Clinical trials: Epiretinal Membrane
Epiretinal Membrane, Macular Oedema
Evaluation of Retinal Parameters in Patients With Epiretinal Membrane After Vitrectomy
The goal of this interventional study is to assess the dynamics of structural and functional retinal changes in eyes with epiretinal membrane (ERM) after pars plana vitrectomy (PPV).
- Conditions
- Epiretinal Membrane, Macular Oedema, Macular Diseases, Retinal Diseases
- Trial name
- NCT07165626
- Testing
- Subtreshold micropulse laser therapy, Pars plana vitrectomy
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Pomeranian Medical University Szczecin
Epiretinal Membrane
Topical Use of Corticosteroid to Prevent Epiretinal Membrane Following Retinal Tear
In this prospective randomized controlled double blind pilot clinical study, we aim to assess whether administration of a topical corticosteroid would attenuate epiretinal membrane formation following development of retinal tears…
- Trial name
- NCT02412059
- Testing
- Prednisolone acetate
- Volunteers
- 200 people
- Sponsor
- Unity Health Toronto
Pseudophakic Cystoid Macular Oedema, Epiretinal Membrane
Epiretinal Membrane and Cystoid Macular Oedema Post-cataract Surgery
This study examines whether the presence of an epiretinal membrane affects the time to resolution, requirement for non-topical treatment, and outcome of pseudophakic cystoid macular oedema.
- Trial name
- EPIC (NCT03965078)
- Testing
- topical (eye drop) anti-inflammatories
- Where
- United Kingdom
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Macular Hole, Epiretinal Membrane
Safety and Efficacy of Double Staining With Brilliant Blue G for Macular Surgery
Study designed to evaluate the safety and efficacy of double staining with brilliant blue G 0.025% as an adjuvant to macular surgery. Patients undergoing surgery for macular hole or epiretinal membrane will be included.
- Trial name
- NCT01820520
- Testing
- brilliant blue G
- Where
- Mexico
- Volunteers
- 22 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Vitrectomy, Retinal Detachment
Pars Plana Vitrectomy With 25-gauge 20000 Cpm, Bevel-tip Cutter
Report efficiency and clinical outcomes using 25-gauge, bevel-tip, 20000 cut per minute vitrectomy probe among eyes with various vitreo-retinal diseases
- Conditions
- Vitrectomy, Retinal Detachment, Vitreous Hemorrhage, Macular Holes
- Trial name
- HYPE (NCT04404296)
- Testing
- 25-gauge, bevel-tip, 20000 cut per minute pars plana vitrectomy
- Where
- Philippines
- Volunteers
- 50 people
- Sponsor
- Peregrine Eye and Laser Institute
Rhegmatogenous Retinal Detachment of Both Eyes (Diagnosis)
Characters of Epiretinal Membranes in Patients With Previous Vitrectomy for Retinal Detachment
31 patients were included in the study,15 cases with ERM in silicone filled eyes and 16 eyes with idiopathic ERM
- Trial name
- RD (NCT04288440)
- Testing
- Surgery, Vitrectomy machine
- Where
- Egypt
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Tanta University
Epiretinal Membrane of Both Eyes
Optical Coherence Tomography Angiography (OCTA) Changes in Patients With Epiretinal Membranes (ERM) With and Without Peeling of the Internal Limiting Membrane (ILM)
Main objective The objective is to compare two surgical options in vitrectomies for epiretinal membranes using parameters of optical coherence tomography angiography.
- Trial name
- NCT05287009
- Testing
- ILM nonpeeling, ILM peeling
- Where
- Austria
- Volunteers
- 51 people
- Sponsor
- Medical University of Graz
Retinal Diseases
UHR-OCT and HD-OCT for Preretinal Membranes: ICG Versus Membrane Blue
Using the UHR-OCT and HD-OCT to evaluate early postoperative changes in patients with diagnosis preretinal membrane after successfully performed pars-plana vitrectomy and membrane peeling with two different types of dyes.
- Trial name
- NCT00437593
- Testing
- ppVE, MP, ICG, ppVE, MP, MB
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery
Macular Pucker, Macular Hole
Brilliant Blue Versus Indocyanine Green
A study of non-inferiority design comparing brilliant blue and indocyanine green as intraoperative dye in macular pucker and macular hole.
- Conditions
- Macular Pucker, Macular Hole, Vitreoretinal Surgery
- Trial name
- NCT01083004
- Testing
- Indocyanine green, Brilliant blue arm
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Cologne
Diabetic Macular Edema, Epiretinal Membrane
Ozurdex for Diabetic Macular Edema Treated With Pars Plana vitrEctomy and Membrane RemovAl (OPERA Study)
This study will examine the use of the dexamethasone implant (Ozurdex) in patients with macular edema associated with an epiretinal or preretinal membrane requiring surgical intervention.
- Trial name
- OPERA (NCT01613716)
- Testing
- Ozurdex
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Cleveland Clinic
Macular Edema
Prophylactic Ketorolac Post Epiretinal Membrane Surgery
Evaluate the efficacy of ketorolac 0.5%, a topical non-steroidal anti-inflammatory drug (NSAID), to prevent macular edema after epiretinal membrane surgery.
- Trial name
- NCT00974753
- Testing
- Ketorolac 0.5%, Saline drops
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Queen's University
Epimacular Membrane
Outcomes Based on the Pre-operative Integrity of IS/OS Junction in Idiopathic Epimacular Membrane Surgery
The aim of this study is to evaluate whether the pre-operative integrity or not of the inner segment (IS) and outer segment (OS) photoreceptoral junction may influence the post-operative visual acuity, the macular morphology…
- Trial name
- NCT04158791
- Testing
- pars plana vitrectomy with epimacular membrane removal and internal limiting membrane peeling
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Retinal Diseases, Fuchs Endothelial Dystrophy
DISCOVER Study: Microscope-integrated Intraoperative OCT Study
Optical coherence tomography (OCT )provides high resolution information regarding the anatomic structure of the tissues of the eye in a cross-sectional and 3 dimensional view.
- Conditions
- Retinal Diseases, Fuchs Endothelial Dystrophy, Macular Hole, Epiretinal Membrane
- Trial name
- DISCOVER (NCT02423213)
- Where
- United States
- Volunteers
- 2,911 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Diabetic Retinopathy, Retinal Vein Occlusion
Computer Aided Diagnosis of Multiple Eye Fundus Diseases From Color Fundus Photograph
Blindness can be caused by many ocular diseases, such as diabetic retinopathy, retinal vein occlusion, age-related macular degeneration, pathologic myopia and glaucoma.
- Conditions
- Diabetic Retinopathy, Retinal Vein Occlusion, Retinal Artery Occlusion, Central Serous Chorioretinopathy
- Trial name
- NCT04723160
- Testing
- Software assisted imaging diagnosis
- Where
- 5 sites in China
- Volunteers
- 748 people, healthy volunteers welcome
- Sponsor
- Visionary Intelligence Ltd.
Epiretinal Membrane
Evaluation of Intraoperative Slow-release Dexamethasone Implant for Epiretinal Membrane
Epiretinal membrane (ERM) is a commonly encountered vitreoretinal interface anomaly with a prevalence of approximately 10% in the adult population.
- Trial name
- NCT05416827
- Testing
- slow-release dexamethasone implant
- Volunteers
- 30 people
- Sponsor
- Peking University People's Hospital
Epiretinal Membrane
Study of Impact of Air vs SF6 20% on Visual Acuity Improvement After Epiretinal Membrane Stripping
The purpose of this study is to determine if one of these gaz (air and sulfur hexafluoride) is better than the other in epiretinal membrane peeling surgery.
- Trial name
- NCT02030262
- Testing
- Epiretinal membrane peeling with fluid-air exchange, Epiretinal membrane peeling with fluid-SF6 exchange
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- CHU de Quebec-Universite Laval
Epiretinal Membrane
Evolution of EIFL Following PPV
Various classification systems have been described for epiretinal membrane (ERM). One of them is a new OCT-based staging scheme based on displacement and reorganization of inner retinal layers called ectopic inner retinal layers…
- Trial name
- NCT06040216
- Testing
- optical coherence tomography
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Kocaeli University
Epiretinal Membrane
Fundus Autofluorescence After Vitrectomy for Epiretinal Membrane
Fundus autofluorescence (FAF) at the macula originates from hyperfluorescence from retinal pigment epithelium (RPE) and blockage of hyperfluorescence by macular pigment.
- Trial name
- NCT02628158
- Testing
- Vitrectomy with internal limiting membrane removal
- Where
- Japan
- Volunteers
- 91 people
- Sponsor
- Kyorin University
Epiretinal Membrane
Cultivation of Hyalocytes From ILM and ERM Samples: a Pilot Study
ILM and ERM are routinely excised during surgery, as part of the surgical technique, and cultivation of hyalocytes will be performed ex vivo after surgery.
- Trial name
- NCT04306718
- Testing
- membrane peeling
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Idiopathic Epiretinal Membranes
Trypan Blue Versus Brillant Blue for Epiretinal Membranes
Membraneppeling alone versus Membranepeeling with Membrane Limitans Interna Pelling using two different Dyes for Epiretinal Membrane Surgery.
- Trial name
- NCT00757380
- Testing
- Trypan Blue, Brillant Blue
- Where
- Austria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery