Clinical trials: Epilepsy Lobe Temporal
Epilepsy, Epilepsy, Temporal Lobe
Language Mapping in Patients With Epilepsy
This study will examine how certain language skills, such as naming objects, understanding spoken language and reading are organized in the brain and how they are affected by seizures.
- Conditions
- Epilepsy, Epilepsy, Temporal Lobe, Partial Epilepsy
- Trial name
- NCT00706160
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Focal Epilepsy
Anti-Epilepsy Medication Valproate Administered Via ICV Route and Catheters and Pumps for CSF Infusion
This is a non-randomized open-label extension study for subjects having completed protocol DA071976 or CLN100P.01.
- Trial name
- NCT04529954
- Testing
- Valproic Acid delivered to ICV
- Where
- 8 sites in Australia, Israel
- Volunteers
- 20 people
- Sponsor
- Cerebral Therapeutics LLC
Epilepsy, Temporal Lobe
Enhanced MRI Imaging in Healthy Participants and Participants With Epilepsy
Temporal lobe epilepsy (TLE) is a common type of epilepsy and one of the most likely to not be controlled by medication. For patients who do not respond to medication, surgery can result in a cure of seizures.
- Trial name
- NCT06483061
- Testing
- Ferumoxytol
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Epilepsy, Hippocampal Sclerosis
Gene Expression Changes of Brain Tissue in Human Temporal Lobe Epilepsy With Hippocampal Sclerosis
Epilepsy is a common neurological disease, manifested in the sudden abnormal discharge of neurons leading to short-term brain dysfunction, has become the neurology after headache the second most common disease.
- Trial name
- NCT04917939
- Testing
- RNA sequencing
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Temporal Lobe Epilepsy (TLE)
MRI Volumetry and Diffusion Tensor Imaging in Temporal Lobe Epilepsy
This works aims at evaluating the diagnostic performance of combined MRI Volumetry, Diffusion tensor imaging and Conventional MRI in lateralizing the epileptogenic focus in patients with temporal lobe epilepsy and correlate these…
- Trial name
- NCT07384351
- Testing
- MRI
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Assiut University
Temporal Lobe Epilepsy (TLE), Drug Resistant Epilepsy
Overnight TI in TLE
The goal of this clinical trial is to gauge whether overnight, non-invasive temporal interference (TI) stimulation aimed at the hippocampus can reduce abnormal brain activity linked to seizures and improve sleep in adults with…
- Conditions
- Temporal Lobe Epilepsy (TLE), Drug Resistant Epilepsy, Sleep
- Trial name
- TI-HPC-TLE (NCT07434986)
- Testing
- Non-invasive Temporal Interference (TI) Stimulation Targeting Bilateral Hippocampi
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Refractory Epilepsy
Study to Assess Intracerebroventricular (ICV) Delivery of CT-010 in Subjects With Focal Seizures, With Temporal Lobe Onset With or Without Secondary Generalization
This is a Phase 2 double-blind, randomized, placebo-controlled study to assess the safety and efficacy of ICV delivery of CT-010 via an implantable pump and a cranial port and dual lumen catheter (CIC) in subjects with focal…
- Trial name
- NCT04153175
- Testing
- ICV delivery of CT-010 via an implantable pump and a cranial port and dual lumen catheter (CIC)
- Where
- 11 sites in Australia, Israel
- Volunteers
- 30 people
- Sponsor
- Cerebral Therapeutics LLC
Epilepsy, Temporal Lobe
A Deep Learning Framework for Pediatric TLE Detection Using 18F-FDG-PET Imaging
This study aims to use radiomics analysis and deep learning approaches for seizure focus detection in pediatric patients with temporal lobe epilepsy (TLE).
