Clinical trials: Epiretinal Macular Membrane
Epiretinal Membrane, Macular Hole
UNITY VCS Vitreoretinal Surgery
This purpose of this study is to compare the safety and effectiveness of two eye surgery systems-UNITY VCS and CONSTELLATION-in treating adults with vitreoretinal diseases or disorders.
- Conditions
- Epiretinal Membrane, Macular Hole, Visually Significant Vitreous Floater, Vitreomacular Traction
- Trial name
- NCT07054281
- Testing
- UNITY Vitreoretinal Cataract System (VCS), CONSTELLATION Vision System, Vitreoretinal ophthalmic surgery
- Where
- 8 sites in United States
- Sponsor
- Alcon Research
Macular Edema, Epiretinal Membrane
Epiretinal Membrane and Pseudophakic Cystoid Macular Edema
Prospective, observational cohort study evaluating the association between pre-surgical existence of an epiretinal membrane (ERM) and the development of pseudophakic cystoid macular edema (PCME) using spectral domain optical…
- Trial name
- NCT02693353
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Loma Linda University
Epiretinal Membrane, Macular Hole
Association of Lutein, Zeaxanthin and Brilliant Blue in Chromovitrectomy
The aim of this study is to test the efficacy of the combination of dye Lutein, Zeaxanthin and brilliant blue to stain the internal limiting membrane as well as the epiretinal membranes during the Vitrectomy surgery.
- Conditions
- Epiretinal Membrane, Macular Hole, Proliferative Diabetic Retinopathy
- Trial name
- NCT01627977
- Testing
- Dye of Lutein, Zeaxanthin and Brilliant Blue
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- Federal University of São Paulo
no Obvious Abnormalities, Diabetic Retinopathy (DR)
Retinal Clinical Assessment With AI-derived Quantitative Information
This randomized controlled trial evaluates whether providing clinicians with AI-derived quantitative retinal information improves the quality and efficiency of retinal clinical assessment.
- Conditions
- no Obvious Abnormalities, Diabetic Retinopathy (DR), AMD, Cup-to-disc Ratio Bigger Than 0.5
- Trial name
- NCT07291960
- Testing
- AI-derived retinal quantitative information-assisted reporting
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Epiretinal Membrane, Cellophane Maculopathy
Ozurdex for Macular Edema Post Membrane Peeling
An epiretinal membrane is scar tissue on the retina that can cause blurring and distortion of vision and lead to swelling, or macular edema.
- Conditions
- Epiretinal Membrane, Cellophane Maculopathy, Macular Edema, Retinal Edema
- Trial name
- NCT01273727
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Retina Specialists, PC
Pseudophakic Cystoid Macular Oedema, Epiretinal Membrane
Epiretinal Membrane and Cystoid Macular Oedema Post-cataract Surgery
This study examines whether the presence of an epiretinal membrane affects the time to resolution, requirement for non-topical treatment, and outcome of pseudophakic cystoid macular oedema.
- Trial name
- EPIC (NCT03965078)
- Testing
- topical (eye drop) anti-inflammatories
- Where
- United Kingdom
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Vitrectomy, Macular Pucker
Assessing the Efficacy and Safety fo DEXTENZA, Sustained Release Dexamethasone 0.4 mg Insert(s) for the Treatment of Pain, Inflammation, and Cystoid Macular Edema Following 27 Gauge Vitrectomy With Internal Limiting Membrane Peel for the Treatment of Retinal Edema Associated With Macular Pucker.
Assessing the efficacy and safety of DEXTENZA, sustained release dexamethasone 0.4 mg inserts following 27 gauge vitrectomy with internal limiting membrane peel
- Conditions
- Vitrectomy, Macular Pucker, Retinal Edema
- Trial name
- NCT04501367
- Testing
- Dexamethasone Intracanalicular Insert, 0.4 mg, Prednisone acetate 1%
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Kovach Eye Institute
Macular Hole
An Objective Evaluation of Postoperative Positioning in Macular Hole Surgery
The macular hole formation takes place in the centre of the retina. A closure of the macular hole is believed to take place if the central retinal area is kept dry in the postoperative period.
- Trial name
- NCT02011165
- Testing
- Positioning measuring device
- Where
- 2 sites in Norway
- Volunteers
- 43 people
- Sponsor
- Helse Stavanger HF
Epiretinal Membrane, Macular Holes
Surgical Outcome of Macular Membrane Peeling Associated With Significant Macular Drusen
Surgical outcome of patients with macular drusen and co-existing abnormalities of the vitreoretinal interface, who routinely undergo pars plana vitrectomy with membrane peeling, is evaluated.
- Conditions
- Epiretinal Membrane, Macular Holes, Age Related Macular Degeneration
- Trial name
- NCT03927430
- Testing
- pars plana vitrectomy with membrane peeling
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Klinikum Chemnitz gGmbH
Epiretinal Membrane, Macular Pucker
Morphologic Changes After Membrane Peeling With Air Tamponade and Balanced Salt Solution
During the last decade optical coherence tomography (OCT) extended the possibilities for in vivo macula diagnostic and was increasingly used for pre- and post-operative imaging of retinal diseases.
