Measurements: A Comparative Study of Supine and Left Lateral Decubitus Positions
This is a prospective, single-center, crossover study comparing EndoFLIP measurements obtained in two patient positions, supine and left lateral decubitus, in pediatric and young adult patients.
- Conditions
- Dysphagia, Esophageal Stricture, Epidermolysis Bullosa (EB), Achalasia
- Trial name
- NCT07780981
- Testing
- EndoFlip
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Johns Hopkins University
Eosinophilic Esophagitis
Changes in Esophageal Distensibility With Proton Pump Inhibitors in Patients With Esophageal Eosinophilia: A Pilot Study
This pilot study will explore whether treatment of eosinophilic inflammation in the esophagus is associated with an improved distensibility of the esophagus.
- Trial name
- EOE (NCT03312686)
- Testing
- endoflip
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Indiana University