- Trial name
- NCT04169581
- Where
- China
- Volunteers
- 201 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Mesial Temporal Lobe Epilepsy
Low Frequency Electrical Stimulation of the Fornix in Intractable Mesial Temporal Lobe Epilepsy (MTLE)
The primary aim of the current proposal is to evaluate safety and tolerability, in terms of neuropsychological effects of low frequency electrical stimulation of the fornix (LFSF) in participants with medically-intractable Mesial…
- Trial name
- MTLE-DBS (NCT02383407)
- Testing
- Medtronic Deep Brain Stimulation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- George Washington University
Epilepsy, MTLE
Exploratory Study of UX-GIP001 Cell Therapy in Adult Patients With Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (MTLE)
This is an exploratory clinical trial (Protocol: UX-GIP001-101) investigating UX-GIP001 Injection, a novel cell therapy product consisting of human GABAergic interneuron progenitor cells (GIP), for treating adult patients with…
- Trial name
- NCT07244328
- Testing
- UX-GIP001
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Depression, Epilepsy, Temporal Lobe
CBT Versus Selective Serotonin Reuptake Inhibitor For Treatment Of Depression In Temporal Lobe Epilepsy Patients
The aim of the study is to compare the effect of group-cognitive-behavioral therapy (CBT)versus treatment as usual with the selective serotonin reuptake inhibitor sertraline, in patients with diagnosis of temporal lobe epilepsy…
- Trial name
- CBTvsSSRI (NCT02262156)
- Testing
- Cognitive behavioral therapy, SSRI
- Where
- Mexico
- Volunteers
- 15 people
- Sponsor
- El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez
Epilepsy, Temporal Lobe
Hippocampal and Thalamic DBS for Bilateral Temporal Lobe Epilepsy
The study aims to compare the safety and effectiveness of deep brain stimulation of the hippocampus and the anterior nucleus of the thalamus for reducing the frequency of seizures in patients with bilateral temporal lobe epilepsy.
- Trial name
- NCT04164056
- Testing
- deep brain stimulation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Epilepsy, Epilepsy, Temporal Lobe
Brain Network Activation Analysis in Epilepsy
This is a prospective study investigating the utility of Brain Network Activation (BNA) analysis in patients with epilepsy.
- Trial name
- NCT03265925
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- ElMindA Ltd
Epilepsy, Drug Resistant
Piriform Cortex Electrical Stimulation for Temporal Lobe Epilepsy With Biliteral Hippocampus Sclerosis
The primary objective of this research is to study the efficacy and safety of deep brain stimulation (DBS) of Piriform cortex as adjunctive therapy for reducing the frequency of seizures in drug-resistant temporal lobe epilepsy…
- Trial name
- NCT07128563
- Testing
- piriform cortex-DBS
- Volunteers
- 5 people
- Sponsor
- Xuanwu Hospital, Beijing
Epilepsy
Human Thalamus in Propagation of Temporal Lobe Seizures and Memory Formation
The goal of the study is to examine how two key subregions of the human thalamus (ANT and PLV) are connected with other brain structures (Aim 1), how seizures involve the two thalamic subregions differently and how the map of…
- Trial name
- NCT07226908
- Testing
- Cognitive experiment, Electrical stimulation of the brain
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Epilepsy
Evaluation of the 24/7 EEG SubQ System for Ultra Long-Term Recording of Patients With Epilepsy Involving the Temporal Lobe Region.
The 24/7 EEG™ SubQ system will be compared to simultaneously recorded video-EEG in the Epilepsy Monitoring Unit (gold standard) and to self-reported seizure log books throughout 12 weeks of outpatient EEG recording.
- Trial name
- NCT04526418
- Testing
- 24/7 EEG™ SubQ system
- Where
- 12 sites in United States, Belgium and 1 more
- Volunteers
- 64 people
- Sponsor
- UNEEG Medical A/S
Epilepsy
Controlled Randomized Stimulation Versus Resection (CoRaStiR)
Patients will be prospectively randomized to 3 different treatment arms: Treatment group 1: patients who undergo medial temporal lobe resection Treatment group 2: patients who receive immediate hippocampal neurostimulation…
- Trial name
- NCT00431457
- Testing
- Implantation of an intracranial electrode, amygddohyppocampertomy
- Where
- 3 sites in Belgium, Germany
- Volunteers
- 12 people
- Sponsor
- University Hospital, Ghent
Temporal Lobe Epilepsy
Subcutaneous EEG in Epilepsy
The study is a two-phase study, which aims to explore the uses of a novel electrode type in detecting epileptic seizures. The electrode is designed for subcutaneous implantation with long-term monitoring in mind.
- Trial name
- NCT02946151
- Testing
- UNEEG implantable EEG electrode and data storage device
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Zealand University Hospital
Epilepsy, Temporal Lobe, Amygdalo-Hippocampal Epilepsy
EASINESS-TRIAL - Enhancing Safety in Epilepsy Surgery
To conduct a retrospective multicenter cohort study to define surgical benchmark values for best achievable outcomes following surgery for mesial temporal lobe epilepsy.
- Trial name
- NCT04952298
- Testing
- Mesial temporal lobe epilepsy surgery
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Temporal Lobe Epilepsy
Closed Loop Auditory Stimulus in Sleep and epilepsY
This is a single-centre pilot study of a non-invasive auditory stimulation during sleep in participants with temporal lobe epilepsy.
- Trial name
- CLASSY (NCT05159609)
- Testing
- Closed loop auditory stimulus
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- Cardiff and Vale University Health Board