Clinical trials: Epicardial Fat
Coronary Artery Disease
Characterization of Epicardial and Pericardial Adipose Tissue in Coronary Artery Disease
Human epicardial fat is the true visceral fat depot of the heart, and its regional distribution and physiology is of growing scientific and clinical interest.
- Trial name
- NCT02965625
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Heart Failure, Heart Failure, Systolic
Predicting Heart Failure Outcomes With Biomarkers and Imaging
This study aims to develop a better model to predict one-year risk of death in patients with heart failure. We will test whether combining information from routine blood tests (like NT-proBNP) and heart scans (measuring features…
- Conditions
- Heart Failure, Heart Failure, Systolic, Heart Failure, Diastolic, Heart Failure With Reduced Ejection Fraction (HFrEF)
- Trial name
- BIOPHF (NCT07332520)
- Volunteers
- 4,000 people
- Sponsor
- Xinjiang Medical University
Metabolic Syndrome
Conjugated Linoleic Acid / Leucine Versus Metformin on Visceral Fat in Metabolic Syndrome
In Mexico, obesity is a major public health problem. In recent years he has presented a considerable increase in the population.
- Trial name
- NCT02629627
- Testing
- Conjugated linoleic acid/Leucine, Metformin
- Volunteers
- 104 people
- Sponsor
- Centro Universitario de Ciencias de la Salud, Mexico
Obesity and Type 2 Diabetes
Effects of Enavogliflozin on Coronary Microvascular and Cardiac Function in Obesity
The goal of this study is to analyze the effects of enavogliflozin on heart function and coronary microvascular function in obese patients compared to a placebo, and to evaluate the improvement in cardiopulmonary exercise…
- Trial name
- ENVY (NCT06782139)
- Testing
- Enavogliflozin
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Korea University Anam Hospital
Breast Cancer Female
Effects of Physical Exercise on Cardio-vascular Efficiency and Quality of Life in Breast Cancer Survivors
To examine the effects of different physical exercise protocols (aerobic training and resistance training) on cardio-vascular efficiency and quality of life in a population of breast cancer survivors (BCS), not treated with…
- Trial name
- NCT04337736
- Testing
- Physical exercise
- Volunteers
- 57 people
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
Coronary Artery Disease, Coronary Arteriosclerosis
Influence of EPICardial Adipose Tissue in HEART Diseases: EPICHEART Study
This translational study was designed to explore the association of the quantity and quality of epicardial adipose tissue (EAT) with coronary artery disease (CAD), left atrial remodeling and postoperative atrial fibrillation in a…
- Conditions
- Coronary Artery Disease, Coronary Arteriosclerosis, Atrial Fibrillation, Left Atrial Abnormality
- Trial name
- EPICHEART (NCT03280433)
- Testing
- Aortic valve replacement
- Where
- 2 sites in Portugal
- Volunteers
- 500 people
- Sponsor
- Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.
Atrial Fibrillation
Volumetric Quantification of Epicardial Fat Using Semiautomated High Resolution Atrial CT Segmentation in Patients With Atrial Fibrillation Receiving Catheter Ablation
The goal of this prospective observational study is to learn about the influence of epicardial fat on the success of catheter ablation in patients with atrial fibrillation.
- Trial name
- AFAT (NCT06559787)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Subclinical Atherosclerosis
Adipose Visceral and Epicardial Risk Evaluation
The goal of this procedure-based interventional study without drugs or devices is to investigate the molecular mechanisms underlying metabolically unfavorable obesity and related clinical phenotypes, in order to identify…
- Trial name
- AVERE (NCT07504679)
- Testing
- Peripheral blood sampling
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pulmonary Embolism, Lung Cancer
Predictive Value of Epicardial Adipose Tissue for Pulmonary Embolism and Death in Patients With Lung Cancer
The occurrence and progression of lung cancer is related to visceral adipose tissue (VAT). Epicardial adipose tissue (EAT) is a kind of VAT, producing a variety of inflammatory cytokines and adipokines, participating in the…
- Trial name
- NCT06017271
- Testing
- CTPA (computed tomography pulmonary angiography)
- Where
- China
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Atrial Fibrillation (AF)
Epicardial Adipose Tissue-Targeted DApagliflozin for Reducing Electrical Remodeling in Atrial Fibrillation
Persistent atrial fibrillation (PeAF) is associated with a high risk of recurrence following catheter ablation despite advances in ablation technology and strategies.
- Trial name
- EAT-DARE-AF (NCT07331727)
- Testing
- Dapagliflozin (10Mg Tab) along with standard medical therapy
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Shanghai Chest Hospital
Type2 Diabetes Mellitus
Relation of Epicardial Fat and Diabetic Nephropathy in Egyptian Patients
The heart and vessels are surrounded by layers of adipose tissue, which is a complex organ composed of adipocytes, stromal cells, macrophages, and a neuronal network, all nourished by a rich microcirculation.
- Trial name
- NCT03470415
- Volunteers
- 100 people
- Sponsor
- Assiut University
Heart Failure With Preserved Ejection Fraction
The Relationship Between Epicardial Fat Tissue and Cardiac Function in HFpEF Patients
Heart failure with preserved ejection fraction (HFpEF) refers to a group of symptoms and signs of heart failure, normal or near-normal left ventricular systolic function (EF>50%), and ventricular muscle diastolic dysfunction and…
- Trial name
- NCT05068934
- Where
- China
- Volunteers
- 1,083 people
- Sponsor
- Dongying Zhang
Acute Coronary Syndrome
Epicardial Adipose Tissue Thickness PredIcts Obstructive Coronary Artery Disease in Acute Coronary Syndrome Patients
Epicardial adipose tissue (EAT) is a visceral adipose tissue that surrounds the heart and the coronary arteries. It is metabolically active, secreting pro- and anti-inflammatory mediators and cytokines.
- Trial name
- EPIC-ACS (NCT03787797)
- Testing
- Echocardiography
- Where
- Germany
- Volunteers
- 657 people
- Sponsor
- University Hospital, Essen
Adiposity
Ectopic Adipose Tissue, Exercise Training and IL-6
Aim: Exercise training improves the risk of cardiometabolic diseases; yet the underlying mechanisms are unclear. Exercise induces release of IL-6 from skeletal muscle.
- Trial name
- NCT02901496
- Testing
- Endurance Exercise Training, Resistance Exercise Training, No Exercise
- Where
- Denmark
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Atrial Fibrillation
ALDOsterone for Prediction of Post-Operative Atrial Fibrillation
Post-operative atrial fibrillation (POAF) is a major and frequent complication occurring after cardiac surgery, contributing to prolonged intensive care and hospital stays and is associated with several cardiovascular…
- Trial name
- ALDO-POAF (NCT02814903)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Caen
Coronary Artery Disease
The Effect of SGLT-2 Inhibitors on Epicardial Adipose Tissue and Cardiac Function in T2DM Patients With CAD (EpiCAD)
Sodium-glucose contrasporter-2 (SGLT-2) inhibitors make up an antidiabetic medication that promotes glycosuria. They are known to have an indirect reduction in cardiovascular complications, based on a series of in-depth studies.
- Trial name
- EpiCAD (NCT06128096)
- Testing
- Sodium Glucose Co-transporter 2 (SGLT2) Inhibitor
- Where
- Malaysia
- Volunteers
- 360 people
- Sponsor
- Clinical Research Centre, Malaysia
Atherosclerosis, Non-alcoholic Fatty Liver Disease
Correlation Between NAFLD, Epicardial Adipose Tissue and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro-deoxyglucose (FDG)
Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular…
- Trial name
- NCT01958411
- Where
- South Korea
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Korea University
Type 2 Diabetes
Trancriptomics and Lipidomics of Epicardial Ectopic Fat
Cohort studies have shown that patients with obesity associated with metabolic abnormalities (metabolically unhealthy obesity) have an accumulation of ectopic fat deposits (EDF) linked to subcutaneous adipose tissue dysfunction.
- Trial name
- GENTLE (NCT06590415)
- Testing
- Subcutaneous adipose tissue biopsy, Blood sampling
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Metabolic Syndrome, Obesity
Epicardial Fat Thickness and Inflammation in People With Metabolic Syndrome and Obesity
Epicardial adipose tissue (EAT) is a type of visceral adipose tissue (VAT), functioning as a metabolically active endocrine organ and suggested to play an important role in the progression of metabolic syndrome (MetS).
- Conditions
- Metabolic Syndrome, Obesity, Inflammation
- Trial name
- NCT04437979
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Antalya Training and Research Hospital
Obesity
Bariatric Surgery and Epicardial Adipose Tissue: a MRI Study
The aim of this study is to measure the volume of the epicardial adispose tissue (EAT) and other morphological and functional cardiovascular parameters in subjects with severe obesity, using an open magnetic resonance unit…
- Trial name
- NCT03273621
- Testing
- Bariatic surgery
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- IRCCS Policlinico S. Donato