Clinical trials: Epidermis
Alcohol Abuse, Peripheral Neuropathy
Cutaneous Denervation in Alcoholic Neuropathy
Peripheral neuropathy is a frequent neurological complication of chronic alcoholism. Most studies evaluated large-fiber involvement by nerve conduction studies (NCS).
- Trial name
- NCT00190073
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Port-Wine Stain
Measurement Skin Temperature During Pulsed Laser Exposure
Lasers are the treatment modality of choice for Port Wine Stain birthmarks.The epidermis is not totally spared due to partial absorption of energy therein by melanin that presents an optical barrier through which the light must…
- Trial name
- NCT00540917
- Testing
- cooling spray during laser treatment
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Cutaneous Atrophy Due to Corticosteroids
Interest of Topical Spironolactone's Administration to Prevent Corticoid-induced Epidermal Atrophy
The purpose of this study is to determine whether spironolactone could significantly reduce cutaneous atrophy due to corticosteroids.
- Trial name
- SPIREPI (NCT01407471)
- Testing
- Clobetasol + Spironolactone
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
p53 Expression
To Evaluate and Compare p53 Epidermal Expression in Healthy Volunteers 3 Months After Treatment With a 2,940-nm Fractional Ablative Erbium Laser and Topical DNA Repair Enzymes
The p53 gene is located on the short arm of chromosome 17 and serves as a tumor suppressor gene. Alteration in p53 is an early event in skin cancer development.
- Trial name
- NCT04277949
- Testing
- Erbium:YAG, UV endonuclease from Micrococcus luteus
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Moy-Fincher-Chipps Facial Plastics and Dermatology
Recurrent Pregnancy Loss
SCUBE-1 and Carotid Intima Media Thickness in Recurrent Pregnancy Loss
Clinical research will be carried out on two groups of patients. It will be performed on people with recurrent pregnancy loss and without a history of pregnancy loss.
- Trial name
- NCT04397042
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Epidermal Thickening, Unspecified
Non-Ablative Fractional Resurfacing of Total Knee Replacement Scars
The condition to be studied is post-surgical scarring following primary total knee replacement, specifically whether fractional non-ablative laser therapy can be used to significantly decrease the morbidity of scarring.
- Trial name
- NCT02166138
- Testing
- Non-Abilative Laser treatment
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Charles Cornell, MD
Healthy
Intra-epidermal Stimulation (IES) of Small Nerve Fibers (A-delta Fibers)
The purpose of the study is to determine whether a particular type of nerve fibers, A-delta fibers, can be tested in an Electromyography (EMG) lab on a routine basis. Normal, healthy volunteers will be enrolled in this study.
- Trial name
- IES (NCT02312752)
- Testing
- Intra-epidermal stimulation electrode
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Minnesota
Breast Cancer
A Dose-Finding Study of Subcutaneous Herceptin (Trastuzumab) in Healthy Male Volunteers and Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Females
This two-part study is designed to select the subcutaneous (SC) dose of Herceptin that results in comparable exposure to intravenous (IV) Herceptin in healthy male participants and in HER2-positive female participants.
- Trial name
- NCT00800436
- Testing
- Herceptin
- Where
- 3 sites in Australia, New Zealand
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Normal Skin
TMFI Enhances Skin Surface and Epidermal PpIX Fluorescence
This study investigates a relatively new device TMFI and incubation of ALA in a cream-vehicle and a gel-vehicle.
- Trial name
- NCT04221126
- Testing
- TMFI, ALA cream, ALA gel
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Merete Haedersdal
Eczema
Omega-3 Monoglyceride Based Topic Products as Skin Prebiotics for Eczema
This exploratory study aims to verify the impact on the severity of eczema as well as the prebiotic potential of a daily application of Omega-3 serum and cream on a skin with eczema.
- Trial name
- NCT06155513
- Testing
- Omega-3 monoglyceride based topical Serum and cream of formulation A (light), Omega-3 monoglyceride based topical Serum and cream of formulation B (rich)
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- SCF Pharma
Epidermis, Ultraviolet Exposure
A Clinical Study to Evaluate the Efficacy and SPF of Two Test Materials According to an Adaptation of the Guidelines of the FDA Sunscreen Drug Products for Over-the-Counter Human Use
Approximately 70 subjects (35 subjects per light and dark group) will be enrolled in this clinical study (to complete with a minimum of 10 subjects per skin type (I-VI) to assess the effects of known UV Radiation dosage on light…
- Trial name
- NCT07789639
- Testing
- Hybrid sunscreen, Chemical sunscreen, No sunscreen
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Good Molecules, LLC
Healthy Skin
Effect of a Basic Skin Care Product on the Structural Strength of the Skin
The main aim of this study is to investigate in a suction blister model, whether the use of a basic skin care formulation increases the mechanical integrity/adhesion of the dermo-epidermal junction.
