Clinical trials: Epigenetics
Head and Neck Cancer, Squamous Cell Carcinoma
Epigenetic Changes in Head and Neck Cancer
With this study, the investigators will investigate the epigenetic changes, which may contribute to the development of head and neck squamous cell carcinomas.
- Conditions
- Head and Neck Cancer, Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma, Head and Neck Neoplasms
- Trial name
- NCT04260074
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Coronary Artery Disease, Acute Coronary Syndrome
DNA Methylation Analysis in Acute Coronary Syndrome and Atrial Fibrillation: DIANA Clinical Trial
Although epigenetics has been identified as one of the most relevant pathophysiological components in the development of cardiovascular diseases, there is still considerable difficulty in finding markers of epigenetic damage…
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Atrial Fibrillation
- Trial name
- NCT04371809
- Testing
- DNA methylome
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Type 2 Diabetes
Epigenetic Contribution to the Pathogenesis of Diabetic Nephropathy in Qatari Population
The main objective is to study the epigenetic contribution to the pathophysiology of diabetic nephropathy in Qatari population.
- Trial name
- NCT02316522
- Where
- Qatar
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Diabetes Mellitus Type 2 in Obese, Obesity
Epigenetics and the Origin of Muscle Insulin Resistance in Humans
The investigators are trying to understand the role of DNA (deoxyribonucleic acid) methylation in insulin resistance in skeletal muscle and blood tissues.
- Trial name
- NCT01726491
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Overweight and Obesity, Body Weight Changes
FatMax Training on Metabolic and Epigenetic Parameters
Exercise is an essential pillar for the health of all individuals, as it contributes to physical, mental, and emotional well-being.
- Trial name
- NCT06553482
- Testing
- FatMAx training intervention, FatMax and physical endurance exercise intervention, Control
- Where
- Mexico
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Blood Pressure, Lung Function
The Use of Air Cleaners to Mitigate Cardiopulmonary Health Impact of Indoor Exposure to Particles and Phthalates
This study aims to evaluate whether a short-term intervention strategy using air cleaner reduces indoor exposure to airborne particles (particulate matter with an aerodynamic diameter ≤2.5μm, PM2.5) and phthalates and improves…
- Conditions
- Blood Pressure, Lung Function, Inflammation, Oxidative Stress
- Trial name
- NCT03500614
- Testing
- Air cleaner use method 1, Air cleaner use method 2
- Where
- China
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Peking University
Alpha 1-Antitrypsin Deficiency
Epigenetic Regulation of Immunity in Alpha-1 Anti-trypsin Deficiency
The investigators hypothesize that environmentally influenced histone modifications regulate AM mediated inflammation, contributing to a variable clinical course of AATD, and may also influence or be influenced by the activity of…
- Trial name
- AATD_Epi (NCT02691611)
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
Periodontitis
Epigenetics and Periodontal Treatment
Objective: The aim of this pilot study is to evaluate the alterations of epigenetic patterns in periodontally diseased individuals, before and after periodontal treatment, also in comparison to periodontally healthy patients.
