Clinical trials: Epilepsy Surgery
Epilepsy
Effect of Music Therapy on Cognitive Recovery
Participation in music therapy will result in improvement in cognitive functioning, as measured by neuropsychological testing 9-12 months following surgery.
- Trial name
- NCT01947088
- Testing
- Music Therapy
- Where
- United States
- Sponsor
- Seton Healthcare Family
Epilepsy
The Influence of SISCOM on Intracranial Electrode Implantation in Epilepsy Surgical Candidates
The aim of this study is to determine the role of SISCOM (see below) in aiding clinicians to manage epilepsy surgery candidates. SISCOM is already a routine component of pre-surgical epilepsy evaluation at Mayo Clinic.
- Trial name
- NCT00587951
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Epilepsy
Cartography of Functional and Epileptic Cerebral Areas by Functional MRI and Electroencephalography in Epileptic Patients Before and After Surgery
Exploring the reorganization (plasticity) of neuroanatomic networks associated with language and memory in patients with left (or dominant hemisphere) temporal lobe epilepsy using functional MRI (fMRI)
- Trial name
- NCT03102957
- Testing
- functional MRI
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Epilepsy
Functional Link Between Hippocampal and Vestibular Systems: a Pilot Study in Epilepsy Surgery
Vestibular signals deeply influence hippocampal spatial representations and may contribute to the navigational deficits of humans with vestibular dysfunction.
- Trial name
- HIPPOCAMPE (NCT01285921)
- Testing
- vestibular test before and after hippocampal surgery
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Epilepsy
Study of Direct Brain Recording and Stimulation for Memory Enhancement
Background: Epilepsy is a seizure disorder. Sometimes it is treated with surgery. During surgery, electrodes are placed on or in the brain. Researchers want to learn more about memory and the brain.
- Trial name
- NCT04095026
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy in Children, Focal Epilepsy
Novel Network Analysis of Intracranial Stereoelectroencephalography
Epilepsy is a disorder of the brain which is associated with disabling seizures and affects 100,000 people under 25. Many children with epilepsy also have a learning disability or problems with development.
- Conditions
- Epilepsy in Children, Focal Epilepsy, Epilepsy Intractable, Epilepsy, Focal
- Trial name
- NNAIS (NCT03916848)
- Testing
- Combined Micro-Macro SEEG Electrodes
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Epilepsy, Cardiac Disease
Epileptic Potentials During Cardiac Surgery and Association With Postoperative Neurological Outcome
Primarily, the investigators want to test the hypothesis that it is possible to detect epileptiform EEG during cardiac surgery under general anesthesia.
- Conditions
- Epilepsy, Cardiac Disease, Peroperative Complications, Anesthesia; Adverse Effect
- Trial name
- EPOCAS (NCT02976584)
- Where
- Switzerland
- Volunteers
- 1,067 people
- Sponsor
- Heiko Kaiser
Partial Drug-resistant Epilepsy
High Resolution Imaging of Cerebral Vasculature by Functional Micro-Doppler Sonography During Brain Surgery
High Resolution Imaging of Cerebral Vasculature by Functional Micro-Doppler Sonography During Brain Surgery (ULYS)
- Trial name
- ULYS (NCT02090569)
- Testing
- Functional micro-Doppler Sonography (fmDS)
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Centre Hospitalier St Anne
Epilepsy, Neurologic Manifestations
Infrared Camera for Brain Mapping During Surgery
It is extremely important to identify and distinguish healthy brain tissue from diseased brain tissue during neurosurgery. If normal tissue is damaged during neurosurgery it can result in long term neurological problems for the…
- Trial name
- NCT00001554
- Testing
- intraoperative infrared (IR) neuroimaging
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Postoperative Seizures After Brain Tumor Surgery
Levetiracetam for Seizure Prevention After Brain Tumor Surgery
This study aims to evaluate the efficacy and safety of levetiracetam for the prevention of postoperative seizures in adult patients undergoing supratentorial brain tumor surgery.
- Trial name
- PREVENT (NCT07239115)
- Testing
- Levetiracetam
- Where
- China
- Volunteers
- 558 people
- Sponsor
- Beijing Tiantan Hospital
Temporal Lobe Epilepsy, Open Surgery
Minimally Invasive Surgical Epilepsy Trial for Temporal Lobe Epilepsy
Temporal lobe epilepsy (TLE) is a chronically neurological disease characterized by progressive seizures. TLE is the most frequent subtype of refractory focal epilepsy in adults.
- Conditions
- Temporal Lobe Epilepsy, Open Surgery, Minimally Invasive Surgery
- Trial name
- MISET-TLE (NCT05019404)
- Testing
- Functional anterior temporal lobectomy (FATL), Anterior temporal lobectomy (ATL)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Refractory Localization-related Epilepsy
A New Method for Delineation of Epileptic Brian Tissue During Epilepsy Surgery (The HFO Study)
Epilepsy occurs in 0.5-0.7% of the population, of which 25% are children. 30% Of patients with focal epilepsy do not respond well to medication and half of them are eligible for epilepsy surgery.
- Trial name
- NCT02207673
- Testing
- Tailoring of the resection based on biomarker in aEcoG during epilepsy surgery
- Where
- 2 sites in Netherlands
- Volunteers
- 78 people
- Sponsor
- UMC Utrecht
Epilepsy Intractable, Focal Epilepsy
National Study on the Interest of EEG-fMRI in the Presurgical Evaluation of Partial Epilepsies Drug
The main goal of this study is to evaluate the additional value of EEG-fMRI method in the presurgical evaluation of focal intractable epilepsy.
- Trial name
- ENERGY (NCT03278210)
- Where
- France
- Volunteers
- 102 people
- Sponsor
- University Hospital, Lille
Refractory Epilepsy, Focal Epilepsy
Study of Predictive Biomarkers for Rational Management of Drug-resistant Epilepsy Associated With Focal Cortical Dysplasia
Focal Cortical Dysplasias (FCDs) are neurodevelopmental disorders that represent a major cause of early onset drug-resistant epilepsies with cognitive and behavioral impairments, carrying a lifelong perspective of disability and…
- Conditions
- Refractory Epilepsy, Focal Epilepsy, Focal Cortical Dysplasia
- Trial name
- SPREAD (NCT03321240)
- Testing
- visual and quantitative SEEG signal analysis, Resective epilepsy surgery procedure
- Where
- 11 sites in France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Strasbourg, France
Parkinson Disease, Essential Tremor
Comparison of the Electric Plasma Surgical Tool "PlasmaBlade" for Replacement of the Deep Brain Stimulation (DBS) Devices With Conventional Surgery
The deep brain stimulation is surgical technique used for the Parkinson's disease, essential tremor, dystonia, epilepsy, and psychiatric diseases.
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia, Epilepsy
- Trial name
- NCT05535556
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Epilepsy
Evaluation of the FYNA Research OPM MEG Device for Locating Epileptic Foci as Part of Pre-surgical Assessment of Epilepsy
The success of epilepsy surgery depends largely on the reliability of the preoperative localization of the epileptogenic zone. The conventional method for determining the area to be removed is based on a complex assessment…
- Trial name
- EPI-OPM (NCT07281222)
- Testing
- MEG OPM, MEG SQUID
- Where
- 3 sites in France
- Volunteers
- 70 people
- Sponsor
- Hospices Civils de Lyon
Epilepsy, Surgery--Complications
Complications After Epilepsy Surgery
Epilepsy surgery is effective for refractory epilepsy, particularly focal epilepsy, but is still underutilized worldwide. In the United States, the annual percentage of surgical procedures for refractory epilepsy was low (range…
- Trial name
- NCT04727892
- Testing
- epilepsy surgery
- Volunteers
- 2,026 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Focal Epilepsy With and Without Secondary Generalization
Psychological and Psychiatric Assessment in Patients Eligible for Epilepsy Surgery
The aim of the study is to describe the socio-demographic, clinical, psychological, and psychiatric characteristics of patients with drug-resistant focal epilepsy eligible for epilepsy surgery and any changes in these parameters…
- Trial name
- PsychoSurgery (NCT06792383)
- Testing
- quality of life
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Tuberous Sclerosis Complex, Epilepsy
The Effectiveness and Safety of Resective Epilepsy Surgery for TRE
A prospective cohort studies to identify clinical seizure control, cognitive changes, and safety in resective epilepsy surgery in patients with TSC-related drug-resistant epilepsy.
- Trial name
- NCT04198181
- Testing
- Surgery
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Children's Hospital
Epilepsy (Treatment Refractory)
Determinants of Adaptive Behavior Through the Vineland Scale in Pediatric Patients With Severe and Drug-resistant Epilepsy
Our interest in studying how pediatric patients develop after epilepsy surgery stems from the fact that difficult-to-control epilepsy causes changes in the brain's formation or functioning, leading some patients to experience…
- Trial name
- NCT06832020
- Where
- Brazil
- Volunteers
- 369 people
- Sponsor
- Ana Valeria Duarte Oliveira