- Trial name
- NCT03625167
- Testing
- Treatment with petrolatum
- Where
- Germany
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Jan Kottner
Healthy Participants, Diabetes Mellitus (Type 2)
Effect of Type 2 Diabetes on Biomarker Levels in Albumin Platelet-Rich Fibrin
Diabetes mellitus is a metabolic disease that can negatively affect wound healing and tissue repair. Albumin platelet-rich fibrin (Alb-PRF) is a blood-derived biomaterial used in periodontal and regenerative treatments.
- Trial name
- NCT07672652
- Testing
- Venous blood sampling and Alb-PRF preparation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Skin Fold, Skin Laxity
A Safety and Effectiveness Study of CELLBOOSTER® Lift (Stabilized Booster Complex Using CHAC Technology)
The current post-market clinical investigation has been designed to evaluate the efficacy and safety of CELLBOOSTER® Lift, a HA-based product marketed by SUISSELLE SA.
- Conditions
- Skin Fold, Skin Laxity, Skin Texture Disorder, Skin Depression
- Trial name
- NCT06000839
- Testing
- (D0) Intradermal injection - micropapula technique, (D14) Intradermal injection - micropapula technique, (D28) Intradermal injection - micropapula technique
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Suisselle
Non-Small Cell Lung Cancer, Brain Metastases
Comparator-Controlled Study for EGFR(+) Patients With Multiple BMs From NSCLC (BROKE) (EGFR-epidermal Growth Factor Receptor;BM-brain Metastases)
1. Compare the effect and safety of gefitinib alone with gefitinib plus concomitant WBRT(whole-brain radiotherapy ) in treatment of NSCLC patients harboring an EGFR mutation with multiple BM. 2.
- Conditions
- Non-Small Cell Lung Cancer, Brain Metastases, EGFR Gene Mutation
- Trial name
- EGFR (NCT02338011)
- Testing
- Gefitinib, WBRT
- Where
- China
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Postnatal Skin Physiology
Clinical Analysis of the Influence of Using the Skin Care Products on the Diaper Area in Comparison with Using a Cotton Wool Cloth, Moistened with Clear Water on the Skin Physiology of the Newborns from the 1st Day to the 4th Week of Life
Study design: The purpose of the present study is to analyse of the influence of the application of the skin care products on the diaper area (Factor A) and the application of a cotton wool cloth, moistened with clear water on…
- Trial name
- NCT01131403
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Kathrin HILLMANN
Wound Closure Techniques
Closure Techniques and Scar Appearance
The goal of this study is to assess whether wound closure with skin adhesive or running stitches combined with skin adhesive will be superior to standard wound sutures.
- Trial name
- NCT01352533
- Testing
- Running polypropylene closure, Tissue Adhesive (Derma-Bond), Subcuticular polyglactin-910 combined with tissue adhesive
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Breast Cancer Stage I, Breast Cancer Stage II
Role of Triggering Receptor Expressed on Myeloid Cells (TREM-1) as a Novel Biomarker in Human Epidermal Growth Factor Receptor -2 (HER-2) Negative Breast Cancer: a Molecular and Clinical Study
Global cancer statistics by world region for the year 2022 estimated breast cancer the 2nd cause of new cancer cases (11.6%). (1) Approximately 80% of all breast cancers (BCs) are currently categorized as human epidermal growth…
- Conditions
- Breast Cancer Stage I, Breast Cancer Stage II, Breast Cancer Stage III, Breast Cancer Invasive
- Trial name
- NCT06950671
- Where
- Egypt
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Rahma Esam Salama Esawi
Atopic Dermatitis, Healthy
Pilot Tape Harvesting Study
The main objectives of the study are: To determine if RNA recovery from tape harvesting allows for the identification of a disease gene signature (e.g., interferon [IFN] signature for lupus) or other biomarkers that may…
- Conditions
- Atopic Dermatitis, Healthy, Discoid Lupus Erythematosus, Subacute Cutaneous Lupus Erythematosus
- Trial name
- NCT02125695
- Testing
- Skin Taping, Blood Sampling, Skin Biopsy
- Where
- 2 sites in United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Biogen
Chronic Pain, Pain Measurement
Relationship of Intra-Epidermal Nerve Fibre Density (IENFD) and Structure to Chronic Post-Mastectomy Pain Syndrome (PMPS)
This is a retrospective, observational study which will utilise the Edinburgh Cancer Research Centre's Tissue Bank to provide samples for IENFD testing in those who have undergone mastectomy surgery for breast cancer.
- Conditions
- Chronic Pain, Pain Measurement, Mastectomy, Postoperative Pain
- Trial name
- NCT02919891
- Testing
- Questionnaire
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Royal Infirmary of Edinburgh