- Trial name
- NCT02835898
- Testing
- Conventional periodontal treatment
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Milan
Overweight and Obesity, Weight Loss
PRE-Pregnancy Weight Loss And the Reducing Effect on CHILDhood Overweight - Aarhus
The study is a single site parallel randomized controlled study. The study will be assessing the effect of a 10% pre-conceptional weight loss intervention vs a control group among healthy couples where the prospective mother is…
- Conditions
- Overweight and Obesity, Weight Loss, Pregnancy Related, Child Nutrition Sciences
- Trial name
- PREPARE CHILD (NCT05798494)
- Testing
- Weight loss intervention
- Where
- Denmark
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Ulla Kampmann Opstrup
Atherosclerosis and Calcific Aortic Stenosis with and Without Diabetes
Potential Role of Sirtuins As Epigenetic Biomarkers of the Patient with Atherosclerosis or Calcific Aortic Stenosis
The project aims to shed light on the role of Sirtuins, enzymes belonging to the third class of histone deacetylases (class III) involved in epigenetic modifications (deacetylation), focusing mainly on Sirtuin 6 (SIRT6), as a…
- Trial name
- NCT06337227
- Testing
- lncRNA signature analyses
- Where
- Italy
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- IRCCS SYNLAB SDN
PCOS
Transcriptional and Epigenetic Program of PCOS Women
The main goal is to reveal differences in global gene expression in two different adipose tissue (AT) depots of females with and without polycystic ovary syndrome (PCOS) and how these are influenced by upstream epigenetic markers
- Trial name
- EPIC (NCT04034706)
- Testing
- DEXA, Magnetic Resonance (MR) Assessment of the Abdomen, MR assessment of Whole Body Fat
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Aging
Greens-Based Crossover Trial to Improve Epigenetic Aging in Adults
The primary purpose of this study is to assess changes in epigenetic markers of aging and physiological parameters in overweight older adults consuming a mixed greens-based supplement over a 30-day period in a randomized…
- Trial name
- NCT06537232
- Testing
- Greens-based Supplement
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Auburn University
Healthy
The Molecular Basis for a Broad Range of Phenotypes Related to hTAS2R38
This single-site, within-subject, experimental study is designed to test the hypothesis that individuals express taste receptors differently and have different sensitivities to bitter taste samples, which results from uneven…
- Trial name
- NCT01399944
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Monell Chemical Senses Center
Heart Rate, Heart Rate Variability
Air Pollution, Epigenetics and Cardiovascular Health: A Human Intervention Trial
In this study, the pills formulated are being used to try to ameliorate the effect of air pollution on epigenetic changes, specifically DNA methylation, potentially linked with particulate matter air pollution inhalation and…
- Conditions
- Heart Rate, Heart Rate Variability, Inflammation
- Trial name
- EPI-Air (NCT01864824)
- Testing
- methyl donor
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Multiple Sclerosis, miRNA
miRNA Biomarkers in Multiple Sclerosis
Multiple Sclerosis (MS) characterized by demyelination and axonal degeneration is a chronic inflammatory disease of the central nervous system (CNS).
- Conditions
- Multiple Sclerosis, miRNA, Epigenetic, Biomarker
- Trial name
- NCT04772495
- Testing
- miRNA
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Aging
Safety and Effectivness of Quercetin & Dasatinib on Epigenetic Aging
Assessing the effects of Quercitin and Dasatinib over a 16 week period on participatns' epigenetic biological aging. The patients are being tested at baseline, halfway point, and after the trial period.
- Trial name
- NCT04946383
- Testing
- Dasatinib plus Quercetin
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- TruDiagnostic
Melasma
DNA Methylation in Malar Melasma and Its Change by Sunscreen, Retinoic Acid and Niacinamide.
BACKGROUND: Malar melasma has a chronic and recurrent character that may be related with epigenetic changes.
- Trial name
- NCT03392623
- Testing
- Retinoic acid, colorimetry measurement, sunscreen
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
microRNAs in Attention-deficit/Hyperactivity Disorder
Epigenetics in ADHD
Attention-deficit/hyperactivity disorder (ADHD) is among the most common psychiatric disorders in children and adolescents. ADHD's nosology is largely based on clinical phenomenology that includes such symptoms as inattention…
- Trial name
- NCT04860024
- Where
- Taiwan
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Turner Syndrome, Klinefelter Syndrome
X-chromosome Inactivation, Epigenetics and the Transcriptome
The human genetic material consists of 46 chromosomes of which two are sex chromosomes. The sex-chromosome from the mother is the X and from the father the Y-chromosome.
- Conditions
- Turner Syndrome, Klinefelter Syndrome, Triple X Syndrome, 47 XYY Syndrome
- Trial name
- NCT01678261
- Where
- Denmark
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Colorectal Cancer
Emerging Role of NOTCH-related Long Non-coding RNA(s) as Biomarkers in Liquid Biopsy From Colorectal Cancer Patients
This work aims to Investigate the role of circulating notch associated lncRNAs SNHG3 and LUNAR1 as possible non invasive prognostic biomarkers for colorectal cancer (CRC) monitoring via measuring the gene expression level of…
- Trial name
- NCT06432413
- Where
- Egypt
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Ain Shams University