Clinical trials: Epigenetics
Arthritis, Rheumatoid
Identification of Epigenetic Biomarkers for Early Detection of Rheumatic Disease
Given the cost and risk associated with biologic disease modifying anti-rheumatic drugs (bDMARDs), selection of the optimal medication is imperative.
- Trial name
- NCT02742337
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Arthritis Northwest PLLC
Full Term Infants, Environmental Exposures
Epigenetic and Developmental Effects of In Utero Exposure to Environmental Toxicants
Metabolic diseases such as obesity and diabetes are modern day epidemics. Early life exposure to an adverse developmental environment, including environmental toxins, are linked to increased susceptibility to obesity, metabolic…
- Conditions
- Full Term Infants, Environmental Exposures, Adiposity
- Trial name
- NCT01815385
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Diabetes Mellitus, Type 2, Obesity
Genetic and Epigenetic Risk of T2D in the UAE
T2D is a global public health crisis and a threat to socioeconomic development of all nations, particularly in developing countries.
- Trial name
- NCT04270097
- Where
- United Arab Emirates
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Imperial College London Diabetes Centre
Sleep Disorders, Circadian Rhythm
Circadian Phase Adjustment and Improvement of Metabolic Control in Night Shift Workers
EuRhythDia II is a multicenter, randomized, double-blind controlled study. The rationale of EuRhythdia is to explore the effects of 12 weeks of timed melatonin treatment on circadian rhythm, metabolic control and cardiovascular…
- Trial name
- NCT02108353
- Testing
- Melatonin 2mg
- Where
- 3 sites in Germany, Italy
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Baker Gordon Syndrome, Rare Neurodevelopmental Conditions
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)
Rare genetic neurodevelopmental disorders, such as Syt-1 or Baker Gordon Syndrome (BAGOS) arise from mutations in genes essential for brain development and function, often disrupting neurotransmission and neuronal connectivity.
- Conditions
- Baker Gordon Syndrome, Rare Neurodevelopmental Conditions, Rare Neurogenetic Conditions, Syt-1 Disorder
- Trial name
- NCT07329257
- Testing
- No Intervention: Observational Cohort
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Obesity, Alzheimer's Disease
Identification of Epigenetic Markers Common to Obesity and Alzheimer's Disease in Women
The purpose of this study is to compare average methylation of epigenetic markers on genomic DNA and some genes (APP, BACE, LRP, SorL1) involved in cerebral amyloid homeostasis: Of obese young adults and healthy young adults Of…
- Trial name
- Oba (NCT02868905)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Nutrition Habits, Biomarkers / Hair
Epigenetic Optimization Through Biofrequency Nutrition
Biomarker-based nutrition has demonstrated superior efficacy compared to population-level approaches in improving health outcomes.
- Conditions
- Nutrition Habits, Biomarkers / Hair, Epigenetic
- Trial name
- NCT07093242
- Testing
- Personalized Nutritional Follow-Up
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universidad de Almeria
Type I Diabetes
Epigenetic Modifications of Diabetes Mellitus Type I
This research is being done to find out if significant changes in blood glucose cause bad outcomes in patients with diabetes.
- Trial name
- NCT01623388
- Testing
- Oral glucose tolerance test for Phase I
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Hodgkin Disease Lymphoma
Sperm Epigenome in Hodgkin Lymphoma
Cancer treatments can have long-term effects on fertility. In men, scientific studies suggest that the process of sperm formation (spermatogenesis) may be disrupted even years after recovery, with potential consequences not only…
- Trial name
- SPELH (NCT07449832)
- Testing
- Additional semen samples
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Asthma, Allergic Rhinitis
Viral Mucosal Reprogramming
This is a mechanistic, controlled, open-label, single-site study to evaluate the effects of RG-RV16 inoculation on airway mucosal gene expression and airway remodeling in 25 healthy controls (HC), in 25 allergic rhinitis subjects…
- Conditions
- Asthma, Allergic Rhinitis, Cat Allergy, Healthy
- Trial name
- VMR (NCT05331170)
- Testing
- Research Grade RG-RV
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Infertility
Epigenetic Safety of Assisted Reproductive Technology
The primary purpose of the study is to investigate the relationship between different protocols of assisted reproductive technology and the epigenetic safety of the offspring.