- Trial name
- NCT02319655
- Testing
- Air tamponade, Balanced salt solution filling
- Where
- Austria
- Volunteers
- 85 people
- Sponsor
- Prim. Prof. Dr. Oliver Findl, MBA
Epiretinal Membrane, Macular Edema
Dexamethasone Intravitreal Implant After Vitrectomy For Epiretinal Membrane
The purpose of this study is to evaluate the effect of dexamethasone intravitreal implant (Ozurdex) in combination with pars plana vitrectomy and membrane peeling for idiopathic epiretinal membrane (ERM).
- Trial name
- OZURDEX2 (NCT01410201)
- Testing
- Dexamethasone Intravitreal Implant
- Where
- 3 sites in United States
- Volunteers
- 6 people
- Sponsor
- Barnes Retina Institute
Epiretinal Membrane, Macular Holes
Comparative Study of Sharkskin Versus Grieshaber Forceps During ILM Peeling
The purpose of this study is to compare the performance and anatomic outcomes of the Sharkskin internal limiting membrane (ILM) forceps and the Grieshaber ILM forceps in macular surgery.
- Trial name
- NCT04459949
- Testing
- Sharkskin, Grieshaber
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Vitrectomy
PK Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Patients Undergoing Vitrectomy
The purpose of this study is to evaluate the pharmacokinetics (PK) of dexamethasone phosphate ophthalmic solution delivered via the EyeGate® II Drug Delivery System (EGDS) in patients undergoing vitrectomy for macular hole repair…
- Trial name
- NCT02644694
- Testing
- Dexamethasone Phosphate Ophthalmic Solution
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Eyegate Pharmaceuticals, Inc.
Macular Pucker, Macular Hole
Brilliant Blue Versus Indocyanine Green
A study of non-inferiority design comparing brilliant blue and indocyanine green as intraoperative dye in macular pucker and macular hole.
- Conditions
- Macular Pucker, Macular Hole, Vitreoretinal Surgery
- Trial name
- NCT01083004
- Testing
- Indocyanine green, Brilliant blue arm
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Cologne
Epiretinal Membrane
Comparision of Retinal Function and Macular Structure After 27G Pars Plana Vitrectomy With Minimal Illuminiation
Purpose: To analyze the clinical benefits of using the NGENUITY 3D Visualization System in vitreoretinal surgery with low levels of endo-illumination, focusing on functional and structural retinal protection in patients with…
- Trial name
- ERM (NCT06798285)
- Testing
- Pars Plana Vitrectomy Standard, Pars Plana Vitrectomy 3D
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Pomeranian Medical University Szczecin
Cataract, Vitreous Hemorrhage
Surgical Procedure Efficiency Evaluation stuDy
The purpose of this real-world evidence study is to compare surgical procedure times for UNITY® VCS and CONSTELLATION® Vision System.
- Conditions
- Cataract, Vitreous Hemorrhage, Retinal Detachment, Macular Pucker
- Trial name
- NCT07228091
- Testing
- UNITY VCS, CONSTELLATION
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- Alcon Research
Macula Edema, Radiation Retinopathy
Phase I Study of Episcleral Celecoxib for Treatment of Macular Edema and Inflammatory Disorders of the Posterior Pole
This phase I trial will assess primarily the safety and secondarily the anti-inflammatory and anti-neovascular effect of Episcleral Celecoxib in patients suffering from macular edema and other inflammatory disorders of the…
- Conditions
- Macula Edema, Radiation Retinopathy, Branch Retinal Vein Occlusion, Epiretinal Membrane
- Trial name
- NCT04120636
- Testing
- Episcleral Celecoxib
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Targeted Therapy Technologies, LLC
Macular Holes, Epiretinal Membrane
Multimodal Imaging in Vitreo-retinal Surgery and Macular Dystrophies
The aim of the study is to identify morphological and functional biomarkers of post-operative recovery after vitreoretinal surgery, using decisional support systems (DSS), based on multimodal big-data analysis by means of machine…
- Conditions
- Macular Holes, Epiretinal Membrane, Retinal Detachment, Macular Dystrophies
- Trial name
- MICAI (NCT05747144)
- Testing
- Biometry, Retinography (Color) + Autofluorescence (AF), OCT B-scan and OCT angiography (OCTA)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Epiretinal Membrane, Macular Hole
Fourier Transformed Infrared Spectroscopy in Macular Surgery
Epiretinal membranes (ERM) are disorders leading to vision loss and metamorphopsia. Vitrectomy with membrane peeling has developed to be the gold-standard in treatment of ERM.
- Trial name
- NCT03452748
- Testing
- FTIR spectroscopy
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Cataract
Caffeine and Cataract After Pars Plana Vitrectomy
Assessment of cataract development in patients with regular caffeine consumption and those without caffeine consumption after pars plana vitrectomy.
- Trial name
- NCT06358664
- Testing
- Pars plana vitrectomy
- Where
- Austria
- Volunteers
- 74 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery