Clinical trials: Epigenomics
Epigenomics, Transcriptomics
Epigenomic and Transcriptomic Analysis in BRCA Mutated Carriers With and Without Serous Tubal Intraepithelial Carcinoma
High-grade serous ovarian cancer (HGSOC) is the most lethal gynecologic malignancy and is typically diagnosed at an advanced stage, limiting opportunities for early detection and intervention.
- Conditions
- Epigenomics, Transcriptomics, BRCA Mutations
- Trial name
- PRE-PROBE (NCT07736300)
- Testing
- Peripheral blood sampling performed for germline DNA extraction and assessment of BRCA1/2 mutation status.
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Retinoid, Skin Aging
A Study to Evaluate the Effect of a Topical Retinol on Epigenetic Changes and Expression of Certain Genes in the Skin Using Non-invasive Measurements
This study is being conducted to confirm whether skin tape stripping methodology can identify changes in gene expression (i.e. whether different genes are turned on to make proteins) in aged skin after use of a retinoid.
- Conditions
- Retinoid, Skin Aging, Epigenomics
- Trial name
- NCT06658847
- Testing
- Night Cream Usage, No Night Cream Usage
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Cachexia, Neoplasms
Cancer-associated Muscle Mass - Molecular Factors and Exercise Mechanisms
Muscle mass loss is a common adverse effect of cancer. Muscle mass loss occurs with or without reduction in body weight. Cancer cachexia (CC) is the involuntary loss of body weight of >5% within 6 months and it occurs in 50-80%…
- Conditions
- Cachexia, Neoplasms, Exercise, Metabolism
- Trial name
- PANACEA (NCT05307367)
- Testing
- Exercise training
- Where
- Denmark
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen