Clinical trials: Epigenetics
Diabetic Retinopathy, Age-Related Macular Degeneration (AMD)
Genetics and Markers of Degenerative and Inflammatory Eye Diseases
This study will identify genes that are associated with inflammation or degeneration of the retina (membrane lining the back of the eye that relays vision signals to the brain).
- Conditions
- Diabetic Retinopathy, Age-Related Macular Degeneration (AMD), Uveitis
- Trial name
- NCT00647439
- Where
- United States
- Volunteers
- 609 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Anemia and Pregnancy, Metabolism and Foetal Growth
Foetal Exposure and Epidemiological Transition: Role of Anaemia in Early Life for Non-communicable Diseases Later
Study Hypotheses: 1. Anaemia, which is frequent before conception as well as during early pregnancy, affects metabolism and foetal growth trajectories, influencing the risk of NCDs in the offspring. 2.
- Conditions
- Anemia and Pregnancy, Metabolism and Foetal Growth, Epigenetics
- Trial name
- FOETALforNCD (NCT02191683)
- Where
- Tanzania
- Volunteers
- 1,748 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Chronic Rhinosinusitis (Diagnosis)
Viral and Epigenetic Influences in CRSwNP
Background/rationale While multiple disorders feature a Type 2 (T2) inflammation, triggers for T2 remains unknown. In Chronic Rhinosinusitis with Nasal Polyposis CRSwNP), a classic Type 2 disorder, dysfunction of the epithelial…
- Trial name
- NCT05857228
- Testing
- Endoscopic sinus surgery (ESS)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Overweight, Type 2 Diabetes Mellitus
Impact of Metabolic Health on Sperm Epigenetic Marks in Humans
This study is designed to evaluate whether epigenetic markers in overweight men with type 1 diabetes (T1D) or type 2 diabetes (T2D) can be improved with a 3 month lifestyle intervention or program focused in glycemic intervention.
- Conditions
- Overweight, Type 2 Diabetes Mellitus, Type 1 Diabetes Mellitus
- Trial name
- NCT03860558
- Testing
- Lifestyle Intervention, No Intervention
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Osteoporosis，Neurological Disorders
Beijing Osteoporosis With Neurological Disorders in Epigenetic Changes Study
Epigenetic modification refers to the change of heritable gene expression occurring in the case of unchanged DNA sequence, including DNA methylation, epigenetic modification, RNAS, chromatin modification, etc.
- Trial name
- BONE (NCT03401619)
- Testing
- Exercise，Nutrition，Bisphosphonates，Statins，Calcitonin,Vitamin D，et al.
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Epigenetic Aging, Immunosenescence
Thymus Regeneration, Immunorestoration, and Insulin Mitigation Extension Trial
The TRIIM-X trial is an expanded pilot clinical study that will evaluate a personalized combination treatment regimen for thymus regeneration.
- Trial name
- TRIIM-X (NCT04375657)
- Testing
- TRIIM Treatment, Active Control
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Intervene Immune, Inc.
Weight Gain, Anemia, Iron Deficiency
Egg Intervention During Pregnancy in Indonesia
The study consists of two arms: 1) intervention group using eggs as supplementary food given from 2nd trimester of pregnancy to birth, and 2) observational group of pregnant mothers.
- Conditions
- Weight Gain, Anemia, Iron Deficiency, Birth Weight, Birth Length
- Trial name
- PRECODE (NCT04694235)
- Testing
- Egg intervention
- Where
- Indonesia
- Volunteers
- 702 people, healthy volunteers welcome
- Sponsor
- SEAMEO Regional Centre for Food and Nutrition
Metabolic Diseases, Neurological and Mental Health Conditions
Growing Up in Singapore Towards Healthy Outcomes
This study aims to examine the role of genetic and epigenetic factors, maternal nutrition, lifestyle, emotional health, and other environmental factors in pregnancy or postpartum period that can influence future maternal risk of…
- Conditions
- Metabolic Diseases, Neurological and Mental Health Conditions, Genetic Predisposition, Skin Condition
- Trial name
- GUSTO (NCT01174875)
- Where
- Singapore
- Volunteers
- 1,247 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Inflammation, Mental Health Wellness 1
Health Effects of Traditional Indigenous Chokeberry
American Indian populations continue to suffer disproportionately from health problems including such nutrition-related chronic diseases as diabetes and heart disease.
