Clinical trials: Epidural
Tubal Ligation, Bilateral Tubal Ligation
Continuous Labor Epidural Catheter for Tubal Ligation Study
This study is to study the success rate of using the epidural catheter that was placed during the labor for the surgical anesthesia to perform a postpartum tubal ligation.
- Trial name
- NCT00898443
- Testing
- Epidural anesthetic, Spinal anesthetic
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Alabama at Birmingham
Gastric Cancer
Propofol EC50 for Inducing Loss of Consciousness in General Combined Epidural Anesthesia
The beneficial of perioperative usage of thoracic epidural anesthesia and analgesia in various thoracic and upper abdominal surgery are well studied.
- Trial name
- NCT05124704
- Testing
- 5-8ml 0.375% ropivacaine, 5-8ml normal saline
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Wang Jiangling
Lumbosacral Radicular Pain
A Research Study to Characterize the Pharmacodynamics and Safety of Repeat Dose SP-102
This is an open-label, single-arm, repeat dose study to characterize the pharmacodynamics and safety/tolerability of SP-102 administered by epidural injection.
- Trial name
- NCT03613662
- Testing
- SP-102
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Semnur Pharmaceuticals, Inc.
Labor Pain
Comparing Effectiveness of CSE Versus DPE for Labor Analgesia
The primary purpose of this study is to determine if there are differences in block quality between the CSE and DPE techniques for labor analgesia in parturients in active labor.
- Trial name
- NCT05068661
- Testing
- Ropivacaine 0.1% Injectable Solution, Bupivacaine 0.25% Injectable Solution
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Duke University
Head Trauma, Craniocerebral Injuries
Assessment of InfraScanner 2000™ in Detecting Subdural and Epidural Hematomas
The goal of this study is to determine the sensitivity, specificity, and positive and negative predictive values of the a portable near-infrared-based device (portable NIR-based device), the InfraScanner 2000™, to detect…
- Conditions
- Head Trauma, Craniocerebral Injuries, Crushing Skull Injury, Head Injuries
- Trial name
- NCT03353246
- Testing
- InfraScanner 2000™
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Duke University
Cervical Radiculopathy
Dispersal Pattern for Spine Injections (Gadolinium Contrast)
This study will analyze injectate dispersal patterns after standard-of-care cervical epidural steroid injections using gadolinium as a marker and magnetic resonance imaging (MRI) to characterize the pattern.
- Trial name
- NCT02217280
- Testing
- Injection with Gadolinium
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Missouri-Columbia
Sciatica, Radiculopathy
Steroids Versus Gabapentin
The purpose of this study is to determine whether pharmacotherapy or epidural steroid injections are a better treatment for lumbosacral radicular pain.
- Trial name
- NCT01495923
- Testing
- epidural steroid injection, Gabapentin
- Where
- 3 sites in United States
- Volunteers
- 145 people
- Sponsor
- Johns Hopkins University
Osteoarthritis of the Knee
Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty
Total knee arthroplasty (TKA) is associated with moderate to severe postoperative pain, causing patient discomfort, mobilisation and hospital discharge. The aim of this study is to: 1.
- Trial name
- NCT00562627
- Testing
- ropivacaine, adrenaline, ketorolac
- Where
- Norway
- Volunteers
- 102 people
- Sponsor
- Asker & Baerum Hospital
Central Nervous System Infections, Pseudotumor Cerebri
A Study to Test Performance of Needle Placements for Neuraxial Procedures Using Tactile Imaging vs Control
This study will compare the VerTouch device to the conventional palpation technique for performing diagnostic and therapeutic neuraxial procedures.
- Conditions
- Central Nervous System Infections, Pseudotumor Cerebri, Neurological Disorder, Cancer
- Trial name
- NCT04796935
- Testing
- Tactile Imaging (VerTouch), Control (palpation)
- Where
- 3 sites in United States
- Volunteers
- 95 people
- Sponsor
- IntuiTap Medical, Inc
Labor Pain
Tetracaine Combined Spinal Epidural (CSE) Versus Bupivacaine CSE
The investigators hypothesis is that spinal tetracaine with fentanyl and epinephrine used for CSE labor analgesia volume will last a significantly longer period of time that that of spinal bupivacaine with fentanyl.
- Trial name
- NCT01005459
- Testing
- Tetracaine, Bupivacaine
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Wake Forest University
Lumbar Herniated Disc
Percutaneous HydroDiscectomy Compared to TESI for Radiculopathy
To compare the outcomes of percutaneous lumbar Hydrodiscectomy (HydroD) with the SpineJet Hydrodiscectomy System to transforaminal epidural steroid injections (TESI) in patients with lumbar radiculopathy due to contained disc…
- Trial name
- NCT02414698
- Testing
- Percutaneous Hydrodiscectomy, TESI
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Montefiore Medical Center
Rib Fractures, Pain, Acute
A Retrospective Review of Rib Fracture Pain Management at a London Major Trauma Centre
Thoracic epidural analgesia (TEA) is widely considered to be the current gold standard treatment for rib fracture pain and is used in the Imperial invasive treatment pathway for rib fractures.
- Trial name
- NCT04863807
- Testing
- Regional Anaesthesia
- Where
- United Kingdom
- Volunteers
- 389 people
- Sponsor
- Imperial College Healthcare NHS Trust
Metastatic Epidural Spinal Cord Compression
Radiotherapy of Motor Deficits From Metastatic Epidural Spinal Cord Compression
The primary aim of this randomized multi-center trial is to investigate the efficacy of the radiotherapy regimens 5 x 4 Gy and 10 x 3 Gy with respect to the effect on motor function in patients with metastatic epidural spinal…
- Trial name
- SCORE-2 (NCT02189473)
- Testing
- radiotherapy
- Where
- 15 sites in United States, Germany and 4 more
- Volunteers
- 203 people
- Sponsor
- Prof. Dirk Rades, MD
Spinal Cord Injuries, Paraplegia
Epidural and Dorsal Root Stimulation in Humans With Spinal Cord Injury
A study to compare electrophysiologic activity of epidural stimulation and dorsal root ganglion stimulation, as well as quantify changes in motor performance with both types of stimulation over the course of 10 rehabilitation…
- Conditions
- Spinal Cord Injuries, Paraplegia, Tetraplegia, Paralysis
- Trial name
- NCT04736849
- Testing
- Percutaneous epidural and dorsal root stimulation
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Peter J. Grahn, Ph.D.
Labor Pain
Comparing Bupivacaine, Lidocaine, and a Combination of Bupivacaine and Lidocaine for Labor Epidural Activation
This study will compare and determine the most ideal local anesthetic (LA) solution to activate a labor epidural: lidocaine, bupivacaine, or a combination of bupivacaine plus lidocaine.
- Trial name
- NCT03103100
- Testing
- 1% Lidocaine, 0.25% Bupivacaine, Bupivacaine plus Lidocaine
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Osteoarthritis
Patient Controlled Epidural Analgesia Versus Local Infiltration Analgesia Following Knee Arthroplasty
The purpose of this study was to determine if the method of peri-operative analgesia used following total Knee Replacement surgery affected the progress towards rehabilitation goals and to determine whether the analgesia had any…
- Trial name
- NCT02478372
- Testing
- Patient Controlled Epidural (PCEA), Local Infiltration Analgesia (LIA)
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Golden Jubilee National Hospital
Spinal Stenosis, Low Back Pain
Lumbar Epidural Steroid Injections for Spinal Stenosis Multicenter Randomized, Controlled Trial (LESS Trial)
The broad, long-term objective of this research protocol is to improve the quality of life for patients suffering from lumbar spinal stenosis.
- Trial name
- LESS (NCT01238536)
- Testing
- Epidural steroid with local anesthetic injection, Epidural local anesthetic injection, Epidural steroid injection
- Where
- 10 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of Washington
Pain Levels
Dural Puncture Epidural Versus Epidural Anesthesia for Cesarean Delivery
This study will compare two anesthetics techniques called Dural Puncture Epidural (DPE) and Standard Epidural as to which of the two can provide faster and potentially better at providing pain relief for cesarean sections.
- Trial name
- NCT03915574
- Testing
- 25G Dural Puncture Epidural, Standard Epidural
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- University of Arkansas
Labor Pain, Pregnancy
The Association Between Decreasing Labor Analgesia Epidural Infusion and Forceps Delivery
The objective of this study will be to compare epidural infusion management, specifically looking at infusion rate changes, in patients who receive forceps deliveries versus normal spontaneous vaginal deliveries.
- Trial name
- NCT00443560
- Testing
- Case controlled analysis of epidural labor analgesia patterns
- Where
- United States
- Volunteers
- 2,162 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Spinal Cord, Epidural
Transesophageal Echocardiography (TEE): A Novel Technique for Spinal Cord Imaging
The aim of this prospective observational study is to assess whether transesophageal echocardiography (TEE) can be used to identify the structures within the vertebral foramen of the spinal column and to determine the range of…
- Trial name
- NCT02415244
- Testing
- TEE
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Kenichi Ueda