- Trial name
- NCT04065945
- Testing
- Completion questionnaires/providing biological samples
- Where
- China
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Type 2 Diabetes, Obesity
Long-term Effects of Lifestyle Intervention During Pregnancy in High Risk Women and in Their Offspring - Role of Environmental, Genetic and Epigenetic Factors
SUBJECTS: All participants in the RADIEL-study (2008-2011) who delivered (n=535), will be invited to this follow-up study, with their children (age 3-5 years) and the father.
- Conditions
- Type 2 Diabetes, Obesity, Metabolic Syndrome
- Trial name
- NCT02048839
- Where
- Finland
- Volunteers
- 680 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Obesity
Impact of Weight Loss on the Human Sperm Epitranscriptome
Increasing evidence suggests that non-communicable diseases such as in particular obesity and its associated metabolic diseases are inherited from parents to children throughout several generations by epigenetic mechanisms.
- Trial name
- EPI-SPERM (NCT03962699)
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Anorexia Nervosa
Orexin Gene in Anorexia Nervosa
The objectives of this study will be to determine the methylation of the promoter of the Orexin A (OX-A) and B (OX-B) genes in young women (> 18 years) with Anorexia Nervosa (AN), compared with a control group; and to evaluate…
- Trial name
- ORESSANNE (NCT06800898)
- Testing
- Blood samples and Questionnaires
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Mild Cognitive Impairment, Metabolic Syndrome
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation
The study explores whether selective memory complaints (SMC), mild cognitive impairment (MCI) and the comorbidity of Metabolic Syndrome symptomatic of peripheral and cerebral hypo-metabolism with corresponding epigenetic shifts…
- Trial name
- NCT03319173
- Testing
- Dietary intervention
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Bristlecone Health, Inc.
Aging
Safety & Efficacy of Extended Longevity Protocol
The purpose of this study is to quantifiably determine if the Extended Longevity Protocol has a significant clinical effect on epigenetic age.
- Trial name
- NCT05296993
- Testing
- Extracts found in the Extended Longevity supplements
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- TruDiagnostic
Major Depressive Disorder
Characterization of Microbial, Immune and Epigenetic Biomarkers for Major Depressive Disorder and ECT Treatment
The investigators aim to characterize fecal microbial biomarkers as well as blood cytokine levels in MDD patients vs. healthy controls.
- Trial name
- NCT03703414
- Testing
- Fecal microbiota composition analysis and blood cytokine level analysis
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ziv Hospital
Anorexia Nervosa
Remission Factors in Anorexia Nervosa
Anorexia Nervosa (AN) is a complex and multifactorial psychiatric disease that affects mostly women and is characterized by a self-restriction of food intake leading to life-threatening consequences whose underlying mechanisms…
- Trial name
- REMANO (NCT04560517)
- Where
- France
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Diabetes Mellitus, Type 2 Diabetes
The Hong Kong Diabetes Biobank
Asia is in the midst of an epidemic of diabetes. Epidemiological figures suggest that there are more than 110 million people affected by diabetes in China, with a significant proportion of young adults already affected.
- Conditions
- Diabetes Mellitus, Type 2 Diabetes, Type 1 Diabetes, Diabetic Nephropathies
- Trial name
- HKDB (NCT05282680)
- Testing
- prospective observational study
- Where
- Hong Kong
- Volunteers
- 48,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Diet, Healthy, Body Weight
Diet-Induced Changes in GEnetic Material
This is a pilot study in 10 men to test the hypothesis that perturbations in substrate flux and the circulating metabolic and pro-inflammatory milieus during a high-fat diet paradigm will modulate DNA methylation of genes in…
- Conditions
- Diet, Healthy, Body Weight, Metabolic Disturbance
- Trial name
- DIG 'EM (NCT06252922)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center