Clinical trials: Epicardial Adipose Tissue
Atrial Fibrillation
Contribution of Computed Tomography and Cardiac-MRI in Atrial Fibrillation Ablation
Atrial fibrillation ablation (AF) is a standard interventional treatment for patients with symptomatic AF refractory to medical treatment.
- Trial name
- CTStrain-AF (NCT04281329)
- Testing
- Magnetic resonance imaging
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Artery Disease
Epicardial Fat in Coronary Artery Disease
We hypothesize that human epicardial fat plays a thermogenic role to the myocardium. We hypothesize that epicardial fat may express genes of brown fat and thyroid function that are down-regulated by the presence of coronary…
- Trial name
- NCT03693261
- Testing
- Coronary artery bypass grafting (CABG), Valve replacement
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Miami
Epicardial Fat
Semaglutide vs Dulaglutide on Epicardial Adipose Tissue
Epicardial Fat (EAT), the visceral fat depot of the heart, is a modifiable cardio-metabolic risk factor and therapeutic target. EAT expresses GLP-1 receptors (GLP-1R).
- Trial name
- NCT04200625
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Miami
Post-Operative Atrial Fibrillation
Botulinum Toxin Type A (AGN-151607) for the Prevention of Post-operative Atrial Fibrillation in Adult Participants Undergoing Open-chest Cardiac Surgery (NOVA)
This was a multi-center, randomized, double-blind, placebo-controlled, parallel group, dose-ranging study to evaluate the efficacy and safety of botulinum toxin type A (AGN-151607) injections into the epicardial fat pads, foci of…
- Trial name
- NCT03779841
- Testing
- AGN-151607
- Where
- 32 sites in United States, Austria and 7 more
- Volunteers
- 323 people
- Sponsor
- AbbVie
Atrial Fibrillation (AF), Obesity (Disorder)
Improving Outcomes After AF Ablation in Obese Patients
Improving Outcomes After AF Ablation in Obese Patients
- Trial name
- OBESE-AF (NCT07618741)
- Testing
- Cardiac Rehabilitation and Lifestyle Modification, Usual Care
- Where
- Taiwan
- Volunteers
- 520 people
- Sponsor
- National Taiwan University Hospital
Type 2 Diabetes
Dapagliflozin Effects on Epicardial Fat
The purpose of this research study is to learn about the effect of Dapagliflozin (Farxiga) on the fat of the heart.
- Trial name
- NCT02235298
- Testing
- Dapagliflozin, Metformin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Miami
Subclinical Atherosclerosis
Adipose Visceral and Epicardial Risk Evaluation
The goal of this procedure-based interventional study without drugs or devices is to investigate the molecular mechanisms underlying metabolically unfavorable obesity and related clinical phenotypes, in order to identify…
- Trial name
- AVERE (NCT07504679)
- Testing
- Peripheral blood sampling
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ankylosing Spondylitis
Epicardial Adipose Tissue Thickness and the Related Factors in Patients With Ankylosing Spondylitis
The aim of this study was to assess the EATT and the related factors in patients with AS and to compare the results with that of the healthy controls'
- Trial name
- NCT06094686
- Testing
- epicardial adipose tissue thickness
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Monoclonal Gammopathies, Overweight
Antigen-Lipid-Driven Monoclonal Gammopathies Targeting Epicardial Fat
The purpose of this research study is to learn about the effect of Liraglutide (Victoza) on the fat of the heart and some fat cells in blood.
- Conditions
- Monoclonal Gammopathies, Overweight, Obesity
- Trial name
- NCT02920190
- Testing
- Liraglutide
- Sponsor
- University of Miami
Heart Failure Preserved Ejection Fraction, Epicardial Adipose Tissue
Epicardial Adipose Tissue Composition and Heart Failure With Preserved Ejection Fraction
This study seeks to develop improved cardiac MRI (CMR) methods to quantify epicardial adipose tissue (EAT) composition and to demonstrate the advantages of EAT composition imaging (a) in advancing the understanding of the…
- Trial name
- NCT07178145
- Testing
- GLP-1RA
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- University of Virginia
Dyslipidemia
Assessment of Epicardial Fat Thickness in Children With Familial Dyslipidemia
Aim of the study: 1- Detect common types of familial dyslipidemia. 2- Significance and relationship between Epicardial fat thickness and familial dyslipidemia.
- Trial name
- NCT06101771
- Testing
- echoCARDIOGRAPHY
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Assiut University
Coronary Artery Disease, Coronary Arteriosclerosis
Influence of EPICardial Adipose Tissue in HEART Diseases: EPICHEART Study
This translational study was designed to explore the association of the quantity and quality of epicardial adipose tissue (EAT) with coronary artery disease (CAD), left atrial remodeling and postoperative atrial fibrillation in a…
- Conditions
- Coronary Artery Disease, Coronary Arteriosclerosis, Atrial Fibrillation, Left Atrial Abnormality
- Trial name
- EPICHEART (NCT03280433)
- Testing
- Aortic valve replacement
- Where
- 2 sites in Portugal
- Volunteers
- 500 people
- Sponsor
- Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.
Coronary Artery Disease, Class I Obesity
EFFECT OF PYRAMIDAL TRAINING ON EPICARDIAL FAT FOR CORONARY ARTERY DISEASE PREVENTION
To show the effect of pyramidal training for coronary artery disease prevention on: -Epicardial fat, BMI, Waist circumference (WC), Lipid profile, Quality of life and Mediterranean Diet Adherence.
- Trial name
- NCT06799104
- Testing
- Pyramidal training, Mediterranean diet
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Obesity, Pre Diabetes
Healthsnap on Epicardial Adipose Tissue Study
The purpose of this research study is to learn about the effectiveness of HealthSnap assessment, to reduce epicardial fat thickness.
- Trial name
- HEATS (NCT03683888)
- Testing
- HealthSnap, dietary counseling
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Miami
Atrial Fibrillation
Role of Exosomes Derived From Epicardial Fat in Atrial Fibrillation
Exosome plays an important role in the pathophysiology of the cardiovascular system. Since the field of cardiovascular exosome is still in its infancy, there are no available data regarding to its role in cardiac arrhythmias.
- Trial name
- NCT03478410
- Testing
- Epicardial fat biopsy
- Where
- Israel
- Volunteers
- 35 people
- Sponsor
- Sheba Medical Center
Diabete Type 2, Unstable Angina
Dapagliflozin Effects on Coronary Calcium and Epicardial Fat Assessed by Cardiotomography
Calcification of the coronary arteries is a direct sign of atherosclerotic disease of the coronary arteries and has been shown to be a strong predictor of the risk of cardiovascular diseases, including myocardial infarction…
- Conditions
- Diabete Type 2, Unstable Angina, Myocardial Infarction, Diabetes Mellitus, Type 2
- Trial name
- NCT05998525
- Testing
- Dapagliflozin 10Mg Tab
- Where
- Mexico
- Volunteers
- 54 people
- Sponsor
- Hilda Elizabeth Macías Cervantes
Atrial Fibrillation
Botulinum Toxin Injection Into Epicardial Fat Pads to Prevent Atrial Fibrillation in Patients Undergoing Cardiac Surgery
The aim of this prospective randomized double-blind study was to compare the efficacy of botulinum toxin injection in epicardial fat pads for preventing recurrences (in early postoperative period) of atrial tachyarrhythmia in…
- Trial name
- NCT02617069
- Testing
- botulinum toxin injection, 0.9% normal saline injection, Implantable loop recorder
- Where
- Russia
- Volunteers
- 170 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Psoriatic Arthritis, Osteoarthitis
CARTIZ Registry: Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts - A Four-Institute Mexican Observational Registry
CARTIZ is a prospective observational clinical registry of adults in Mexico receiving tirzepatide (a dual GLP-1/GIP receptor agonist) under an independent clinical indication - typically type 2 diabetes, insulin resistance…
- Conditions
- Psoriatic Arthritis, Osteoarthitis, Knee, Diabetes (DM)
- Trial name
- CARTIZ (NCT07567378)
- Testing
- Tirzepatide
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- JULIO GRANADOS MONTIEL
Type 2 Diabetes, Overweight
Effect of Liraglutide on Epicardial Fat in Subjects With Type 2 Diabetes
The purpose of this research study is to learn about the effect of Liraglutide, (Victoza®), on the fat surrounding the heart.Excessive amount of the fat around the heart is common in people with type 2 diabetes and can be…
- Conditions
- Type 2 Diabetes, Overweight, Obesity
- Trial name
- NCT02014740
- Testing
- Liraglutide, Metformin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Miami
Epicardial Fat Tissue
Epicardial Fat Tissue and Severity of Coronary Artery Disease in Diabetic vs Non Diabetic Patients
correlation between EFT volume measured by Cardiac MRI and the angiographic severity of coronary artery disease (Syntax Score) in diabetic vs non diabetic CAD population and detect if there is a cut off value for each group that…
- Trial name
- NCT04111198
- Testing
- Cardiac MRI
- Volunteers
- 80 people
- Sponsor
- Bakeer Mohamed Bakeer