Clinical trials: Epigenetics
Colorectal Cancer (CRC)
Colon Cancer Liquid Biopsy Investigation of Methylation-based Biomarkers Evaluation Using Delta-HLD (CLIMBED)
CLIMBED (Colon cancer Liquid biopsy Investigation of Methylation-based Biomarkers Evaluation using Delta-HLD) is a non-randomized, observational, cross-sectional clinical validation study designed to assess the performance of…
- Trial name
- CLIMBED (NCT07168876)
- Where
- Argentina
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Epiliquid Holding, Inc
Malnutrition Pregnancy, Malnutrition in Children
Early Life Malnutrition, Environmental Enteric Dysfunction and Microbiome Trajectories
Malnutrition in women of reproductive age remains a public health concern in Sub-Saharan Africa (SSA). Malnutrition during pregnancy affects foetal growth with a tendency of the exposed infants to also develop it.
- Conditions
- Malnutrition Pregnancy, Malnutrition in Children, Malnutrition (Calorie), Environmental Enteric Dysfunction
- Trial name
- UZBCS-2 (NCT07195006)
- Testing
- Malnutrition in pregnancy as exposure, Poor WASH living conditions as exposure
- Where
- Zimbabwe
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Depression, Depression Secondary to Other Disease
A Neuroimaging and Epigenetic Investigation of Antidepressants in Depression
The purpose of this study is: 1. to find out the structural or functional effects of selective serotonin reuptake inhibitors (SSRI) in major depressive disorder (MDD); 2.
- Trial name
- NCT00703742
- Testing
- Escitalopram
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kunming Medical University
Epigenetics
Biomarker Study to Evaluate Correlations Between Epigenetic Aging and NAD+ Levels in Healthy Volunteers
This is a single center, prospective study to evaluate correlations between epigenetic aging (as measured via DNA methylation) and NAD+ levels in healthy volunteers.
- Trial name
- NCT04220658
- Testing
- Biomarker study
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Elysium Health
Body Weight Changes
Development of a Nutrigenetic Test for Personalized Prescription of Body Weight Loss Diets (Obekit)
This study evaluates the relationship between several genetic variants and the response to a hypocaloric diet, in order to design a genetic test which permits prescribe the more personalized diet for each individual according to…
- Trial name
- Obekit (NCT02737267)
- Testing
- Moderately high protein diet, Low fat diet
- Where
- Spain
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Childhood Cancer
Epigenetic and Metabolomic Changes in Childhood Cancer Survivors
The purpose of this research study is to try and identify markers in childhood cancer survivors to help predict if they will develop late effects from their cancer treatment.
- Trial name
- NCT03866707
- Testing
- One-time blood draw, Evaluation of CpG methylation, Metabolomic analysis
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Obesity, Periodontitis
Periodontal Inflammation and Epigenetics in Obese Individuals
The goal of this study is to investigate the long-term changes in host epigenetic modifications in obese individuals with periodontitis.
- Trial name
- NCT07610902
- Testing
- Non-surgical periodontal therapy will be administered
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Sensorineural Hearing Loss, Turner Syndrome
Genetic and Epigenetic Background of Inner Ear Dysfunction in Turner Syndrome
The goal of this case-control study is to pave the way for new revolutionary treatment measures within hearing loss that could either replace or delay the need for hearing aids.
- Conditions
- Sensorineural Hearing Loss, Turner Syndrome, Inner Ear Disease
- Trial name
- EPIHEAR (NCT06507007)
- Where
- Denmark
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Gødstrup Hospital
Female Infertility
Looking for a Blood Epigenetic Signature to Predict Female Infertility
The present research project aims to study the DNAm mechanisms underlying the reduction of fertility due to the progressive depletion of oocyte quality.
- Trial name
- FIB_CARIPLO (NCT06098495)
- Testing
- search for epigenetic profile of infertility
- Where
- Italy
- Volunteers
- 1,456 people, healthy volunteers welcome
- Sponsor
- Università Vita-Salute San Raffaele
Breast Cancer (Locally Advanced or Metastatic), Healthy Volunteers (HV)
Signature Development and Validation Protocol for an Epigenetic Assay in Diagnosing Breast Cancer
The purpose of this research study is to test a new process for diagnosing breast cancer by examining changes to your DNA that can be detected from a blood test.
- Conditions
- Breast Cancer (Locally Advanced or Metastatic), Healthy Volunteers (HV), Unhealthy Volunteers, Breast Cancer Screening
- Trial name
- NCT07374796
- Testing
- Epigenetic Assay
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Parent Child Relationship, Child Social-Emotional Development
The Impact of an Evidence-Based Parenting Service on Maternal Sensitivity and Infant Cellular Aging in a Population of Under-Resourced Families
The goal of this clinical trial study is to learn how stress in childhood, or Early Life Adversity (ELA), gets "under the skin" and influences long-term health.
- Conditions
- Parent Child Relationship, Child Social-Emotional Development, Telomere Length, Epigenetic Aging
- Trial name
- NCT06740266
- Testing
- Promoting First Relationships in Primary Care (PFR-PC)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Washington
Post Partum Depression, Bipolar Disorder
Neuroimaging Epigenetics of Prospective Postpartum Depression Biomarkers
Through a recent cross species translational experiment, researchers have identified a set of epigenetic marks capable of predicting postpartum depression with greater than 85% accuracy.
- Trial name
- NCT03638687
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Bowel Cancer, Bowel Disease
Exploratory Study of Rectal Mucus for Diagnosing Disease
The identification of patients with colorectal cancer is challenging as they present with a variable symptom profile and require invasive tests (colonoscopy) for diagnosis (through histological analysis of biopsies) and…
- Conditions
- Bowel Cancer, Bowel Disease, Genomic, Epigenetic Disorder
- Trial name
- ORI-EGI-02 (NCT04659590)
- Where
- 4 sites in United Kingdom
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Origin Sciences
Lung Cancer, Non-Small Cell
Novel Epigenetic Mapping in Cell-Free DNA for the Detection of Lung Cancer
This trial is a multicenter, open-label, non-interventional controlled study to identify and characterize epigenetic signatures of lung cancer.
- Trial name
- LumenDx (NCT06963307)
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- JaxBio Ltd
Healthy
Investigating ELSI Issues That May Facilitate or Impede Clinical Translation of Epigenetic Research. Phase 3a Survey
Few people realize that environmental pollution and some behaviors like physical activity and tobacco smoking can affect their health by "turning on" or "turning off" certain genes through a process called "epigenetic…
- Trial name
- NCT07713667
- Testing
- Uncertainty Video, Uncertainty Normalization Video, Epigenetics Video
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Aging
Does Alpha-ketoglutarate Supplementation Lower BiologicaL agE in Middle- Aged Adults?
Geroscience is an emerging interdisciplinary field of study in gerontological sciences. With emphasis on understanding the mechanistic drivers of aging, it seeks translational approaches that could eventually be applied to…
- Trial name
- ABLE (NCT05706389)
- Testing
- Ca-AKG
- Where
- Singapore
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
BDNF, DNA Methylation, Suicide, Drug Responses.
Epigenetic Regulation of BDNF in Schizophrenia
In this proposal, we will (1) detect the associations between BDNF and Trk B gene DNA methylation, histone modification, psychotic symptoms, obesity, suicide and antipsychotic drug responses in Taiwanese patients (2) discuss the…
- Trial name
- NCT01021449
- Where
- Taiwan
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Overweight and Obesity
Effectiveness of a Precision Diet Based on Gene Expression Versus a Personalized Mediterranean-Style Diet in Weight Loss
The present randomized controlled trial aims to evaluate the relationship between gene expression profiling and the response to a precision diet compared to a personalized Mediterranean-style diet (control diet) in metabolically…
- Trial name
- NCT06435325
- Testing
- Precision diet, Control diet
- Where
- Spain
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Epigenetics, DNA Methylation
Methylated Biomarkers of Smoking as a Selection Tool in Participants for Lung Cancer Screening
The MET-SELS study aims to revolutionize how we identify individuals for lung cancer screening by moving beyond the limitations of self-reported smoking history.
- Conditions
- Epigenetics, DNA Methylation, Lung Cancer Screening, Risk Stratification With Biomarker
- Trial name
- MET-SELS (NCT07631624)
- Testing
- DNA-methylation in saliva
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Colorectal Cancer, Colorectal Polyp
Epigenetic Regulation of Colorectal Polyps and Cancer
The goal of this study is to learn about the epigenetic and genetic regulation (microRNA/mRNA) of colorectal polyps and their evolvement as polyps and to colorectal cancer.
- Conditions
- Colorectal Cancer, Colorectal Polyp, Colorectal Adenoma, Colorectal Neoplasms
- Trial name
- NCT06206603
- Testing
- Intestinal biopsies, Blood sample
- Where
- Sweden
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Region Skane