Clinical trials: Epigenetics
Triple Negative Breast Cancer
Epigenetics of TNBC in Overweight and Obese Hispanic & Non-Hispanic White Women
A key tenet of this project is that of reaching translational human diagnosis and biomarker end points. To lay a foundation and make progress towards these translational goals, investigators will address the following specific…
- Trial name
- NCT04291950
- Testing
- Needle core biopsy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Arizona
Turner Syndrome, Klinefelter Syndrome
X-chromosome Inactivation, Epigenetics and the Transcriptome
The human genetic material consists of 46 chromosomes of which two are sex chromosomes. The sex-chromosome from the mother is the X and from the father the Y-chromosome.
- Conditions
- Turner Syndrome, Klinefelter Syndrome, Triple X Syndrome, 47 XYY Syndrome
- Trial name
- NCT01678261
- Where
- Denmark
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cortisol Excess, Stress, Psychological
Effects of "Vitamin N" Nature Immersion Therapy on Stress Levels in Health Care Workers in the City of Bogotá
Recent studies on health personnel in Colombia have evidenced the considerable increase in the levels of stress and anxiety, among other psychological disorders, as a product of the COVID-19 pandemic that is being experienced…
- Conditions
- Cortisol Excess, Stress, Psychological, Anxiety, Epigenetic Disorder
- Trial name
- NCT05315388
- Testing
- Immersion therapy in nature - Vitamin N
- Where
- Colombia
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Jeadran N. Malagón-Rojas
Metabolic Syndrome
Exercise-Induced Epigenetic Modifications in Obese Aging Women
Our greatest public health challenge is obesity and the co-morbidities of metabolic syndrome (MetS). Age is an established risk factor for MetS and specific to women, data indicates that the prevalence of MetS increases…
- Trial name
- DIVAS2 (NCT01977885)
- Testing
- High Protein Diet, Exercise
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Aging
Project SIRT6 Activator
The global ageing population is increasingly affected by age-related diseases, which are challenging healthcare systems. Current treatments often extend lifespan without improving healthspan.
- Trial name
- NCT07500649
- Testing
- Fucoidan
- Where
- 2 sites in Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Stress, Stress, Psychological
The Effect of SKY Breath Meditation on Health and Well-being
The goal of this pilot SKY (Sudarshan Kriya Yoga) Breath Meditation study is to establish feasibility and acceptability of the intervention; and investigate preliminary effectiveness of the intervention at the DNA methylation…
- Conditions
- Stress, Stress, Psychological, Stress, Physiological, Anxiety
- Trial name
- NCT05523414
- Testing
- SKY
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Exposure to Environmental Pollution, Non-occupational
Epigenetic Effect Modifications With Ozone Exposure on Healthy Volunteers
The purpose of this protocol is to assess whether epigenetic factors in healthy individuals make a person more or less responsive to lung inflammation following ozone exposures.
- Trial name
- Geminoz (NCT02469428)
- Testing
- Clean air, Ozone
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
Bipolar Disorder
Bipolar Disorder Integrative Staging: Incorporating Biomarkers Into Progression Across Stages
Bipolar disorder (BD) is a lifelong, recurrent condition with growing evidence supporting a neuroprogressive course, entailing the need to adopt staging models to guide stage-speci c interventions.
- Trial name
- BOARDING-PASS (NCT07343739)
- Testing
- psychometric clinical assessment, biological acquisition, neuroimaging data
- Where
- Italy
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- ASST Fatebenefratelli Sacco
Obesity, Alzheimer's Disease
Identification of Epigenetic Markers Common to Obesity and Alzheimer's Disease in Women
The purpose of this study is to compare average methylation of epigenetic markers on genomic DNA and some genes (APP, BACE, LRP, SorL1) involved in cerebral amyloid homeostasis: Of obese young adults and healthy young adults Of…
- Trial name
- Oba (NCT02868905)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Biological Aging
Translational Initiative to Map Epigenetics in Sleep
The primary aim of TIME-ZZZ is to explore the relationship between chronotype, incidence of depression and biological age, and whether individuals working "out-of-phase" with their chronotype are more likely to exhibit signs of…
- Trial name
- TIME-ZZZ (NCT06333301)
- Testing
- Surveys
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Elysium Health
Healthy
Natural Product System and Lifestyle Modification
The goal of this clinical trial is to learn whether four dietary supplements and lifestyle changes can affect gene expression and blood markers in healthy volunteers. The main questions it aims to answer are: 1.
- Trial name
- NCT06931977
- Testing
- Supplement system + copaiba softgels
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- dōTERRA International
Type 2 Diabetes
Exercise Resistance in Type 2 Diabetes
The purpose of this study is to collect data to help researchers identify factors that prevent certain individuals from receiving the beneficial effects of exercise.
- Trial name
- RESIST (NCT01911104)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Fertility Issues, Nutrition, Healthy
Food Intake and Epigenetic Alteration in the Spermatozoa of Singletons and Twins
The purpose of this study is to elucidate the role of acute dietary intake in male populations, and its impact on spermatozoa quality, integrity, content and epigenetic programming.
- Conditions
- Fertility Issues, Nutrition, Healthy, Epigenetic Disorder, Overnutrition
- Trial name
- FEASST (NCT05368194)
- Testing
- Isocaloric Unprocessed Diet, Isocaloric Processed Diet, Excess Calorie Unprocessed Diet
- Where
- Denmark
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Demyelinating Autoimmune Diseases, CNS
Epigenetic Evaluation of HAT/HDAC Activity in PBMC From Patients With Clinically Isolated Syndrome
The aim of the study is to compare the enzymatic activity of HATs and HDACs in peripheral blood mononuclear cell (PBMC) of patients with a clinically isolated syndrome (CIS group) and healthy controls (control group).
- Trial name
- EPIC (NCT02862301)
- Testing
- blood sample
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Hepatocellular Carcinoma
Epigenetic Changes in Hepatocellular Carcinoma Developed After Direct Acting Antiviral Therapy for Chronic Hepatitis C
Hepatocellular carcinoma (HCC) is the most common type of liver cancer, its survival rate ranks only second to lung cancer and it is a severe threat to human health. In Egypt, HCC constitutes a significant public health problem.
- Trial name
- NCT04220151
- Testing
- DNA methylation
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Age Over 50 Years
The Impact of Exercise Intervention on Biological and Functional Aging Through the Lens of Epigenetic Clocks
This study investigated the effects of a structured 6-month high-intensity interval training (HIIT) program on blood DNA methylation-based measures of biological ageing, physical fitness, cardiovascular function, body…
- Trial name
- NCT07799103
- Testing
- Exercise - Relative High-Intensity Interval Training (HIIT)
- Where
- Hungary
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Hungarian University of Sports Science
PARKINSON DISEASE (Disorder), Alzheimer s Disease
Precision Medicine and Neurodegenerative Diseases: Advanced Systems for the Diagnosis and Treatment of Parkinson's Disease and Alzheimer's Disease.
In recent decades, advances in medicine have significantly improved both quality of life and life expectancy. However, these positive effects are also associated with a considerable increase in the prevalence of age-related…
- Conditions
- PARKINSON DISEASE (Disorder), Alzheimer s Disease, Diabete Type 2
- Trial name
- NEUROTECHNO (NCT07467460)
- Where
- Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Autism Spectrum Disorder (ASD)
Investigation of the Genetic and Environmental Causes of Autism: a Multi-Center Study
The goal of this observational study is to investigate the genetic and epigenetic mechanisms that may contribute to the development of Autism Spectrum Disorder (ASD) in individuals of different age groups.
- Trial name
- ASD-Omics-TR (NCT06662591)
- Where
- 20 sites in Turkey (Türkiye)
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Research and Treatment Society of Genetic Disorders
Colorectal Cancer
Emerging Role of NOTCH-related Long Non-coding RNA(s) as Biomarkers in Liquid Biopsy From Colorectal Cancer Patients
This work aims to Investigate the role of circulating notch associated lncRNAs SNHG3 and LUNAR1 as possible non invasive prognostic biomarkers for colorectal cancer (CRC) monitoring via measuring the gene expression level of…
- Trial name
- NCT06432413
- Where
- Egypt
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Diabetes Mellitus Type 2 in Obese, Obesity
Epigenetics and the Origin of Muscle Insulin Resistance in Humans
The investigators are trying to understand the role of DNA (deoxyribonucleic acid) methylation in insulin resistance in skeletal muscle and blood tissues.
- Trial name
- NCT01726491
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic