Clinical trials: Epigenetics
Cardiovascular Diseases (CVD), Type 2 Diabetes
Epigenetics and NCD Prevention in Kazakhstan: Personalized Approaches and Biological Age Prediction
This study aims to enhance personalized and preventive care for non-communicable diseases (NCDs) in Kazakhstan by examining epigenetic factors, predicting biological age and reproductive function using machine learning, and…
- Conditions
- Cardiovascular Diseases (CVD), Type 2 Diabetes, Chronic Respiratory Diseases, Obesity (Disorder)
- Trial name
- NCT06953180
- Testing
- Genetic: DNA analysis
- Where
- Kazakhstan
- Volunteers
- 6,720 people, healthy volunteers welcome
- Sponsor
- Asfendiyarov Kazakh National Medical University
Fetal Origin of Adult Diseases
Maternal Transcriptomic Regulation of the Preimplantation Embryo
The aim of this study is to understand the epigenetic and transcriptomic mechanisms that regulate the fetal origin of adult diseases (FOAD), either for the presence of metabolic disorders in the future mothers, such as obesity or…
- Trial name
- NCT02813746
- Testing
- Fitness program, Stop smoking, Endometrial fluid collection
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Igenomix
Premenstrual Dysphoric Disorder (PMDD)
Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric Disorder
Premenstrual dysphoric disorder (PMDD) is a severe affective disorder impacting millions of women worldwide, thought to be due to altered sensitivity to hormone fluctuations across the menstrual cycle.
- Trial name
- BLOOM (NCT06704594)
- Testing
- sertraline 50 mg daily
- Where
- 2 sites in United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Healthy
Effect of a Multivitamin/Multimineral/Phytochemical Dietary Supplement on Indices of Human Health
This is a global transcriptomics and epigenetic pilot study designed to identify changes in gene expression and DNA methylation patterns following the consumption of an MVM/phytochemical supplement in a small group of healthy…
- Trial name
- NCT03146312
- Testing
- MVM/phytochemical supplement
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- USANA Health Sciences
Chronic Beryllium Disease
Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Disease (CBD)
This study will provide important results for each aim, while also providing an integrative transcriptional and epigenomic profile of CBD.
- Trial name
- BeEpiGen (NCT02604693)
- Testing
- Nothing
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
Healthy
Natural Product System and Lifestyle Modification
The goal of this clinical trial is to learn whether four dietary supplements and lifestyle changes can affect gene expression and blood markers in healthy volunteers. The main questions it aims to answer are: 1.
- Trial name
- NCT06931977
- Testing
- Supplement system + copaiba softgels
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- dōTERRA International
Healthy
Placenta Development Study
This study will help us learn more about how the placenta develops.
- Trial name
- NCT03614312
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Anemia, Coronary Disease
PBM as Strategy to CABG Anemic Patients Bypass Graft (CABG)
Anemia poses risks during coronary artery bypass grafting (CABG), increasing complications and mortality rates. Blood transfusions in cardiac surgery have negative outcomes, prompting the use of erythropoietin in Patient Blood…
- Conditions
- Anemia, Coronary Disease, Coronary Artery Disease, Coronary Stenosis
- Trial name
- NCT06542393
- Testing
- Erythropoietin, blood transfusion
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Aberrant DNA Methylation
Methyl-Donors and EpiGenetics in The Gambia
Accumulating evidence suggests that early-life nutrition can affect metabolism and thus increase the risk of disease in adulthood (e.g. type II diabetes and obesity).
- Trial name
- MDEG (NCT01811641)
- Testing
- season, dietary intake
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Medical Research Council
Periimplantitis
The Role of Functional Epigenetic Modifications in Peri-Implantitis
The aim of this pilot, exploratory, single blind clinical trial is to evaluate the epigenetic changes associated with peri-implantitis.
- Trial name
- NCT03753464
- Testing
- Gingival biopsy and blood sample collection
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- NYU College of Dentistry
Female Infertility, Gene Deregulation
Characterization of Methylation Pattern in Human Germ Cells of Patients Undergoing ICSI Treatment
There is increasing evidence that exposure to environmental factors in early development is associated with an increased risk of metabolic and other common diseases.
- Trial name
- NCT03565107
- Where
- Germany
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Infertility Treatment Center Dortmund
Aging
Reversing Epigenetic & Other Markers of Senescence by Transfusing Young Plasma To Older Human Subjects
This trial is designed to study the effects of monthly transfusions of young healthy male donor plasma on biological age as assessed by DNA methylation levels, and changes in cognitive, renal, and pulmonary function, muscle…
- Trial name
- RESET-YOUTH (NCT03353597)
- Testing
- Plasma Transfusion
- Where
- United States
- Volunteers
- 2,120 people, healthy volunteers welcome
- Sponsor
- Chandra Duggirala
Self-harm, Personality Disorder, Borderline
Self-harm Behaviour Among the Most At-risk Adolescents
In the proposed study, three objectives will be pursued: 1. To develop a method to identify more effectively the acute and long-term risk of adolescents with the most threatening self-harm behaviours. 2.
- Conditions
- Self-harm, Personality Disorder, Borderline, Epigenetic Disorder, Non-Suicidal Self Injury
- Trial name
- SH-MARA (NCT05765864)
- Testing
- Enrollment questionnaire, General questionnaire1, General questionnaire2, General questionnaire3, Columbia Suicide Severity Rating Scale (CSSRS), The Brief Non-Suicidal Self-Injury Assessment Tool (B-NSSI-AT)
- Where
- 2 sites in Slovenia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Ljubljana, Faculty of Medicine
Fat Mass, Risk Factors Cardiovascular Disease
Follow up Study of Varapodio Trial: Effect of Longevity and Fasting Mimicking Diet on Risk Factors Age Correlated and Biomarkers of Aging
A large ongoing randomized, open-label trial aimed at evaluating the effects of two different dietary interventions, FMD and LD, on body composition and cardiovascular (CV) biomarkers in a real word population (NCT05698654) is…
- Conditions
- Fat Mass, Risk Factors Cardiovascular Disease, Epigenetic Aging, Metabolism Changes
- Trial name
- NCT07255300
- Testing
- fasting mimicking diet
- Where
- Italy
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Fondazione Valter Longo
Bipolar Disorder, Frontotemporal Dementia, Behavioral Variant
A Study of the Behavioral Variant of Frontotemporal Dementia and Bipolar Disorder: a Neuroimaging and Epigenetics Integrated Approach
The aim of this study is to investigate the selective epigenetic modifications and their effect on brain's morphology and functionality in the frontotemporal dementia behavioral variant and bipolar disorder.
- Trial name
- DISBAND (NCT06706687)
- Testing
- DISBAND protocol
- Where
- Italy
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Down Syndrome
Genetic and Epigenetic Variations in Heterokaryotypic Monozygotic Twins Discordant for Down Syndrome
Heterokaryotypic monozygotic twins discordant for Down syndrome (DS) are very rare, with an incidence estimated to be less than 1 over 7,000,000 pregnancy in the general population.
- Trial name
- Colibri (NCT05767216)
- Testing
- Biological sampling
- Where
- France
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Institut Jerome Lejeune
Bipolar Disorder
Bipolar Disorder Integrative Staging: Incorporating Biomarkers Into Progression Across Stages
Bipolar disorder (BD) is a lifelong, recurrent condition with growing evidence supporting a neuroprogressive course, entailing the need to adopt staging models to guide stage-speci c interventions.
- Trial name
- BOARDING-PASS (NCT07343739)
- Testing
- psychometric clinical assessment, biological acquisition, neuroimaging data
- Where
- Italy
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- ASST Fatebenefratelli Sacco
Puberty, Healthy
Negative Emotionality and Epigenetics During Puberty
Pubertal transition leads to enduring neuroendocrine changes along with changes in the epigenome. The prevalence of psychiatric disorders significantly increases in females compared to males after puberty.
- Conditions
- Puberty, Healthy, Stress
- Trial name
- NCT06690866
- Testing
- Stress
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- International Research Training Group 2804
Inflammatory Bowel Diseases
Biobank - Investigating the Gut Microbiota, Genetics, Epigenetics and Metabolites
Inflammatory bowel disease (IBD) affects 1 in 500 to 1,000 people in the West. Previously a disease predominantly of the West, there is now a marked increase in the incidence of ulcerative colitis (UC) and Crohn's disease (CD) in…
- Trial name
- NCT03855657
- Where
- Hong Kong
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Pregnancy Related, Physical Activity
FitMum: Fitness for Good Health of Mother and Child
A physically active lifestyle during pregnancy has potential to improve maternal and child health. However, less than four out of ten Danish pregnant women succeed to achieve 30 minutes of daily physical activity at moderate…
- Trial name
- FitMum-RCT (NCT03679130)
- Testing
- Structured supervised exercise training, Motivational counseling supported by health technology
- Where
- Denmark
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Nordsjaellands Hospital