- Conditions
- Inflammation, Mental Health Wellness 1, Oxidative Stress
- Trial name
- NCT05410327
- Testing
- Chokeberry (Aronia melanocarpa) juice
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of North Dakota
Colorectal Cancer, Early Onset Colorectal Cancer
Exogenous and Endogenous Risk Factors for Early-onset Colorectal Cancer
An increase in early-onset colorectal cancers (eoCRC), defined as a CRC before 50 years, is confirmed globally. CRC pathogenesis has been associated with several risk factors (family history, germline pathogenic variants…
- Conditions
- Colorectal Cancer, Early Onset Colorectal Cancer, Diet Habit, Risk Reduction
- Trial name
- DEMETRA (NCT05732623)
- Testing
- Semi Quantitative Food Frequency Questionnaire (SQFFQ)
- Where
- 8 sites in United States, Finland and 4 more
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- San Raffaele University
Periodontal Diseases, Epigenetics
DNA Methylation Profile of the SOCS-1 Gene Promoter in Smokers Patients With Chronic Periodontitis.
Periodontitis is related to host genetics, constitution of the dental biofilm and environmental factors such as smoking. DNA methylation is a mechanism of genetic expression that can inhibit or silence gene expression.
- Trial name
- NCT03371446
- Testing
- oral epithelial cells obtained by rinsing with 3% sucrose
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Exposure to Environmental Pollution, Non-occupational
Epigenetic Effect Modifications With Ozone Exposure on Healthy Volunteers
The purpose of this protocol is to assess whether epigenetic factors in healthy individuals make a person more or less responsive to lung inflammation following ozone exposures.
- Trial name
- Geminoz (NCT02469428)
- Testing
- Clean air, Ozone
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
Diabetes Mellitus, Type 2, Obesity
Epigenetics of Muscle Insulin Resistance
The investigators are trying to understand the role of DNA (deoxyribonucleic acid) methylation in insulin resistance in skeletal muscle and blood tissues.
- Trial name
- NCT03259984
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Aging
Project SIRT6 Activator
The global ageing population is increasingly affected by age-related diseases, which are challenging healthcare systems. Current treatments often extend lifespan without improving healthspan.
- Trial name
- NCT07500649
- Testing
- Fucoidan
- Where
- 2 sites in Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Aging
The Effects Of Therapeutic Plasma Exchange (TPE) On Age Related Biomarkers And Epigenetics
The goal of this clinical trial is to assure the safety of long term therapeutic plasma exchange (TPE) with and without Intravenous Immunoglobulin (IVIG) and its effects on biomarkers and epigenetic biologic clocks in forty…
- Trial name
- NCT06534450
- Testing
- Therapeutic Plasma Exchange, IVIG
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dobri Kiprov
Stage III Colorectal Cancer
Genetic and Epigenetic Determinants of Response to Fluorouracil-based Adjuvant Chemotherapy in Patients With Stage III Colorectal Cancer
The goal of this laboratory research is to look for genetic and epigenetic markers that can predict which patients with stage III colorectal cancer will benefit from fluorouracil-based adjuvant chemotherapy.
- Trial name
- NCT03127111
- Testing
- Gene mutations analysis, Gene methylation analysis, Gene expression analysis
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Renmin Hospital of Wuhan University
Biological Aging
The Translational Initiative to Map Epigenetics in Aging (TIME-A)
The Translational Initiative to Map Epigenetics in Aging (TIME-A) study aims to advance our understanding of the connections between epigenetics, lifestyle, demographics, and health and aging.
- Trial name
- TIME-A (NCT05760547)
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Elysium Health
Typhoid and/or Cholera Vaccination
CVD 38000: Study of Responses to Vaccination With Typhoid and/or Cholera
This is an open-label, non-randomized study. The purpose of this study is to better understand how vaccines against typhoid fever and cholera affect the normal immune system and bacteria in the intestine.
- Trial name
- NCT03705585
- Testing
- Vivotif Typhoid Oral Vaccine, Vaxchora
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Atrial Fibrillation
Biomarkers and Epigenetic Markers Associated With Pain in Patients With Symptomatic Atrial Fibrillation
Atrial fibrillation (AF) is the most common sustained arrhythmia and the number of patients with AF is expected to increase substantially in the coming decades.
- Trial name
- PAIN (NCT05201989)
- Where
- Sweden
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Metabolic Syndrome, Obesity
Mobile Health (M-health) Intervention to Reduce the Epigenetic Signature in Metabolic Syndrome (MetS)
The goal of this interventional study is to learn about the improvement in body composition effects of lifestyle intervention in subjects with metabolic syndrome.
- Trial name
- NCT06448806
- Testing
- mobile health lifestyle intervention
- Where
- Pakistan
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Aga Khan University